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  1. AU="Kiyota, Tatiana A"
  2. AU="Whiteson, D" AU="Whiteson, D"

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  1. Article ; Online: Increased Serum Mir-150-3p Expression Is Associated with Radiological Lung Injury Improvement in Patients with COVID-19.

    Bueno, Larissa C M / Paim, Layde R / Minin, Eduarda O Z / da Silva, Luís Miguel / Mendes, Paulo R / Kiyota, Tatiana A / Schreiber, Angelica Z / Bombassaro, Bruna / Mansour, Eli / Moretti, Maria Luiza / Chow, Jonathan Tak-Sum / Salmena, Leonardo / Coelho-Filho, Otavio R / Velloso, Licio A / Nadruz, Wilson / Schreiber, Roberto

    Viruses

    2022  Volume 14, Issue 7

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, responsible for an atypical pneumonia that can progress to acute lung injury. MicroRNAs are small non-coding RNAs that control specific genes and pathways. This study evaluated the ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, responsible for an atypical pneumonia that can progress to acute lung injury. MicroRNAs are small non-coding RNAs that control specific genes and pathways. This study evaluated the association between circulating miRNAs and lung injury associated with COVID-19.
    MeSH term(s) COVID-19/genetics ; Computational Biology/methods ; Humans ; Lung Injury ; MicroRNAs/metabolism ; SARS-CoV-2
    Chemical Substances MIRN150 microRNA, human ; MIRN212 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Increased Serum Mir-150-3p Expression Is Associated with Radiological Lung Injury Improvement in Patients with COVID-19

    Bueno, Larissa C. M. / Paim, Layde R. / Minin, Eduarda O. Z. / da Silva, Luís Miguel / Mendes, Paulo R. / Kiyota, Tatiana A. / Schreiber, Angelica Z. / Bombassaro, Bruna / Mansour, Eli / Moretti, Maria Luiza / Chow, Jonathan Tak-Sum / Salmena, Leonardo / Coelho-Filho, Otavio R. / Velloso, Licio A. / Nadruz, Wilson / Schreiber, Roberto

    Viruses. 2022 June 23, v. 14, no. 7

    2022  

    Abstract: Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, responsible for an atypical pneumonia that can progress to acute lung injury. MicroRNAs are small non-coding RNAs that control specific genes and pathways. This study evaluated the ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, responsible for an atypical pneumonia that can progress to acute lung injury. MicroRNAs are small non-coding RNAs that control specific genes and pathways. This study evaluated the association between circulating miRNAs and lung injury associated with COVID-19. Methods: We evaluated lung injury by computed tomography at hospital admission and discharge and the serum expression of 754 miRNAs using the TaqMan OpenArray after hospital discharge in 27 patients with COVID-19. In addition, miR-150-3p was validated by qRT-PCR on serum samples collected at admission and after hospital discharge. Results: OpenArray analysis revealed that seven miRNAs were differentially expressed between groups of patients without radiological lung improvement compared to those with lung improvement at hospital discharge, with three miRNAs being upregulated (miR-548c-3p, miR-212-3p, and miR-548a-3p) and four downregulated (miR-191-5p, miR-151a-3p, miR-92a-3p, and miR-150-3p). Bioinformatics analysis revealed that five of these miRNAs had binding sites in the SARS-CoV-2 genome. Validation of miR-150-3p by qRT-PCR confirmed the OpenArray results. Conclusions: The present study shows the potential association between the serum expression of seven miRNAs and lung injury in patients with COVID-19. Furthermore, increased expression of miR-150 was associated with pulmonary improvement at hospital discharge.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; bioinformatics ; blood serum ; computed tomography ; hospitals ; lungs ; microRNA ; pneumonia ; viruses
    Language English
    Dates of publication 2022-0623
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14071363
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Gender influences the relationship between lung function and cardiac remodeling in hypertensive subjects.

    Mendes, Paulo R / Kiyota, Tatiana A / Cipolli, José A / Schreiber, Roberto / Paim, Layde R / Bellinazzi, Vera R / Matos-Souza, José R / Sposito, Andrei C / Nadruz, Wilson

    Hypertension research : official journal of the Japanese Society of Hypertension

    2015  Volume 38, Issue 4, Page(s) 264–268

    Abstract: Hypertensive patients are predisposed to left ventricular (LV) remodeling and frequently exhibit decline in lung function as compared with the general population. Here, we investigated the association between spirometric and echocardiographic data in non- ...

    Abstract Hypertensive patients are predisposed to left ventricular (LV) remodeling and frequently exhibit decline in lung function as compared with the general population. Here, we investigated the association between spirometric and echocardiographic data in non-smoking hypertensive subjects and the role of gender in this regard. In a cross-sectional study, 107 hypertensive patients (60 women) enrolled from a university outpatient clinic were evaluated by clinical, hemodynamic, laboratory and echocardiographic analysis. Vital capacity, forced vital capacity (FVC), forced expired volume in 1 s (FEV1) and in 6 s (FEV6), FEV1/FVC ratio and FEV1/FEV6 ratio were estimated by spirometry. In women, higher LV mass index and E/Em ratio correlated with markers of restrictive lung alterations, such as reduced FVC (r=-044; P<0.001; r=-0.42; P<0.001, respectively) and FEV6 (r=-0.43; P<0.001; r=-0.39; P<0.01, respectively), while higher left atrial volume index correlated with markers of obstructive lung alterations, such as reduced FEV1/FVC (r=-055; P<0.001) and FEV1/FEV6 (r=-0.45; P<0.001) ratios. These relationships were further confirmed by stepwise regression analysis adjusted for potential confounders. In men, LV mass index correlated with FVC and FEV6, but these associations did not remain statistically significant after adjustment for confounding variables. Furthermore, inflammatory markers such as plasma C-reactive protein and matrix-metalloproteinases-2 and -9 levels did not influence the association between spirometric and cardiac parameters. In conclusion, these results indicate that LV remodeling is related to restrictive lung alterations while left atrial remodeling is associated with obstructive lung alterations in hypertensive women.
    MeSH term(s) Adult ; Aged ; Atrial Function, Left ; Cross-Sectional Studies ; Echocardiography ; Female ; Forced Expiratory Volume ; Humans ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/etiology ; Hypertrophy, Left Ventricular/physiopathology ; Lung/physiopathology ; Male ; Middle Aged ; Sex Characteristics ; Spirometry ; Ventricular Remodeling ; Vital Capacity
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/hr.2014.168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lung age is related to carotid structural alterations in hypertensive subjects.

    Kiyota, Tatiana A / Mendes, Paulo R / Cipolli, José A / Schreiber, Roberto / Paim, Layde R / Bellinazzi, Vera R / Matos-Souza, José R / Sposito, Andrei C / Nadruz, Wilson

    Journal of the American Society of Hypertension : JASH

    2014  Volume 8, Issue 6, Page(s) 381–387

    Abstract: Hypertensive patients exhibit higher cardiovascular risk and reduced lung function compared with the general population. Whether this association stems from the coexistence of two highly prevalent diseases or from direct or indirect links of ... ...

    Abstract Hypertensive patients exhibit higher cardiovascular risk and reduced lung function compared with the general population. Whether this association stems from the coexistence of two highly prevalent diseases or from direct or indirect links of pathophysiological mechanisms is presently unclear. This study investigated the association between lung function and carotid features in non-smoking hypertensive subjects with supposed normal lung function. Hypertensive patients (n = 67) were cross-sectionally evaluated by clinical, hemodynamic, laboratory, and carotid ultrasound analysis. Forced vital capacity, forced expired volume in 1 second and in 6 seconds, and lung age were estimated by spirometry. Subjects with ventilatory abnormalities according to current guidelines were excluded. Regression analysis adjusted for age and prior smoking history showed that lung age and the percentage of predicted spirometric parameters associated with common carotid intima-media thickness, diameter, and stiffness. Further analyses, adjusted for additional potential confounders, revealed that lung age was the spirometric parameter exhibiting the most significant regression coefficients with carotid features. Conversely, plasma C-reactive protein and matrix-metalloproteinases-2/9 levels did not influence this relationship. The present findings point toward lung age as a potential marker of vascular remodeling and indicate that lung and vascular remodeling might share common pathophysiological mechanisms in hypertensive subjects.
    MeSH term(s) Aging ; Blood Pressure/physiology ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/physiopathology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Disease Progression ; Female ; Follow-Up Studies ; Forced Expiratory Volume ; Humans ; Hypertension/physiopathology ; Lung/physiopathology ; Male ; Middle Aged
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2276144-5
    ISSN 1878-7436 ; 1933-1711
    ISSN (online) 1878-7436
    ISSN 1933-1711
    DOI 10.1016/j.jash.2014.03.322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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