Article ; Online: The association of a healthy lifestyle index and imaging-based body fat distribution with glycemic status and Type 2 diabetes in the Multi Ethnic Cohort: a cross-sectional analysis.
European journal of clinical nutrition
2023 Volume 78, Issue 3, Page(s) 236–242
Abstract: Introduction: As several behaviors captured by the Lifestyle Risk Factor Index (LSRI) are protective against Type 2 diabetes (T2D) and may affect body fat distribution, we examined its relation with both outcomes.: Methods: In a subset of the ... ...
| Abstract | Introduction: As several behaviors captured by the Lifestyle Risk Factor Index (LSRI) are protective against Type 2 diabetes (T2D) and may affect body fat distribution, we examined its relation with both outcomes. Methods: In a subset of the Multiethnic Cohort, participants from five ethnic groups (60-77 years) were assigned LSRI scores (one point each for consuming <1 (women)/<2 (men) alcoholic drinks/day, ≥1.5 physical activity hours/week, not smoking, and adhering to ≥3/7 dietary recommendations). All participants completed an extensive Quantitative Food Frequency Questionnaire to allow estimation of adherence to intake recommendations for fruits, vegetables, refined and whole grains, fish, processed and non-processed meat. Glycemic/T2D status was classified according to self-reports and fasting glucose. We estimated prevalence odds ratios (POR) of LSRI with glycemic/T2D status and DXA- and MRI-based body fat distribution using logistic regression. Results: Of 1713 participants, 43% had normoglycemia, 30% Pre-T2D, 9% Undiagnosed T2D, and 18% T2D. Overall, 39% scored 0-2, 49% 3, and 12% 4 LSRI points. T2D prevalence was 55% (POR 0.45; 95% confidence intervals 0.27, 0.76) lower for 4 vs. 0-2 LSRI points with weaker associations for abnormal glycemic status. Despite the low adherence to dietary recommendations (22%), this was the only component related to lower T2D prevalence. The inverse LSRI-T2D association was only observed among Latinos and Japanese Americans in ethnic-specific models. Visceral fat measures were higher in T2D patients and attenuated the LSRI-T2D association. Conclusion: These findings support the role of a healthy lifestyle, especially diet, in T2D prevention with differences across ethnicity. |
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| MeSH term(s) | Male ; Animals ; Humans ; Female ; Diabetes Mellitus, Type 2/epidemiology ; Cross-Sectional Studies ; Diet ; Risk Factors ; Healthy Lifestyle |
| Language | English |
| Publishing date | 2023-12-14 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 639358-5 |
| ISSN | 1476-5640 ; 0954-3007 |
| ISSN (online) | 1476-5640 |
| ISSN | 0954-3007 |
| DOI | 10.1038/s41430-023-01381-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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