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Article ; Online: Hepatic Steatosis Associated With Exposure to Elvitegravir and Raltegravir.

Kirkegaard-Klitbo, Ditte Marie / Thomsen, Magda Teresa / Gelpi, Marco / Bendtsen, Flemming / Nielsen, Susanne Dam / Benfield, Thomas

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2021 Volume 73, Issue 3, Page(s) e811–e814

Abstract: Moderate-to-severe hepatic steatosis in people living with human immunodeficiency virus (HIV) without viral hepatitis or excessive alcohol intake was associated with cumulative exposure to stavudine, elvitegravir, and raltegravir. Prospective trials are ... ...

Abstract	Moderate-to-severe hepatic steatosis in people living with human immunodeficiency virus (HIV) without viral hepatitis or excessive alcohol intake was associated with cumulative exposure to stavudine, elvitegravir, and raltegravir. Prospective trials are required to establish a causal association. Clinical Trials Registration. NCT02382822.
MeSH term(s)	HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Prospective Studies ; Quinolones/adverse effects ; Raltegravir Potassium/adverse effects
Chemical Substances	Quinolones ; Raltegravir Potassium (43Y000U234) ; elvitegravir (4GDQ854U53)
Language	English
Publishing date	2021-01-25
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab057
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Article ; Online: Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis.

Kirkegaard-Klitbo, Ditte Marie / Bendtsen, Flemming / Lundgren, Jens / Nielsen, Susanne Dam / Benfield, Thomas

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2019 Volume 18, Issue 13, Page(s) 3049–3050

Abstract: People living with human immunodeficiency virus (PLWH) are at higher risk of liver fibrosis compared with the general population. As liver fibrosis is independently associated with poor long-term liver related outcomes and mortality, ...

Abstract	People living with human immunodeficiency virus (PLWH) are at higher risk of liver fibrosis compared with the general population. As liver fibrosis is independently associated with poor long-term liver related outcomes and mortality,
MeSH term(s)	Aspartate Aminotransferases ; Biomarkers ; Biopsy ; Elasticity Imaging Techniques ; Fibrosis ; HIV Infections/complications ; HIV Infections/pathology ; Hepatitis, Viral, Human/pathology ; Humans ; Liver/pathology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology
Chemical Substances	Biomarkers ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2019-10-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2019.10.024
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Article ; Online: High incidence of subclinical peripheral artery disease in people with HIV.

Suarez-Zdunek, Moises Alberto / Høgh, Julie / Kirkegaard-Klitbo, Ditte Marie / Jensen, Anne Marie R / Rupert, Adam / Trøseid, Marius / Gerstoft, Jan / Nielsen, Susanne D / Knudsen, Andreas D

AIDS (London, England)

2022 Volume 36, Issue 10, Page(s) 1355–1362

Abstract: Objective: Atherosclerosis is common in people with HIV (PWH). Peripheral artery disease (PAD) is the peripheral manifestation of atherosclerosis, but little is known about the incidence of PAD in PWH. Our objective was to determine the PAD incidence in ...

Abstract	Objective: Atherosclerosis is common in people with HIV (PWH). Peripheral artery disease (PAD) is the peripheral manifestation of atherosclerosis, but little is known about the incidence of PAD in PWH. Our objective was to determine the PAD incidence in PWH and to investigate potential risk factors. Design: Prospective longitudinal study on PWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) study cohort. Methods: We performed ankle-brachial index (ABI) measurements at study entry and at 2-year follow-up and included participants with normal ABI at study entry. We defined de novo PAD as ABI ≤0.9 at follow-up. Using Poisson regression adjusted for age, sex, and smoking, we investigated the role of traditional and HIV-related risk factors, including inflammatory markers. Results: Of 844 PWH followed for a median duration of 2.3 years, 30 (3.6%) developed de novo PAD. All cases were subclinical. Diabetes (relative risk [RR] = 4.90 [95% confidence interval [CI]: 1.99-12.1]), current CD4 + cell count <350 cells/μl (2.66 [1.06-6.71]), longer duration of antiretroviral therapy (antiretroviral therapy [ART], 1.88 [1.06-3.33] per decade), and concentrations of high-sensitivity C-reactive protein (1.33 [1.08-1.63] per doubling) and interleukin-6 (1.38 [1.06-1.80] per doubling), were associated with de novo PAD. Conclusions: PWH had a high incidence of de novo subclinical PAD. Diabetes, low current CD4 + cell count, duration of ART, and inflammatory markers were associated with de novo PAD, indicating a possible role in PAD pathogenesis in PWH.
MeSH term(s)	Atherosclerosis/complications ; Biomarkers ; Diabetes Mellitus/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Incidence ; Longitudinal Studies ; Peripheral Arterial Disease/epidemiology ; Prospective Studies ; Risk Factors
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003252
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Article ; Online: Increased Prevalence of Liver Fibrosis in People Living With Human Immunodeficiency Virus Without Viral Hepatitis Compared to Population Controls.

Kirkegaard-Klitbo, Ditte Marie / Bendtsen, Flemming / Lundgren, Jens / de Knegt, Robert J / Kofoed, Klaus Fuglsang / Nielsen, Susanne Dam / Benfield, Thomas

The Journal of infectious diseases

2020 Volume 224, Issue 3, Page(s) 443–452

Abstract: Background: Liver fibrosis is associated with poor liver-related outcomes and mortality. People with human immunodeficiency virus (PWH) may be at increased risk. We aimed to estimate the prevalence and factors associated with liver fibrosis in PWH ... ...

Abstract	Background: Liver fibrosis is associated with poor liver-related outcomes and mortality. People with human immunodeficiency virus (PWH) may be at increased risk. We aimed to estimate the prevalence and factors associated with liver fibrosis in PWH compared to population controls. Methods: This was a cross-sectional cohort study comparing 342 PWH with 2190 population controls aged 50-70 years.Transient elastography was performed and elevated liver stiffness measurement (LSM) defined as 7.6 kPa as a proxy for significant liver fibrosis. Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were computed by logistic regression. Results: The prevalence of elevated LSM was higher in PWH than in uninfected controls (12% vs 7%; P < .01). Human immunodeficiency virus (HIV) infection was independently associated with elevated LSM. In multivariate analysis, elevated LSM was associated with HIV (aOR, 1.84 [95% CI, 1.17-2.88]; P < .01); higher age (per decade: aOR, 3.34 [95% CI, 1.81-6.18]; P < .01); alanine aminotransferase (ALT) (per 10 IU/L: aOR, 1.25 [95% CI, 1.05-1.49]; P < .01); body mass index (BMI) (per 1 kg/m2: aOR, 1.17 [95% CI, 1.05-1.29]; P < .01), and previous exposure to didanosine (per year: aOR, 2.26 [95% CI, 1.01-5.06]; P = .04). Conclusions: The prevalence of elevated LSM was higher in PWH compared to population controls. Higher age, BMI, ALT, previous exposure to didanosine, and positive HIV status were independently associated with higher odds of elevated LSM.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Didanosine ; Elasticity Imaging Techniques ; HIV ; HIV Infections/complications ; HIV Infections/pathology ; Hepatitis, Viral, Human ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Middle Aged ; Population Control ; Prevalence
Chemical Substances	Didanosine (K3GDH6OH08)
Language	English
Publishing date	2020-12-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiaa763
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Article ; Online: Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication.

Fink, Asbjørn / Knudsen, Andreas Dehlbæk / Thudium, Rebekka Faber / Von Stemann, Jakob Hjorth / Afzal, Shoaib / Lundgren, Jens / Kirkegaard-Klitbo, Ditte Marie / Ostrowski, Sisse Rye / Nordestgaard, Børge G / Nielsen, Susanne Dam

Scientific reports

2021 Volume 11, Issue 1, Page(s) 4383

Abstract: Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross- ... ...

Abstract	Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II-VII-X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II-VII-X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II-VII-X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7-2.9), P < 0.001) and low coagulation factor II-VII-X (aOR 1.4 (95% CI 1.0-1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II-VII-X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II-VII-X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection.
MeSH term(s)	Adult ; Blood Coagulation ; Blood Coagulation Factors/metabolism ; Female ; HIV Infections/blood ; HIV Infections/virology ; Humans ; Male ; Middle Aged ; Phenotype ; Virus Replication
Chemical Substances	Blood Coagulation Factors
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-83731-x
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Article ; Online: [Magnetic resonance imaging for the diagnosis of non-alcoholic fatty liver disease].

Kirkegaard-Klitbo, Ditte Marie / Danielsen, Karen Vagner / Hanson, Lars G / Gluud, Lise Lotte / Siebner, Hartwig Roman / Bendtsen, Flemming / Benfield, Thomas

Ugeskrift for laeger

2019 Volume 181, Issue 9

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease with an estimated overall prevalence of 25% in the global adult population. Liver biopsy is the gold standard for the diagnosis of NAFLD. However, the risk of ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver disease with an estimated overall prevalence of 25% in the global adult population. Liver biopsy is the gold standard for the diagnosis of NAFLD. However, the risk of complications and collection of only 1/50,000 of the total liver volume, limits this diagnostic method in an unselected population. Non-invasive diag-nostic methods are warranted, and magnetic resonance imaging of the liver for NAFLD has shown promising results.
MeSH term(s)	Adult ; Humans ; Liver/diagnostic imaging ; Magnetic Resonance Imaging ; Non-alcoholic Fatty Liver Disease/diagnostic imaging
Language	Danish
Publishing date	2019-02-25
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Article ; Online: Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades.

Harritshøj, Lene Holm / Kirkegaard-Klitbo, Ditte Marie / Mejer, Niels / Panum, Inge / Midgley, Sofie Elisabeth / Ullum, Henrik / Benfield, Thomas

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2019 Volume 84, Page(s) 67–72

Abstract: Background: Hepatitis E virus (HEV) genotype 3 is endemic in Europe, and the infection is mostly subclinical or acute and self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV ( ...

Abstract	Background: Hepatitis E virus (HEV) genotype 3 is endemic in Europe, and the infection is mostly subclinical or acute and self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV (anti-HEV) among HIV-infected persons varies geographically and is unknown in Denmark. Rates of co-infection with HEV among HIV-infected individuals in Denmark over three decades, from the early 1980s to 2013, were investigated. Methods: A total of 2506 HIV-infected persons were investigated from two cohorts followed at Hvidovre Hospital, Denmark. Blood samples were tested retrospectively for anti-HEV, including samples from 2216 persons who were enrolled in a prospective clinical cohort and followed between 1995 and 2013, as well as samples from 290 persons from a historical cohort followed between 1980 and 1994. For anti-HEV seroconverting individuals, serial samples were tested for HEV RNA. Factors associated with anti-HEV status were explored using multivariable logistic regression analysis. Results: The overall HEV seroprevalence rates were stable during the 1980s, 1990s, and 2000-2013 (23.1%, 22.9%, and 23.7%, respectively). In all decades, rates of anti-HEV increased with older age, and anti-HEV seropositivity was associated with older generations, HIV risk group, and geographic origin. Persistent HEV infection was not detected in any of 57 individuals with anti-HEV seroconversion. Conclusions: HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is rare among HIV-infected individuals.
MeSH term(s)	Adult ; Coinfection/epidemiology ; Female ; HIV Infections/complications ; Hepatitis Antibodies/blood ; Hepatitis E virus/immunology ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Risk Factors ; Seroepidemiologic Studies
Chemical Substances	Hepatitis Antibodies ; Immunoglobulin G
Language	English
Publishing date	2019-05-04
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2019.04.029
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Article ; Online: Iodine excretion in school children in Copenhagen.

Rasmussen, Lone B / Kirkegaard-Klitbo, Ditte Marie / Laurberg, Peter / Jørgensen, Torben / Ovesen, Lars / Perrild, Hans

Danish medical journal

2016 Volume 63, Issue 5

Abstract: Introduction: Studies of dietary habits show a high iodine intake in children in Denmark. Iodine excretion in children has not previously been assessed. Iodine excretion in adults is below the recommended threshold, and it is therefore being discussed ... ...

Abstract	Introduction: Studies of dietary habits show a high iodine intake in children in Denmark. Iodine excretion in children has not previously been assessed. Iodine excretion in adults is below the recommended threshold, and it is therefore being discussed to increase the fortification level. The main objective of this study was to assess iodine excretion in children living in Copenhagen to establish whether a moderate increase in iodine fortification would lead to excess iodine intake in this group. Methods: Children in first and fifth grade were recruited through schools in Copenhagen. In total, 244 children de-ivered a urine sample. Urine samples were analysed for iodine and creatinine, and the results were expressed as urinary iodine concentration (UIC) and as estimated 24-h iodine excretion. Iodine excretion in children was also compared with that of adults living in the same area, investigated in a prior study. Results: The median UIC was within the recommended level; 145 (range: 116-201) µg/l for boys and 128 (range: 87-184) µg/l for girls, and was lower in fifth grade students than in first grade students. Estimated 24-h iodine excretion was higher in boys than in girls, but did not differ according to grade. The UIC was higher in children than in adults from the same area. Conclusions: The iodine excretion among schoolchildren in Copenhagen, an area with a relatively high iodine content in tap water, was within the recommended range as assessed by the UIC. An increased iodine fortification will not have negative consequences for this group. Funding: The Ministry of Food, Agriculture and Fisheries. Trial registration: not relevant.
MeSH term(s)	Adult ; Child ; Child Nutritional Physiological Phenomena ; Creatine/urine ; Denmark ; Drinking Water/chemistry ; Female ; Follow-Up Studies ; Food, Fortified ; Humans ; Iodine/analysis ; Iodine/urine ; Male ; Sex Factors ; Sodium Chloride/chemistry
Chemical Substances	Drinking Water ; Sodium Chloride (451W47IQ8X) ; Iodine (9679TC07X4) ; Creatine (MU72812GK0)
Language	English
Publishing date	2016-05
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	2648771-8
ISSN	2245-1919 ; 2245-1919
ISSN (online)	2245-1919
ISSN	2245-1919
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Article ; Online: Prevalence and Risk Factors of Moderate-to-Severe Hepatic Steatosis in Human Immunodeficiency Virus Infection: The Copenhagen Co-morbidity Liver Study.

Kirkegaard-Klitbo, Ditte Marie / Fuchs, Andreas / Stender, Stefan / Sigvardsen, Per Ejlstrup / Kühl, Jørgen Tobias / Kofoed, Klaus Fuglsang / Køber, Lars / Nordestgaard, Børge G / Bendtsen, Flemming / Mocroft, Amanda / Lundgren, Jens / Nielsen, Susanne Dam / Benfield, Thomas

The Journal of infectious diseases

2020 Volume 222, Issue 8, Page(s) 1353–1362

Abstract: Background: People with human immunodeficiency virus (PWH) may be at risk of nonalcoholic fatty liver disease. We compared the prevalence of moderate-to-severe hepatic steatosis (M-HS) in PWH with human immunodeficiency virus (HIV)-uninfected controls ... ...

Abstract	Background: People with human immunodeficiency virus (PWH) may be at risk of nonalcoholic fatty liver disease. We compared the prevalence of moderate-to-severe hepatic steatosis (M-HS) in PWH with human immunodeficiency virus (HIV)-uninfected controls and determined risk factors for M-HS in PWH. Methods: The Copenhagen Co-Morbidity in HIV Infection study included 453 participants, and the Copenhagen General Population Study included 765 participants. None had prior or current viral hepatitis or excessive alcohol intake. Moderate-to-severe hepatic steatosis was assessed by unenhanced computed tomography liver scan defined by liver attenuation ≤48 Hounsfield units. Adjusted odds ratios (aORs) were computed by adjusted logistic regression. Results: The prevalence of M-HS was lower in PWH compared with uninfected controls (8.6% vs 14.2%, P < .01). In multivariable analyses, HIV (aOR, 0.44; P < .01), female sex (aOR, 0.08; P = .03), physical activity level (aOR, 0.09; very active vs inactive; P < .01), and alcohol (aOR, 0.89 per unit/week; P = .02) were protective factors, whereas body mass index (BMI) (aOR, 1.58 per 1 kg/m2; P < .01), alanine transaminase (ALT) (aOR, 1.76 per 10 U/L; P < .01), and exposure to integrase inhibitors (aOR, 1.28 per year; P = .02) were associated with higher odds of M-HS. Conclusions: Moderate-to-severe hepatic steatosis is less common in PWH compared with demographically comparable uninfected controls. Besides BMI and ALT, integrase inhibitor exposure was associated with higher prevalence of steatosis in PWH.
MeSH term(s)	Alanine Transaminase/blood ; Body Mass Index ; Comorbidity ; Denmark/epidemiology ; Fatty Liver/epidemiology ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Integrase Inhibitors/adverse effects ; Male ; Middle Aged ; Odds Ratio ; Prevalence ; Risk Factors
Chemical Substances	Integrase Inhibitors ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2020-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiaa246
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Article ; Online: Increased Risk of Anemia, Neutropenia, and Thrombocytopenia in People With Human Immunodeficiency Virus and Well-Controlled Viral Replication.

Akdag, Delal / Knudsen, Andreas Dehlbæk / Thudium, Rebekka Faber / Kirkegaard-Klitbo, Ditte Marie / Nielsen, Chivit / Brown, Peter / Afzal, Shoaib / Nordestgaard, Børge G / Lundgren, Jens / Nielsen, Susanne Dam

The Journal of infectious diseases

2019 Volume 220, Issue 11, Page(s) 1834–1842

Abstract: Background: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with human immunodeficiency virus (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this ... ...

Abstract	Background: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with human immunodeficiency virus (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia. Methods: PWH with undetectable viral replication and absence of chronic hepatitis infection (n = 796) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n = 2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and high-sensitivity C-reactive protein were performed to determine possible associations between HIV and cytopenias. Results: PWH had a higher prevalence of anemia (6.9% vs 3.4%, P < .001), neutropenia (1.3% vs 0.2%, P < .001), and thrombocytopenia (5.5% vs 2.7%, P < .001) compared with uninfected controls. HIV was independently associated with anemia-adjusted odds ratio (aOR) of 2.0 (95% confidence interval [CI], 1.4-3.0); neutropenia aOR, 6.3 (95% CI, 2.0-19.6); and thrombocytopenia aOR, 2.7 (95% CI, 1.8-4.2). No association was found between HIV and lymphocytopenia. Conclusions: Cytopenia is rare in people with well-controlled HIV, but HIV remains a risk factor for anemia, neutropenia, and thrombocytopenia and requires ongoing attention and monitoring.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anemia/epidemiology ; Anti-HIV Agents/therapeutic use ; Denmark/epidemiology ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Longitudinal Studies ; Lymphopenia/epidemiology ; Male ; Middle Aged ; Neutropenia/epidemiology ; Prevalence ; Risk Assessment ; Sustained Virologic Response ; Thrombocytopenia/epidemiology ; Young Adult
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2019-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiz394
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In stock of ZB MED Cologne/Königswinter

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito