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  1. Article: Human Cord Blood Derived Unrestricted Somatic Stem Cells Restore Aquaporin Channel Expression, Reduce Inflammation and Inhibit the Development of Hydrocephalus After Experimentally Induced Perinatal Intraventricular Hemorrhage.

    Purohit, Deepti / Finkel, Dina A / Malfa, Ana / Liao, Yanling / Ivanova, Larisa / Kleinman, George M / Hu, Furong / Shah, Shetal / Thompson, Carl / Joseph, Etlinger / Wolin, Michael S / Cairo, Mitchell S / La Gamma, Edmund F / Vinukonda, Govindaiah

    Frontiers in cellular neuroscience

    2021  Volume 15, Page(s) 633185

    Abstract: Intraventricular hemorrhage (IVH) is a severe complication of preterm birth associated with cerebral palsy, intellectual disability, and commonly, accumulation of cerebrospinal fluid (CSF). Histologically, IVH leads to subependymal gliosis, fibrosis, and ...

    Abstract Intraventricular hemorrhage (IVH) is a severe complication of preterm birth associated with cerebral palsy, intellectual disability, and commonly, accumulation of cerebrospinal fluid (CSF). Histologically, IVH leads to subependymal gliosis, fibrosis, and disruption of the ependymal wall. Importantly, expression of aquaporin channels 1 and 4 (AQP1 and AQP4) regulating respectively, secretion and absorption of cerebrospinal fluids is altered with IVH and are associated with development of post hemorrhagic hydrocephalus. Human cord blood derived unrestricted somatic stem cells (USSCs), which we previously demonstrated to reduce the magnitude of hydrocephalus, as having anti-inflammatory, and beneficial behavioral effects, were injected into the cerebral ventricles of rabbit pups 18 h after glycerol-induced IVH. USSC treated IVH pups showed a reduction in ventricular size when compared to control pups at 7 and 14 days (both,
    Language English
    Publishing date 2021-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2021.633185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hemangiopericytoma: collision with meningioma and recurrence.

    Binello, Emanuela / Bederson, Joshua B / Kleinman, George M

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2010  Volume 31, Issue 5, Page(s) 625–630

    Abstract: Intracranial hemangiopericytomas are a rare type of primary brain tumor, representing only about 0.5% of all primary brain tumors. Even more rare is the co-existence of two juxtaposed primary brain tumors, termed a "collision" tumor. This report provides ...

    Abstract Intracranial hemangiopericytomas are a rare type of primary brain tumor, representing only about 0.5% of all primary brain tumors. Even more rare is the co-existence of two juxtaposed primary brain tumors, termed a "collision" tumor. This report provides the first documentation in the literature of a hemangiopericytoma colliding with a meningioma, and recurring after treatment with gross total resection. Surgical samples were fully evaluated with hematoxylin and eosin and reticulin staining, as well as immunohistochemical analysis. Results were classically representative of a hemangiopericytoma (World Health Organization grade II) and of a meningioma (World Health Organization grade I). This report of a unique collision tumor not only augments the repertoire of collision tumor combinations described in literature but also provides follow-up on the clinical outcome of the patient, thereby raising clinically relevant issues ranging from presentation to treatment paradigms.
    MeSH term(s) Adult ; Antigens, CD34/metabolism ; Brain Neoplasms/complications ; Brain Neoplasms/diagnosis ; Brain Neoplasms/metabolism ; Hemangiopericytoma/complications ; Hemangiopericytoma/diagnosis ; Hemangiopericytoma/metabolism ; Humans ; Magnetic Resonance Imaging ; Male ; Meningeal Neoplasms/complications ; Meningeal Neoplasms/diagnosis ; Meningeal Neoplasms/metabolism ; Meningioma/complications ; Meningioma/diagnosis ; Meningioma/metabolism ; Neoplasm Recurrence, Local/complications ; Neoplasm Recurrence, Local/metabolism ; Recurrence
    Chemical Substances Antigens, CD34
    Language English
    Publishing date 2010-03-03
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-010-0227-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1877: Show issues Location:
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  3. Article ; Online: Estrogen Treatment Reverses Prematurity-Induced Disruption in Cortical Interneuron Population.

    Panda, Sanjeet / Dohare, Preeti / Jain, Samhita / Parikh, Nirzar / Singla, Pranav / Mehdizadeh, Rana / Klebe, Damon W / Kleinman, George M / Cheng, Bokun / Ballabh, Praveen

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2018  Volume 38, Issue 34, Page(s) 7378–7391

    Abstract: Development of cortical interneurons continues until the end of human pregnancy. Premature birth deprives the newborns from the supply of maternal estrogen and a secure intrauterine environment. Indeed, preterm infants suffer from neurobehavioral ... ...

    Abstract Development of cortical interneurons continues until the end of human pregnancy. Premature birth deprives the newborns from the supply of maternal estrogen and a secure intrauterine environment. Indeed, preterm infants suffer from neurobehavioral disorders. This can result from both preterm birth and associated postnatal complications, which might disrupt recruitment and maturation of cortical interneurons. We hypothesized that interneuron subtypes, including parvalbumin-positive (PV
    MeSH term(s) Animals ; Animals, Newborn ; Calbindin 2/analysis ; Cell Count ; Cerebral Cortex/pathology ; Estradiol/pharmacology ; Female ; Gestational Age ; Glutamate Decarboxylase/analysis ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/pathology ; Interneurons/chemistry ; Interneurons/classification ; Interneurons/drug effects ; Interneurons/physiology ; Male ; Nerve Tissue Proteins/analysis ; Nerve Tissue Proteins/biosynthesis ; Nerve Tissue Proteins/genetics ; Neuropeptide Y/analysis ; Parvalbumins/analysis ; Rabbits ; Somatostatin/analysis ; Transcription Factors/biosynthesis ; Transcription Factors/genetics
    Chemical Substances CALB2 protein, human ; Calbindin 2 ; Nerve Tissue Proteins ; Neuropeptide Y ; Parvalbumins ; Transcription Factors ; Estradiol (4TI98Z838E) ; Somatostatin (51110-01-1) ; Glutamate Decarboxylase (EC 4.1.1.15) ; glutamate decarboxylase 1 (EC 4.1.1.15)
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0478-18.2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Epithelioid ependymoma: a new variant of ependymoma: report of three cases.

    Kleinman, George M / Zagzag, David / Miller, Douglas C

    Neurosurgery

    2003  Volume 53, Issue 3, Page(s) 743–7; discussion 747–8

    Abstract: Objective: To describe the pathological features of three very similar and unusual primary central nervous system tumors that are not readily recognized as conventional ependymomas but which, by ultrastructural examination, have an ependymomatous ... ...

    Abstract Objective: To describe the pathological features of three very similar and unusual primary central nervous system tumors that are not readily recognized as conventional ependymomas but which, by ultrastructural examination, have an ependymomatous character.
    Methods: Three distinctive tumors were found in a review of our files for cases of ependymoma. In each case, hematoxylin and eosin-stained sections were reviewed, and immunostains for epithelial membrane antigen, cytokeratin, vimentin, and glial fibrillary acidic protein were performed on formalin-fixed, paraffin-embedded sections. Electron microscopy was performed in each case.
    Results: The tumors had a diffuse myxoid background, often containing tightly clustered cells that mimicked multinucleated giant cells, but lacking perivascular pseudorosettes or central lumen rosettes. Glial fibrillary acidic protein and vimentin immunostains did not reveal perivascular processes. Epithelial membrane antigen immunostains showed a dot-like cytoplasmic immunoreactivity in some cell clusters in two of the three cases. Cytokeratin was negative in all three cases. However, ultrastructurally, the cells of each tumor had extensive surface microvilli; the giant cell-like clusters had cells with extensive close appositions, some junctions, and, in two cases, lumina with microvilli. Two of the patients were adults (both with temporal lobe tumors), and one patient was 13 years old and had a cervical spinal cord intramedullary tumor. Each tumor was sharply circumscribed from adjacent central nervous system tissue but was not encapsulated. One of the cases in an adult was mitotically highly active; this tumor recurred locally 4 years after initial gross total excision.
    Conclusion: These tumors are unusual variants of ependymoma. This pattern of ependymoma is sufficiently distinctive to be recognized in hematoxylin and eosin stains once the architecture of the epithelioid clusters is appreciated.
    MeSH term(s) Adolescent ; Adult ; Brain Neoplasms/pathology ; Brain Neoplasms/surgery ; Brain Neoplasms/ultrastructure ; Ependymoma/pathology ; Ependymoma/surgery ; Ependymoma/ultrastructure ; Epithelioid Cells/pathology ; Epithelioid Cells/ultrastructure ; Female ; Humans ; Male ; Spinal Cord Neoplasms/pathology ; Spinal Cord Neoplasms/surgery ; Spinal Cord Neoplasms/ultrastructure
    Language English
    Publishing date 2003-05-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.neu.0000079628.55729.12
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    Zs.MO 539: Show issues

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  5. Article: CA-125 and Carcinoembryonic Antigen Assay vs. Cytodiagnostic Experience in the Classification of Benign Ovarian Cysts

    Pinto, Marguerite M. / Greenebaum, Ellen / Simsir, Aylin / Kleinman, George M. / Portnoy, Lewis M. / Garfinkel, Robin

    Acta Cytologica

    2011  Volume 41, Issue 5, Page(s) 1456–1462

    Institution From Bridgeport Hospital, Bridgeport, Connecticut, and the Columbia-Presbyterian Medical Center and Departments of Pathology and of Child and Adolescent Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, U.S.A
    Keywords ovarian cysts ; aspiration biopsy ; CA-125 antigen ; carcinoembryonic antigen
    Language English
    Publishing date 2011-09-08
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Original Articles
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
    DOI 10.1159/000332859
    Database Karger publisher's database

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  6. Article ; Online: Intravascular lymphomatosis of the brain in a patient with myelodysplastic syndrome.

    Sips, Gregorius J / Amory, Colum F / Delman, Bradley N / Kleinman, George M / Lipsey, Lewis R / Tuhrim, Stanley

    Nature reviews. Neurology

    2009  Volume 5, Issue 5, Page(s) 288–292

    Abstract: Background: A 77-year-old retired research pharmacologist with a long-standing history of anemia and a recent pathologically confirmed diagnosis of myelodysplastic syndrome was referred to a stroke unit for evaluation of slowly progressive cognitive ... ...

    Abstract Background: A 77-year-old retired research pharmacologist with a long-standing history of anemia and a recent pathologically confirmed diagnosis of myelodysplastic syndrome was referred to a stroke unit for evaluation of slowly progressive cognitive deterioration, confusion and paroxysmal stroke-like episodes. A previous neurological work-up had revealed no noteworthy abnormalities except for chronic bilateral caudate infarctions seen on MRI and CT examinations of the brain.
    Investigations: Physical examination, laboratory testing, brain MRI scanning, EEG, transesophageal echocardiography, cerebral angiography, CT scanning, and brain biopsy.
    Diagnosis: Intravascular lymphomatosis of the brain.
    Management: Combined chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) and rituximab.
    MeSH term(s) Aged ; Angiography/methods ; Blood Vessels/pathology ; Brain Neoplasms/complications ; Brain Neoplasms/diagnostic imaging ; Cognition Disorders/etiology ; Humans ; Lymphoma, B-Cell/complications ; Lymphoma, B-Cell/radiotherapy ; Magnetic Resonance Imaging/methods ; Male ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/diagnostic imaging ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2009-06-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/nrneurol.2009.36
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  7. Article: A murine photochemical stroke model with histologic correlates of apoptotic and nonapoptotic mechanisms.

    Eichenbaum, Joseph W / Pevsner, Paul H / Pivawer, Gabriel / Kleinman, George M / Chiriboga, Luis / Stern, Arnold / Rosenbach, Ari / Iannuzzi, Kathryn / Miller, Douglas C

    Journal of pharmacological and toxicological methods

    2002  Volume 47, Issue 2, Page(s) 67–71

    Abstract: Introduction: The neuronal cell death that occurs after ischemia-induced cerebral infarction (stroke) contains elements of apoptosis and necrosis, an intermediary form of the two, and a distinct excitotoxic process. We previously developed a ... ...

    Abstract Introduction: The neuronal cell death that occurs after ischemia-induced cerebral infarction (stroke) contains elements of apoptosis and necrosis, an intermediary form of the two, and a distinct excitotoxic process. We previously developed a photochemical model of stroke in the rat. We have now adapted this model for use in the mouse. The present manuscript describes the mouse model.
    Methods: Minimal beam intensity (0.1 W/cm(2)) cold white light (8 min exposure) was used to evoke discrete infarcts in the parietal lobes of 11 mice sensitized by the administration of fresh Rose Bengal (10 mg/kg by rapid iv infusion).
    Results: At 2 h, five out of five mice and at 6 h, six out of six mice demonstrated light microscopic histologic features like those in the rat model. These included a superior ischemic zone with shrunken and pyknotic nuclei, a middle transition zone of edematous vacuolated neuropil but normal neurons with open chromatin and retained Nissl granules, and an inferior zone with normal neurons. There was widespread nuclear terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL) in the superior infarct zone in 11/11 mice. However, in the edematous vacuolated transition zone, 11/11 mice had TUNEL positive and negative nuclei randomly mixed. Light microscopic analysis of that same transition zone showed no pyknosis or chromatin bodies in the TUNEL positive or negative cells.
    Discussion: In mice, photoactivation of Rose Bengal evoked similar infarct and transition zone patterns found previously in rats, with TUNEL evidence of apoptotic and nonapoptotic events. Thus, it will be possible to use this model for further quantitative study of apoptotic and excitotoxic events in wild and transgenic mice.
    MeSH term(s) Animals ; Apoptosis/radiation effects ; Cell Death/radiation effects ; Cerebral Infarction/pathology ; Disease Models, Animal ; Female ; In Situ Nick-End Labeling ; Light ; Mice ; Neurons/pathology ; Neurons/radiation effects ; Parietal Lobe/pathology ; Parietal Lobe/radiation effects ; Photosensitizing Agents ; Rose Bengal ; Stroke/pathology
    Chemical Substances Photosensitizing Agents ; Rose Bengal (1ZPG1ELY14)
    Language English
    Publishing date 2002-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1105919-9
    ISSN 1873-488X ; 1056-8719
    ISSN (online) 1873-488X
    ISSN 1056-8719
    DOI 10.1016/s1056-8719(02)00215-0
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