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  1. Article ; Online: SARS-CoV-2 test positivity rate in Reno, Nevada: association with PM2.5 during the 2020 wildfire smoke events in the western United States.

    Kiser, Daniel / Elhanan, Gai / Metcalf, William J / Schnieder, Brendan / Grzymski, Joseph J

    Journal of exposure science & environmental epidemiology

    2021  Volume 31, Issue 5, Page(s) 797–803

    Abstract: Background: Air pollution has been linked to increased susceptibility to SARS-CoV-2. Thus, it has been suggested that wildfire smoke events may exacerbate the COVID-19 pandemic.: Objectives: Our goal was to examine whether wildfire smoke from the ... ...

    Abstract Background: Air pollution has been linked to increased susceptibility to SARS-CoV-2. Thus, it has been suggested that wildfire smoke events may exacerbate the COVID-19 pandemic.
    Objectives: Our goal was to examine whether wildfire smoke from the 2020 wildfires in the western United States was associated with an increased rate of SARS-CoV-2 infections in Reno, Nevada.
    Methods: We conducted a time-series analysis using generalized additive models to examine the relationship between the SARS-CoV-2 test positivity rate at a large regional hospital in Reno and ambient PM2.5 from 15 May to 20 Oct 2020.
    Results: We found that a 10 µg/m
    Significance: Wildfire smoke may have greatly increased the number of COVID-19 cases in Reno. Thus, our results substantiate the role of air pollution in exacerbating the pandemic and can help guide the development of public preparedness policies in areas affected by wildfire smoke, as wildfires are likely to coincide with the COVID-19 pandemic in 2021.
    MeSH term(s) Air Pollutants/adverse effects ; Air Pollutants/analysis ; COVID-19 ; Humans ; Nevada ; Pandemics ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; SARS-CoV-2 ; Smoke/adverse effects ; United States/epidemiology ; Wildfires
    Chemical Substances Air Pollutants ; Particulate Matter ; Smoke
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-021-00366-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Incomplete Penetrance of Population-Based Genetic Screening Results in Electronic Health Record.

    Elhanan, Gai / Kiser, Daniel / Neveux, Iva / Dabe, Shaun / Bolze, Alexandre / Metcalf, William J / Lu, James T / Grzymski, Joseph J

    Frontiers in genetics

    2022  Volume 13, Page(s) 866169

    Abstract: The clinical value of population-based genetic screening projects depends on the actions taken on the findings. The Healthy Nevada Project (HNP) is an all-comer genetic screening and research project based in northern Nevada. HNP participants with CDC ... ...

    Abstract The clinical value of population-based genetic screening projects depends on the actions taken on the findings. The Healthy Nevada Project (HNP) is an all-comer genetic screening and research project based in northern Nevada. HNP participants with CDC Tier 1 findings of hereditary breast and ovarian cancer syndrome (HBOC), Lynch syndrome (LS), or familial hypercholesterolemia (FH) are notified and provided with genetic counseling. However, the HNP subsequently takes a "hands-off" approach: it is the responsibility of notified participants to share their findings with their healthcare providers, and providers are expected to implement the recommended action plans. Thus, the HNP presents an opportunity to evaluate the efficiency of participant and provider responses to notification of important genetic findings, using electronic health records (EHRs) at Renown Health (a large regional hospital in northern Nevada). Out of 520 HNP participants with findings, we identified 250 participants who were notified of their findings and who had an EHR. 107 of these participants responded to a survey, with 76 (71%) indicating that they had shared their findings with their healthcare providers. However, a sufficiently specific genetic diagnosis appeared in the EHRs and problem lists of only 22 and 10%, respectively, of participants without prior knowledge. Furthermore, review of participant EHRs provided evidence of possible relevant changes in clinical care for only a handful of participants. Up to 19% of participants would have benefited from earlier screening due to prior presentation of their condition. These results suggest that continuous support for both participants and their providers is necessary to maximize the benefit of population-based genetic screening. We recommend that genetic screening projects require participants' consent to directly document their genetic findings in their EHRs. Additionally, we recommend that they provide healthcare providers with ongoing training regarding documentation of findings and with clinical decision support regarding subsequent care.
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.866169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Particulate matter and emergency visits for asthma: a time-series study of their association in the presence and absence of wildfire smoke in Reno, Nevada, 2013-2018.

    Kiser, Daniel / Metcalf, William J / Elhanan, Gai / Schnieder, Brendan / Schlauch, Karen / Joros, Andrew / Petersen, Craig / Grzymski, Joseph

    Environmental health : a global access science source

    2020  Volume 19, Issue 1, Page(s) 92

    Abstract: Background: Health risks due to particulate matter (PM) from wildfires may differ from risk due to PM from other sources. In places frequently subjected to wildfire smoke, such as Reno, Nevada, it is critical to determine whether wildfire PM poses ... ...

    Abstract Background: Health risks due to particulate matter (PM) from wildfires may differ from risk due to PM from other sources. In places frequently subjected to wildfire smoke, such as Reno, Nevada, it is critical to determine whether wildfire PM poses unique risks. Our goal was to quantify the difference in the association of adverse asthma events with PM on days when wildfire smoke was present versus days when wildfire smoke was not present.
    Methods: We obtained counts of visits for asthma at emergency departments and urgent care centers from a large regional healthcare system in Reno for the years 2013-2018. We also obtained dates when wildfire smoke was present from the Washoe County Health District Air Quality Management Division. We then examined whether the presence of wildfire smoke modified the association of PM
    Results: Air quality was affected by wildfire smoke on 188 days between 2013 and 2018. We found that the presence of wildfire smoke increased the association of a 5 μg/m
    Conclusions: Since we found significantly stronger associations of PM
    MeSH term(s) Asthma/chemically induced ; Asthma/epidemiology ; Cities ; Emergency Service, Hospital/statistics & numerical data ; Environmental Exposure/adverse effects ; Hospitalization/statistics & numerical data ; Nevada/epidemiology ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Smoke/adverse effects ; Wildfires
    Chemical Substances Particulate Matter ; Smoke
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1476-069X
    ISSN (online) 1476-069X
    DOI 10.1186/s12940-020-00646-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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