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  1. Article ; Online: Metabolic path toward TCF3 inactivation in Burkitt lymphoma.

    Klein, Ulf

    Blood

    2022  Volume 139, Issue 4, Page(s) 475–476

    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/genetics ; Burkitt Lymphoma/genetics ; Humans ; Mutation
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; TCF3 protein, human
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021014133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  2. Article ; Online: Science, industry, and the German

    Klein, Ursula

    Annals of science

    2020  Volume 77, Issue 3, Page(s) 366–376

    MeSH term(s) Germany ; History, 19th Century ; Industry/history ; Science/history
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 337-2
    ISSN 1464-505X ; 0003-4924 ; 0003-3790
    ISSN (online) 1464-505X
    ISSN 0003-4924 ; 0003-3790
    DOI 10.1080/00033790.2020.1748228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 73/720: Show issues

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  3. Article ; Conference proceedings: PR3-Antikörper assoziierte alveoläre Hämorrhagie nach Cannabis- und Kokaininhalation

    Garcia, M Vidal / Klein, U / Westhoff, M

    Pneumologie

    2024  Volume 78, Issue S 01

    Event/congress 64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Mannheim, 2024-03-20
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0044-1778912
    Database Thieme publisher's database

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    Uh II Zs.142: Show issues Location:
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    Zs.MO 54: Show issues

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  4. Article ; Online: An MYC-Driven Vicious Circuit Is a Targetable Achilles' Heel in Lymphoma.

    Wilson, Erica B / Klein, Ulf

    Blood cancer discovery

    2023  Volume 4, Issue 4, Page(s) 248–251

    Abstract: Summary: In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by ... ...

    Abstract Summary: In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine-hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development. See related article by Nakanishi et al., p. 294 (4).
    MeSH term(s) Humans ; Polyamines ; Protein Processing, Post-Translational ; Neoplasms ; Lymphoma
    Chemical Substances Polyamines ; hypusine (3874VXF092)
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3028898-8
    ISSN 2643-3249 ; 2643-3230
    ISSN (online) 2643-3249
    ISSN 2643-3230
    DOI 10.1158/2643-3230.BCD-23-0053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: B cells ferment sugar before they (affinity) mature.

    Brownlie, Rebecca J / Klein, Ulf

    Nature immunology

    2023  Volume 24, Issue 8, Page(s) 1217–1219

    MeSH term(s) Sugars ; B-Lymphocytes
    Chemical Substances Sugars
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01536-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  6. Article ; Online: Resolving PI3K-δ inhibitor resistance in CLL.

    Klein, Ulf

    Blood

    2019  Volume 134, Issue 6, Page(s) 496–498

    MeSH term(s) Animals ; Disease Models, Animal ; Leukemia, Lymphocytic, Chronic, B-Cell ; Mice ; Phosphatidylinositol 3-Kinases ; Protein Kinase Inhibitors ; Quinazolinones
    Chemical Substances Protein Kinase Inhibitors ; Quinazolinones
    Language English
    Publishing date 2019-08-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019001177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 364: Show issues

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  7. Article ; Online: Losing control of nutrient sensing in the germinal centre drives lymphomagenesis.

    Klein, Ulf

    Nature metabolism

    2019  Volume 1, Issue 8, Page(s) 750–751

    Language English
    Publishing date 2019-08-12
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-019-0103-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Untersuchungen zur Auswirkung ausgewählter, intrazellulärer Mutationen im RET-Proto-Onkogen auf die Entstehung von medullären Schilddrüsen-Karzinomen

    Klein, Ulrike

    2002  

    Author's details vorgelegt von Ulrike Klein
    Language German
    Size VI, 102 Bl. : Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2002
    HBZ-ID HT013922359
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 E 420 order for loan Magazin

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  9. Article: NF-κB Mutations in Germinal Center B-Cell Lymphomas: Relation to NF-κB Function in Normal B Cells.

    Pasqualucci, Laura / Klein, Ulf

    Biomedicines

    2022  Volume 10, Issue 10

    Abstract: Most B cell lymphomas arise from the oncogenic transformation of B cells that have undergone the germinal center (GC) reaction of the T cell-dependent immune response, where high-affinity memory B cells and plasma cells are generated. The high ... ...

    Abstract Most B cell lymphomas arise from the oncogenic transformation of B cells that have undergone the germinal center (GC) reaction of the T cell-dependent immune response, where high-affinity memory B cells and plasma cells are generated. The high proliferation of GC B cells coupled with occasional errors in the DNA-modifying processes of somatic hypermutation and class switch recombination put the cell at a risk to obtain transforming genetic aberrations, which may activate proto-oncogenes or inactivate tumour suppressor genes. Several subtypes of GC lymphomas harbor genetic mutations leading to constitutive, aberrant activation of the nuclear factor-κB (NF-κB) signaling pathway. In normal B cells, NF-κB has crucial biological roles in development and physiology. GC lymphomas highjack these activities to promote tumour-cell growth and survival. It has become increasingly clear that the separate canonical and non-canonical routes of the NF-κB pathway and the five downstream NF-κB transcription factors have distinct functions in the successive stages of GC B-cell development. These findings may have direct implications for understanding how aberrant NF-κB activation promotes the genesis of various GC lymphomas corresponding to the developmentally distinct GC B-cell subsets. The knowledge arising from these studies may be explored for the development of precision medicine approaches aimed at more effective treatments of the corresponding tumours with specific NF-κB inhibitors, thus reducing systemic toxicity. We here provide an overview on the patterns of genetic NF-κB mutations encountered in the various GC lymphomas and discuss the consequences of aberrant NF-κB activation in those malignancies as related to the biology of NF-κB in their putative normal cellular counterparts.
    Language English
    Publishing date 2022-10-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10102450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Compartmentation of glycolysis and of the oxidative pentose-phosphate pathway in Chlamydomonas reinhardii.

    Klein, U

    Planta

    2013  Volume 167, Issue 1, Page(s) 81–86

    Abstract: Glycolytic enzyme activities and enzyme activities of the oxidative pentose-phosphate pathway were measured in intact chloroplasts from Chlamydomonas reinhardii. By comparison with the total enzyme activities of intact protoplasts of the alga the data ... ...

    Abstract Glycolytic enzyme activities and enzyme activities of the oxidative pentose-phosphate pathway were measured in intact chloroplasts from Chlamydomonas reinhardii. By comparison with the total enzyme activities of intact protoplasts of the alga the data were used to locate these enzymes quantitatively in the algal chloroplast. It was found that the glycolytic chain in C. reinhardii is roughly split into a plastidic and an extraplastidic part. More than 90% of the first part of glycolysis (from fructose-6-phosphate to triose-phosphate is located in the plastid while more than 95% of the second part (from glycerate-3-phosphate to pyruvate) is outside. Around 70% of glucose-6-phosphate dehydrogenase and gluconate-6-phosphate dehydrogenase, two key enzymes of the oxidative pentose phosphate pathway, are located in the plastid. It is concluded that in C. reinhardii the major part of hexose breakdown to triose-phosphate occurs in the chloroplast and that a tight cooperation between the plastid and the cytoplasm is required for appreciable sugar breakdown to occur in the algal cell.
    Language English
    Publishing date 2013-11-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/BF00446372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 46/303: Show issues

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