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  1. Article ; Online: Neural Circuits for Emotion.

    Malezieux, Meryl / Klein, Alexandra S / Gogolla, Nadine

    Annual review of neuroscience

    2023  Volume 46, Page(s) 211–231

    Abstract: Emotions are fundamental to our experience and behavior, affecting and motivating all aspects of our lives. Scientists of various disciplines have been fascinated by emotions for centuries, yet even today vigorous debates abound about how to define ... ...

    Abstract Emotions are fundamental to our experience and behavior, affecting and motivating all aspects of our lives. Scientists of various disciplines have been fascinated by emotions for centuries, yet even today vigorous debates abound about how to define emotions and how to best study their neural underpinnings. Defining emotions from an evolutionary perspective and acknowledging their important functional roles in supporting survival allows the study of emotion states in diverse species. This approach enables taking advantage of modern tools in behavioral, systems, and circuit neurosciences, allowing the precise dissection of neural mechanisms and behavior underlying emotion processes in model organisms. Here we review findings about the neural circuit mechanisms underlying emotion processing across species and try to identify points of convergence as well as important next steps in the pursuit of understanding how emotions emerge from neural activity.
    MeSH term(s) Emotions ; Neurosciences ; Biological Evolution ; Brain
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 282459-0
    ISSN 1545-4126 ; 0147-006X
    ISSN (online) 1545-4126
    ISSN 0147-006X
    DOI 10.1146/annurev-neuro-111020-103314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: How mice feel each other's pain or fear.

    Klein, Alexandra S / Gogolla, Nadine

    Science (New York, N.Y.)

    2021  Volume 371, Issue 6525, Page(s) 122–123

    MeSH term(s) Analgesia ; Animals ; Fear ; Gyrus Cinguli ; Mice ; Nucleus Accumbens ; Pain
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abf5940
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  3. Article ; Online: Fear balance is maintained by bodily feedback to the insular cortex in mice.

    Klein, Alexandra S / Dolensek, Nate / Weiand, Caroline / Gogolla, Nadine

    Science (New York, N.Y.)

    2021  Volume 374, Issue 6570, Page(s) 1010–1015

    Abstract: How does the brain maintain fear within an adaptive range? We found that the insular cortex acts as a state-dependent regulator of fear that is necessary to establish an equilibrium between the extinction and maintenance of fear memories in mice. Whereas ...

    Abstract How does the brain maintain fear within an adaptive range? We found that the insular cortex acts as a state-dependent regulator of fear that is necessary to establish an equilibrium between the extinction and maintenance of fear memories in mice. Whereas insular cortex responsiveness to fear-evoking cues increased with their certainty to predict harm, this activity was attenuated through negative bodily feedback that arose from heart rate decelerations during freezing. Perturbation of body-brain communication by vagus nerve stimulation disrupted the balance between fear extinction and maintenance similar to insular cortex inhibition. Our data reveal that the insular cortex integrates predictive sensory and interoceptive signals to provide graded and bidirectional teaching signals that gate fear extinction and illustrate how bodily feedback signals are used to maintain fear within a functional equilibrium.
    MeSH term(s) Animals ; Conditioning, Classical ; Cues ; Extinction, Psychological ; Fear ; Feedback, Physiological ; Heart Rate ; Insular Cortex/physiology ; Interoception ; Male ; Mental Recall ; Mice ; Mice, Inbred C57BL ; Vagus Nerve/physiology
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abj8817
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  4. Article ; Online: Facial expressions of emotion states and their neuronal correlates in mice.

    Dolensek, Nate / Gehrlach, Daniel A / Klein, Alexandra S / Gogolla, Nadine

    Science (New York, N.Y.)

    2020  Volume 368, Issue 6486, Page(s) 89–94

    Abstract: Understanding the neurobiological underpinnings of emotion relies on objective readouts of the emotional state of an individual, which remains a major challenge especially in animal models. We found that mice exhibit stereotyped facial expressions in ... ...

    Abstract Understanding the neurobiological underpinnings of emotion relies on objective readouts of the emotional state of an individual, which remains a major challenge especially in animal models. We found that mice exhibit stereotyped facial expressions in response to emotionally salient events, as well as upon targeted manipulations in emotion-relevant neuronal circuits. Facial expressions were classified into distinct categories using machine learning and reflected the changing intrinsic value of the same sensory stimulus encountered under different homeostatic or affective conditions. Facial expressions revealed emotion features such as intensity, valence, and persistence. Two-photon imaging uncovered insular cortical neuron activity that correlated with specific facial expressions and may encode distinct emotions. Facial expressions thus provide a means to infer emotion states and their neuronal correlates in mice.
    MeSH term(s) Animals ; Cerebral Cortex/cytology ; Cerebral Cortex/physiology ; Emotions/physiology ; Facial Expression ; Male ; Mice ; Neural Pathways/physiology ; Neurons/physiology
    Language English
    Publishing date 2020-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aaz9468
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  5. Article ; Online: A whole-brain connectivity map of mouse insular cortex.

    Gehrlach, Daniel A / Weiand, Caroline / Gaitanos, Thomas N / Cho, Eunjae / Klein, Alexandra S / Hennrich, Alexandru A / Conzelmann, Karl-Klaus / Gogolla, Nadine

    eLife

    2020  Volume 9

    Abstract: The insular cortex (IC) plays key roles in emotional and regulatory brain functions and is affected across psychiatric diseases. However, the brain-wide connections of the mouse IC have not been comprehensively mapped. Here, we traced the whole-brain ... ...

    Abstract The insular cortex (IC) plays key roles in emotional and regulatory brain functions and is affected across psychiatric diseases. However, the brain-wide connections of the mouse IC have not been comprehensively mapped. Here, we traced the whole-brain inputs and outputs of the mouse IC across its rostro-caudal extent. We employed cell-type-specific monosynaptic rabies virus tracings to characterize afferent connections onto either excitatory or inhibitory IC neurons, and adeno-associated viral tracings to label excitatory efferent axons. While the connectivity between the IC and other cortical regions was highly bidirectional, the IC connectivity with subcortical structures was often unidirectional, revealing prominent cortical-to-subcortical or subcortical-to-cortical pathways. The posterior and medial IC exhibited resembling connectivity patterns, while the anterior IC connectivity was distinct, suggesting two major functional compartments. Our results provide insights into the anatomical architecture of the mouse IC and thus a structural basis to guide investigations into its complex functions.
    MeSH term(s) Animals ; Brain Mapping ; Cerebral Cortex/anatomy & histology ; Female ; Male ; Mice/anatomy & histology ; Neurons/cytology
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.55585
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  6. Article: Early Cortical Changes in Gamma Oscillations in Alzheimer's Disease.

    Klein, Alexandra S / Donoso, José R / Kempter, Richard / Schmitz, Dietmar / Beed, Prateep

    Frontiers in systems neuroscience

    2016  Volume 10, Page(s) 83

    Abstract: The entorhinal cortices in the temporal lobe of the brain are key structures relaying memory related information between the neocortex and the hippocampus. The medial entorhinal cortex (MEC) routes spatial information, whereas the lateral entorhinal ... ...

    Abstract The entorhinal cortices in the temporal lobe of the brain are key structures relaying memory related information between the neocortex and the hippocampus. The medial entorhinal cortex (MEC) routes spatial information, whereas the lateral entorhinal cortex (LEC) routes predominantly olfactory information to the hippocampus. Gamma oscillations are known to coordinate information transfer between brain regions by precisely timing population activity of neuronal ensembles. Here, we studied the organization of
    Language English
    Publishing date 2016-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2016.00083
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  7. Article ; Online: Aversive state processing in the posterior insular cortex.

    Gehrlach, Daniel A / Dolensek, Nejc / Klein, Alexandra S / Roy Chowdhury, Ritu / Matthys, Arthur / Junghänel, Michaela / Gaitanos, Thomas N / Podgornik, Alja / Black, Thomas D / Reddy Vaka, Narasimha / Conzelmann, Karl-Klaus / Gogolla, Nadine

    Nature neuroscience

    2019  Volume 22, Issue 9, Page(s) 1424–1437

    Abstract: Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The insular cortex has been suggested to process emotions and homeostatic signals, but how the insular cortex detects internal states and mediates behavioral ... ...

    Abstract Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The insular cortex has been suggested to process emotions and homeostatic signals, but how the insular cortex detects internal states and mediates behavioral adaptation is poorly understood. By combining data from fiber photometry, optogenetics, awake two-photon calcium imaging and comprehensive whole-brain viral tracings, we here uncover a role for the posterior insula in processing aversive sensory stimuli and emotional and bodily states, as well as in exerting prominent top-down modulation of ongoing behaviors in mice. By employing projection-specific optogenetics, we describe an insula-to-central amygdala pathway to mediate anxiety-related behaviors, while an independent nucleus accumbens-projecting pathway regulates feeding upon changes in bodily state. Together, our data support a model in which the posterior insular cortex can shift behavioral strategies upon the detection of aversive internal states, providing a new entry point to understand how alterations in insula circuitry may contribute to neuropsychiatric conditions.
    MeSH term(s) Adaptation, Physiological/physiology ; Animals ; Behavior, Animal/physiology ; Cerebral Cortex/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neural Pathways/physiology
    Language English
    Publishing date 2019-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-019-0469-1
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