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  1. Article ; Online: Barrier Performance of Spray Coated Cellulose Nanofibre Film

    Kirubanandan Shanmugam / Narendhar Chandrasekar / Ramachandran Balaji

    Micro, Vol 3, Iss 14, Pp 192-

    2023  Volume 207

    Abstract: Cellulose nanofibre (CNF) is the sustainable nanomaterial used for developing high-performance barrier materials that are renewable, recyclable, and biodegradable. The CNF film has very low oxygen permeability; however, its water vapor permeability is ... ...

    Abstract Cellulose nanofibre (CNF) is the sustainable nanomaterial used for developing high-performance barrier materials that are renewable, recyclable, and biodegradable. The CNF film has very low oxygen permeability; however, its water vapor permeability is significantly higher than that of conventional packaging plastics. The fabrication method influences their barrier properties of the film. A spray-coating CNF on a stainless-steel plate was developed to form a compact film with two unique surfaces, namely a smooth layer on the base side and rough layer on the free side. It improves both the ease of preparation of the film and reduces the water vapour permeability via tailoring the basis weight and thickness of the film through simple adjusting CNF content in the suspension. The air permanence of the film from 1.0 wt.% to 2.0 wt.% CNF suspension is less than 0.003 µm/Pa·S confirming that is an impermeable film and proves a good packaging material. SEM, optical profilometry, and AFM revealed that the spray-coated surface was smooth and glossy. For sprayed CNF films with basis weight between 86.26 ± 13.61 and 155.85 ± 18.01 g/m 2 , WVP were ranged from 6.99 ± 1.17 × 10 −11 to 4.19 ± 1.45 × 10 −11 g/m·Pa·S. In comparison, the WVP of 100 g/m 2 vacuum filtered CNF film was 5.50 ± 0.84 × 10 −11 g/m·Pa·S, spray-coated film (of 96.6 g/m 2 ) also show similar permeability at around 5.34 ± 0.603 × 10 −11 g/m·Pa·S. The best performance was achieved with spraying of 2.0 wt.% CNF and a water vapour permeability of 3.91 × 10 −11 g/m·s·Pa. Spray coated CNF film is impermeable against air and water vapour and a potential alternative to synthetic plastics.
    Keywords cellulose nanofibre (CNF) ; spray coating ; basis weight ; thickness ; water vapour transmission rate ; water vapour permeability ; Physics ; QC1-999 ; Microscopy ; QH201-278.5 ; Microbiology ; QR1-502 ; Chemistry ; QD1-999
    Subject code 333
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Triphala incorporated collagen sponge--a smart biomaterial for infected dermal wound healing.

    Kumar, Muthusamy Senthil / Kirubanandan, Shanmugam / Sripriya, Ramasamy / Sehgal, Praveen Kumar

    The Journal of surgical research

    2010  Volume 158, Issue 1, Page(s) 162–170

    Abstract: Background: Wound infection is a major problem in the medical community since many types of wounds are more prone to microbial contamination leading to infection. Triphala (a traditional ayurvedic herbal formulation) incorporated collagen sponge was ... ...

    Abstract Background: Wound infection is a major problem in the medical community since many types of wounds are more prone to microbial contamination leading to infection. Triphala (a traditional ayurvedic herbal formulation) incorporated collagen sponge was investigated for its healing potential on infected dermal wound in albino rats.
    Materials and methods: Methanol extract of triphala was prepared and analyzed for the presence of catechin by high-pressure liquid chromatography analysis. Collagen sponge was prepared by incorporating triphala into collagen sponge. The triphala incorporated collagen was characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and water uptake analysis. Infected wound was dressed with triphala incorporated collagen sponge. Wound reduction rate, collagen content, and matrix metalloproteinases in the granulation tissue, histology, and Fourier transform electron microscopy analysis were done to obtain the healing pattern.
    Results: High-pressure liquid chromatography analysis showed the presence of (-)epigallocatechin gallate. FT-IR spectroscopy study revealed the interaction of polyphenols with the collagen. Triphala incorporated collagen sponge has shown to increase thermal stability and water uptake capability, faster wound closure, improved tissue regeneration, collagen content at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression was correlated well with reduction in the inflammatory phase, thus confirming efficacy of the dressing.
    Conclusions: Better healing efficacy of triphala incorporated collagen sponge may provides a scientific rationale for the use of this dressing as an effective wound cover in the management of infected dermal wound.
    MeSH term(s) Animals ; Bandages ; Biocompatible Materials ; Calorimetry, Differential Scanning ; Catechin/analysis ; Collagen/administration & dosage ; Immunohistochemistry ; Male ; Matrix Metalloproteinase 8/analysis ; Matrix Metalloproteinase 9/analysis ; Plant Extracts/administration & dosage ; Porifera ; Rats ; Rats, Wistar ; Spectroscopy, Fourier Transform Infrared ; Wound Healing/drug effects ; Wound Infection/drug therapy ; Wound Infection/microbiology
    Chemical Substances Biocompatible Materials ; Plant Extracts ; triphala ; Catechin (8R1V1STN48) ; Collagen (9007-34-5) ; Matrix Metalloproteinase 8 (EC 3.4.24.34) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2008.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Triphala promotes healing of infected full-thickness dermal wound.

    Kumar, Muthusamy Senthil / Kirubanandan, Shanmugam / Sripriya, Ramasamy / Sehgal, Praveen Kumar

    The Journal of surgical research

    2008  Volume 144, Issue 1, Page(s) 94–101

    Abstract: Background: Infection is a major problem in the management of wounds. Even though the development of synthetic antimicrobial agents persists, drug resistance and toxicity hinder their way. Many plants with multi-potent pharmaceutical activities may ... ...

    Abstract Background: Infection is a major problem in the management of wounds. Even though the development of synthetic antimicrobial agents persists, drug resistance and toxicity hinder their way. Many plants with multi-potent pharmaceutical activities may offer better treatment options, and Triphala (dried fruits of Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica) are potential formulations evaluated for healing activity on infected wound as it possesses numerous activities.
    Materials and methods: Alcoholic extract of Triphala has shown in vitro antimicrobial activity against wound pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes. An ointment was prepared from the Triphala extract (10% w/w) and assessed for in vivo wound healing on infected rat model by rate of healing, bacterial count, biochemical analysis, and expression of matrix metalloproteinases.
    Results: The treated group has shown significantly improved wound closure. Assessment of granulation tissue on every fourth day showed significant reduction in bacterial count with significant level of collagen, hexosamine, uronic acid, and superoxide dismutase in the treated group (P < 0.01). Reduction of matrix metalloproteinase expression observed in the treated group by gelatin zymography and immunoblotting confirms our in vivo assessment.
    Conclusions: The above results showed the antibacterial, wound healing, and antioxidant activities of Triphala ointment, necessary for the management of infected wounds. Active principles of the Triphala may be further evaluated and used as an excellent therapeutic formulation for infected wounds.
    MeSH term(s) 3T3 Cells ; Administration, Topical ; Animals ; Anti-Bacterial Agents/pharmacology ; Dermis/injuries ; Dermis/microbiology ; Granulation Tissue/drug effects ; Granulation Tissue/metabolism ; Keratinocytes/cytology ; Male ; Matrix Metalloproteinases/metabolism ; Medicine, Ayurvedic ; Mice ; Ointments ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Pseudomonas Infections/drug therapy ; Rats ; Rats, Wistar ; Staphylococcal Skin Infections/drug therapy ; Streptococcal Infections/drug therapy ; Wound Healing/drug effects
    Chemical Substances Anti-Bacterial Agents ; Ointments ; Plant Extracts ; triphala ; Matrix Metalloproteinases (EC 3.4.24.-)
    Language English
    Publishing date 2008-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2007.02.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 178: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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