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  1. Book ; Audio / Video ; Thesis: Nachweis von Amelogenin im Schmelz bei Molaren-Inzisiven-Hypomineralisation

    Kirsch, Svenja

    2019  

    Author's details vorgelegt von Svenja Kirsch
    Language German
    Size 1 CD-ROM, Illustrationen
    Publishing place Witten ; Herdecke
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Witten/Herdecke, 2020
    HBZ-ID HT020528097
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Future perfect: From the pandemic to the Paris climate agreement.

    Kirsch, Stuart

    Anthropological theory

    2022  Volume 23, Issue 2, Page(s) 167–185

    Abstract: Fifteen years ago, Jane Guyer (2007) argued that the near future had largely disappeared from collective imaginaries, replaced by longer-term horizons associated with evangelical Christianity and free market capitalism. While not seeking to repudiate ... ...

    Abstract Fifteen years ago, Jane Guyer (2007) argued that the near future had largely disappeared from collective imaginaries, replaced by longer-term horizons associated with evangelical Christianity and free market capitalism. While not seeking to repudiate Guyer, this article argues that recent developments have radically altered relationships to the future. It points to a previously unrecognized connection between two of the most significant challenges facing humanity today: the experience of living through a global pandemic and international efforts to limit the harmful consequences of climate change. Responses to both phenomena invoke the grammatical structure of the future perfect tense. During the pandemic, people began to imagine themselves living at a future moment in time when they have already resumed participating in those activities they have been prevented from undertaking, an example of the future perfect. The Paris Climate Agreement, which encourages states and other parties to take action in the present so that in the future they will already have saved the planet, also relies on the future perfect. In reaction to the pandemic and climate change, the near future has reemerged as a focal point of temporal attention. This article examines how the future appears in the present and the contribution of the future perfect tense to the creation of alternative futures.
    Language English
    Publishing date 2022-06-26
    Publishing country United States
    Document type Journal Article
    ISSN 1741-2641
    ISSN (online) 1741-2641
    DOI 10.1177/14634996221107961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Analyse der experimentellen autoimmunen Enzephalomyelitis sowie der LPS-induzierten Sepsis in Mäusen mit einem Knock-Out des Hypoxia-inducible-factor 1alpha in myeloiden Zellen

    Kirsch, Sebastian

    2011  

    Author's details vorgelegt von Sebastian Kirsch
    Language German
    Size 72 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Univ., Diss., 2011
    HBZ-ID HT017111787
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Single Cell Micro RNA Sequencing Library Preparation.

    Hücker, Sarah M / Kirsch, Stefan

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2752, Page(s) 189–199

    Abstract: Micro RNAs represent important post-transcriptional regulators in health and are involved in the onset of many diseases. Therefore, the further characterization of physiological miRNA functions is an important basic research question, and miRNAs even ... ...

    Abstract Micro RNAs represent important post-transcriptional regulators in health and are involved in the onset of many diseases. Therefore, the further characterization of physiological miRNA functions is an important basic research question, and miRNAs even have high potential as biomarkers both for prognosis and diagnosis. In order to exploit this potential, it is mandatory to accurately quantify the miRNA expression not only in bulk but also on the single-cell level. Here, we describe a protocol, which facilitates miRNA sequencing library preparation of very low input samples, single cells, and even clinical samples such as circulating tumor cells. The protocol can be combined with different single-cell isolation methods (e.g., micromanipulation and FACS sorting). After cell lysis, sequencing adapters are ligated to the miRNAs, other ncRNA species, and adapter dimers are reduced by exonuclease digest, the miRNA library is reverse transcribed, amplified, and purified. Furthermore, quality controls are described to select only high-quality samples for sequencing.
    MeSH term(s) Gene Library ; Cell Death ; Cell Movement ; MicroRNAs/genetics ; Sequence Analysis, RNA
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3621-3_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Running out? Rethinking resource depletion.

    Kirsch, Stuart

    The extractive industries and society

    2020  Volume 7, Issue 3, Page(s) 838–840

    Abstract: Since the 1970s, environmentalists have warned that overconsumption, especially of minerals and fossil fuels, will lead to resource depletion. But there are compelling reasons to question the assertion that we are running out. On the one hand, new ... ...

    Abstract Since the 1970s, environmentalists have warned that overconsumption, especially of minerals and fossil fuels, will lead to resource depletion. But there are compelling reasons to question the assertion that we are running out. On the one hand, new technologies and discoveries have increased the supply of petroleum and natural gas. On the other, concerns about global climate change and the competitiveness of renewable energy are turning coal into a sunset industry and threaten to transform oil reserves into stranded assets. In contrast to fossil fuels, which are consumed in the process of generating energy, virtually all of the metals excavated in the past remain available even after they have been put to use. Even though the average size and degree of mineralization of recently-discovered ore bodies is on the decline, there has never been as much copper, silver, and gold available for human consumption as there is today. Whether incorporated into digital technology or infrastructure, the majority of metals remain available for recycling, which is generally less expensive, uses less energy, and has fewer environmental impacts than extracting minerals from the earth. The threat posed by climate change from continued use of fossil fuels, and the impacts of environmental degradation caused by resource extraction, demand greater attention than the misleading specter of peak oil or running out of metals.
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2214-7918
    ISSN (online) 2214-7918
    DOI 10.1016/j.exis.2020.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Was läuft schief in Krankenhäusern bei freiheitsentziehenden Maßnahmen? Neun provokante Thesen

    Kirsch, S.

    Journal für Anästhesie und Intensivbehandlung

    2018  Volume -, Issue 2, Page(s) 66

    Language German ; English
    Document type Article
    ZDB-ID 1232203-9
    ISSN 0941-4223
    Database Current Contents Medicine

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  7. Book ; Thesis: Lebensqualität von Tumorpatienten unter Strahlentherapie

    Kirsch, Stefanie

    2005  

    Author's details vorgelegt von Stefanie Kirsch
    Language German
    Size 139 S., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Univ., Diss., 2005
    HBZ-ID HT014521177
    Database Catalogue ZB MED Medicine, Health

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  8. Book ; Thesis: Interaktion von Thrombozyten und Leukozyten unter inhaliertem Stickstoffmonoxid (iNO)

    Kirsch, Sylvia

    bei gesunden Probanden und Patienten mit acute respiratory distress syndrome (ARDS)

    2004  

    Author's details vorgelegt von Sylvia Kirsch
    Language German
    Size 130 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2004
    HBZ-ID HT016068348
    Database Catalogue ZB MED Medicine, Health

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  9. Article: Running out? Rethinking resource depletion

    Kirsch, Stuart

    Extr Ind Soc

    Abstract: Since the 1970s, environmentalists have warned that overconsumption, especially of minerals and fossil fuels, will lead to resource depletion. But there are compelling reasons to question the assertion that we are running out. On the one hand, new ... ...

    Abstract Since the 1970s, environmentalists have warned that overconsumption, especially of minerals and fossil fuels, will lead to resource depletion. But there are compelling reasons to question the assertion that we are running out. On the one hand, new technologies and discoveries have increased the supply of petroleum and natural gas. On the other, concerns about global climate change and the competitiveness of renewable energy are turning coal into a sunset industry and threaten to transform oil reserves into stranded assets. In contrast to fossil fuels, which are consumed in the process of generating energy, virtually all of the metals excavated in the past remain available even after they have been put to use. Even though the average size and degree of mineralization of recently-discovered ore bodies is on the decline, there has never been as much copper, silver, and gold available for human consumption as there is today. Whether incorporated into digital technology or infrastructure, the majority of metals remain available for recycling, which is generally less expensive, uses less energy, and has fewer environmental impacts than extracting minerals from the earth. The threat posed by climate change from continued use of fossil fuels, and the impacts of environmental degradation caused by resource extraction, demand greater attention than the misleading specter of peak oil or running out of metals.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #635696
    Database COVID19

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  10. Article ; Online: A novel approach to generate enzyme-free single cell suspensions from archived tissues for miRNA sequencing.

    Scheuermann, Stefan / Hücker, Sarah / Engel, Annika / Ludwig, Nicole / Lebhardt, Philipp / Langejürgen, Jens / Kirsch, Stefan

    SLAS technology

    2024  , Page(s) 100133

    Abstract: Obtaining high-quality omics data at the single-cell level from archived human tissue samples is crucial for gaining insights into cellular heterogeneity and pushing the field of personalized medicine forward. In this technical brief we present a ... ...

    Abstract Obtaining high-quality omics data at the single-cell level from archived human tissue samples is crucial for gaining insights into cellular heterogeneity and pushing the field of personalized medicine forward. In this technical brief we present a comprehensive methodological framework for the efficient enzyme-free preparation of tissue-derived single cell suspensions and their conversion into single-cell miRNA sequencing libraries. The resulting data from this study have the potential to deepen our understanding of miRNA expression at the single-cell level and its relevance in the context of the examined tissues. The workflow encompasses tissue collection, RNALater immersion, storage, thawing, TissueGrinder-mediated dissociation, miRNA lysis, library preparation, sequencing, and data analysis. Quality control measures ensure reliable miRNA data, with specific attention to sample quality. The UMAP analysis reveals tissue-specific cell clustering, while miRNA diversity reflects tissue variations. The presented workflow effectively processes preserved tissues, extending opportunities for retrospective analysis and biobank utilization.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2900310-6
    ISSN 2472-6311 ; 2472-6303
    ISSN (online) 2472-6311
    ISSN 2472-6303
    DOI 10.1016/j.slast.2024.100133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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