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  1. Book: Sex and gender differences in infection and treatments for infectious diseases

    Klein, Sabra L. / Roberts, Craig W.

    2015  

    Author's details Sabra L. Klein ; Craig W. Roberts ed
    Keywords immune response ; virus infection ; vaccination ; bacterial infection ; personalised treatment
    Language English
    Size X, 400 S. : Ill., graph. Darst., Kt.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018737541
    ISBN 978-3-319-16437-3 ; 3-319-16437-6 ; 9783319164380 ; 3319164384
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3085 available for loan (reading room) Lesesaal EG

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  2. Book: Sex hormones and immunity to infection

    Klein, Sabra L.

    2010  

    Author's details Sabra L. Klein ..., ed
    Keywords Infektion ; Immunreaktion ; Sexualhormon ; Geschlechtsunterschied
    Subject Geschlechterdifferenz ; Geschlechtsdimorphismus ; Geschlechtsspezifisch ... ; Geschlechtsspezifische Differenz ; Sexualdimorphismus ; Geschlechterunterschied ; Geschlecht ; Geschlechtsunterschiede ; Gender Diversity ; Geschlechtsspezifische Diversität ; Ansteckung ; Erstinfektion ; Infektionen ; Geschlechtshormon ; Abwehrreaktion ; Immunantwort ; Immunoreaktivität ; Immunabwehr
    Language English
    Size X, 319 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016163123
    ISBN 978-3-642-02154-1 ; 9783642021558 ; 3-642-02154-9 ; 3642021557
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 6410 order for loan Magazin

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  3. Article ; Online: My story of sex, gender, and women's health in a pandemic.

    Klein, Sabra L

    Immunological reviews

    2022  Volume 309, Issue 1, Page(s) 86–89

    Abstract: After more than 20 years of studying sex differences in viral pathogenesis and immunity to vaccines, the COVID-19 pandemic provided me with a unique opportunity to raise awareness about biological sex differences. The scientific community and public, ... ...

    Abstract After more than 20 years of studying sex differences in viral pathogenesis and immunity to vaccines, the COVID-19 pandemic provided me with a unique opportunity to raise awareness about biological sex differences. The scientific community and public, alike, embraced the clinical and epidemiological data and supported inquiries into how males are twice as likely to be hospitalized and die from COVID-19. Immunological changes associated with pregnancy also contribute to worse outcomes from COVID-19. Collectively, we are finding that inflammation is a critical mediator of worse outcomes for males and pregnant females. The pandemic gave me a platform to discuss and address sex differences on a bigger stage, but two decades of studies working with other viruses prepared me for this moment in history.
    MeSH term(s) COVID-19/epidemiology ; Female ; Humans ; Male ; Pandemics ; Pregnancy ; Women's Health
    Language English
    Publishing date 2022-06-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Pathogenesis of viral infections during pregnancy.

    Creisher, Patrick S / Klein, Sabra L

    Clinical microbiology reviews

    2024  , Page(s) e0007323

    Abstract: SUMMARYViral infections during pregnancy are associated with significant adverse perinatal and fetal outcomes. Pregnancy is a unique immunologic and physiologic state, which can influence control of virus replication, severity of disease, and vertical ... ...

    Abstract SUMMARYViral infections during pregnancy are associated with significant adverse perinatal and fetal outcomes. Pregnancy is a unique immunologic and physiologic state, which can influence control of virus replication, severity of disease, and vertical transmission. The placenta is the organ of the maternal-fetal interface and provides defense against microbial infection while supporting the semi-allogeneic fetus via tolerogenic immune responses. Some viruses, such as cytomegalovirus, Zika virus, and rubella virus, can breach these defenses, directly infecting the fetus and having long-lasting consequences. Even without direct placental infection, other viruses, including respiratory viruses like influenza viruses and severe acute respiratory syndrome coronavirus 2, still cause placental damage and inflammation. Concentrations of progesterone and estrogens rise during pregnancy and contribute to immunological adaptations, placentation, and placental development and play a pivotal role in creating a tolerogenic environment at the maternal-fetal interface. Animal models, including mice, nonhuman primates, rabbits, and guinea pigs, are instrumental for mechanistic insights into the pathogenesis of viral infections during pregnancy and identification of targetable treatments to improve health outcomes of pregnant individuals and offspring.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645015-5
    ISSN 1098-6618 ; 0893-8512
    ISSN (online) 1098-6618
    ISSN 0893-8512
    DOI 10.1128/cmr.00073-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2409: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Of mice, men, women, and cancer.

    Mueller, Alice L / Klein, Sabra L

    Immunity

    2022  Volume 55, Issue 7, Page(s) 1150–1152

    Abstract: The prevalence and severity of cancers in non-reproductive tissues are greater in males than females, but the sex-specific factors contributing to this remain ill described. In this issue of Immunity, Yang et al. (2022) uncover a mechanism of androgen ... ...

    Abstract The prevalence and severity of cancers in non-reproductive tissues are greater in males than females, but the sex-specific factors contributing to this remain ill described. In this issue of Immunity, Yang et al. (2022) uncover a mechanism of androgen signaling leading to an exhausted, terminally differentiated CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Cell Differentiation ; Female ; Humans ; Male ; Mice ; Neoplasms
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  6. Article ; Online: Mechanisms and consequences of sex differences in immune responses.

    Dunn, Shannon E / Perry, Whitney A / Klein, Sabra L

    Nature reviews. Nephrology

    2023  Volume 20, Issue 1, Page(s) 37–55

    Abstract: Biological sex differences refer to differences between males and females caused by the sex chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of testes or ovaries), and concentrations of sex steroids (that is, ... ...

    Abstract Biological sex differences refer to differences between males and females caused by the sex chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of testes or ovaries), and concentrations of sex steroids (that is, testosterone or oestrogens and progesterone). Although these sex differences are binary for most human individuals and mice, transgender individuals receiving hormone therapy, individuals with genetic syndromes (for example, Klinefelter and Turner syndromes) and people with disorders of sexual development reflect the diversity in sex-based biology. The broad distribution of sex steroid hormone receptors across diverse cell types and the differential expression of X-linked and autosomal genes means that sex is a biological variable that can affect the function of all physiological systems, including the immune system. Sex differences in immune cell function and immune responses to foreign and self antigens affect the development and outcome of diverse diseases and immune responses.
    MeSH term(s) Animals ; Female ; Mice ; Humans ; Male ; Sex Characteristics ; Sex Chromosomes/metabolism ; Ovary/metabolism ; Gonadal Steroid Hormones ; Immunity
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00787-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 107: Show issues

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  7. Article ; Online: Sex Differences in Immunity to Viral Infections.

    Jacobsen, Henning / Klein, Sabra L

    Frontiers in immunology

    2021  Volume 12, Page(s) 720952

    Abstract: The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias in COVID-19 disease severity is hypothesized to be mediated by sex differential ... ...

    Abstract The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias in COVID-19 disease severity is hypothesized to be mediated by sex differential immune responses against SARS-CoV-2. This hypothesis is based on data from other viral infections, including influenza viruses, HIV, hepatitis viruses, and others that have demonstrated sex-specific immunity to viral infections. Although males are more susceptible to most viral infections, females possess immunological features that render them more vulnerable to distinct immune-related disease outcomes. Both sex chromosome complement and related genes as well as sex steroids play important roles in mediating the development of sex differences in immunity to viral infections.
    MeSH term(s) CD4 Lymphocyte Count ; CD4-CD8 Ratio ; COVID-19/pathology ; Cytokines/blood ; Female ; Humans ; Immunity, Innate/genetics ; Immunity, Innate/immunology ; Male ; SARS-CoV-2/immunology ; Severity of Illness Index ; Sex Characteristics ; Sex Factors
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.720952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sex Differences in Respiratory Viral Pathogenesis and Treatments.

    Ursin, Rebecca L / Klein, Sabra L

    Annual review of virology

    2021  Volume 8, Issue 1, Page(s) 393–414

    Abstract: Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome coronavirus 2 ... ...

    Abstract Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome coronavirus 2 differs between the sexes across the life course. Generally, males are more susceptible to severe outcomes from respiratory viral infections at younger and older ages. During reproductive years (i.e., after puberty and prior to menopause), females are often at greater risk than males for severe outcomes. Pregnancy and biological sex affect the pathogenesis of respiratory viral infections. In addition to sex differences in the pathogenesis of disease, there are consistent sex differences in responses to treatments, with females often developing greater immune responses but experiencing more adverse reactions than males. Animal models provide mechanistic insights into the causes of sex differences in respiratory virus pathogenesis and treatment outcomes, where available.
    MeSH term(s) Age Factors ; Animals ; Female ; Humans ; Male ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/therapy ; Respiratory Tract Infections/virology ; Severity of Illness Index ; Sex Characteristics ; Sex Factors ; Virus Physiological Phenomena ; Viruses/classification
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2764224-0
    ISSN 2327-0578 ; 2327-056X
    ISSN (online) 2327-0578
    ISSN 2327-056X
    DOI 10.1146/annurev-virology-091919-092720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sex hormone signaling and regulation of immune function.

    Hoffmann, Joseph P / Liu, Jennifer A / Seddu, Kumba / Klein, Sabra L

    Immunity

    2023  Volume 56, Issue 11, Page(s) 2472–2491

    Abstract: Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine antigens, differ between males and females. The quest to uncover the mechanisms for biological sex differences in the immune system has intensified, with considerable ... ...

    Abstract Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine antigens, differ between males and females. The quest to uncover the mechanisms for biological sex differences in the immune system has intensified, with considerable literature pointing toward sex hormonal influences on immune cell function. Sex steroids, including estrogens, androgens, and progestins, have profound effects on immune function. As such, drastic changes in sex steroid concentrations that occur with aging (e.g., after puberty or during the menopause transition) or pregnancy impact immune responses and the pathogenesis of immune-related diseases. The effect of sex steroids on immunity involves both the concentration of the ligand and the density and distribution of genomic and nongenomic receptors that serve as transcriptional regulators of immune cellular responses to affect autoimmunity, allergy, infectious diseases, cancers, and responses to vaccines. The next frontier will be harnessing these effects of sex steroids to improve therapeutic outcomes.
    MeSH term(s) Pregnancy ; Female ; Male ; Humans ; Gonadal Steroid Hormones ; Estrogens/pharmacology ; Estrogens/physiology ; Progestins ; Androgens/pharmacology ; Neoplasms ; Steroids ; Immunity ; Sex Characteristics
    Chemical Substances Gonadal Steroid Hormones ; Estrogens ; Progestins ; Androgens ; Steroids
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Biological Sex and Pregnancy Affect Influenza Pathogenesis and Vaccination.

    Creisher, Patrick S / Seddu, Kumba / Mueller, Alice L / Klein, Sabra L

    Current topics in microbiology and immunology

    2023  Volume 441, Page(s) 111–137

    Abstract: Males and females differ in the outcome of influenza A virus (IAV) infections, which depends significantly on age. During seasonal influenza epidemics, young children (< 5 years of age) and aged adults (65+ years of age) are at greatest risk for severe ... ...

    Abstract Males and females differ in the outcome of influenza A virus (IAV) infections, which depends significantly on age. During seasonal influenza epidemics, young children (< 5 years of age) and aged adults (65+ years of age) are at greatest risk for severe disease, and among these age groups, males tend to suffer a worse outcome from IAV infection than females. Following infection with pandemic strains of IAVs, females of reproductive ages (i.e., 15-49 years of age) experience a worse outcome than their male counterparts. Although females of reproductive ages experience worse outcomes from IAV infection, females typically have greater immune responses to influenza vaccination as compared with males. Among females of reproductive ages, pregnancy is one factor linked to an increased risk of severe outcome of influenza. Small animal models of influenza virus infection and vaccination illustrate that immune responses and repair of damaged tissue following IAV infection also differ between the sexes and impact the outcome of infection. There is growing evidence that sex steroid hormones, including estrogens, progesterone, and testosterone, directly impact immune responses during IAV infection and vaccination. Greater consideration of the combined effects of sex and age as biological variables in epidemiological, clinical, and animal studies of influenza pathogenesis is needed.
    MeSH term(s) Male ; Animals ; Female ; Pregnancy ; Humans ; Influenza, Human/prevention & control ; Vaccination ; Models, Animal ; Pandemics ; Reproduction
    Language English
    Publishing date 2023-09-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 210099-X
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-031-35139-6_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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