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  1. Article ; Online: 2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction.

    Kishigami, Takehiro / Ishikane, Shin / Arioka, Masaki / Igawa, Kazunobu / Nishimura, Yosuke / Takahashi-Yanaga, Fumi

    Journal of pharmacological sciences

    2024  Volume 154, Issue 2, Page(s) 97–107

    Abstract: In our previous study, we reported that 2, 5-dimethyl-celecoxib (DM-C), a derivative of celecoxib, prevents cardiac remodeling in different mouse models of heart failure, including myocardial infarction (MI). The inflammatory response after MI affects ... ...

    Abstract In our previous study, we reported that 2, 5-dimethyl-celecoxib (DM-C), a derivative of celecoxib, prevents cardiac remodeling in different mouse models of heart failure, including myocardial infarction (MI). The inflammatory response after MI affects the progression of cardiac remodeling, wherein the immune cells, mainly macrophages, play crucial roles. Therefore, we evaluated the effect of DM-C on macrophages in a cryoinjury-induced myocardial infarction (CMI) mouse model. We observed that DM-C attenuated the deterioration of left ventricular ejection fraction and cardiac fibrosis 14 d after CMI. Gene expression of pro-inflammatory cytokines at the infarct site was reduced by DM-C treatment. Analysis of macrophage surface antigens revealed that DM-C induced transient accumulation of macrophages at the infarct site without affecting their polarization. In vitro experiments using peritoneal monocytes/macrophages revealed that DM-C did not directly increase the phagocytic ability of the macrophages but increased their number, thereby upregulating the clearance capacity. Moreover, DM-C rapidly excluded the cells expressing necrotic cell marker from the infarct site. These results suggested that DM-C enhanced the clearance capacity of macrophages by transiently increasing their number at the infarct site, and terminated the escape from the inflammatory phase earlier, thereby suppressing excessive cardiac remodeling and ameliorating cardiac dysfunction.
    MeSH term(s) Animals ; Mice ; Celecoxib/pharmacology ; Celecoxib/therapeutic use ; Stroke Volume ; Ventricular Remodeling ; Ventricular Function, Left ; Myocardial Infarction/drug therapy ; Macrophages ; Disease Models, Animal ; Pyrazoles ; Sulfonamides
    Chemical Substances Celecoxib (JCX84Q7J1L) ; 2,5-dimethylcelecoxib ; Pyrazoles ; Sulfonamides
    Language English
    Publishing date 2024-01-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1016/j.jphs.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Impact of sarcopenia on long-term survival after cardiac surgery for end-stage renal disease patients.

    Ikushima, Eigo / Yasutsune, Toru / Kishigami, Takehiro / Takigawa, Tomoya / Jinzai, Yuki / Kado, Yuichiro / Nishimura, Yosuke

    Asian cardiovascular & thoracic annals

    2023  Volume 31, Issue 8, Page(s) 699–705

    Abstract: Background: The long-term mortality of end-stage renal disease (ESRD) patients is still unsatisfactory. Therefore, long-term risk assessments in ESRD patients undergoing cardiac surgery are needed. Recently, sarcopenia is major concern in cardiac ... ...

    Abstract Background: The long-term mortality of end-stage renal disease (ESRD) patients is still unsatisfactory. Therefore, long-term risk assessments in ESRD patients undergoing cardiac surgery are needed. Recently, sarcopenia is major concern in cardiac surgery because of its association with poor long-term survival. However, the impact of sarcopenia on the long-term survival of ESRD patients undergoing cardiac surgery is not well understood.
    Methods: Eighty-two ESRD patients who underwent elective cardiac surgery were enrolled. Sarcopenia was identified based on noncontrast abdominal computed tomography. The impact of preoperative and intraoperative factors on long-term survival was investigated.
    Results: Forty-three patients (52%) were diagnosed with sarcopenia. The in-hospital mortality rate was 4.9%. The 5-year overall survival rate was 48%. The multivariate analyses revealed that STS score ≥ 4 (odds ratio, 6.0; confidence interval, 2.5-14.7;
    Conclusions: Among the ESRD patients, the low risk without sarcopenia group showed an excellent long-term survival, in contrast to more than intermediate-risk patients with sarcopenia, who can expect poor long-term survival. Preoperative assessment of sarcopenia in addition to the surgical risk score can be useful in developing a therapeutic strategy.
    MeSH term(s) Humans ; Sarcopenia/complications ; Sarcopenia/diagnostic imaging ; Retrospective Studies ; Risk Factors ; Cardiac Surgical Procedures/adverse effects ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/diagnosis
    Language English
    Publishing date 2023-09-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/02184923231200555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5193: Show issues Location:
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  3. Article: [A Case of Successful Surgery for Adult Partial Atrioventricular Septal Defect].

    Kishigami, Takehiro / Ikushima, Eigo / Yasutsune, Toru / Nishimura, Yosuke

    Journal of UOEH

    2019  Volume 41, Issue 2, Page(s) 239–242

    Abstract: We report a case of a 55-year-old male who had been diagnosed with mitral regurgitation and atrial septal defect 5 years earlier. He was referred to our institution because of worsening of mitral regurgitation accompanied by exertional dyspnea. As an ... ...

    Abstract We report a case of a 55-year-old male who had been diagnosed with mitral regurgitation and atrial septal defect 5 years earlier. He was referred to our institution because of worsening of mitral regurgitation accompanied by exertional dyspnea. As an echocardiography showed atrioventricular valve regurgitation and ostium primum atrial septal defect, but without ventricular septal defect, he was diagnosed as having partial atrioventricular septal defect (pAVSD). An operation was performed through median sternotomy. The anterior atrioventricular leaflet had a cleft and thickening with calcification. Suturing the cleft could not control the regurgitation. Incomplete coaptation was seen at the edge of the anastomosis site of the cleft, where the severe calcification had been identified. A rough zone including a part of the chordae tendineae was sutured in order to compensate for the gap. The atrioventricular septal defect was closed with an autologous pericardial patch. He was discharged uneventfully on the 24th postoperative day and has been followed up without complications for 1.5 years.
    MeSH term(s) Cardiac Surgical Procedures/methods ; Echocardiography ; Echocardiography, Transesophageal ; Heart Septal Defects, Ventricular/diagnostic imaging ; Heart Septal Defects, Ventricular/pathology ; Heart Septal Defects, Ventricular/surgery ; Humans ; Male ; Middle Aged ; Mitral Valve Insufficiency ; Pericardium/transplantation ; Transplantation, Autologous ; Treatment Outcome
    Language Japanese
    Publishing date 2019-07-10
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 632724-2
    ISSN 2187-2864 ; 0387-821X
    ISSN (online) 2187-2864
    ISSN 0387-821X
    DOI 10.7888/juoeh.41.239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2868: Show issues Location:
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  4. Article ; Online: A case of giant right coronary artery aneurysm due to IgG4-related disease.

    Matsuyama, Sho / Kishigami, Takehiro / Sakamoto, Masato

    General thoracic and cardiovascular surgery

    2019  Volume 68, Issue 12, Page(s) 1453–1456

    Abstract: A man diagnosed with immunoglobulin G4 (IgG4)-related disease at the age of 65 years underwent abdominal aortic replacement due to an abdominal aortic aneurysm. In the same hospitalization period, a small coronary artery aneurysm was noticed. He was ... ...

    Abstract A man diagnosed with immunoglobulin G4 (IgG4)-related disease at the age of 65 years underwent abdominal aortic replacement due to an abdominal aortic aneurysm. In the same hospitalization period, a small coronary artery aneurysm was noticed. He was treated with corticosteroids and his serum IgG levels returned to normal. After experiencing sudden chest pain at age 74 years, coronary angiography showed that the size of the aneurysm had increased dramatically. He underwent coronary artery bypass graft and coronary artery resection without using cardiopulmonary bypass. Thus, we conclude that observation of aneurysms in patients with IgG4-related disease is important, even under corticosteroid therapy.
    MeSH term(s) Aged ; Aortic Aneurysm, Abdominal ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/surgery ; Coronary Artery Bypass ; Coronary Artery Disease ; Coronary Vessels ; Humans ; Immunoglobulin G4-Related Disease ; Male
    Language English
    Publishing date 2019-12-17
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2376888-5
    ISSN 1863-6713 ; 1863-6705
    ISSN (online) 1863-6713
    ISSN 1863-6705
    DOI 10.1007/s11748-019-01272-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1173: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: 2,5-Dimethylcelecoxib attenuates cardiac fibrosis caused by cryoinjury-induced myocardial infarction by suppressing the fibroblast-to-myofibroblast transformation via inhibition of the TGF-β signaling pathway.

    Ikushima, Eigo / Ishikane, Shin / Kishigami, Takehiro / Matsunaga, Hiroaki / Igawa, Kazunobu / Tomooka, Katsuhiko / Nishimura, Yosuke / Takahashi-Yanaga, Fumi

    Biochemical pharmacology

    2022  Volume 197, Page(s) 114950

    Abstract: We previously reported that 2,5-dimethylcelecoxib (DM-C), a derivative of celecoxib, lacks cyclooxygenase-2 inhibitory effects and suppresses cardiac remodeling by activating glycogen synthase kinase-3 (GSK-3). However, it remains unclear whether DM-C ... ...

    Abstract We previously reported that 2,5-dimethylcelecoxib (DM-C), a derivative of celecoxib, lacks cyclooxygenase-2 inhibitory effects and suppresses cardiac remodeling by activating glycogen synthase kinase-3 (GSK-3). However, it remains unclear whether DM-C attenuates fibroblast-to-myofibroblast transformation (FMT), which plays a key role in cardiac fibrosis. Therefore, we evaluated the effect of DM-C on FMT using a cryoinjury-induced myocardial infarction (CMI) mouse model. We found that DM-C attenuated the deterioration of left ventricular ejection fraction after CMI by decreasing cardiac fibrosis. Analysis of the expression level of α-smooth muscle actin (α-SMA), a marker for myofibroblasts, indicated that DM-C decreased FMT at the cardiac injury site. To investigate the mechanism by which DM-C attenuated FMT, fibroblasts obtained from the heart were stimulated with TGF-β to induce FMT, and the effect of DM-C was analyzed. DM-C suppressed the expression of α-SMA and the phosphorylation levels of Smad 2/3 and GSK-3, indicating that DM-C suppressed α-SMA expression by inhibiting the transforming growth factor (TGF)-β signaling pathway via activation of GSK-3. DM-C decreased the expression of collagen, connective tissue growth factor (CTGF) and Snail, which are also known to accelerate cardiac fibrosis. These results suggested that DM-C attenuated cardiac fibrosis by suppressing FMT at the injured site after CMI by inhibiting the TGF-β signaling pathway via activation of GSK-3. Thus, DM-C has potential against cardiac disease as a novel anti-fibrotic agent.
    MeSH term(s) Animals ; Cells, Cultured ; Fibroblasts/drug effects ; Fibroblasts/enzymology ; Fibroblasts/pathology ; Fibrosis ; Freezing/adverse effects ; Glycogen Synthase Kinase 3/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Infarction/drug therapy ; Myocardial Infarction/enzymology ; Myocardial Infarction/etiology ; Myocardial Infarction/pathology ; Myofibroblasts/drug effects ; Myofibroblasts/enzymology ; Myofibroblasts/pathology ; Nitrogen/toxicity ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Rats ; Rats, Inbred Lew ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use
    Chemical Substances 2,5-dimethylcelecoxib ; Pyrazoles ; Sulfonamides ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-02-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2022.114950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 19: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Significant delayed aortic dilatation after tetralogy of Fallot repair: a case report.

    Nishimura, Yosuke / Yasutsune, Toru / Shimajiri, Shohei / Jinzai, Yuki / Ikushima, Eigo / Kishigami, Takehiro / Takigawa, Tomoya

    Surgical case reports

    2020  Volume 6, Issue 1, Page(s) 173

    Abstract: Background: Aortic dilatation may occur in some patients even after complete repair of tetralogy of Fallot (TOF). The progression rate of the aortic diameter is so slow, and the incidence of aortic dissection is so low that it is suspected that frequent ...

    Abstract Background: Aortic dilatation may occur in some patients even after complete repair of tetralogy of Fallot (TOF). The progression rate of the aortic diameter is so slow, and the incidence of aortic dissection is so low that it is suspected that frequent imaging of the aorta may not be necessary.
    Case presentation: We describe an asymptomatic 41-year-old man with hypertension in whom aortic dilatation was accidentally discovered 39 years after TOF repair. He underwent ambulatory follow-up without any difficulty for 21 years after the repair. Contrast-enhanced computed tomography revealed significant aortic dilatation (maximum diameter of 88 mm at the sinus of Valsalva), and echocardiography revealed severe aortic regurgitation, which seemed to progress during the last 18 years without any evaluation or follow-up. The Bentall procedure was successfully performed using a valved graft, under deep hypothermic circulatory arrest with antegrade cerebral perfusion, and his postoperative course was uneventful. Histopathological examination of ascending aorta specimens revealed severe cystic medial degeneration.
    Conclusions: Keeping in mind that a patient with rapid progression of the aortic dilatation after TOF repair exist, periodic follow-up for evaluation of the aorta is essential in patients with TOF.
    Language English
    Publishing date 2020-07-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-020-00935-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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