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  1. Article ; Online: Synthetic biology: Learning the way toward high-precision biological design.

    Kitano, Shohei / Lin, Ciai / Foo, Jee Loon / Chang, Matthew Wook

    PLoS biology

    2023  Volume 21, Issue 4, Page(s) e3002116

    Abstract: Since its inception, synthetic biology has overcome many technical barriers but is at a crossroads for high-precision biological design. Devising ways to fully utilize big biological data may be the key to achieving greater heights in synthetic biology. ...

    Abstract Since its inception, synthetic biology has overcome many technical barriers but is at a crossroads for high-precision biological design. Devising ways to fully utilize big biological data may be the key to achieving greater heights in synthetic biology.
    MeSH term(s) Synthetic Biology ; Big Data
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3002116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6193: Show issues Location:
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  2. Article ; Online: Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies.

    Aggarwal, Nikhil / Kitano, Shohei / Puah, Ginette Ru Ying / Kittelmann, Sandra / Hwang, In Young / Chang, Matthew Wook

    Chemical reviews

    2022  Volume 123, Issue 1, Page(s) 31–72

    Abstract: The human microbiome is composed of a collection of dynamic microbial communities that inhabit various anatomical locations in the body. Accordingly, the coevolution of the microbiome with the host has resulted in these communities playing a profound ... ...

    Abstract The human microbiome is composed of a collection of dynamic microbial communities that inhabit various anatomical locations in the body. Accordingly, the coevolution of the microbiome with the host has resulted in these communities playing a profound role in promoting human health. Consequently, perturbations in the human microbiome can cause or exacerbate several diseases. In this Review, we present our current understanding of the relationship between human health and disease development, focusing on the microbiomes found across the digestive, respiratory, urinary, and reproductive systems as well as the skin. We further discuss various strategies by which the composition and function of the human microbiome can be modulated to exert a therapeutic effect on the host. Finally, we examine technologies such as multiomics approaches and cellular reprogramming of microbes that can enable significant advancements in microbiome research and engineering.
    MeSH term(s) Humans ; Microbiota ; Technology
    Language English
    Publishing date 2022-11-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.2c00431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Voltammetric and

    Kitano, Shohei / Tanabe, Ichiro / Shioya, Nobutaka / Hasegawa, Takeshi / Murata, Tsuyoshi / Morita, Yasushi / Tsuji, Ryotaro / Fukui, Ken-Ichi

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 19, Page(s) 6846–6854

    Abstract: To investigate the microscopic electrochemical dynamics of a stable trioxotriangulene (TOT) organic neutral π-radical on a graphite electrode surface, voltammetric ... ...

    Abstract To investigate the microscopic electrochemical dynamics of a stable trioxotriangulene (TOT) organic neutral π-radical on a graphite electrode surface, voltammetric and
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c00438
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  4. Article ; Online: Transposable elements shape the human proteome landscape via formation of cis-acting upstream open reading frames.

    Kitano, Shohei / Kurasawa, Hikaru / Aizawa, Yasunori

    Genes to cells : devoted to molecular & cellular mechanisms

    2018  Volume 23, Issue 4, Page(s) 274–284

    Abstract: Transposons are major drivers of mammalian genome evolution. To obtain new insights into the contribution of transposons to the regulation of protein translation, we here examined how transposons affected the genesis and function of upstream open reading ...

    Abstract Transposons are major drivers of mammalian genome evolution. To obtain new insights into the contribution of transposons to the regulation of protein translation, we here examined how transposons affected the genesis and function of upstream open reading frames (uORFs), which serve as cis-acting elements to regulate translation from annotated ORFs (anORFs) located downstream of the uORFs in eukaryotic mRNAs. Among 39,786 human uORFs, 3,992 had ATG trinucleotides of a transposon origin, termed "transposon-derived upstream ATGs" or TuATGs. Luciferase reporter assays suggested that many TuATGs modulate translation from anORFs. Comparisons with transposon consensus sequences revealed that most TuATGs were generated by nucleotide substitutions in non-ATG trinucleotides of integrated transposons. Among these non-ATG trinucleotides, GTG and ACG were converted into TuATGs more frequently, indicating a CpG methylation-mediated process of TuATG formation. Interestingly, it is likely that this process accelerated human-specific upstream ATG formation within transposon sequences in 5' untranslated regions after divergence between human and nonhuman primates. Methylation-mediated TuATG formation seems to be ongoing in the modern human population and could alter the expression of disease-related proteins. This study shows that transposons have potentially been shaping the human proteome landscape via cis-acting uORF creation.
    MeSH term(s) 5' Untranslated Regions ; Computational Biology ; DNA Methylation ; DNA Transposable Elements ; Evolution, Molecular ; Genome, Human ; Humans ; Open Reading Frames ; Polymorphism, Single Nucleotide ; Proteome/genetics ; Regulatory Sequences, Nucleic Acid
    Chemical Substances 5' Untranslated Regions ; DNA Transposable Elements ; Proteome
    Language English
    Publishing date 2018-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330000-3
    ISSN 1365-2443 ; 1356-9597
    ISSN (online) 1365-2443
    ISSN 1356-9597
    DOI 10.1111/gtc.12567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4539: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration.

    Foo, Jee Loon / Kitano, Shohei / Susanto, Adelia Vicanatalita / Jin, Zhu / Lin, Yicong / Luo, Zhouqing / Huang, Linsen / Liang, Zhenzhen / Mitchell, Leslie A / Yang, Kun / Wong, Adison / Cai, Yizhi / Cai, Jitong / Stracquadanio, Giovanni / Bader, Joel S / Boeke, Jef D / Dai, Junbiao / Chang, Matthew Wook

    Cell genomics

    2023  Volume 3, Issue 11, Page(s) 100435

    Abstract: Chromosome-level design-build-test-learn cycles (chrDBTLs) allow systematic combinatorial reconfiguration of chromosomes with ease. Here, we established chrDBTL with a redesigned ... ...

    Abstract Chromosome-level design-build-test-learn cycles (chrDBTLs) allow systematic combinatorial reconfiguration of chromosomes with ease. Here, we established chrDBTL with a redesigned synthetic
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2023.100435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Low-temperature growth of near-infrared luminescent Bi-doped SiO(x)N(y) thin films.

    Fujii, Minoru / Morimoto, Satoshi / Kitano, Shohei / Imakita, Kenji / Qiu, Jianrong / Sun, Hong-Tao

    Optics letters

    2013  Volume 38, Issue 20, Page(s) 4224–4227

    Abstract: Bi-doped siliconoxynitride (SiON:Bi) thin films were prepared by a sputtering method and the photoluminescence (PL) properties were studied. Without any thermal treatments, broad Bi-related luminescence was observed in the near-infrared (NIR) range. The ... ...

    Abstract Bi-doped siliconoxynitride (SiON:Bi) thin films were prepared by a sputtering method and the photoluminescence (PL) properties were studied. Without any thermal treatments, broad Bi-related luminescence was observed in the near-infrared (NIR) range. The luminescence efficiency depended strongly on the film composition. It was found that N atoms play a crucial role for the formation of Bi NIR luminescence centers. The effect of annealing on the luminescence efficiency was also studied. The optimum annealing temperature to have the largest number of Bi NIR luminescence centers depended strongly on the film composition and it was lower for films with lower N concentration. The PL excitation spectra revealed that two different Bi NIR luminescence centers exist in the films.
    Language English
    Publishing date 2013-10-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.38.004224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cranial remodeling to treat craniosynostosis by gradual distraction using a new device.

    Imai, Keisuke / Komune, Hiroyuki / Toda, Chiaya / Nomachi, Takeru / Enoki, Eiji / Sakamoto, Hiroaki / Kitano, Shohei / Hatoko, Mitsuo / Fujimoto, Takuya

    Journal of neurosurgery

    2002  Volume 96, Issue 4, Page(s) 654–659

    Abstract: Object: The authors describe their experience in remodeling the shape of the cranium in children with craniosynostosis by using gradual distraction. In half of the cases, a new distraction device developed by the authors was used.: Methods: Twenty ... ...

    Abstract Object: The authors describe their experience in remodeling the shape of the cranium in children with craniosynostosis by using gradual distraction. In half of the cases, a new distraction device developed by the authors was used.
    Methods: Twenty children with craniosynostosis underwent frontoorbital advancement and cranial remodeling assisted by gradual distraction. There were five children with brachycephaly, two with oxycephaly, five with scaphocephaly, two with plagiocephaly, one with combined scaphocephaly and plagiocephaly, and five with trigonocephaly. Four cases were syndromic and 16 were nonsyndromic. The patients ranged in age from 3 to 50 months (mean 14.5 months) at the first surgery. Simulated surgery was first performed on a three-dimensional solid model made of polyurethane, which accurately represented cranial flexibility, to determine the most favorable osteotomy line. Distraction was initiated 1 week postoperatively. The speed and extent of advancement (maximum extension 45 mm) were predetermined on the basis of previously reported criteria and the results of simulated surgery. Postoperatively, the cranial configuration was favorable in all cases. Spontaneous remodeling of irregularities and/or gaps apparent after distraction was found to occur 2 to 5 months after removal of the distraction devices, especially in patients with trigonocephaly or scaphocephaly. No major perioperative complication was observed in any patient. There were minor complications in six of the first 10 cases, including exposure of the device, shaft slippage, and fluid discharge. A new device was developed and used on the last 10 patients treated; it successfully eliminated device exposure and shaft slippage. A 3-year follow-up review confirmed that there was no relapse of advanced bones.
    Conclusions: Highly satisfactory results were achieved in cases of both syndromic and nonsyndromic craniosynostosis when gradual distraction was performed.
    MeSH term(s) Bone Remodeling/physiology ; Child, Preschool ; Craniosynostoses/physiopathology ; Craniosynostoses/surgery ; Equipment Design ; External Fixators ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Osteogenesis, Distraction/instrumentation ; Osteogenesis, Distraction/methods ; Osteotomy/instrumentation ; Osteotomy/methods ; Skull/physiopathology ; Skull/surgery ; Treatment Outcome
    Language English
    Publishing date 2002-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/jns.2002.96.4.0654
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    Uk I Zs.135: Show issues Location:
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