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  1. Article ; Online: Repurposing antibiotics to treat syphilis.

    Stafylis, Chrysovalantis / Klausner, Jeffrey D

    The Lancet. Infectious diseases

    2024  Volume 24, Issue 4, Page(s) 335–336

    MeSH term(s) Humans ; Syphilis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Antibiotics, Antitubercular
    Chemical Substances Anti-Bacterial Agents ; Antibiotics, Antitubercular
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00693-X
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    Zs.A 5743: Show issues Location:
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  2. Article ; Online: Doxycycline to Prevent Sexually Transmitted Infections in Women.

    Kojima, Noah / Klausner, Jeffrey D

    The New England journal of medicine

    2024  Volume 390, Issue 13, Page(s) 1248–1249

    MeSH term(s) Female ; Humans ; Doxycycline/therapeutic use ; Sexually Transmitted Diseases/prevention & control ; Sexually Transmitted Diseases/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Doxycycline (N12000U13O) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2401273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Detrimental to public health: Royal Australasian College of Physicians' recent policy on infant circumcision.

    Morris, Brian J / Klausner, Jeffrey D

    Pediatric research

    2024  

    Language English
    Publishing date 2024-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-024-03190-8
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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  4. Article ; Online: Approach to Managing Sex Partners of People with Sexually Transmitted Infections.

    Hansman, Emily / Klausner, Jeffrey D

    Infectious disease clinics of North America

    2023  Volume 37, Issue 2, Page(s) 405–426

    Abstract: Partner management of sexually transmitted infection (STIs) is essential to identify and treat new cases, prevent reinfection in the index case, interrupt chains of transmission, reduce STI-related morbidity, and target STI screening and treatment ... ...

    Abstract Partner management of sexually transmitted infection (STIs) is essential to identify and treat new cases, prevent reinfection in the index case, interrupt chains of transmission, reduce STI-related morbidity, and target STI screening and treatment interventions. The responsibility for partner notification and treatment falls on the health care provider. Approaches to partner management include patient referral, provider referral, contractual referral, and expedited partner therapy (EPT), with EPT and enhanced partner referral outperforming other methods. This article provides an overview of clinical recommendations regarding partner management, with particular emphasis on EPT, and an update on new and emerging evidence in the field.
    MeSH term(s) Humans ; Sexual Partners ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/prevention & control ; Sexually Transmitted Diseases/epidemiology ; Contact Tracing/methods ; Referral and Consultation ; Chlamydia Infections
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2023.02.003
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  5. Article ; Online: Case Report: Unusual Bullous Reaction to Physalia physalis Venom after Recurrent Envenomation.

    Yang, Kevin / Klausner, Jeffrey D

    The American journal of tropical medicine and hygiene

    2023  Volume 109, Issue 1, Page(s) 201–204

    Abstract: Physalia physalis, often referred to colloquially as Portuguese man-of-war or bluebottle jellyfish, is a jellyfish-like organism found in tropical and subtropical areas of the Pacific, Atlantic, and Indian Oceans. Most often, envenomation by P. physalis ... ...

    Abstract Physalia physalis, often referred to colloquially as Portuguese man-of-war or bluebottle jellyfish, is a jellyfish-like organism found in tropical and subtropical areas of the Pacific, Atlantic, and Indian Oceans. Most often, envenomation by P. physalis tentacles results in painful but self-resolving epidermal stings. We report on two clinic visits of a patient who suffered from worsening reactions to recurrent P. physalis envenomation. The first clinical episode involved urticaria and severe pruritus that was worse than the pruritus the patient had experienced upon envenomation in the past. The second episode involved an unusual bullous reaction. Further study into the compounds present in P. physalis venom may help elucidate the mechanism of the present case and other abnormal reactions to envenomation. Patients and providers who care for patients at risk for recurrent stings (e.g., surfers, fishermen) should be cognizant of the potential for worsening reactions to envenomation. Further study into therapies such as oral antihistamines and Aloe vera gel may uncover additional appropriate treatments for symptomatic relief of P. physalis envenomation.
    MeSH term(s) Male ; Animals ; Humans ; Cnidarian Venoms ; Hydrozoa ; Bites and Stings/complications ; Ethnicity ; Pruritus
    Chemical Substances Cnidarian Venoms
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.23-0027
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  6. Article ; Online: Managing treatment failure in Neisseria gonorrhoeae infection: current guidelines and future directions.

    Allan-Blitz, Lao-Tzu / Fifer, Helen / Klausner, Jeffrey D

    The Lancet. Infectious diseases

    2024  

    Abstract: Due to the continued emergence of resistance to extended-spectrum cephalosporin antibiotics, clinicians are increasingly more likely to encounter cases of Neisseria gonorrhoeae treatment failure. The current international treatment guidelines offer few ... ...

    Abstract Due to the continued emergence of resistance to extended-spectrum cephalosporin antibiotics, clinicians are increasingly more likely to encounter cases of Neisseria gonorrhoeae treatment failure. The current international treatment guidelines offer few regimens for cases of N gonorrhoeae infection that do not respond to first-line therapy, and there are many complexities that should be considered with such regimens; these include regional variations in resistance to alternative agents, access to different antibiotics, and penetration of those antibiotics within different tissues. Further, such regimens do not account for the challenges of treating pharyngeal infections; many patients who have not responded to treatment with extended-spectrum cephalosporin antibiotics to date have had pharyngeal involvement. In addition, pharyngeal infections play a pivotal role in the emergence and spread of antimicrobial resistance in N gonorrhoeae and are more difficult to treat than urogenital infections because of the unfavourable pharmacokinetics of cephalosporins in pharyngeal tissues. Here, we summarise the current guidelines, provide additional approaches and considerations for clinicians, and highlight knowledge gaps that should be addressed to ensure appropriate therapy in cases of treatment failure.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(24)00001-X
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  7. Article ; Online: Neonatal Herpes Reporting in the United States: Review of Current Policies by State.

    Saremi, Natalie / Lewis, Katherine A / Klausner, Jeffrey D

    Journal of the Pediatric Infectious Diseases Society

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piae031
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  8. Article ; Online: Viral infection: A missed cause of chronic spontaneous urticaria?

    Chong, Albert C / Khan, David A / Klausner, Jeffrey D

    Diagnostic microbiology and infectious disease

    2024  Volume 109, Issue 2, Page(s) 116292

    MeSH term(s) Humans ; Chronic Urticaria/drug therapy ; Female ; Virus Diseases/diagnosis ; Virus Diseases/complications ; Male ; Adult ; Middle Aged ; Urticaria/diagnosis ; Urticaria/etiology
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Letter ; Case Reports
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116292
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  9. Article ; Online: Usage and Awareness of Antiviral Medications for Coronavirus Disease 2019 (COVID-19) Among Individuals at Risk for Severe COVID-19, March 2021 to 1 August 2022.

    Kojima, Noah / Klausner, Jeffrey D

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 76, Issue 4, Page(s) 775–776

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Antiviral Agents/therapeutic use
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac743
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    Zs.MO 480: Show issues

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  10. Article ; Online: The great imitator revealed: syphilis.

    Klausner, Jeffrey D

    Topics in antiviral medicine

    2019  Volume 27, Issue 2, Page(s) 71–74

    Abstract: Rates of syphilis and other sexually transmitted infections are on the rise in the United States. The lesions of early syphilis can be mistaken for those of other infections and conditions, and syphilis should be suspected in all sexually active patients ...

    Abstract Rates of syphilis and other sexually transmitted infections are on the rise in the United States. The lesions of early syphilis can be mistaken for those of other infections and conditions, and syphilis should be suspected in all sexually active patients presenting with a new skin rash or an oral or genital lesion. Rapid diagnosis and treatment of syphilis as well as rapid identification and treatment of sexual contacts are needed to reverse the trend of increasing incidence. Available data indicate success in reducing acquisition of syphilis with doxycyclinepre- and postexposure prophylaxis. This article is based on a presentation by Jeffrey D. Klausner, MD, MPH, at the 2018 Clinical Conference at the National Ryan White Conference on HIV Care and Treatment in December 2018.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Centers for Disease Control and Prevention (U.S.) ; Female ; HIV Infections ; Humans ; Male ; Penicillin G Benzathine/therapeutic use ; Sexual Behavior ; Syphilis/diagnosis ; Syphilis/drug therapy ; Syphilis/epidemiology ; Syphilis/transmission ; United States/epidemiology
    Chemical Substances Anti-Bacterial Agents ; Penicillin G Benzathine (RIT82F58GK)
    Language English
    Publishing date 2019-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5861
    ISSN (online) 2161-5853
    ISSN 2161-5861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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