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  1. Article ; Online: Antiviral activity of the high-molecular-weight plant polysaccharides (Panavir®).

    Kalinina, Tatiana S / Zlenko, Dmitry V / Kiselev, Aleksei V / Litvin, Alexander A / Stovbun, Sergey V

    International journal of biological macromolecules

    2020  Volume 161, Page(s) 936–938

    Abstract: This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir®. Panavir® is a high-molecular-weight fraction of the polysaccharides extracted from the shoots of the Solanum ... ...

    Abstract This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir®. Panavir® is a high-molecular-weight fraction of the polysaccharides extracted from the shoots of the Solanum tuberosum. It demonstrates activity against many types of viruses, including animal coronavirus and also against bacterial infections. These properties look very promising considering the COVID-19 epidemy and allow propose that Panavir® would be effective in the therapy of the SARS-CoV-2 infection.
    MeSH term(s) Adult ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Disease Models, Animal ; Dysentery, Bacillary/drug therapy ; Female ; Glycosides/chemistry ; Glycosides/pharmacology ; Glycosides/therapeutic use ; Herpes Genitalis/drug therapy ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella pneumoniae/drug effects ; Male ; Mice ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Shigella flexneri/drug effects ; Young Adult
    Chemical Substances Antiviral Agents ; Glycosides ; Panavir (Solanum tuberosum)
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.06.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity.

    Stovbun, Sergey V / Kalinina, Tatiana S / Zlenko, Dmitry V / Kiselev, Aleksei V / Litvin, Alexander A / Bukhvostov, Alexander A / Usachev, Sergey V / Kuznetsov, Dmitry A

    International journal of biological macromolecules

    2021  Volume 182, Page(s) 743–749

    Abstract: The development of high-end targeted drugs and vaccines against modern pandemic infections, such as COVID-19, can take a too long time that lets the epidemic spin up and harms society. However, the countermeasures must be applied against the infection in ...

    Abstract The development of high-end targeted drugs and vaccines against modern pandemic infections, such as COVID-19, can take a too long time that lets the epidemic spin up and harms society. However, the countermeasures must be applied against the infection in this period until the targeted drugs became available. In this regard, the non-specific, broad-spectrum anti-viral means could be considered as a compromise allowing overcoming the period of trial. One way to enhance the ability to resist the infection is to activate the nonspecific immunity using a suitable driving-up agent, such as plant polysaccharides, particularly our drug Panavir isolated from the potato shoots. Earlier, we have shown the noticeable anti-viral and anti-bacterial activity of Panavir. Here we demonstrate the pro-inflammation activity of Panavir, which four-to-eight times intensified the ATP and MIF secretion by HL-60 cells. This effect was mediated by the active phagocytosis of the Panavir particles by the cells. We hypothesized the physiological basis of the Panavir proinflammatory activity is mediated by the indol-containing compounds (auxins) present in Panavir and acting as a plant analog of serotonin.
    MeSH term(s) Adolescent ; Adult ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/pharmacology ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Drug Carriers/pharmacology ; HL-60 Cells ; Humans ; Male ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use ; Phagocytosis/drug effects ; Plants/chemistry ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Probucol/chemistry ; Probucol/pharmacokinetics ; Probucol/pharmacology ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Drug Carriers ; Polysaccharides ; Probucol (P3CTH044XJ)
    Language English
    Publishing date 2021-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2021.03.135
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Antiviral activity of the high-molecular-weight plant polysaccharides (Panavir®)

    Kalinina, Tatiana S / Zlenko, Dmitry V / Kiselev, Aleksei V / Litvin, Alexander A / Stovbun, Sergey V

    International journal of biological macromolecules. 2020 Oct. 15, v. 161

    2020  

    Abstract: This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir®. Panavir® is a high-molecular-weight fraction of the polysaccharides extracted from the shoots of the Solanum ... ...

    Abstract This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir®. Panavir® is a high-molecular-weight fraction of the polysaccharides extracted from the shoots of the Solanum tuberosum. It demonstrates activity against many types of viruses, including animal coronavirus and also against bacterial infections. These properties look very promising considering the COVID-19 epidemy and allow propose that Panavir® would be effective in the therapy of the SARS-CoV-2 infection.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; Solanum tuberosum ; animals ; antibacterial properties ; antiviral properties ; immunomodulators ; polysaccharides ; therapeutics
    Language English
    Dates of publication 2020-1015
    Size p. 936-938.
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.06.031
    Database NAL-Catalogue (AGRICOLA)

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Antiviral activity of the high-molecular-weight plant polysaccharides (Panavir®)

    Kalinina, Tatiana S / Zlenko, Dmitry V / Kiselev, Aleksei V / Litvin, Alexander A / Stovbun, Sergey V

    Int J Biol Macromol

    Abstract: This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir®. Panavir® is a high-molecular-weight fraction of the polysaccharides extracted from the shoots of the Solanum ... ...

    Abstract This short report is dedicated to the description of the wide antiviral and antibacterial activity of the immune-modulating agent Panavir®. Panavir® is a high-molecular-weight fraction of the polysaccharides extracted from the shoots of the Solanum tuberosum. It demonstrates activity against many types of viruses, including animal coronavirus and also against bacterial infections. These properties look very promising considering the COVID-19 epidemy and allow propose that Panavir® would be effective in the therapy of the SARS-CoV-2 infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #593423
    Database COVID19

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