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  1. Book ; Online ; Thesis: DNA methylation patterns reflect individual’s lifestyle independent of obesity

    Klemp, Ireen [Verfasser]

    2024  

    Author's details Ireen Klemp
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Leipzig
    Publishing place Leipzig
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: DNA methylation patterns reflect individual's lifestyle independent of obesity.

    Klemp, Ireen / Hoffmann, Anne / Müller, Luise / Hagemann, Tobias / Horn, Kathrin / Rohde-Zimmermann, Kerstin / Tönjes, Anke / Thiery, Joachim / Löffler, Markus / Burkhardt, Ralph / Böttcher, Yvonne / Stumvoll, Michael / Blüher, Matthias / Krohn, Knut / Scholz, Markus / Baber, Ronny / Franks, Paul W / Kovacs, Peter / Keller, Maria

    Clinical and translational medicine

    2022  Volume 12, Issue 6, Page(s) e851

    Abstract: Objective: Obesity is driven by modifiable lifestyle factors whose effects may be mediated by epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in participants of the LIFE-Adult study, a well-characterised population- ... ...

    Abstract Objective: Obesity is driven by modifiable lifestyle factors whose effects may be mediated by epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in participants of the LIFE-Adult study, a well-characterised population-based cohort from Germany.
    Research design and methods: Lifestyle scores (LS) based on diet, physical activity, smoking and alcohol intake were calculated in 4107 participants of the LIFE-Adult study. Fifty subjects with an extremely healthy lifestyle and 50 with an extremely unhealthy lifestyle (5th and 95th percentiles LS) were selected for genome-wide DNA methylation analysis in blood samples employing Illumina Infinium® Methylation EPIC BeadChip system technology.
    Results: Differences in DNA methylation patterns between body mass index groups (<25 vs. >30 kg/m
    Conclusions: DNA methylation patterns help discriminate individuals with a healthy versus unhealthy lifestyle, which may mask subtle methylation differences derived from obesity.
    MeSH term(s) Adult ; DNA Methylation/genetics ; Epigenesis, Genetic ; Epigenomics ; Healthy Lifestyle ; Humans ; Obesity/genetics
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Conference proceedings: 37 DNA methylation pattern in blood may reflect individuals’ daily lifestyle

    Klemp, Ireen / Hoffmann, Anne / Müller, Luise / Hagemann, Tobias / Rohde-Zimmermann, Kerstin / Böttcher, Yvonne / Stumvoll, Michael / Blüher, Matthias / Scholz, Markus / Krohn, Knut / Baber, Ronny / Franks, PaulW. / Kovacs, Peter / Keller, Maria

    Adipositas - Ursachen, Folgeerkrankungen, Therapie

    2021  Volume 15, Issue 03

    Event/congress Adipositas-Kongress 2021 - 37. Jahrestagung der Deutschen Adipositas-Gesellschaft e.V., Wiesbaden, 2021-11-05
    Language German
    Publishing date 2021-09-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2393396-3
    ISSN 2567-6334 ; 1865-1739
    ISSN (online) 2567-6334
    ISSN 1865-1739
    DOI 10.1055/s-0041-1735699
    Database Thieme publisher's database

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