LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 71

Search options

  1. Article ; Online: Cranial radiotherapy has minimal benefit in children with central nervous system involvement in T-ALL.

    O'Connor, David / Joy, Melvin / Enshaei, Amir / Kirkwood, Amy / Kearns, Pamela R / Samarasinghe, Sujith / Moppett, John / Moorman, Anthony V / Vora, Ajay

    Blood advances

    2023  Volume 7, Issue 23, Page(s) 7231–7234

    MeSH term(s) Humans ; Child ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Brain Neoplasms ; Cranial Irradiation/adverse effects ; Central Nervous System
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011267
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: A robust and validated integrated prognostic index for defining risk groups in adult acute lymphoblastic leukemia: an EWALL collaborative study.

    Enshaei, Amir / Joy, Melvin / Butler, Ellie / Kirkwood, Amy A / Messina, Monica / Pavoni, Chiara / Morgades, Mireia / Harrison, Christine J / Foà, Robin / Ribera, Josep-Maria / Chiaretti, Sabina / Bassan, Renato / Fielding, Adele K / Moorman, Anthony V

    Blood advances

    2024  Volume 8, Issue 5, Page(s) 1155–1166

    Abstract: Abstract: Risk stratification is crucial to the successful treatment of acute lymphoblastic leukemia (ALL). Although numerous risk factors have been identified, an optimal prognostic model for integrating variables has not been developed. We used ... ...

    Abstract Abstract: Risk stratification is crucial to the successful treatment of acute lymphoblastic leukemia (ALL). Although numerous risk factors have been identified, an optimal prognostic model for integrating variables has not been developed. We used individual patient data from 4 contemporary academic national clinical trials, UKALL14, NILG-ALL10/07, GIMEMA-LAL1913, and PETHEMA-ALL-HR2011, to generate and validate the European Working Group for Adult ALL prognostic index (EWALL-PI), which is based on white blood cell count, genetics, and end of induction minimal residual disease (MRD). Individual patient risk scores were calculated for 778 patients aged 15 to 67 years in complete remission using the validated UKALL-PI formula, applying minor modifications to reflect differences between pediatric and adult ALL. Per-trial analysis revealed that EWALL-PI correlated with relapse and death. Regression analysis revealed that each unit increase in EWALL-PI increased the risk of relapse or death by ∼30% with no evidence of heterogeneity across trials or patient subgroups. EWALL-PI-defined risk models outperformed the stratification algorithms used by each trial. Threshold analysis revealed an EWALL-PI threshold that divided patients with B cell and T cell into standard (EWALL-PI <2.50) and high (EWALL-PI ≥2.50) risk groups, respectively. Per-trial analysis showed that patients at high risk had a significantly increased relapse rate and inferior survival compared with patients with standard risk (subdistribution hazard ratio for relapse, ranged from 1.85 to 3.28; hazard ratio for death, 1.73 to 3.03). Subgroup analysis confirmed the robustness of these risk groups by sex, age, white blood cell count, and lineage. In conclusion, we validated an integrated risk model across 4 independent adult ALL clinical trials, demonstrating its utility defining clinically relevant risk groups.
    MeSH term(s) Adult ; Humans ; Child ; Prognosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Algorithms ; Risk Factors ; Recurrence
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011661
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Efficacy of central nervous system prophylaxis with stand-alone intrathecal chemotherapy in diffuse large B-cell lymphoma patients treated with anthracycline-based chemotherapy in the rituximab era: a systematic review.

    Eyre, Toby A / Djebbari, Faouzi / Kirkwood, Amy A / Collins, Graham P

    Haematologica

    2019  Volume 105, Issue 7, Page(s) 1914–1924

    Abstract: Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the ...

    Abstract Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the evidence for stand-alone intrathecal prophylaxis has been performed in the era of anti-CD20 monoclonal antibody therapy. A comprehensive search (01/2002-01/2019) was systematically performed using Ovid MEDLINE
    MeSH term(s) Anthracyclines ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Central Nervous System ; Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/prevention & control ; Cyclophosphamide/therapeutic use ; Doxorubicin/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Neoplasm Recurrence, Local ; Prednisone/therapeutic use ; Retrospective Studies ; Rituximab/therapeutic use ; Vincristine/therapeutic use
    Chemical Substances Anthracyclines ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2019-09-05
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2019.229948
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Limited utility of Mayo 2012 cardiac staging system for risk stratification of patients with advanced cardiac AL amyloidosis - analysis of a uniformly treated cohort of 1,275 patients.

    Khwaja, Jahanzaib / Ravichandran, Sriram / Bomsztyk, Joshua / Cohen, Oliver / Foard, Darren / Martinez-Naharro, Ana / Venneri, Lucia / Fontana, Marianna / Hawkins, Philip N / Gillmore, Julian / Lachmann, Helen J / Mahmood, Shameem / Whelan, Carol / Kirkwood, Amy A / Wechalekar, Ashutosh

    Haematologica

    2024  Volume 109, Issue 5, Page(s) 1598–1602

    MeSH term(s) Humans ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Immunoglobulin Light-chain Amyloidosis/mortality ; Immunoglobulin Light-chain Amyloidosis/pathology ; Immunoglobulin Light-chain Amyloidosis/therapy ; Female ; Male ; Aged ; Risk Assessment ; Middle Aged ; Prognosis ; Cohort Studies
    Language English
    Publishing date 2024-05-01
    Publishing country Italy
    Document type Letter ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284348
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Long-Term Follow-Up of the Response-Adjusted Therapy for Advanced Hodgkin Lymphoma Trial.

    Luminari, Stefano / Fossa, Alexander / Trotman, Judith / Molin, Daniel / d'Amore, Francesco / Enblad, Gunilla / Berkahn, Leanne / Barrington, Sally F / Radford, John / Federico, Massimo / Kirkwood, Amy A / Johnson, Peter W M

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 42, Issue 1, Page(s) 13–18

    Abstract: Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial ... ...

    Abstract Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in
    MeSH term(s) Adult ; Humans ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bleomycin/adverse effects ; Cyclophosphamide/therapeutic use ; Dacarbazine/adverse effects ; Doxorubicin/adverse effects ; Follow-Up Studies ; Hodgkin Disease/pathology ; Neoplasms, Second Primary/drug therapy ; Prednisone/therapeutic use ; Vinblastine/adverse effects ; Vincristine/adverse effects
    Chemical Substances Bleomycin (11056-06-7) ; Cyclophosphamide (8N3DW7272P) ; Dacarbazine (7GR28W0FJI) ; Doxorubicin (80168379AG) ; Prednisone (VB0R961HZT) ; Vinblastine (5V9KLZ54CY) ; Vincristine (5J49Q6B70F)
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Clinical Study ; Equivalence Trial ; Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.01177
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Central statistical monitoring in clinical trials

    Kirkwood Amy A / Hackshaw Allan

    Trials, Vol 12, Iss Suppl 1, p A

    2011  Volume 55

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2011-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Outcomes after chimeric antigen receptor T-cell therapy across large B-cell lymphoma subtypes.

    Bourlon, Christianne / Roddie, Claire / Menne, Tobias / Norman, Jane / O'Reilly, Maeve / Gibb, Adam / Besley, Caroline / Chaganti, Sridhar / Arias, Carlos Gonzalez / Jones, Ceri / Dikair, Abdalla / Allen, Sharon / Seymour, Frances / Osborne, Wendy / Mathew, Amrith / Townsend, William / Patten, Piers Em / Thoulouli, Eleni / Abdulgawad, Ahmed /
    Lugthart, Sanne / Sanderson, Robin / Kirkwood, Amy A / Kuhnl, Andrea

    Haematologica

    2024  

    Abstract: Not available. ...

    Abstract Not available.
    Language English
    Publishing date 2024-04-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2024.285010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia.

    O'Connor, David / Demeulemeester, Jonas / Conde, Lucia / Kirkwood, Amy / Fung, Kent / Papaleonidopoulou, Foteini / Bloye, Gianna / Farah, Nadine / Rahman, Sunniyat / Hancock, Jeremy / Bateman, Caroline / Inglott, Sarah / Mee, Jon / Herrero, Javier / Van Loo, Peter / Moorman, Anthony V / Vora, Ajay / Mansour, Marc R

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 19, Page(s) 3545–3556

    Abstract: Purpose: Failure to respond to induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent in T-cell ALL (T-ALL) than B-cell ALL. We aimed to address the limited understanding of clinical and ... ...

    Abstract Purpose: Failure to respond to induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent in T-cell ALL (T-ALL) than B-cell ALL. We aimed to address the limited understanding of clinical and genetic factors that influence outcome in a cohort of patients with T-ALL induction failure (IF).
    Methods: We studied all cases of T-ALL IF on two consecutive multinational randomized trials, UKALL2003 and UKALL2011, to define risk factors, treatment, and outcomes. We performed multiomic profiling to characterize the genomic landscape.
    Results: IF occurred in 10.3% of cases and was significantly associated with increasing age, occurring in 20% of patients age 16 years and older. Five-year overall survival (OS) rates were 52.1% in IF and 90.2% in responsive patients (
    Conclusion: The outcome of IF in T-ALL remains poor with current therapy. The lack of a unifying genetic driver suggests alternative approaches, particularly using immunotherapy, are urgently needed.
    MeSH term(s) Humans ; Young Adult ; Adolescent ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Treatment Outcome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Hematopoietic Stem Cell Transplantation ; T-Lymphocytes ; Prognosis
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02734
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Effective bridging therapy can improve CD19 CAR-T outcomes while maintaining safety in patients with large B-cell lymphoma.

    Roddie, Claire / Neill, Lorna / Osborne, Wendy / Iyengar, Sunil / Tholouli, Eleni / Irvine, David / Chaganti, Sridhar / Besley, Caroline / Bloor, Adrian / Jones, Ceri / Uttenthal, Ben / Johnson, Rod / Sanderson, Robin / Cheok, Kathleen / Marzolini, Maria / Townsend, William / O'Reilly, Maeve / Kirkwood, Amy A / Kuhnl, Andrea

    Blood advances

    2023  Volume 7, Issue 12, Page(s) 2872–2883

    Abstract: The impact of bridging therapy (BT) on CD19-directed chimeric antigen receptor T-cell (CD19CAR-T) outcomes in large B-cell lymphoma (LBCL) is poorly characterized. Current practice is guided through physician preference rather than established evidence. ... ...

    Abstract The impact of bridging therapy (BT) on CD19-directed chimeric antigen receptor T-cell (CD19CAR-T) outcomes in large B-cell lymphoma (LBCL) is poorly characterized. Current practice is guided through physician preference rather than established evidence. Identification of effective BT modalities and factors predictive of response could improve both CAR-T intention to treat and clinical outcomes. We assessed BT modality and response in 375 adult patients with LBCL in relation to outcomes after axicabtagene ciloleucel (Axi-cel) or tisagenlecleucel (Tisa-cel) administration. The majority of patients received BT with chemotherapy (57%) or radiotherapy (17%). We observed that BT was safe for patients, with minimal morbidity or mortality. We showed that complete or partial response to BT conferred a 42% reduction in disease progression and death after CD19CAR-T therapy. Multivariate analysis identified several factors associated with likelihood of response to BT, including response to last line therapy, the absence of bulky disease, and the use of polatuzumab-containing chemotherapy regimens. Our data suggested that complete or partial response to BT may be more important for Tisa-cel than for Axi-cel, because all patients receiving Tisa-cel with less than partial response to BT experienced frank relapse within 12 months of CD19CAR-T infusion. In summary, BT in LBCL should be carefully planned toward optimal response and disease debulking, to improve patient outcomes associated with CD19CAR-T. Polatuzumab-containing regimens should be strongly considered for all suitable patients, and failure to achieve complete or partial response to BT before Tisa-cel administration may prompt consideration of further lines of BT where possible.
    MeSH term(s) Adult ; Humans ; Receptors, Chimeric Antigen ; Neoplasm Recurrence, Local ; Bridge Therapy ; Adaptor Proteins, Signal Transducing ; Antigens, CD19/therapeutic use ; Lymphoma, Large B-Cell, Diffuse/drug therapy
    Chemical Substances Receptors, Chimeric Antigen ; Adaptor Proteins, Signal Transducing ; Antigens, CD19
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2022009019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Improved COVID-19 outcomes in CAR-T patients in the age of vaccination and preemptive pharmacotherapeutics.

    Cheok, Kathleen P L / Kirkwood, Amy A / Creasey, Thomas / Tholouli, Eleni / Chaganti, Sridhar / Mathew, Amrith / Dulobdas, Vaishali / Irvine, David / Besley, Caroline / Neil, Lorna / Lown, Robert / Menne, Tobias / Townsend, William / Kuhnl, Andrea / O'Reilly, Maeve / Sanderson, Robin / Sanchez, Emilie / Roddie, Claire

    Leukemia & lymphoma

    2023  Volume 64, Issue 12, Page(s) 2037–2041

    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; COVID-19/prevention & control ; Vaccination ; Immunotherapy, Adoptive
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2248329
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top