LIVIVO - Search results -

Search results

Result 1 - 10 of total 83

Search options

Article ; Online: Colon-cancer liver metastasis is effectively targeted by recombinant methioninase (rMETase) in an orthotopic mouse model.

Miyake, Kentaro / Han, Qinghong / Murakami, Takashi / Kiyuna, Tasuku / Kawaguchi, Kei / Igarashi, Kentaro / Lwin, Thinzar M / Miyake, Masuyo / Yamamoto, Jun / Bouvet, Michael / Endo, Itaru / Hoffman, Robert M

Tissue & cell

2023 Volume 83, Page(s) 102125

Abstract: Background: Colorectal cancer liver metastasis (CCLM) is the most frequent cause of death of colorectal cancer. Development of novel new effective therapy is needed for CCLM patients to improve outcome. The aim of the present study was to investigate ... ...

Abstract	Background: Colorectal cancer liver metastasis (CCLM) is the most frequent cause of death of colorectal cancer. Development of novel new effective therapy is needed for CCLM patients to improve outcome. The aim of the present study was to investigate the efficacy of recombinant methioninase (rMETase) on a CCLM orthotopic mouse model of liver metastasis established using the human colon cancer cell line HT29 expressing red fluorescent protein (RFP). Materials and methods: Orthotopic CCLM nude mouse models were randomized into two groups: control group (n = 6, PBS 200 µl, i.p., daily); rMETase group (n = 6, 100 units/200 µl, i.p., daily). Tumor volume was measured on day 0 and day 15. Body weight was measured twice a week. All mice were sacrificed on day 15. Results: rMETase significantly inhibited the increase of the liver metastasis as determined by RFP fluorescence area and intensity (p = 0.016 and 0.015, respectively). There was no significant difference of body weight between either group on any day. Conclusions: The present study suggests that rMETase has future potential therapy for CCLM in the clinic.
MeSH term(s)	Humans ; Mice ; Animals ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/pathology ; Body Weight ; Liver Neoplasms/drug therapy
Chemical Substances	L-methionine gamma-lyase (EC 4.4.1.11)
Language	English
Publishing date	2023-06-02
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2023.102125
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1016: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Synergy of oral recombinant methioninase (rMETase) and 5-fluorouracil on poorly differentiated gastric cancer.

Miyake, Masuyo / Miyake, Kentaro / Han, Qinghong / Igarashi, Kentaro / Kawaguchi, Kei / Barangi, Maryam / Kiyuna, Tasuku / Sugisawa, Norihiko / Higuchi, Takashi / Oshiro, Hiromichi / Zhang, Zhiying / Razmjooei, Sahar / Bouvet, Michael / Endo, Itaru / Hoffman, Robert M

Biochemical and biophysical research communications

2022 Volume 643, Page(s) 48–54

Abstract: Gastric cancer is highly malignant and recalcitrant to first line chemotherapies that include 5-fluorouracil (5-FU). Cancer cells are addicted to methionine for their proliferation and survival. Methionine addiction of cancer is known as the Hoffman ... ...

Abstract	Gastric cancer is highly malignant and recalcitrant to first line chemotherapies that include 5-fluorouracil (5-FU). Cancer cells are addicted to methionine for their proliferation and survival. Methionine addiction of cancer is known as the Hoffman effect. Methionine restriction with recombinant methioninase (rMETase) has been shown to selectively starve cancer cells and has shown synergy with cytotoxic chemotherapy including 5-FU. The present study aimed to investigate the efficacy of rMETase alone and the combination with 5-FU on poorly differentiated human gastric cancer cell lines (MKN45, NUGC3, and NUGC4) in vitro and vivo. rMETase suppressed the tumor growth of 3 kinds of poorly differentiated gastric cancer cells in vitro. The fluorescence ubiquitination-based cell cycle indicator (FUCCI) demonstrated cancer cells treated with rMETase were selectively trapped in the S/G
MeSH term(s)	Mice ; Humans ; Animals ; Fluorouracil/therapeutic use ; Stomach Neoplasms/drug therapy ; Carbon-Sulfur Lyases ; Methionine/metabolism ; Recombinant Proteins/pharmacology
Chemical Substances	Fluorouracil (U3P01618RT) ; L-methionine gamma-lyase (EC 4.4.1.11) ; Carbon-Sulfur Lyases (EC 4.4.-) ; Methionine (AE28F7PNPL) ; Recombinant Proteins
Language	English
Publishing date	2022-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.12.062
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Efficacy of Tumor-Targeting

Murakami, Takashi / Hiroshima, Yukihiko / Miyake, Kentaro / Kiyuna, Tasuku / Endo, Itaru / Zhao, Ming / Hoffman, Robert M

Cells

2019 Volume 8, Issue 6

Abstract: We developed tumor- ... ...

Abstract	We developed tumor-targeting
MeSH term(s)	Animals ; Humans ; Mice ; Neoplasms/therapy ; Salmonella typhimurium/physiology ; Xenograft Model Antitumor Assays
Language	English
Publishing date	2019-06-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409
ISSN	2073-4409
DOI	10.3390/cells8060599
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Imaging the interaction of α

Tome, Yasunori / Kiyuna, Tasuku / Uehara, Fuminari / Bouvet, Michael / Tsuchiya, Hiroyuki / Kanaya, Fuminori / Hoffman, Robert M

Journal of cellular biochemistry

2018 Volume 120, Issue 1, Page(s) 283–289

Abstract: Human osteosarcoma 143B cells were previously stably transfected with an ... ...

Abstract	Human osteosarcoma 143B cells were previously stably transfected with an α
MeSH term(s)	Animals ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Line, Tumor ; Collagen/metabolism ; Fibroblasts/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Integrin alphaV/genetics ; Integrin alphaV/metabolism ; Luminescent Proteins/metabolism ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Macrophages/metabolism ; Male ; Mice ; Mice, Nude ; Mice, Transgenic ; Microscopy, Confocal ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; Stromal Cells/metabolism ; Transfection ; Transplantation, Heterologous ; Tumor Microenvironment ; Red Fluorescent Protein
Chemical Substances	Integrin alphaV ; Luminescent Proteins ; Green Fluorescent Proteins (147336-22-9) ; Collagen (9007-34-5)
Language	English
Publishing date	2018-08-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.27353
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1114: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Tumor-targeting

Kiyuna, Tasuku / Tome, Yasunori / Uehara, Fuminari / Murakami, Takashi / Zhang, Yong / Zhao, Ming / Kanaya, Fuminori / Hoffman, Robert M

Anticancer research

2018 Volume 38, Issue 1, Page(s) 159–164

Abstract: Background: We previously developed a color-coded imaging model that can quantify the length of nascent blood vessels using Gelfoam® implanted in nestin-driven green fluorescent protein (ND-GFP) nude mice. In this model, nascent blood vessels ... ...

Abstract	Background: We previously developed a color-coded imaging model that can quantify the length of nascent blood vessels using Gelfoam® implanted in nestin-driven green fluorescent protein (ND-GFP) nude mice. In this model, nascent blood vessels selectively express GFP. We also previously showed that osteosarcoma cells promote angiogenesis in this assay. We have also previously demonstrated the tumor-targeting bacteria Salmonella typhimurium A1-R (S. typhimurium A1-R) can inhibit or regress all tested tumor types in mouse models. The aim of the present study was to determine if S. typhimurium A1-R could inhibit osteosarcoma angiogenesis in the in vivo Gelfoam® color-coded imaging assay. Materials and methods: Gelfoam® was implanted subcutaneously in ND-GFP nude mice. Skin flaps were made 7 days after implantation and 143B-RFP human osteosarcoma cells expressing red fluorescent protein (RFP) were injected into the implanted Gelfoam. After establishment of tumors in the Gelfoam®, control-group mice were treated with phosphate buffered saline via tail-vein injection (iv) and the experimental group was treated with S. typhimurium A1-R iv Skin flaps were made at day 7, 14, 21, and 28 after implantation of the Gelfoam® to allow imaging of vascularization in the Gelfoam® using a variable-magnification small-animal imaging system and confocal fluorescence microscopy. Results: Nascent blood vessels expressing ND-GFP extended into the Gelfoam® over time in both groups. However, the extent of nascent blood-vessel growth was significantly inhibited by S. typhimurium A1-R treatment by day 28. Conclusion: The present results indicate S. typhimurium A1-R has potential for anti-angiogenic targeted therapy of osteosarcoma.
MeSH term(s)	Animals ; Bone Neoplasms/blood supply ; Bone Neoplasms/pathology ; Bone Neoplasms/therapy ; Cell Line, Tumor ; Female ; Humans ; Mice, Nude ; Mice, Transgenic ; Neovascularization, Pathologic/therapy ; Osteosarcoma/blood supply ; Osteosarcoma/pathology ; Osteosarcoma/therapy ; Salmonella typhimurium
Language	English
Publishing date	2018
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1642: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Fluorescence-guided Surgery with Splenic Preservation Prevents Tumor Recurrence in an Orthotopic Nude-mouse Model of Human Pancreatic Cancer.

Hwang, Ho Kyoung / Kang, Chang Moo / Lee, Sung Hwan / Murakami, Takashi / Kiyuna, Tasuku / Kim, Se Hoon / Hoffman, Robert M / Bouvet, Michael

Anticancer research

2018 Volume 38, Issue 2, Page(s) 665–670

Abstract: Aim: The purpose of this study was to investigate whether splenectomy influences tumor recurrence after fluorescence-guided surgery (FGS) in an orthotopic nude-mouse model of pancreatic cancer.: Materials and methods: Green fluorescence protein (GFP)- ...

Abstract	Aim: The purpose of this study was to investigate whether splenectomy influences tumor recurrence after fluorescence-guided surgery (FGS) in an orthotopic nude-mouse model of pancreatic cancer. Materials and methods: Green fluorescence protein (GFP)-labeled human pancreatic cancer cells (MiaPaCa2-GFP) were subcutaneously injected into the flanks of nude mice. Subcutaneous tumors were harvested and surgical orthotopic implantation (SOI) was performed in the tail of the pancreas with small tumor fragments. FGS was performed 21 days after SOI. Mice were then randomly divided into FGS-only control group (n=7) and FGS plus splenectomy group (n=8). Tumor recurrence was analyzed by laparotomy 21 days after FGS. Results: In the control group, no recurrence was found. In contrast, multiple peritoneal seeded nodules were observed in two mice of the splenectomy group (0% vs. 25%, p=0.467). Conclusion: Postoperative tumor recurrence only occurred in the splenectomy-treated group suggesting that FGS can spare the patient the morbidity of splenectomy.
MeSH term(s)	Animals ; Cell Line, Tumor ; Fluorescence ; Humans ; Mice, Nude ; Neoplasm Recurrence, Local ; Organ Sparing Treatments/methods ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Spleen/pathology ; Spleen/surgery ; Splenectomy/methods ; Xenograft Model Antitumor Assays
Language	English
Publishing date	2018
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.12270
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1642: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A novel patient-derived orthotopic xenograft (PDOX) mouse model of highly-aggressive liver metastasis for identification of candidate effective drug-combinations.

Zhang, Zhiying / Hu, Kaiwen / Miyake, Kentaro / Kiyuna, Tasuku / Oshiro, Hiromichi / Wangsiricharoen, Sintawat / Kawaguchi, Kei / Higuchi, Takashi / Razmjooei, Sahar / Miyake, Masuyo / Chawla, Sant P / Singh, Shree Ram / Hoffman, Robert M

Scientific reports

2020 Volume 10, Issue 1, Page(s) 20105

Abstract: Liver metastasis is a recalcitrant disease that usually leads to death of the patient. The present study established a unique patient-derived orthotopic xenograft (PDOX) nude mouse model of a highly aggressive liver metastasis of colon cancer. The aim of ...

Abstract	Liver metastasis is a recalcitrant disease that usually leads to death of the patient. The present study established a unique patient-derived orthotopic xenograft (PDOX) nude mouse model of a highly aggressive liver metastasis of colon cancer. The aim of the present study was to demonstrate proof-of-concept that candidate drug combinations could significantly inhibit growth and re-metastasis of this recalcitrant tumor. The patient's liver metastasis was initially established subcutaneously in nude mice and the subcutaneous tumor tissue was then orthotopically implanted in the liver of nude mice to establish a PDOX model. Two studies were performed to test different drugs or drug combination, indicating that 5-fluorouracil (5-FU) + irinotecan (IRI) + bevacizumab (BEV) and regorafenib (REG) + selumetinib (SEL) had significantly inhibited liver metastasis growth (p = 0.013 and p = 0.035, respectively), and prevented liver satellite metastasis. This study is proof of concept that a PDOX model of highly aggressive colon-cancer metastasis can identify effective drug combinations and that the model has future clinical potential.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Benzimidazoles/administration & dosage ; Bevacizumab/administration & dosage ; Body Weight/drug effects ; Colonic Neoplasms/pathology ; Fluorouracil/administration & dosage ; Humans ; Irinotecan/administration & dosage ; Liver Neoplasms, Experimental/drug therapy ; Liver Neoplasms, Experimental/pathology ; Liver Neoplasms, Experimental/secondary ; Mice, Nude ; Phenylurea Compounds/administration & dosage ; Proof of Concept Study ; Pyridines/administration & dosage ; Xenograft Model Antitumor Assays/methods
Chemical Substances	AZD 6244 ; Benzimidazoles ; Phenylurea Compounds ; Pyridines ; regorafenib (24T2A1DOYB) ; Bevacizumab (2S9ZZM9Q9V) ; Irinotecan (7673326042) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2020-11-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-76708-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model.

Igarashi, Kentaro / Kawaguchi, Kei / Kiyuna, Tasuku / Miyake, Kentaro / Higuchi, Takashi / Yamamoto, Norio / Hayashi, Katsuhiro / Kimura, Hiroaki / Miwa, Shinji / Singh, Shree Ram / Tsuchiya, Hiroyuki / Hoffman, Robert M

Cancer genomics & proteomics

2020 Volume 17, Issue 4, Page(s) 351–358

Abstract: Background/aim: Dedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS ...

Abstract	Background/aim: Dedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model for precision oncology. To establish the PDOX model, a tumor from a patient who had recurrent high-grade DDLPS from the retroperitoneum was previously grown orthotopically in the retroperitoneum of nude mice. Materials and methods: We randomized DDLPS PDOX models into 8 treatment groups when tumor volume became approximately 100 mm Results: At the end of treatment (day 14), all treatments significantly inhibited DDLPS PDOX tumor growth compared to the untreated control, except DOX. ERB was significantly more effective and regressed tumor volume compared to other treatments on day 14 after initiation of treatment. No significant differences were found in the relative body weight on day 14 compared to day 0 in any group. Conclusion: The clinical potential of ERB against DDLPS is herein presented in a PDOX model.
MeSH term(s)	Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Apoptosis ; Cell Dedifferentiation ; Cell Proliferation ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Docetaxel/administration & dosage ; Doxorubicin/administration & dosage ; Drug Resistance, Neoplasm/drug effects ; Furans/administration & dosage ; Humans ; Ketones/administration & dosage ; Liposarcoma/drug therapy ; Liposarcoma/pathology ; Male ; Mice ; Mice, Nude ; Piperazines/administration & dosage ; Pyridines/administration & dosage ; Pyrimidines/administration & dosage ; Sulfonamides/administration & dosage ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Chemical Substances	Furans ; Ketones ; Piperazines ; Pyridines ; Pyrimidines ; Sulfonamides ; Deoxycytidine (0W860991D6) ; Docetaxel (15H5577CQD) ; pazopanib (7RN5DR86CK) ; Doxorubicin (80168379AG) ; gemcitabine (B76N6SBZ8R) ; palbociclib (G9ZF61LE7G) ; eribulin (LR24G6354G)
Language	English
Publishing date	2020-06-21
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2144517-5
ISSN	1790-6245 ; 1109-6535
ISSN (online)	1790-6245
ISSN	1109-6535
DOI	10.21873/cgp.20194
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5873: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Splenectomy is associated with an aggressive tumor growth pattern and altered host immunity in an orthotopic syngeneic murine pancreatic cancer model.

Hwang, Ho Kyoung / Murakami, Takashi / Kiyuna, Tasuku / Kim, Se Hoon / Lee, Sung Hwan / Kang, Chang Moo / Hoffman, Robert M / Bouvet, Michael

Oncotarget

2017 Volume 8, Issue 51, Page(s) 88827–88834

Abstract: The purpose of this study was to investigate whether splenectomy influences the tumor growth and metastatic pattern in an orthotopic syngeneic murine pancreatic cancer model. Murine pancreatic cancer cells (PAN02) were subcutaneously injected into the ... ...

Abstract	The purpose of this study was to investigate whether splenectomy influences the tumor growth and metastatic pattern in an orthotopic syngeneic murine pancreatic cancer model. Murine pancreatic cancer cells (PAN02) were subcutaneously injected into the flanks of nude mice. A small tumor fragment (3 mm
Keywords	covid19
Language	English
Publishing date	2017-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.21331
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A patient-derived orthotopic xenograft (PDOX) nude-mouse model precisely identifies effective and ineffective therapies for recurrent leiomyosarcoma.

Zhang, Zhiying / Hu, Kaiwen / Kiyuna, Tasuku / Miyake, Kentaro / Kawaguchi, Kei / Igarashi, Kentaro / Nelson, Scott D / Li, Yunfeng / Singh, Shree Ram / Hoffman, Robert M

Pharmacological research

2019 Volume 142, Page(s) 169–175

Abstract: Leiomyosarcoma is a rare and recalcitrant disease. Doxorubicin (DOX) is usually considered first-line treatment for this disease, but frequently is ineffective. In order to individualize therapy for this and other cancers, we have developed the patient- ... ...

Abstract	Leiomyosarcoma is a rare and recalcitrant disease. Doxorubicin (DOX) is usually considered first-line treatment for this disease, but frequently is ineffective. In order to individualize therapy for this and other cancers, we have developed the patient-derived orthotopic xenograft (PDOX) mouse model. In the present study, we implanted a recurrent leiomyosarcoma from a resected tumor from the patient's thigh into the femoral muscle of nude mice. The following drugs were tested on the leiomyosarcoma PDOX model: DOX, the combination of gemcitabine (GEM) and docetaxel (DOC), trabectedin (TRA), temozolomide (TEM), pazopanib (PAZ) and olaratumab (OLA). Of these agents GEM/DOC, TRA and TEM were highly effective in the leiomyosarcoma PDOX model, the other agents, including first-line therapy DOX, were ineffective. Thus the leiomyosarcoma PDOX model could precisely distinguish effective and ineffective drugs, demonstrating the potential of the PDOX model for leiomyosarcoma treatment.
MeSH term(s)	Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Disease Models, Animal ; Humans ; Leiomyosarcoma/drug therapy ; Mice, Nude ; Muscle Neoplasms/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Treatment Outcome ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2019-02-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2019.02.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 721: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito