Article ; Online: A novel Foley catheter made of high-intensity near-infrared fluorescent silicone rubber for image-guided surgery of lower rectal cancer.
Photodiagnosis and photodynamic therapy
2024 Volume 45, Page(s) 103976
Abstract: Background: Urethral injury occurs in 1-6 % of male cases during minimally invasive surgery of lower rectal cancer. A Foley catheter emitting near-infrared (NIR) fluorescence of sufficient intensity has been expected to locate the urethra during image- ... ...
| Abstract | Background: Urethral injury occurs in 1-6 % of male cases during minimally invasive surgery of lower rectal cancer. A Foley catheter emitting near-infrared (NIR) fluorescence of sufficient intensity has been expected to locate the urethra during image-guided surgery. Although it has been difficult to impart NIR fluorescent properties to biocompatible thermosetting polymers, we have recently succeeded in developing a NIR fluorescent compound for silicone rubber and a NIR fluorescent Foley catheter (HICARL). Here, we evaluated its NIR fluorescence properties and visibility performance using porcine anorectal isolation specimens. Methods: The HICARL catheter was made of a mixture of solid silicone rubber and a NIR fluorescent compound that emits fluorescence with a wavelength of 820-880 nm, while a conventional transparent Foley catheter was made of solid silicone rubber only. As a standard for comparison of the intensity of NIR fluorescence, a transparent Foley catheter the lumen of which was filled with a mixture of indocyanine green (ICG) and human plasma was used. As a comparison to assess the visibility performance of the HICARL catheter, a transparent Foley catheter into which a commercially available NIR fluorescent polyurethane ureteral catheter (NIRC) was placed was used. Results: A NIR fluorescence quantitative imaging analysis revealed that the Foley-NIRC catheter and the HICARL catheter emitted 3.42 ± 0.42 and 6.43 ± 0.07 times more fluorescence than the Foley-ICG catheter, respectively. The location of the HICARL catheter placed in the anorectum with a wall thickness of 3.8 ± 0.1 mm was clearly delineated in its entirety by NIR fluorescence, while that of the Foley-NIRC catheter was faintly or only partially visible. Conclusions: The HICARL catheter emitting NIR fluorescence of sufficient intensity is a promising and easy-to-use tool for urethral visualization during image-guided surgery of lower rectal cancer. |
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| MeSH term(s) | Humans ; Male ; Animals ; Swine ; Silicone Elastomers ; Photochemotherapy/methods ; Photosensitizing Agents ; Coloring Agents ; Indocyanine Green/pharmacology ; Surgery, Computer-Assisted ; Catheters ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/surgery |
| Chemical Substances | Silicone Elastomers ; Photosensitizing Agents ; Coloring Agents ; Indocyanine Green (IX6J1063HV) |
| Language | English |
| Publishing date | 2024-01-14 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2149918-4 |
| ISSN | 1873-1597 ; 1572-1000 |
| ISSN (online) | 1873-1597 |
| ISSN | 1572-1000 |
| DOI | 10.1016/j.pdpdt.2024.103976 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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