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  1. Article ; Online: Upstream Enzyme of Natriuretic Peptide Pathway: Is Soluble Corin a Predictor of Future Stroke Events?

    Kitamura, Mitsunobu

    JACC. Asia

    2022  Volume 2, Issue 4, Page(s) 502–503

    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Editorial
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2022.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bail-out edge-to-edge mitral repair for an acute single leaflet device attachment: a case report.

    Kitamura, Mitsunobu / Besler, Christian / Lurz, Philipp / Noack, Thilo

    European heart journal. Case reports

    2021  Volume 5, Issue 4, Page(s) ytab147

    Abstract: Background: An acute single leaflet device attachment (SLDA) may occur during transcatheter mitral valve edge-to-edge repair (TMVr), if an inadequate grasping of the target leaflet and/or a leaflet injury are concomitant. The bail-out TMVr often fails ... ...

    Abstract Background: An acute single leaflet device attachment (SLDA) may occur during transcatheter mitral valve edge-to-edge repair (TMVr), if an inadequate grasping of the target leaflet and/or a leaflet injury are concomitant. The bail-out TMVr often fails due to the complex pathophysiology.
    Case summary: We report a case of an acute SLDA after TMVr with the PASCAL Repair System for severe mitral regurgitation (MR) with mixed aetiology, i.e., a thin-appeared posterior leaflet and pseudo-prolapse of the anterior mitral leaflet due to mitral annular dilatation. An acute SLDA occurred 2 min after the deployment, with device detachment of the posterior leaflet. A bail-out TMVr with the MitraClip XTR system led to an optimal MR reduction with the PASCAL stabilized. Despite an adequate leaflet insertion of the 1st device achieved, the posterior leaflet was tear due to its fragile tissue characteristics. At discharge, echocardiography confirmed an optimal MR reduction to mild grade with both devices stabilized.
    Discussion: The pathology of the mitral valve leaflet is essential to achieve successful TMVr procedure using edge-to-edge repair device. Since the mechanical stress to the target leaflet appears to vary according to the edge-to-edge repair devices, the leaflet tissue characteristics should be respected during device selection.
    Language English
    Publishing date 2021-04-30
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab147
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  3. Article ; Online: Quantitative assessment of aortic regurgitation following transcatheter aortic valve replacement.

    Kitamura, Mitsunobu / Von Roeder, Maximilian / Abdel-Wahab, Mohamed

    Expert review of cardiovascular therapy

    2021  Volume 19, Issue 7, Page(s) 633–645

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/etiology ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis/adverse effects ; Humans ; Prosthesis Design ; Risk Factors ; Severity of Illness Index ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1080/14779072.2021.1924675
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    Zs.A 6107: Show issues Location:
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  4. Article ; Online: Reply: The CHOICE Randomized Clinical Trial.

    Abdel-Wahab, Mohamed / Kitamura, Mitsunobu / Richardt, Gert

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 13, Page(s) 1610–1611

    MeSH term(s) Humans ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.05.044
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    Zs.A 6669: Show issues Location:
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  5. Article ; Online: Predictors of Repeated Septal Reduction After Alcohol Septal Ablation in Patients With Hypertrophic Cardiomyopathy.

    Hiruma, Takashi / Kitamura, Mitsunobu / Takamisawa, Itaru / Izumi, Yuki / Higuchi, Ryosuke / Nanasato, Mamoru / Shimokawa, Tomoki / Takanashi, Shuichiro / Isobe, Mitsuaki / Takayama, Morimasa

    Journal of the American College of Cardiology

    2023  Volume 83, Issue 4, Page(s) 546–548

    MeSH term(s) Humans ; Cardiomyopathy, Hypertrophic/surgery ; Cardiac Surgical Procedures ; Vascular Surgical Procedures
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Letter
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.11.013
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    Zs.MO 196: Show issues

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  6. Article ; Online: TAVI and horizontal aorta: a "no impact" relationship?

    Abdel-Wahab, Mohamed / Kitamura, Mitsunobu / Thiele, Holger

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2019  Volume 15, Issue 9, Page(s) e736–e738

    MeSH term(s) Aorta/surgery ; Aortic Valve Stenosis ; Humans ; Transcatheter Aortic Valve Replacement
    Language English
    Publishing date 2019-10-04
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJV15I9A136
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    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  7. Article ; Online: Supra-normal and mildly reduced ejection fraction in women -An overlooked vulnerable subpopulation in heart failure.

    Kawai, Akane / Nagatomo, Yuji / Yukino-Iwashita, Midori / Ikegami, Yukinori / Takei, Makoto / Goda, Ayumi / Kohno, Takashi / Mizuno, Atsushi / Kitamura, Mitsunobu / Nakano, Shintaro / Sakamoto, Munehisa / Shiraishi, Yasuyuki / Kohsaka, Shun / Adachi, Takeshi / Yoshikawa, Tsutomu

    International journal of cardiology

    2024  , Page(s) 132166

    Abstract: Background: Recently, patients with supra-normal left ventricular ejection fraction (snEF) are reported to have high risk of adverse outcomes, especially in women. We sought to evaluate sex-related differences in the association between LVEF and long- ... ...

    Abstract Background: Recently, patients with supra-normal left ventricular ejection fraction (snEF) are reported to have high risk of adverse outcomes, especially in women. We sought to evaluate sex-related differences in the association between LVEF and long-term outcomes in heart failure (HF) patients.
    Methods: The multicenter WET-HF Registry enrolled all patients hospitalized for acute decompensated HF (ADHF). We analyzed 3943 patients (age 77 years; 40.1% female) registered from 2006 to 2017. According to LVEF the patients were divided into the 3 groups: HF with reduced EF (HFrEF), mildly reduced EF (HFmrEF) and preserved EF. The primary endpoint was defined as the composite of cardiac death and ADHF rehospitalization after discharge.
    Results: In HFmrEF, implementation of guideline-directed medical therapy (GDMT) such as the combination of renin-angiotensin-system inhibitor (RASi) and β-blocker at discharge was significantly lower in women than men even after adjustment for covariates (p = 0.007). There were no such sex-related differences in HFrEF. Female sex was associated with higher incidence of the primary endpoint and ADHF rehospitalization after adjustment for covariates exclusively in HFmrEF. Restricted cubic spline analysis demonstrated a U-shaped relationship between LVEF and the hazard ratio of the primary endpoint showing higher event rate in HFmrEF and HFsnEF in women, but such relationship was not observed in men (p for interaction = 0.037).
    Conclusions: In women, mrEF and snEF were associated with worse long-term outcomes. Additionally, sex-related differences in the GDMT implementation for HFmrEF highlight the need for further exploration, which might lead to creation of sex-specific guidelines to optimize HF management.
    Language English
    Publishing date 2024-05-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.132166
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    Zs.A 1673: Show issues Location:
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  8. Article ; Online: Renin-angiotensin system inhibitors for patients with mild or moderate chronic kidney disease and heart failure with mildly reduced or preserved ejection fraction.

    Takeuchi, Shinsuke / Kohno, Takashi / Goda, Ayumi / Shiraishi, Yasuyuki / Kitamura, Mitsunobu / Nagatomo, Yuji / Takei, Makoto / Nomoto, Michiru / Soejima, Kyoko / Kohsaka, Shun / Yoshikawa, Tsutomu

    International journal of cardiology

    2024  , Page(s) 132190

    Abstract: Background: Renin-angiotensin system inhibitors (RASI) reduce adverse cardiovascular events in patients with heart failure (HF) with left ventricular ejection fraction (LVEF) ≤40% and mild or moderate chronic kidney disease (CKD). However, RASI ... ...

    Abstract Background: Renin-angiotensin system inhibitors (RASI) reduce adverse cardiovascular events in patients with heart failure (HF) with left ventricular ejection fraction (LVEF) ≤40% and mild or moderate chronic kidney disease (CKD). However, RASI administration rate and its association with long-term outcomes in patients with CKD complicated by HF with LVEF >40% remain unclear.
    Methods: We analyzed 1923 consecutive patients with LVEF >40% registered within the multicenter database for hospitalized HF. We assessed RASI administration rate and its association with all-cause mortality among patients with mild or moderate CKD (estimated glomerular filtration rate [eGFR]: 30-60 mL/min/1.73 m
    Results: Among patients with LVEF >40%, 980 (51.0%) had mild or moderate CKD (age: 81 [74-86] years; male, 52.6%; hypertension, 69.7%; diabetes, 25.9%), and 370 (37.8%) did not receive RASI. RASI use was associated with hypertension, absence of atrial fibrillation, and MRA use. After multivariable adjustments, RASI use was independently associated with lower all-cause mortality over a 2-year median follow-up (hazard ratio: 0.58, 95% confidence interval: 0.43-0.79, P = 0.001), and the mortality rate difference was predominantly due to cardiac death, consistent in all subgroups.
    Conclusions: Approximately one-third of HF patients with mild or moderate CKD and LVEF >40% were discharged without RASI administration and demonstrated relatively guarded outcomes.
    Language English
    Publishing date 2024-05-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2024.132190
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  9. Article ; Online: Leaflet Prolapse After BASILICA and Transcatheter Aortic Valve Replacement.

    Kitamura, Mitsunobu / Pighi, Michele / Ribichini, Flavio / Abdel-Wahab, Mohamed

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 15, Page(s) e143–e145

    MeSH term(s) Aged ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/physiopathology ; Aortic Valve Stenosis/surgery ; Bioprosthesis ; Coronary Occlusion/etiology ; Coronary Occlusion/physiopathology ; Coronary Occlusion/prevention & control ; Drug-Eluting Stents ; Heart Valve Prosthesis ; Hemodynamics ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/instrumentation ; Prosthesis Design ; Transcatheter Aortic Valve Replacement/adverse effects ; Transcatheter Aortic Valve Replacement/instrumentation ; Treatment Outcome
    Language English
    Publishing date 2020-05-27
    Publishing country United States
    Document type Case Reports ; Video-Audio Media
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.04.016
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  10. Article ; Online: Single leaflet BASILICA for bilateral coronary artery protection.

    Kitamura, Mitsunobu / Holzhey, David / Thiele, Holger / Abdel-Wahab, Mohamed

    European heart journal

    2020  Volume 42, Issue 26, Page(s) 2612

    MeSH term(s) Coronary Vessels/diagnostic imaging ; Heart Valve Prosthesis ; Humans ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa710
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    Zs.MO 640: Show issues

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