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Artikel: Referenzintervalle bei Kindern: Wenn Tabellen an ihre Grenzen stoßen

Klawitter, Sandra / Klawonn, Frank / Hoffmann, Georg

2023 Band 21, Heft 1, Seite(n) 61

Sprache	Deutsch
Dokumenttyp	Artikel
ZDB-ID	2741151-5
ISSN	2198-1310
Datenquelle	Current Contents Medizin

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Artikel ; Online: A zlog-based algorithm and tool for plausibility checks of reference intervals.

Klawitter, Sandra / Hoffmann, Georg / Holdenrieder, Stefan / Kacprowski, Tim / Klawonn, Frank

Clinical chemistry and laboratory medicine

2022 Band 61, Heft 2, Seite(n) 260–265

Abstract: Objectives: Laboratory information systems typically contain hundreds or even thousands of reference limits stratified by sex and age. Since under these conditions a manual plausibility check is hardly feasible, we have developed a simple algorithm that ...

Abstract	Objectives: Laboratory information systems typically contain hundreds or even thousands of reference limits stratified by sex and age. Since under these conditions a manual plausibility check is hardly feasible, we have developed a simple algorithm that facilitates this check. An open-source R tool is available as a Shiny application at github.com/SandraKla/Zlog_AdRI. Methods: Based on the zlog standardization, we can possibly detect critical jumps at the transitions between age groups, regardless of the analytical method or the measuring unit. Its advantage compared to the standard z-value is that means and standard deviations are calculated from the reference limits rather than from the underlying data itself. The purpose of the tool is illustrated by the example of reference intervals of children and adolescents from the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER). Results: The Shiny application identifies the zlog values, lists them in a colored table format and plots them additionally with the specified reference intervals. The algorithm detected several strong and rapid changes in reference intervals from the neonatal period to puberty. Remarkable jumps with absolute zlog values of more than five were seen for 29 out of 192 reference limits (15.1%). This might be attenuated by introducing shorter time periods or mathematical functions of reference limits over age. Conclusions: Age-partitioned reference intervals will remain the standard in laboratory routine for the foreseeable future, and as such, algorithmic approaches like our zlog approach in the presented Shiny application will remain valuable tools for testing their plausibility on a wide scale.
Mesh-Begriff(e)	Adolescent ; Infant, Newborn ; Child ; Humans ; Reference Values ; Reference Standards ; Canada ; Algorithms
Sprache	Englisch
Erscheinungsdatum	2022-11-03
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0688
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Association of long COVID with health-related Quality of Life and Social Participation in Germany: Finding from an online-based cross-sectional survey.

Schröder, Dominik / Heinemann, Stephanie / Heesen, Gloria / Hummers, Eva / Schmachtenberg, Tim / Dopfer-Jablonka, Alexandra / Vahldiek, Kai / Klawonn, Frank / Klawitter, Sandra / Steffens, Sandra / Mikuteit, Marie / Niewolik, Jacqueline / Müller, Frank

Heliyon

2024 Band 10, Heft 4, Seite(n) e26130

Abstract: Purpose: This study aims to examine the health-related Quality of Life (hrQoL) and social participation in participants with Long COVID compared to participants without symptoms after COVID-19 and participants with no prior SARS-CoV-2 infection.: ... ...

Abstract	Purpose: This study aims to examine the health-related Quality of Life (hrQoL) and social participation in participants with Long COVID compared to participants without symptoms after COVID-19 and participants with no prior SARS-CoV-2 infection. Methods: A cross-sectional online survey was conducted in Germany. The non-random sample consists of participants 18 years or older. Participants were divided in three groups: Lg COVID with a prior SARS-CoV-2 infection and new or persistent symptoms 28 days after infection, ExCOVID with a prior SARS-CoV-2 infection and without new or persistent symptoms after 28 days, and NoCOVID when participants had no prior SARS-CoV-2 infection. EQ-5D-3L was used as hrQoL measure and the Index for the Assessment of Health Impairments (IMET) to reflect social participation. Descriptive and inferential statistics were performed. Results: A total of 3188 participants were included in the analysis (1421 Lg COVID, 260 ExCOVID, 1507 NoCOVID). Lg COVID was associated with the lowest EQ-5D-3L index values (p < 0.001), Visual Analogue Scale (VAS) scores (p < 0.001), and IMET (p < 0.001) scores followed by NoCOVID and ExCOVID. After adjusting for sociodemographic and medical conditions in a multivariable model Long COVID was still associated with lower hrQoL compared to NoCOVID (p < 0.001). About 10% of Lg COVID participants showed no health impairments in all EQ-5D dimensions while 51.1% of NoCOVID and 60% of ExCOVID participants showed no health impairments. Conclusion: This study highlights the impairments of persons with Long COVID on hrQoL and social participation compared to individuals without Long COVID in Germany. Trial registration: German Clinical Trial Registry, DRKS00026007.
Sprache	Englisch
Erscheinungsdatum	2024-02-09
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26130
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluating the Feasibility, Acceptance, and Beneficial Effects of Online Occupational Therapy for Post-COVID-19 Condition: Protocol for a Randomized Controlled Trial (ErgoLoCo Study).

Müllenmeister, Christina / Stoelting, Andrea / Schröder, Dominik / Schmachtenberg, Tim / Ritter, Simon / El-Sayed, Iman / Steffens, Sandra / Klawonn, Frank / Klawitter, Sandra / Homann, Stefanie / Mikuteit, Marie / Berg, Christoph / Behrens, Georg / Hummers, Eva / Cook, Aisha / Müller, Frank / Dopfer-Jablonka, Alexandra / Happle, Christine

JMIR research protocols

2024 Band 13, Seite(n) e50230

Abstract: Background: Post-COVID-19 syndrome (PCS; also known as "long COVID") is a relatively novel disease comprising physical, psychological, and cognitive complaints persisting several weeks to months after acute infection with SARS-CoV-2. Approximately 10% ... ...

Abstract	Background: Post-COVID-19 syndrome (PCS; also known as "long COVID") is a relatively novel disease comprising physical, psychological, and cognitive complaints persisting several weeks to months after acute infection with SARS-CoV-2. Approximately 10% of patients with COVID-19 are affected by long-term symptoms. However, effective treatment strategies are lacking. The ErgoLoCo (Occupational Therapy [Ergotherapie] for Long COVID) study was designed to develop and evaluate a novel occupational therapy (OT) concept of online delivery of therapy for long COVID. Objective: The primary study objective is to assess the feasibility of the online OT intervention in PCS. Secondary aims include the evaluation of online OT concerning cognitive problems, occupational performance, and social participation. Methods: This randomized controlled interventional pilot study involves parallel mixed methods process analyses and a realist evaluation approach. A total of 80 clients with PCS aged at least 16 years will be recruited into two interventional groups. The control cohort (watch and wait) comprises 80 clients with long COVID. Treatment is provided through teletherapy (n=40) or delivery of prerecorded videos (n=40) using the same standardized OT concept twice weekly over 12 weeks. Analyses of quantitative questionnaires and qualitative interviews based on the theoretical framework of acceptability will be performed to assess feasibility. Focus group meetings will be used to assess how acceptable and helpful the intervention was to the participating occupational therapists. Standardized tests will be used to assess the initial efficacy of the intervention on neurocognitive performance; limitations in mobility, self-care, and everyday activities; pain; disabilities; quality of life (QoL); social participation; and anxiety and depression in PCS, and the possible effects of online OT on these complaints. Results: The German Ministry of Education and Research provided funding for this research in March 2022. Data collection took place from October 2022 to August 31, 2023. Data analysis will be completed by the end of April 2024. We anticipate publishing the results in the fall of 2024. Conclusions: Despite the enormous clinical need, effective and scalable treatment options for OT clients who have PCS remain scarce. The ErgoLoCo study will assess whether online-delivered OT is a feasible treatment approach in PCS. Furthermore, this study will assess the effect of the intervention on cognitive symptoms, QoL, and occupational performance and participation in everyday life. Particular emphasis will be placed on the experiences of clients and occupational therapists with digitally delivered OT. This study will pave the way for novel and effective treatment strategies in PCS. Trial registration: German Clinical Trial Registry DRKS00029990; https://drks.de/search/de/trial/DRKS00029990. International registered report identifier (irrid): PRR1-10.2196/50230.
Mesh-Begriff(e)	Humans ; COVID-19/psychology ; Occupational Therapy/methods ; Feasibility Studies ; Pilot Projects ; Telemedicine/methods ; Male ; Adult ; Female ; Germany ; SARS-CoV-2 ; Middle Aged
Sprache	Englisch
Erscheinungsdatum	2024-05-13
Erscheinungsland	Canada
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial ; Clinical Trial Protocol
ZDB-ID	2719222-2
ISSN	1929-0748 ; 1929-0748
ISSN (online)	1929-0748
ISSN	1929-0748
DOI	10.2196/50230
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Migrant healthcare workers during COVID-19: bringing an intersectional health system-related approach into pandemic protection. A German case study.

Kuhlmann, Ellen / Ungureanu, Marius-Ionut / Behrens, Georg M N / Cossmann, Anne / Fehr, Leonie Mac / Klawitter, Sandra / Mikuteit, Marie / Müller, Frank / Thilo, Nancy / Brînzac, Monica Georgina / Dopfer-Jablonka, Alexandra

Frontiers in public health

2023 Band 11, Seite(n) 1152862

Abstract: Introduction: Migrant healthcare workers played an important role during the COVID-19 pandemic, but data are lacking especially for high-resourced European healthcare systems. This study aims to research migrant healthcare workers through an ... ...

Abstract	Introduction: Migrant healthcare workers played an important role during the COVID-19 pandemic, but data are lacking especially for high-resourced European healthcare systems. This study aims to research migrant healthcare workers through an intersectional health system-related approach, using Germany as a case study. Methods: An intersectional research framework was created and a rapid scoping study performed. Secondary analysis of selected items taken from two COVID-19 surveys was undertaken to compare perceptions of national and foreign-born healthcare workers, using descriptive statistics. Results: Available research is focused on worst-case pandemic scenarios of Brazil and the United Kingdom, highlighting racialised discrimination and higher risks of migrant healthcare workers. The German data did not reveal significant differences between national-born and foreign-born healthcare workers for items related to health status including SARS-CoV-2 infection and vaccination, and perception of infection risk, protective workplace measures, and government measures, but items related to social participation and work conditions with higher infection risk indicate a higher burden of migrant healthcare workers. Conclusions: COVID-19 pandemic policy must include migrant healthcare workers, but simply adding the migration status is not enough. We introduce an intersectional health systems-related approach to understand how pandemic policies create social inequalities and how the protection of migrant healthcare workers may be improved.
Mesh-Begriff(e)	Humans ; COVID-19/epidemiology ; Pandemics/prevention & control ; Transients and Migrants ; SARS-CoV-2 ; Health Personnel ; Delivery of Health Care
Sprache	Englisch
Erscheinungsdatum	2023-07-18
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1152862
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Amino acids, post-translational modifications, nitric oxide, and oxidative stress in serum and urine of long COVID and ex COVID human subjects.

Mikuteit, Marie / Baskal, Svetlana / Klawitter, Sandra / Dopfer-Jablonka, Alexandra / Behrens, Georg M N / Müller, Frank / Schröder, Dominik / Klawonn, Frank / Steffens, Sandra / Tsikas, Dimitrios

Amino acids

2023 Band 55, Heft 9, Seite(n) 1173–1188

Abstract: In this study, we investigated the status of amino acids, their post-translational modifications (PTM), major nitric oxide (NO) metabolites and of malondialdehyde (MDA) as a biomarker of oxidative stress in serum and urine samples of long COVID (LoCo, n = ...

Abstract	In this study, we investigated the status of amino acids, their post-translational modifications (PTM), major nitric oxide (NO) metabolites and of malondialdehyde (MDA) as a biomarker of oxidative stress in serum and urine samples of long COVID (LoCo, n = 124) and ex COVID (ExCo, n = 24) human subjects collected in 2022. Amino acids and metabolites were measured by gas chromatography-mass spectrometry (GC-MS) methods using stable-isotope labelled analogs as internal standards. There were no differences with respect to circulating and excretory arginine and asymmetric dimethylarginine (ADMA). LoCo participants excreted higher amounts of guanidino acetate than ExCo participants (17.8 ± 10.4 µM/mM vs. 12.6 ± 8.86 µM/mM, P = 0.005). By contrast, LoCo participants excreted lower amounts of the advanced glycation end-product (AGE) N
Sprache	Englisch
Erscheinungsdatum	2023-07-29
Erscheinungsland	Austria
Dokumenttyp	Journal Article
ZDB-ID	1121341-3
ISSN	1438-2199 ; 0939-4451
ISSN (online)	1438-2199
ISSN	0939-4451
DOI	10.1007/s00726-023-03305-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Improvement in quality of life and cognitive function in Post Covid Syndrome after online occupational therapy: results from a randomized controlled pilot study

Schröder, Dominik / Stölting, Andrea / Müllenmeister, Christina / Behrens, Georg M.N. / Klawitter, Sandra / Klawonn, Frank / Cook, Aisha / Wegner, Nadja / Wetzke, Martin / Schmachtenberg, Tim / Dopfer-Jablonka, Alexandra / Müller, Frank / Happle, Christine

medRxiv

Abstract: Background: Post-COVID-Syndrome (PCS) poses enormous clinical challenges. Occupational therapy (OT) is recommended in PCS, but structural validation of this concept is pending. Methods: In an unblinded randomized pilot study (clinical trial # DRKS0026007) ...

Abstract	Background: Post-COVID-Syndrome (PCS) poses enormous clinical challenges. Occupational therapy (OT) is recommended in PCS, but structural validation of this concept is pending. Methods: In an unblinded randomized pilot study (clinical trial # DRKS0026007), feasibility and effects of online OT in PCS were tested. Probands received structured online OT over 12 weeks either via interactive online treatment sessions (interactive group) or prerecorded videos (video group). 50% of probands received no online OT (control group). At week 0, 12, and 24, we analyzed study experience, health-related quality of life, and impairment in performance, participation, and cognitive functions. Results: N=158 probands (mean age 38 yrs., 86% female) were included into the analyses. 83.3% of probands in the interactive versus 48.1% of probands in the video group described their study experience as positive or very positive (p=0.001). After 12 weeks, all groups displayed significant improvement in concentration, memory, and performance of daily tasks. After 24 weeks, significant improvement in concentration and memory were observed in control- and video-probands, and social participation had improved after video-OT. However, only probands that had received interactive online OT showed improvement of all measured endpoints including concentration, memory, quality of life, and social participation. Conclusion: We show that online OT is feasible and that interactive online OT is a promising treatment strategy for affected patients. We present exploratory data on its efficacy and describe variables that can be employed for further investigations in confirmatory trials.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2024-05-10
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2024.05.09.24307158
Datenquelle	COVID19

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Artikel: Long-term Consequences of COVID-19 and the Pandemic: Protocol for a Web-Based, Longitudinal Observational Study (DEFEAT).

Mikuteit, Marie / Heinemann, Stephanie / Roder, Sascha / Niewolik, Jacqueline / Schröder, Dominik / Vahldiek, Kai / Klawitter, Sandra / Cossmann, Anne / Bergemann, Torsten / Degen, Chantal / Klawonn, Frank / Behrens, Georg Martin Norbert / Müller, Frank / Dopfer-Jablonka, Alexandra / Steffens, Sandra

JMIR research protocols

2022 Band 11, Heft 10, Seite(n) e38718

Abstract: Background: With population-wide vaccination availability, the global COVID-19 pandemic entered a new phase. Despite vaccination status, some people who were infected with SARS-CoV-2 experience long-term symptoms.: Objective: In this study, we aim to ...

Abstract	Background: With population-wide vaccination availability, the global COVID-19 pandemic entered a new phase. Despite vaccination status, some people who were infected with SARS-CoV-2 experience long-term symptoms. Objective: In this study, we aim to characterize the long-term effects of SARS-CoV-2 infection and the pandemic. We also aim to build symptom clusters and determine risk factors for developing long COVID symptoms. Furthermore, we assess social participation and health-related quality of life in patients with long COVID and in the general population during a global pandemic. Methods: With a mixed-methods, web-based approach, we aim to recruit 2000 people in Germany who are older than 18 years and can provide informed consent. In the quantitative arm of the study, we identify symptoms of and predictive factors for long COVID manifestations with cluster analysis and assess social participation during the pandemic with standardized questionnaires. The qualitative arm of the study uses individual interviews and focus group discussions to better understand the illness experience of persons who experience long COVID. Results: Recruitment started in September 2021. Up until July 2022, we recruited approximately 4500 participants via our web-based database. Conclusions: This study aims to build an innovative, patient-centered, web-based research platform appropriate for the pandemic by minimizing physical contact between study personnel and participants. All study activities are designed to better understand the long COVID syndrome, social participation during the pandemic, and the illness experiences of persons affected by long COVID. Trial registration: German Clinical Trial Registry DRKS00026007; https://tinyurl.com/yh282fkt. International registered report identifier (irrid): DERR1-10.2196/38718.
Sprache	Englisch
Erscheinungsdatum	2022-10-26
Erscheinungsland	Canada
Dokumenttyp	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/38718
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Migrant healthcare workers during COVID-19: bringing an intersectional health system-related approach into pandemic protection. A German case study

Kuhlmann, Ellen / Ungureanu, Marius-Ionut / Behrens, Georg MN / Cossmann, Anne / Fehr, Leonie Mac / Klawitter, Sandra / Mikuteit, Marie / Müller, Frank / Thilo, Nancy / Brînzac, Monica Georgina / Dopfer-Jablonka, Alexandra

medRxiv

Abstract: Introduction. Migrant healthcare workers played an important role during the COVID-19 pandemic, but data are lacking especially for high-resourced European healthcare systems. This study aims to research migrant healthcare workers through an ... ...

Abstract	Introduction. Migrant healthcare workers played an important role during the COVID-19 pandemic, but data are lacking especially for high-resourced European healthcare systems. This study aims to research migrant healthcare workers through an intersectional health system-related approach, using Germany as a case study. Methods. An intersectional research framework was created and a rapid scoping study performed. Secondary analysis of selected items taken from two COVID-19 surveys was undertaken to compare perceptions of national and foreign-born healthcare workers, using descriptive statistics. Results. Available research is focused on worst-case pandemic scenarios of Brazil and the United Kingdom, highlighting racialised discrimination and higher risks of migrant healthcare workers. The German data did not reveal significant differences between national-born and foreign-born healthcare workers for items related to health status including SARS-CoV-2 infection and vaccination, and perception of infection risk, protective workplace measures, and government measures, but items related to social participation and work conditions with higher infection risk indicate a higher burden of migrant healthcare workers. Conclusions. COVID-19 pandemic policy must include migrant healthcare workers, but simply adding the migration status is not enough. We introduce an intersectional health systems-related approach to understand how pandemic policies create social inequalities and how the protection of migrant healthcare workers may be improved.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2023-01-30
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2023.01.28.23285135
Datenquelle	COVID19

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Artikel ; Online: Migrant healthcare workers during COVID-19: bringing an intersectional health system-related approach into pandemic protection. A German case study

Kuhlmann, Ellen / Ungureanu, Marius Ionut / Behrens, Georg / Cossmann, Anne / Klawitter, Sandra / Mac Fehr, Leonie / Mikuteit, Marie / Mueller, Frank / Thilo, Nancy / Brinzac, Monica Georgina / Dopfer-Jablonka, Alexandra

medRxiv

Abstract	Introduction. Migrant healthcare workers played an important role during the COVID-19 pandemic, but data are lacking especially for high-resourced European healthcare systems. This study aims to research migrant healthcare workers through an intersectional health system-related approach, using Germany as a case study. Methods. An intersectional research framework was created and a rapid scoping study performed. Secondary analysis of selected items taken from two COVID-19 surveys was undertaken to compare perceptions of national and foreign-born healthcare workers, using descriptive statistics. Results. Available research is focused on worst-case pandemic scenarios of Brazil and the United Kingdom, highlighting racialised discrimination and higher risks of migrant healthcare workers. The German data did not reveal significant differences between national-born and foreign-born healthcare workers for items related to health status including SARS-CoV-2 infection and vaccination, and perception of infection risk, protective workplace measures, and government measures, but items related to social participation and work conditions with higher infection risk indicate a higher burden of migrant healthcare workers. Conclusions. COVID-19 pandemic policy must include migrant healthcare workers, but simply adding the migration status is not enough. We introduce an intersectional health systems-related approach to understand how pandemic policies create social inequalities and how the protection of migrant healthcare workers may be improved.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2023-01-30
Verlag	Cold Spring Harbor Laboratory Press
Dokumenttyp	Artikel ; Online
DOI	10.1101/2023.01.28.23285135
Datenquelle	COVID19

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