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Article ; Online: Association of Fructosamine Levels with Glycemic Control in Children with Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results from the CGM TIME Trial.

Verbeeten, Kate C / Tang, Ken / Courtney, Jennilea M / Bradley, Brenda J / McAssey, Karen / Clarson, Cheril / Kirsch, Susan / Curtis, Jacqueline R / Mahmud, Farid H / Richardson, Christine / Cooper, Tammy / Lawson, Margaret L

Canadian journal of diabetes

2024

Abstract: Objectives: To determine the correlation between fructosamine, used to assess glycemia when HbA1c is not appropriate, with average blood glucose as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes.: Methods: 97 blood ... ...

Abstract	Objectives: To determine the correlation between fructosamine, used to assess glycemia when HbA1c is not appropriate, with average blood glucose as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes. Methods: 97 blood samples were collected from 70 participants in the CGM TIME Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence prior to blood collection. Ordinary least squares linear regression incorporating restricted cubic splines was used to determine association between fructosamine and mean blood glucose. Results: An association was found between fructosamine levels and mean blood glucose with F-statistic of 9.543 p-value <0.001). Data were used to create formulae and a conversion chart for calculating mean blood glucose from fructosamine levels for clinical use. Conclusions: There is a complex relationship between average blood glucose and fructosamine.
Language	English
Publishing date	2024-04-11
Publishing country	Canada
Document type	Journal Article
ISSN	2352-3840
ISSN (online)	2352-3840
DOI	10.1016/j.jcjd.2024.04.007
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Article ; Online: Motivational Stage at Continuous Glucose Monitoring (CGM) Initiation in Pediatric Type 1 Diabetes Is Associated With Current Glycemic Control but Does Not Predict Future CGM Adherence or Glycemic Control.

Verbeeten, Kate C / Chan, Jason / Sourial, Nadia / Courtney, Jennilea M / Bradley, Brenda J / McAssey, Karen / Clarson, Cheril / Kirsch, Susan / Curtis, Jacqueline R / Mahmud, Farid H / Cooper, Tammy / Richardson, Christine / Lawson, Margaret L

Canadian journal of diabetes

2021 Volume 45, Issue 5, Page(s) 466–472.e4

Abstract: Objectives: The Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes (CGM TIME) Trial is a multicenter, randomized controlled trial in children with type 1 diabetes, comparing simultaneous pump and CGM with CGM ... ...

Abstract	Objectives: The Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes (CGM TIME) Trial is a multicenter, randomized controlled trial in children with type 1 diabetes, comparing simultaneous pump and CGM with CGM initiation 6 months later (Paradigm, Veo, Enlite Sensor, Medtronic Canada). This study addresses the ability of SOCRATES (Stages Of Change Readiness And Treatment Eagerness Scale) to classify children and parents into distinct motivational stages and identify the stages' association with glycated hemoglobin (A1C) at trial entry and outcomes 6 months after CGM initiation. Methods: Ninety-eight of 99 eligible children 10 to 18 years of age and 137 of 141 eligible parents completed SOCRATES at trial entry and 6 months later. Parent-child agreement for motivational stage was determined by weighted kappa. Linear regression was used to examine association between motivational stage and i) A1C at trial entry and ii) change in A1C and CGM adherence 6 months after CGM initiation. Results: More than 87% of children and 88% of parents were classified into distinct motivational stages, with weak parent-child agreement. At trial entry, motivational stage was associated with A1C, which was 1.02% higher for children in the Action stage than in the Precontemplation stage (p<0.0001). When compared with children of parents in Precontemplation, A1C for children of parents in the Maintenance and Action stages were 0.83% (p=0.02) and 0.36% (p=0.048) higher, respectively. Precontemplation was associated with shorter diabetes duration. Motivational stage at CGM initiation did not predict change in A1C or CGM adherence 6 months later. Conclusions: SOCRATES can categorize children with type 1 diabetes and their parents into motivational stages. Although motivational stage was associated with glycemic control at trial entry, it did not predict future diabetes-related behaviour or A1C.
MeSH term(s)	Adolescent ; Blood Glucose Self-Monitoring/psychology ; Blood Glucose Self-Monitoring/statistics & numerical data ; Child ; Diabetes Mellitus, Type 1/therapy ; Female ; Follow-Up Studies ; Forecasting ; Glycemic Control/statistics & numerical data ; Humans ; Male ; Motivation ; Treatment Adherence and Compliance/statistics & numerical data
Language	English
Publishing date	2021-04-21
Publishing country	Canada
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ISSN	2352-3840
ISSN (online)	2352-3840
DOI	10.1016/j.jcjd.2021.04.004
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Article: Anorexia nervosa in a patient with congenital adrenal hyperplasia.

Galle, Jennifer / Kirsch, Susan / Kaufman, Miriam

Journal of pediatric endocrinology & metabolism : JPEM

2013 Volume 26, Issue 1-2, Page(s) 167–172

Abstract: Life stressors and hormonal dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis are common factors that play a role in both anorexia nervosa (AN) and congenital adrenal hyperplasia (CAH). The complexity of combined CAH and AN on the HPA axis ... ...

Abstract	Life stressors and hormonal dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis are common factors that play a role in both anorexia nervosa (AN) and congenital adrenal hyperplasia (CAH). The complexity of combined CAH and AN on the HPA axis has not, to our knowledge, been previously illustrated. We present a report of an adolescent with CAH who developed AN, requiring hospitalized management. We use this case to review the pathophysiology of CAH and AN as it relates to the stress response and hormonal dysregulation within the HPA axis. We then highlight the interplay between these conditions, and provide support to the theory that AN acts as a chronic stressor in patients with CAH, leading to HPA axis hyperactivity and elevated levels of androgen precursors. It is prudent for the medical team to monitor and modify CAH steroid dosing during the acute phase of AN, weaning appropriately with AN treatment success.
MeSH term(s)	Adolescent ; Adrenal Hyperplasia, Congenital/complications ; Adrenal Hyperplasia, Congenital/diagnosis ; Adrenal Hyperplasia, Congenital/drug therapy ; Anorexia Nervosa/complications ; Anorexia Nervosa/diagnosis ; Anorexia Nervosa/drug therapy ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydrocortisone/administration & dosage ; Hydrocortisone/therapeutic use
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2013
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2012-0193
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Zs.A 2258: Show issues

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Article: Growth hormone treatment of Canadian children: results from the GeNeSIS phase IV prospective observational study.

Deal, Cheri / Kirsch, Susan / Chanoine, Jean-Pierre / Lawrence, Sarah / Cummings, Elizabeth / Rosolowsky, Elizabeth T / Marks, Seth D / Jia, Nan / Child, Christopher J

CMAJ open

2018 Volume 6, Issue 3, Page(s) E372–E383

Abstract: Background: Country-specific data on outcomes of treatment with recombinant human growth hormone are lacking. We present such data for children treated with growth hormone in Canada.: Methods: We describe characteristics and outcomes of 850 children ( ...

Abstract	Background: Country-specific data on outcomes of treatment with recombinant human growth hormone are lacking. We present such data for children treated with growth hormone in Canada. Methods: We describe characteristics and outcomes of 850 children (mean age at baseline 8.5 yr) treated with growth hormone constituting the Canadian cohort of the multinational phase IV prospective observational Genetics and Neuroendocrinology of Short-stature International Study (GeNeSIS). The diagnosis associated with short stature was as determined by the investigator. Auxological data were evaluated yearly until near-adult height. Adverse events were assessed in all growth-hormone-treated patients. Results: The diagnosis ascribed as the cause of short stature was growth hormone deficiency in 526 children (61.9%), predominantly organic rather than idiopathic, particularly congenital pituitary abnormalities and intracranial tumours. All diagnostic groups with sufficient patients for analysis had increased height velocity standard deviation score (SDS) and height SDS during growth hormone treatment. For patients who reached near-adult height ( Interpretation: Growth hormone treatment was effective and had a good safety profile in Canadian children. Growth hormone dosages were lower than in the US and global GeNeSIS cohorts, and a greater proportion of treated Canadian children had organic growth hormone deficiency. Study registration: ClinicalTrials.gov, no. NCT01088412.
Language	English
Publishing date	2018-09-10
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2701622-5
ISSN	2291-0026
ISSN	2291-0026
DOI	10.9778/cmajo.20180020
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Article ; Online: Timing of CGM initiation in pediatric diabetes: The CGM TIME Trial.

Lawson, Margaret L / Verbeeten, Kate C / Courtney, Jennilea M / Bradley, Brenda J / McAssey, Karen / Clarson, Cheril / Kirsch, Susan / Curtis, Jacqueline R / Mahmud, Farid H / Richardson, Christine / Cooper, Tammy / Chan, Jason / Tang, Ken

Pediatric diabetes

2020 Volume 22, Issue 2, Page(s) 279–287

Abstract: Objective: To determine whether timing of CGM initiation offering low glucose suspend (LGS) affects CGM adherence in children and youth starting insulin pump therapy.: Methods: A 5-site RCT of pump-naïve subjects (aged 5-18 years) with type 1 ... ...

Abstract	Objective: To determine whether timing of CGM initiation offering low glucose suspend (LGS) affects CGM adherence in children and youth starting insulin pump therapy. Methods: A 5-site RCT of pump-naïve subjects (aged 5-18 years) with type 1 diabetes (T1D) for at least 1 year compared simultaneous pump and CGM initiation offering LGS vs standard pump therapy with CGM initiation delayed for 6 months. Primary outcome was CGM adherence (hours per 28 days) (MiniMed™ Paradigm™ Veo™ system; CareLink Pro™ software) over 6 months after CGM initiation. Secondary outcome HbA1c was measured centrally. Linear mixed-models and ordinary least squares models were fitted to estimate effect of intervention, and covariates baseline age, T1D duration, HbA1c, gender, ethnicity, hypoglycemia history, clinical site, and association between CGM adherence and HbA1c. Results: The trial randomized 144/152 (95%) eligible subjects. Baseline mean age was 11.5 ± 3.3(SD) years, T1D duration 3.4 ± 3.1 years, and HbA1c 7.9 ± 0.9%. Six months after CGM initiation, adjusted mean difference in CGM adherence was 62.4 hours per 28 days greater in the Simultaneous Group compared to Delayed Group (P = .007). There was no difference in mean HbA1c at 6 months. However, for each 100 hours of CGM use per 28-day period, HbA1c was 0.39% (95% CI 0.10%-0.69%) lower. Higher CGM adherence was associated with reduced time with glucose >10 mmol/L (P < .001). Conclusion: CGM adherence was higher after 6 months when initiated at same time as pump therapy compared to starting CGM 6 months after pump therapy. Greater CGM adherence was associated with improved HbA1c.
MeSH term(s)	Adolescent ; Blood Glucose/metabolism ; Blood Glucose Self-Monitoring ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Female ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage ; Insulin Infusion Systems ; Male ; Patient Compliance ; Time Factors
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2020-11-04
Publishing country	Denmark
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1502504-4
ISSN	1399-5448 ; 1745-1426 ; 1399-543X
ISSN (online)	1399-5448
ISSN	1745-1426 ; 1399-543X
DOI	10.1111/pedi.13144
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Zs.A 5422: Show issues

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Article ; Online: Fear of hypoglycemia in children with type 1 diabetes and their parents: Effect of pump therapy and continuous glucose monitoring with option of low glucose suspend in the CGM TIME trial.

Verbeeten, Kate C / Perez Trejo, Maria Esther / Tang, Ken / Chan, Jason / Courtney, Jennilea M / Bradley, Brenda J / McAssey, Karen / Clarson, Cheril / Kirsch, Susan / Curtis, Jacqueline R / Mahmud, Farid H / Richardson, Christine / Cooper, Tammy / Lawson, Margaret L

Pediatric diabetes

2020 Volume 22, Issue 2, Page(s) 288–293

Abstract: To determine if pump therapy with continuous glucose monitoring offering low glucose suspend (LGS) decreases fear of hypoglycemia among children with type 1 diabetes and their parents. The CGM TIME trial is a multicenter randomized controlled trial that ... ...

Abstract	To determine if pump therapy with continuous glucose monitoring offering low glucose suspend (LGS) decreases fear of hypoglycemia among children with type 1 diabetes and their parents. The CGM TIME trial is a multicenter randomized controlled trial that enrolled 144 children with type 1 diabetes for at least 1 year (mean duration 3.4 ± 3.1 years) starting pump therapy (MiniMed™ Veo™, Medtronic Canada). CGM (MiniMed™ Enlite™ sensor) offering LGS was introduced simultaneously or delayed for 6 months. Hypoglycemia Fear Scale (HFS) was completed by children ≥10 years old and all parents, at study entry and 12 months later. Simultaneous and Delayed Group participants were combined for all analyses. Subscale scores were compared with paired t-tests, and individual items with paired Wilcoxon tests. Linear regression examined association with CGM adherence. 121/140 parents and 91/99 children ≥10 years had complete data. Mean Behavior subscale score decreased from 21.1 (SD 5.9) to 17.2 (SD 6.1) (p < .001) for children, and 20.7 (SD 7.5) to 17.4 (7.4) (p < .001) for parents. Mean Worry subscale score decreased from 17.9 (SD 11.9) to 11.9 (SD 11.4) (p < .001) for children, and 23.1 (SD 13.2) to 17.6 (SD 10.4) (p < .001) for parents. Median scores for 10/25 child items and 12/25 parent items were significantly lower at 12 months (p < .001). Linear regression found no association between HFS scores and CGM adherence. Insulin pump therapy with CGM offering LGS significantly reduced fear of hypoglycemia not related to CGM adherence in children with type 1 diabetes and their parents.
MeSH term(s)	Adolescent ; Adult ; Blood Glucose Self-Monitoring ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/psychology ; Fear ; Female ; Humans ; Hypoglycemia/etiology ; Hypoglycemia/psychology ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage ; Insulin Infusion Systems ; Male ; Parents/psychology ; Young Adult
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2020-11-27
Publishing country	Denmark
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1502504-4
ISSN	1399-5448 ; 1745-1426 ; 1399-543X
ISSN (online)	1399-5448
ISSN	1745-1426 ; 1399-543X
DOI	10.1111/pedi.13150
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Article ; Online: Health-related Quality of Life in Children With Prune-belly Syndrome and Their Caregivers.

Arlen, Angela M / Kirsch, Susan S / Seidel, Natan E / Garcia-Roig, Michael / Smith, Edwin A / Kirsch, Andrew J

Urology

2016 Volume 87, Page(s) 224–227

Abstract: Objective: To compare health-related quality of life (HRQoL) in children with prune-belly syndrome (PBS) and their caregivers to healthy controls, as children and adolescents with PBS face numerous potential physical and psychosocial challenges.: ... ...

Abstract	Objective: To compare health-related quality of life (HRQoL) in children with prune-belly syndrome (PBS) and their caregivers to healthy controls, as children and adolescents with PBS face numerous potential physical and psychosocial challenges. Materials and methods: Study participants completed the Pediatric Quality of Life Inventory Generic Core Scales (PedsQL) 4.0 generic core scales (children) or Quality of Life Enjoyment and Satisfaction Questionnaire Short Form (Q-LES-Q-SF) (caregivers) in an online, anonymous format. The PedsQL 4.0 is a 23-item, age-adjusted, validated questionnaire that assesses physical, emotional, social, and school functioning in pediatric patients. The Q-LES-Q-SF is a validated, self-report measure that assesses various areas of daily functioning in adults. Results: PedsQL 4.0 was completed by 32 children with PBS. Individual physical (66.3 ± 20 vs 84.4 ± 17.3; P < .0001), emotional (68.4 ± 23.4 vs 80.9 ± 19.6; P < .01), social (63.1 ± 21.3 vs 87.4 ± 17.2; P < .0001), and school (53 ± 21.7 vs 78.6 ± 20.5; P < .0001) functioning scales were all significantly lower than in healthy children. Nineteen caregivers completed the Q-LES-Q-SF. Caregivers had a mean raw score of 54.8 ± 9.6, which was significantly lower (P = .02) than the comparative healthy adult cohort (59.8 ± 11.3). Conclusion: PBS profoundly impacts HRQoL in children, negatively affecting physical, emotional, social, and school functioning. Caregivers of PBS patients also report an overall lower quality of life, highlighting the challenges that families with chronically ill children often face.
MeSH term(s)	Adolescent ; Adult ; Caregivers/psychology ; Child ; Child, Preschool ; Emotions ; Female ; Follow-Up Studies ; Health Status ; Humans ; Male ; Prune Belly Syndrome/psychology ; Quality of Life ; Retrospective Studies ; Surveys and Questionnaires
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2015.09.028
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article ; Online: Imaging of SHOX-associated anomalies.

Gahunia, Harpal K / Babyn, Paul S / Kirsch, Susan / Mendoza-Londono, Roberto

Seminars in musculoskeletal radiology

2009 Volume 13, Issue 3, Page(s) 236–254

Abstract: Human growth is a multifactorial trait influenced by environmental, hormonal, and genetic factors. Although it is clear that multiple factors contribute to an individual's final height and limb development, genetic factors play a crucial role. One such ... ...

Abstract	Human growth is a multifactorial trait influenced by environmental, hormonal, and genetic factors. Although it is clear that multiple factors contribute to an individual's final height and limb development, genetic factors play a crucial role. One such gene is the short stature homeobox ( SHOX) containing gene. Knowledge about the SHOX gene has rapidly increased since its discovery in 1997, and we now know that SHOX haploinsufficiency affects the development of the extremities and is an important cause of short stature. Currently, SHOX mutations occur with an estimated incidence of roughly 1 in 1000 newborns, making mutations of this gene one of the most common genetic defects associated with growth failure and skeletal deformities. Heterozygous mutations of SHOX have been implicated in patients with Madelung's deformity, Leri-Weill dyschondrosteosis (77%), Turner's syndrome (66%), and idiopathic short stature (3%), and homozygous mutations of SHOX gene have been identified in patients with Langer's mesomelic dysplasia (100%). Recognition of the early radiographic features encountered in SHOX haploinsufficiency maybe pivotal for the diagnosis. In this article, we summarize the genetic and clinical features of the various SHOX haploinsufficiency-associated disorders. We present the characteristic imaging features of these disorders and the results of growth hormone treatment trials.
MeSH term(s)	Body Height/genetics ; Growth Disorders/diagnostic imaging ; Growth Disorders/genetics ; Haploidy ; Humans ; Limb Deformities, Congenital/genetics ; Radiography
Language	English
Publishing date	2009-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1360919-1
ISSN	1098-898X ; 1089-7860
ISSN (online)	1098-898X
ISSN	1089-7860
DOI	10.1055/s-0029-1237691
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Zs.A 4887: Show issues

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Article ; Online: Phantom urinary incontinence in children with bladder-bowel dysfunction.

Arlen, Angela M / Dewhurst, Liisa L / Kirsch, Susan S / Dingle, Arden D / Scherz, Hal C / Kirsch, Andrew J

Urology

2014 Volume 84, Issue 3, Page(s) 685–688

Abstract: Objective: To report a previously undescribed condition in which children present with the sensation of wetness because of presumed urinary incontinence when they are actually completely dry. We have termed this entity "phantom" urinary incontinence ( ... ...

Abstract	Objective: To report a previously undescribed condition in which children present with the sensation of wetness because of presumed urinary incontinence when they are actually completely dry. We have termed this entity "phantom" urinary incontinence (PUI). Materials and methods: Twenty children referred to our pediatric urology clinic were diagnosed with PUI between 2009 and 2013. Patient demographics, associated bladder and bowel symptoms, concomitant diagnoses, imaging, management, and treatment outcomes were evaluated. Results: Twenty children (18 females and 2 males) were diagnosed with PUI over a 5-year interval. Mean age at diagnosis was 6.9 ± 2.5 years (range, 4-12 years). Nineteen patients (95%) had concomitant lower urinary tract symptoms, and all were also diagnosed with constipation. Urgency (75%) and frequency (50%) were the most common associated bladder symptoms. Of the 18 girls, 13 (72%) had associated vaginitis. Fourteen children (70%) carried a parent-reported diagnosis of obsessive-compulsive disorder or obsessive-compulsive disorder personality traits. Patients were managed with timed voiding, dietary modifications, and a bowel regimen. Ninety percent children experienced improvement of bladder-bowel dysfunction and resolution of PUI at a mean follow-up of 14.4 months. Conclusion: Children with PUI have a high incidence of obsessive-compulsive traits. Phantom incontinence as well as associated lower urinary tract symptoms resolve with adherence to a strict bladder-bowel regimen.
MeSH term(s)	Child ; Child, Preschool ; Enuresis/complications ; Enuresis/psychology ; Female ; Humans ; Incidence ; Male ; Obsessive-Compulsive Disorder/complications ; Rectal Diseases/complications ; Rectal Diseases/psychology ; Treatment Outcome ; Urinary Bladder/pathology ; Urinary Incontinence/complications ; Urinary Incontinence/psychology
Language	English
Publishing date	2014-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2014.04.046
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study.

Mahmud, Farid H / Clarke, Antoine B M / Joachim, Kariym C / Assor, Esther / McDonald, Charlotte / Saibil, Fred / Lochnan, Heather A / Punthakee, Zubin / Parikh, Amish / Advani, Andrew / Shah, Baiju R / Perkins, Bruce A / Zuijdwijk, Caroline S / Mack, David R / Koltin, Dror / De Melo, Emilia N / Hsieh, Eugene / Mukerji, Geetha / Gilbert, Jeremy /

Bax, Kevin / Lawson, Margaret L / Cino, Maria / Beaton, Melanie D / Saloojee, Navaaz A / Lou, Olivia / Gallego, Patricia H / Bercik, Premysl / Houlden, Robyn L / Aronson, Ronnie / Kirsch, Susan E / Paterson, William G / Marcon, Margaret A

Diabetes care

2020 Volume 43, Issue 7, Page(s) 1553–1556

Abstract: Objective: To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.: Research design and methods: Asymptomatic patients (8-45 years) were screened ... ...

Abstract	Objective: To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD. Research design and methods: Asymptomatic patients (8-45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA Results: Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9-8.2%, Conclusions: CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.
MeSH term(s)	Adolescent ; Adult ; Asymptomatic Diseases ; Autoantibodies/analysis ; Autoantibodies/blood ; Biopsy ; Blood Glucose/analysis ; Blood Glucose/metabolism ; Blood Glucose Self-Monitoring ; Canada ; Celiac Disease/blood ; Celiac Disease/complications ; Celiac Disease/diagnosis ; Celiac Disease/diet therapy ; Child ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/diet therapy ; Diet, Gluten-Free ; Female ; Humans ; Male ; Mass Screening ; Middle Aged ; Postprandial Period ; Serologic Tests ; Treatment Outcome ; Young Adult
Chemical Substances	Autoantibodies ; Blood Glucose
Language	English
Publishing date	2020-04-28
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc19-1944
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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito