Article ; Online: The use of electroporation to deliver DNA-based vaccines.
2023 Volume 23, Issue 1, Page(s) 102–123
Abstract: Introduction: Nucleic acids represent a promising platform for creating vaccines. One disadvantage of this approach is its relatively low immunogenicity. Electroporation (EP) is an effective way to increase the DNA vaccines immunogenicity. However, due ... ...
| Abstract | Introduction: Nucleic acids represent a promising platform for creating vaccines. One disadvantage of this approach is its relatively low immunogenicity. Electroporation (EP) is an effective way to increase the DNA vaccines immunogenicity. However, due to the different configurations of devices used for EP, EP protocols optimization is required not only to enhance immunogenicity, but also to ensure greater safety and tolerability of the EP procedure. Area covered: An data analysis for recent years on the DNA vaccines delivery against viral and parasitic infections using EP was carried out. The study of various EP physical characteristics, such as frequency, pulse duration, pulse interval, should be considered along with the immunogenic construct design and the site of delivery of the vaccine, through the study of the immunogenic and protective characteristics of the latter. Expert opinion: Future research should focus on regulating the humoral and cellular response required for protection against infectious agents by modifying the EP protocol. Significant efforts will be directed to establishing the possibility of redirecting the immune response toward the Th1 or Th2 response by changing the EP physical parameters. It will allow for an individual selective approach during EP, depending on the pathogen type of an infectious disease. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Humans ; Vaccines, DNA ; Electroporation/methods ; DNA | |||||
| Chemical Substances | Vaccines, DNA ; DNA (9007-49-2) | |||||
| Language | English | |||||
| Publishing date | 2023-12-18 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2181284-6 | |||||
| ISSN | 1744-8395 ; 1476-0584 | |||||
| ISSN (online) | 1744-8395 | |||||
| ISSN | 1476-0584 | |||||
| DOI | 10.1080/14760584.2023.2292772 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 6077: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.