LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 376

Search options

  1. Book: Mucosal vaccines

    Kiyono, Hiroshi / Pascual, David W.

    innovation for preventing infectious diseases

    2020  

    Author's details edited by Hiroshi Kiyono, David W. Pascual
    Keywords Mucous membrane/Immunology ; Vaccines
    Language English
    Size xxiv, 915 Seiten, Illustrationen, 24 cm
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT020341880
    ISBN 978-0-12-811924-2 ; 9780128119259 ; 0-12-811924-1 ; 012811925X
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 209 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: US Japan AIDS

    Kiyono, Hiroshi

    recent progress in virology, immunology and animal models of HIV infection

    (Vaccine ; 28, Suppl. 2)

    2010  

    Title variant US-Japan AIDS
    Author's details co-guest ed.: Hiroshi Kiyono
    Series title Vaccine ; 28, Suppl. 2
    Collection
    Language English
    Size B84 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016423440
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1930 -28,Suppl.2- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book: Mucosal vaccines

    Kiyono, Hiroshi

    1996  

    Author's details ed. by Hiroshi Kiyono
    Keywords Vaccines / immunology ; Vaccines / administration & dosage ; Mucous Membrane / immunology ; Adjuvants, Immunologic / physiology ; Immunity, Mucosal ; Impfstoff ; Orale Applikation ; Schleimhaut ; Immunologie
    Subject Mucosa ; Orale Verabreichung ; Vaccine ; Vakzine ; Antikörperhaltiges Arzneimittel ; Klinische Immunologie
    Language English
    Size XIX, 479 S. : Ill., graph. Darst.
    Publisher Acad. Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007478234
    ISBN 0-12-410580-7 ; 978-0-12-410580-5
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 2858 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book: Mucosal immunology

    Kiyono, Hiroshi

    intraepithelial lymphocytes

    (Advances in host defense mechanisms ; 9)

    1994  

    Author's details eds. Hiroshi Kiyono
    Series title Advances in host defense mechanisms ; 9
    Collection
    Keywords Intestinal Mucosa / immunology ; T-Lymphocyte Subsets / immunology ; Magenschleimhaut ; Immunologie ; Lymphozyt
    Subject Lymphocyt ; Lymphzelle ; Lymphozyten ; Lymphocyten ; Klinische Immunologie
    Language English
    Size XVII, 204 S. : Ill., graph. Darst.
    Publisher Raven Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT006207311
    ISBN 0-7817-0117-1 ; 978-0-7817-0117-4
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 1416 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book: Special issue on mucosal immunology

    Kiyono, Hiroshi

    [this meeting was held March, 1990 at Seascape, Destin, Fla.]

    (Regional immunology ; 4,2)

    1992  

    Title variant Mucosal immunology
    Author's details guest eds.: Hiroshi Kiyono
    Series title Regional immunology ; 4,2
    Keywords Intestinal Mucosa / immunology / congresses
    Size S. 53 - 117 : Ill., graph. Darst.
    Publisher Wiley
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004376183
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2443 -4- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Conference proceedings: Molecular aspects of immune response and infectious diseases

    Kiyono, Hiroshi

    [proceedings of the International Conference on Molecular Aspects of Immune Response and Infectious Diseases, held in Rome July 25 - 28, 1989]

    (Advances in host defense mechanisms ; 7)

    1990  

    Event/congress International Conference on Molecular Aspects of Immune Response and Infectious Diseases (1989, Rom)
    Author's details [guest ed.] H. Kiyono
    Series title Advances in host defense mechanisms ; 7
    Collection
    Keywords Communicable Diseases / immunology / congresses ; Immunity, Cellular / physiology / congresses ; Lymphocytes / physiology / congresses ; Receptors, Interleukin-2 / immunology / congresses ; Immunreaktion ; Molekularbiologie ; Infektionskrankheit
    Subject Ansteckende Krankheit ; Kontagiöse Krankheit ; Infektionskrankheiten ; Molekulare Biologie ; Abwehrreaktion ; Immunantwort ; Immunoreaktivität ; Immunabwehr
    Size XXII, 202 S. : Ill., graph. Darst.
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003675487
    ISBN 0-88167-686-1 ; 978-0-88167-686-0
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 7163 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Abstract: Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. ... ...

    Abstract Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.
    Language English
    Publishing date 2024-01-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-023-00999-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Correction: Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.

    Zhang, Zhongwei / Tanaka, Izumi / Nakahashi-Ouchida, Rika / Ernst, Peter B / Kiyono, Hiroshi / Kurashima, Yosuke

    Seminars in immunopathology

    2024  

    Language English
    Publishing date 2024-04-22
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-024-01002-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: A review of criteria strictness in "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials".

    Amai, Motoki / Nojima, Masanori / Yuki, Yoshikazu / Kiyono, Hiroshi / Nagamura, Fumitaka

    Vaccine

    2023  Volume 41, Issue 38, Page(s) 5622–5629

    Abstract: To assess safety in vaccine development, stricter grading scales, such as the "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials" issued by the U.S. Food and Drug Administration (FDA grading ...

    Abstract To assess safety in vaccine development, stricter grading scales, such as the "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials" issued by the U.S. Food and Drug Administration (FDA grading scale), are required. However, concern exists that their strictness may lead to an overestimation of some adverse events (AEs). We analyzed the details of AEs in a phase I clinical trial of a preventive vaccine for infectious diseases. In this trial, we observed the high occurrence of Grade 1 or greater AEs in hemoglobin changes from baseline value, and hypernatremia, and hypokalemia by FDA grading scale. The range considered as non-AE according to the FDA grading scale shifted or became narrower when compared to reference intervals, especially for a Japanese cohort. For sodium grading, the criterion for hypernatremia was around 2 to mEq/L lower than the upper limit of most standards in several countries. Also, the criterion for hypokalemia was around 0.2 mEq/L higher than the lower limit of most standards. Regarding a decrease in hemoglobin from baseline, the criterion of "any decrease" used for a Grade 1 AE was too strict and we suggest this be omitted. Upper and lower limits of AE criteria for sodium and potassium should be equal to, or 10-20% above, the reference interval consistent with other toxicities determined by laboratory tests. Consideration should be given to the issues surrounding the criteria that determine AEs before conducting clinical trials.
    MeSH term(s) Humans ; Adult ; Adolescent ; Hypernatremia ; Hypokalemia ; Vaccines/adverse effects ; Volunteers ; Hemoglobins
    Chemical Substances Vaccines ; Hemoglobins
    Language English
    Publishing date 2023-08-01
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.07.072
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 458: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Mucosal vaccination: onward and upward.

    Tsai, Catherine J Y / Loh, Jacelyn M S / Fujihashi, Kohtaro / Kiyono, Hiroshi

    Expert review of vaccines

    2023  Volume 22, Issue 1, Page(s) 885–899

    Abstract: Introduction: The unique mucosal immune system allows the generation of robust protective immune responses at the front line of pathogen encounters. The needle-free delivery route and cold chain-free logistic requirements also provide additional ... ...

    Abstract Introduction: The unique mucosal immune system allows the generation of robust protective immune responses at the front line of pathogen encounters. The needle-free delivery route and cold chain-free logistic requirements also provide additional advantages in ease and economy. However, the development of mucosal vaccines faces several challenges, and only a handful of mucosal vaccines are currently licensed. These vaccines are all in the form of live attenuated or inactivated whole organisms, whereas no subunit-based mucosal vaccine is available.
    Areas covered: The selection of antigen, delivery vehicle, route and adjuvants for mucosal vaccination are highly important. This is particularly crucial for subunit vaccines, as they often fail to elicit strong immune responses. Emerging research is providing new insights into the biological and immunological uniqueness of mucosal tissues. However, many aspects of the mucosal immunology still await to be investigated.
    Expert opinion: This article provides an overview of the current understanding of mucosal vaccination and discusses the remaining knowledge gaps. We emphasize that because of the potential benefits mucosal vaccines can bring from the biomedical, social and economic standpoints, the unmet goal to achieve mucosal vaccine success is worth the effort.
    MeSH term(s) Humans ; Vaccination ; Mucous Membrane ; Vaccines ; Immunity ; Adjuvants, Immunologic ; Immunity, Mucosal
    Chemical Substances Vaccines ; Adjuvants, Immunologic
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181284-6
    ISSN 1744-8395 ; 1476-0584
    ISSN (online) 1744-8395
    ISSN 1476-0584
    DOI 10.1080/14760584.2023.2268724
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6077: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top