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Article ; Online: Association of Imaging-based Predictors with Outcome in Different Treatment Options for Intracerebral Hemorrhage.

Krzyżewski, Roger M / Kwinta, Borys M / Stachura, Krzysztof / Popiela, Tadeusz J / Pułyk, Roman / Słowik, Agnieszka / Gąsowski, Jerzy / Kliś, Kornelia M

Clinical neuroradiology

2024

Abstract: Purpose: Intracerebral hemorrhage is the deadliest form of stroke. This study aimed to enhance the prediction of 30-day mortality in intracerebral hemorrhage patients by integrating computational parameters.: Methods: This study retrospectively ... ...

Abstract	Purpose: Intracerebral hemorrhage is the deadliest form of stroke. This study aimed to enhance the prediction of 30-day mortality in intracerebral hemorrhage patients by integrating computational parameters. Methods: This study retrospectively analyzed 435 patients with spontaneous intracerebral hemorrhage (ICH). Utilizing the acquired computed tomography (CT) images, we extracted the contour and visual representation of ICH. For the extracted contour, the analysis encompassed factors including compactness, fractal dimension, Fourier factor, and circle factor. For the images depicting ICH, we calculated various factors related to density distribution including mean, coefficient of variance, skewness and kurtosis, as well as texture parameters, such as energy, entropy, contrast and homogeneity. To assess the impact of surgical treatment on 30-day mortality, logistic regression analysis was used. Results: A total of 126 patients (29.09%) died within 30 days. A total of 62 (14.25%) patients underwent surgical treatment. Multivariate logistic regression analysis revealed that surgical treatment was independently associated with a lower risk of 30-day mortality (odds ratio, OR 0.226, 95% confidence interval, CI 0.049-0.85; p = 0.039). Based on the moderated analysis, we found that the volume of ICH (OR 0.905, 95% CI 0.902-0.908; p < 0.001) and ICH energy (OR 1.389, 95%CI 0.884-0.988; p = 0.010) had positive moderating effect on such associations while the presence of intraventricular blood had negative moderating effect (OR 1.154, 95% CI 1.034-1.628; p = 0.010). Conclusion: Patients exhibiting a higher volume and energy of ICH might benefit from surgical treatment; however, this efficacy was found to be diminished in cases involving the presence of intraventricular blood.
Language	English
Publishing date	2024-04-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2234662-4
ISSN	1869-1447 ; 0939-7116 ; 1869-1439
ISSN (online)	1869-1447
ISSN	0939-7116 ; 1869-1439
DOI	10.1007/s00062-024-01406-2
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Zs.A 3413: Show issues

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Article ; Online: The influence of embolization of internal carotid artery aneurysms on arterial tortuosity: a prospective cohort study.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Stachura, Krzysztof / Popiela, Tadeusz J / Brzegowy, Paweł / Łasocha, Bartłomiej / Urbanik, Andrzej / Grodzicki, Tomasz / Milczarek, Olga / Gąsowski, Jerzy

Journal of vascular and interventional radiology : JVIR

2024

Abstract: Purpose: To compare quantitative tortuosity descriptors of Internal Carotid Artery (ICA) on aneurysmal and non-aneurysmal side before and after embolization of aneurysm and to determine possible factors associated with its change.: Material and ... ...

Abstract	Purpose: To compare quantitative tortuosity descriptors of Internal Carotid Artery (ICA) on aneurysmal and non-aneurysmal side before and after embolization of aneurysm and to determine possible factors associated with its change. Material and methods: An analysis of 52 patients with intracranial aneurysm, treated with endovascular procedure, was performed. Based on their Digital Subtraction Angiography images, obtained prior to the procedure and after first follow-up examination, tortuosity of ICA, both on the side of embolization and on the other side was analysed. For each patient tortuosity descriptors were calculated: Relative Length, Sum of Angle Metrics, Triangular Index, Product of Angle Distance, and Inflection Count Metric. To represent changes in tortuosity, for each descriptor delta value (Δ) was defined as value of the descriptor prior to embolization - value of the descriptor on follow-up examination. Results: In the follow-up We found no statistically significant changes in tortuosity on non-embolized side. On the embolized side SOAM (2.89±0.92 vs. 2.38±0.94;p<0.001), PAD (5.01±1.83 vs. 3.95±1.72 ;p<0.001) and ICM (12.18±4.55 vs. 9.76±4.04 vs.;p = 0.006) was significantly higher after embolization than before embolization. Mean ΔRelative Length (-0.02 [-0.045--0.002] vs. -0.01 [-0.02-0.003];p - 0.003),ΔProduct of Angle Distance (0.84 [0.30 - 1.82] vs. 0.10 [-0.001 - 1.10];p<0.001) and ΔInflection Count Metric (2.05 [0.42 - 3.50] vs. 0.27 [0.02 - 2.16];p = 0.004) were significantly higher on the embolized side. Conclusion: Following study showed that embolization may increase the tortuosity of ICA.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2024.04.012
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Zs.A 3720: Show issues

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Article ; Online: Possible association between β-blocker use and a risk of intracranial aneurysm rupture.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Stachura, Krzysztof / Piotrowicz, Karolina / Popiela, Tadeusz J / Frączek, Maciej J / Grodzicki, Tomasz / Gąsowski, Jerzy

Polish archives of internal medicine

2024 Volume 134, Issue 2

Abstract: Introduction: Aneurysmal subarachnoid hemorrhage is a devastating type of stroke, associated with high mortality and morbidity. One of modifiable risk factors of aneurysm rupture is hypertension, however, it is still not clear whether any particular ... ...

Abstract	Introduction: Aneurysmal subarachnoid hemorrhage is a devastating type of stroke, associated with high mortality and morbidity. One of modifiable risk factors of aneurysm rupture is hypertension, however, it is still not clear whether any particular antihypertensive drugs play a significant role in the prevention of aneurysm rupture. Objectives: We decided to investigate whether there is any association between acetylsalicylic acid, α-blockers, β‑blockers, angiotensin‑converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, diuretics, statins, and anticoagulants and a risk of intracranial aneurysm rupture. Patients and methods: We retrospectively analyzed 334 patients with ruptured and unruptured intracranial aneurysm. Based on logistic regression models, we obtained unadjusted and adjusted odds ratios (ORs) of subarachnoid hemorrhage associated with the use of vasoactive medications and with indices of tortuosity. Results: We found that β‑blocker intake was significantly related to higher tortuosity of the cerebral arteries. Also, the intake of β‑blockers (OR, 0.41; 95% CI, 0.21-0.77; P = 0.01) and statins (OR, 0.23; 95% CI, 0.05-0.68; P = 0.01) significantly decreased the risk of aneurysm rupture, a result driven by a decreased rupture risk of anterior circulation aneurysms. No such association was found for the posterior part of the cerebral circulation. Conclusions: Aneurysm located in the anterior cerebral circulation might be less likely to rupture if patients receive β‑blockers or statins.
MeSH term(s)	Humans ; Intracranial Aneurysm/complications ; Retrospective Studies ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Subarachnoid Hemorrhage/complications ; Risk Factors ; Aneurysm, Ruptured/complications ; Adrenergic beta-Antagonists/adverse effects
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Adrenergic beta-Antagonists
Language	English
Publishing date	2024-01-02
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16642
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Article ; Online: Predictors of intraoperative intracranial aneurysm rupture in patients with subarachnoid hemorrhage: a retrospective analysis.

Frączek, Maciej J / Błoński, Miłosz J / Kliś, Kornelia M / Krzyżewski, Roger M / Polak, Jarosław / Stachura, Krzysztof / Kwinta, Borys M

Acta neurologica Belgica

2022 Volume 123, Issue 5, Page(s) 1717–1724

Abstract: Purpose: Intraoperative cerebral aneurysm rupture (IOR) is a common phenomenon with a frequency of around 19%. Research regarding IOR lacks an analysis of its predictors.: Methods: We retrospectively examined all saccular aneurysms, in 198 patients ... ...

Abstract	Purpose: Intraoperative cerebral aneurysm rupture (IOR) is a common phenomenon with a frequency of around 19%. Research regarding IOR lacks an analysis of its predictors. Methods: We retrospectively examined all saccular aneurysms, in 198 patients with subarachnoid hemorrhage, surgically treated from 2013 to 2019. Operative reports, patient histories, blood test results, discharge summaries, and radiological data were reviewed. IOR was defined as any bleeding from the aneurysm during surgery, preceding putting a clip on its neck, regardless of how trivial. Results: The frequency of IOR was 20.20%. Patients with IOR had higher aneurysm dome size (9.43 ± 8.39 mm vs. 4.96 ± 2.57 mm; p < 0.01). The presence of blood clot on the aneurysm dome was significantly associated with IOR (12.50% vs. 2.53%; p < 0.01). We also associated lamina terminalis fenestration during surgery (7.50% vs. 21.52%; p = 0.04) and multiple aneurysms (5.00% vs. 18.35%; p = 0.038) with a lower risk of IOR. Glucose blood levels were also elevated in patients with IOR (7.47 ± 2.78 mmol/l vs. 6.90 ± 2.22 mmol/l; p = 0.04). Multivariate analysis associated that urea blood levels (OR 0.55, 0.33 to 0.81, p < 0.01) and multiple aneurysms (OR 0.04, 0.00 to 0.37, p = 0.014) were protective factors against the occurrence of IOR. Conclusion: Large dome size of an aneurysm, a blood clot on the aneurysm dome and elevated glucose blood levels can be IOR predictive. Lamina terminalis fenestration, the appearance of multiple aneurysms, and high urea blood levels may be associated with a lower risk of such an event.
MeSH term(s)	Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/surgery ; Retrospective Studies ; Intraoperative Complications/epidemiology ; Intraoperative Complications/surgery ; Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/surgery ; Glucose ; Urea
Chemical Substances	Glucose (IY9XDZ35W2) ; Urea (8W8T17847W)
Language	English
Publishing date	2022-06-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-02005-z
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Article ; Online: Subarachnoid Hemorrhage from Ruptured Internal Carotid Artery Aneurysm: Association with Arterial Tortuosity.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Łasocha, Bartłomiej / Brzegowy, Paweł / Popiela, Tadeusz J / Gąsowski, Jerzy

World neurosurgery

2022 Volume 166, Page(s) e84–e92

Abstract: Objective: Many researchers have found a correlation between tortuous arteries and development of aneurysms in cerebral arteries. We decided to determine whether tortuosity of the internal carotid artery can be related to its aneurysm rupture.: ... ...

Abstract	Objective: Many researchers have found a correlation between tortuous arteries and development of aneurysms in cerebral arteries. We decided to determine whether tortuosity of the internal carotid artery can be related to its aneurysm rupture. Methods: We retrospectively analyzed the internal carotid artery anatomy of 149 patients with internal carotid artery aneurysms. For each patient, we calculated relative length (RL), sum of angle metrics (SOAM), triangular index (TI), product of angle distance (PAD), and inflection count metrics (ICM). Results: A total of 33 patients (22.15%) had subarachnoid hemorrhage. These patients had significantly lower SOAM (0.31 ± 0.17 vs. 0.42 ± 0.21; P < 0.01), TI (0.27 ± 0.09 vs. 0.31 ± 0.11; P = 0.03) and ICM (0.25 ± 0.11 vs. 0.31 ± 0.17; P = 0.04). In multivariate logistic regression analysis, higher SOAM (odds ratio, 0.780; 95% confidence interval, 0.619-0.961; P = 0.025) remained independently associated with lower risk of internal carotid artery aneurysm rupture. In addition, we found significant positive correlation of aneurysm dome size with SOAM (R = 0.224; P = 0.013) and PAD (0.269; P < 0.01). Our study also showed that age (R = 0.252; P = 0.036), Glasgow Coma Scale score (R = -0.706; P < 0.01), and TI (R = -0.249; P = 0.042) were independently correlated with modified Rankin Scale score on discharge. Conclusions: Lower tortuosity might be a protective factor against internal carotid artery aneurysm rupture and poor outcome after subarachnoid hemorrhage. Higher tortuosity is correlated with internal carotid artery aneurysm growth.
MeSH term(s)	Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/diagnostic imaging ; Arteries/abnormalities ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery, Internal/diagnostic imaging ; Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Joint Instability ; Retrospective Studies ; Skin Diseases, Genetic ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/etiology ; Vascular Malformations
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.06.101
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Article ; Online: Association of Arterial Tortuosity with Hemodynamic Parameters-A Computational Fluid Dynamics Study.

Kliś, Kornelia M / Wójtowicz, Dominika / Kwinta, Borys M / Stachura, Krzysztof / Popiela, Tadeusz J / Frączek, Maciej J / Łasocha, Bartłomiej / Gąsowski, Jerzy / Milczarek, Olga / Krzyżewski, Roger M

World neurosurgery

2023 Volume 180, Page(s) e69–e76

Abstract: Background: Tortuosity of intracranial arteries has been proven to be associated with the risk of intracranial aneurysm development. We decided to analyze which aspects of tortuosity are correlated with hemodynamics parameters promoting intracranial ... ...

Abstract	Background: Tortuosity of intracranial arteries has been proven to be associated with the risk of intracranial aneurysm development. We decided to analyze which aspects of tortuosity are correlated with hemodynamics parameters promoting intracranial aneurysm development. Methods: We constructed 73 idealized models of tortuous artery (length: 25 mm, diameter: 2.5 mm) with single bifurcation. For each model, on the course of segment before bifurcation, we placed 1-3 angles with measures 15, 30, 45, 60, or 75 degrees and arc lengths 2, 5, 7, 10, or 15 mm. We performed computational fluid dynamics analysis. Blood was modeled as Newtonian fluid. We have set velocity wave of 2 cardiac cycles. After performing simulation we calculated following hemodynamic parameters at the bifurcation: time average wall shear stress (TAWSS), time average wall shear stress gradient (TAWSSG), oscillatory shear index (OSI), and relative residence time (RRT). Results: We found a significant positive correlation with number of angles and TAWSS (R = 0.329; P < 0.01), TAWSSG (R = 0.317; P < 0.01), and negative with RRT (R = -0.335; P < 0.0.01). Similar results were obtained in terms of arcs lengths. On the other hand, mean angle measure was negatively correlated to TAWSS (R = -0.333; P < 0.01), TAWSSG (R = -0.473 P < 0.01), OSI (R = -0.463; P < 0.01), and positively to RRT (R = 0.332; P < 0.01). On the basis of the obtained results, we developed new tortuosity descriptor, which considered angle measures normalized to its arc length and distance from bifurcation. For such descriptor we found strong negative correlation with TAWSS (R = -0.701; P < 0.01), TAWSSG (R = 0.778; P < 0.01), OSI (R = -0.776; P < 0.01), and positive with RRT (R = 0.747; P < 0.01). Conclusions: Hemodynamic parameters promoting aneurysm development are correlated with larger number of smaller angles located on larger arcs.
MeSH term(s)	Humans ; Intracranial Aneurysm ; Hydrodynamics ; Models, Cardiovascular ; Hemodynamics ; Arteries ; Stress, Mechanical ; Computer Simulation
Language	English
Publishing date	2023-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.07.152
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Article ; Online: Increased tortuosity of ACA might be associated with increased risk of ACoA aneurysm development and less aneurysm dome size: a computer-aided analysis.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Gackowska, Małgorzata / Gąsowski, Jerzy

European radiology

2019 Volume 29, Issue 11, Page(s) 6309–6318

Abstract: Objectives: We decided to perform computer-aided analysis of the anterior cerebral artery (ACA) to check for a potential correlation with anterior communicating artery (ACoA) aneurysm presence and growth.: Methods: We retrospectively analyzed the ACA ...

Abstract	Objectives: We decided to perform computer-aided analysis of the anterior cerebral artery (ACA) to check for a potential correlation with anterior communicating artery (ACoA) aneurysm presence and growth. Methods: We retrospectively analyzed the ACA anatomy of 121 patients with ACoA aneurysms along with 121 age, risk factors, and vessel side-matched control patients without an ACoA aneurysm. We obtained their medical history and digital subtraction angiography (DSA) data from their medical records. For each patient's DSA, we extracted curve representing the course of their ACA and calculated its relative length (RL), sum of angle metrics (SOAM), triangular index (TI), product of angle distance (PAD), and inflection count metrics (ICM). Results: Patients with ACoA aneurysm had significantly higher RL (0.64 ± 0.23 vs. 0.56 ± 0.22; p < 0.01), SOAM (0.27 ± 0.19 vs. 0.18 ± 0.15; p < 0.01), PAD (0.12 ± 0.13 vs. 0.09 ± 0.11; p = 0.02), and TI (0.57 ± 0.14 vs. 0.44 ± 0.15; p < 0.01). In multivariate logistic regression analysis, after adjustment for possible confounders, SOAM (OR, 1.34; 95% CI, 1.12-1.63; p < 0.01) and TI (OR, 1.84; 95% CI, 1.47-2.35; p < 0.01) remained independently associated with higher risk of ACoA aneurysm. Additionally, we found significant negative correlations between TI and aneurysm dome size (R = - 0.194; p = 0.047). Conclusions: Increased tortuosity of ACA might increase the risk of ACoA aneurysm development and decrease the risk of aneurysm growth. Key points: • Anterior cerebral artery's sum of angle metrics is associated with hypertension as well as with history of ischemic stroke and myocardial infarction. • Increased tortuosity of anterior cerebral artery might be associated with anterior communicating artery aneurysm development. • Tortuosity of anterior cerebral artery is negatively correlated with anterior communicating artery aneurysm dome size.
MeSH term(s)	Adult ; Aged ; Algorithms ; Angiography, Digital Subtraction/methods ; Anterior Cerebral Artery/anatomy & histology ; Anterior Cerebral Artery/diagnostic imaging ; Case-Control Studies ; Cerebral Angiography/methods ; Female ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/pathology ; Logistic Models ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2019-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-019-06146-3
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Article: Tortuosity of the Internal Carotid Artery and Its Clinical Significance in the Development of Aneurysms.

Kliś, Kornelia M / Krzyżewski, Roger M / Kwinta, Borys M / Stachura, Krzysztof / Gąsowski, Jerzy

Journal of clinical medicine

2019 Volume 8, Issue 2

Abstract: Tortuosity of blood vessels is a common angiographic finding that may indicate systemic disease and can be correlated with vascular pathologies. In this work, we determined whether patients with and without internal carotid artery (ICA) aneurysm ... ...

Abstract	Tortuosity of blood vessels is a common angiographic finding that may indicate systemic disease and can be correlated with vascular pathologies. In this work, we determined whether patients with and without internal carotid artery (ICA) aneurysm presented with differences in its tortuosity descriptors. We retrospectively analysed data of 298 patients hospitalized between January 2014 and June 2018. For each patient's imaging data, we extracted a curve representing the ICA course and measured its Relative Length (RL), Sum of Angle Metrics (SOAM), Product of Angle Distance (PAD), Triangular Index (TI), and Inflection Count Metrics (ICM). We found that patients with an ICA aneurysm had significantly lower RL (0.46 ± 0.19 vs. 0.51 ± 0.17;
Language	English
Publishing date	2019-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm8020237
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Article ; Online: High Leukocyte Count and Risk of Poor Outcome After Subarachnoid Hemorrhage: A Meta-Analysis.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Stachura, Krzysztof / Guzik, Tomasz J / Gąsowski, Jerzy

World neurosurgery

2019 Volume 135, Page(s) e541–e547

Abstract: Background: Subarachnoid hemorrhage is (SAH) is a devastating neurologic emergency often associated with systemic inflammatory response. Many reports have demonstrated an association between elevated inflammatory markers and poor outcome. We performed ... ...

Abstract	Background: Subarachnoid hemorrhage is (SAH) is a devastating neurologic emergency often associated with systemic inflammatory response. Many reports have demonstrated an association between elevated inflammatory markers and poor outcome. We performed an observational study and a meta-analysis of the impact of high leukocyte count on outcome after SAH. Methods: We initially retrospectively analyzed 147 patients with SAH through assessment of medical records database. Poor outcome was defined as modified Rankin Scale score >3. Then, we performed a systematic literature search of PubMed, EMBASE, and the Cochrane Library. Prospective and retrospective studies were included if they assessed impact of leukocytosis on outcome after aneurysmal SAH in adults. We used a random-effect model and quality-effect model, based on the study quality assessment tool, an adapted version of inventory to assess quality of intervention studies. Results: Within our initial observational study, a total of 63 (42.86%) patients had poor treatment outcome. Those patients significantly more often had elevated white blood cell count upon admission (60.32 vs. 40.48%; P = 0.02). A literature search identified 10,119 articles, of which 13 were included into the meta-analysis. Pooled impact of high leukocyte count on outcome was odds ratio 1.42 (95% confidence interval 1.24-1.63) for random-effect model and OR 1.86 (95% confidence interval 1.46-2.36) for the quality-effect model. However, the studies were heterogenous (I = 54%). Conclusions: Elevated white blood cells is a marker of poor outcome after SAH. Despite the fact that it is unlikely to be causative, it may be treated as a useful risk predictor.
MeSH term(s)	Female ; Humans ; Leukocyte Count/statistics & numerical data ; Leukocytosis/mortality ; Male ; Middle Aged ; Observational Studies as Topic ; Prognosis ; Prospective Studies ; Retrospective Studies ; Subarachnoid Hemorrhage/mortality
Language	English
Publishing date	2019-12-19
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2019.12.056
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Article ; Online: Increased tortuosity of basilar artery might be associated with higher risk of aneurysm development.

Kliś, Kornelia M / Krzyżewski, Roger M / Kwinta, Borys M / Łasocha, Bartłomiej / Brzegowy, Paweł / Stachura, Krzysztof / Popiela, Tadeusz J / Borek, Radosław / Gąsowski, Jerzy

European radiology

2020 Volume 30, Issue 10, Page(s) 5625–5632

Abstract: Objectives: We analysed tortuosity of basilar artery (BA) to determine its relationship with the presence of aneurysm.: Methods: We retrospectively analysed 71 patients with BA aneurysms along with 71 age- and risk factors-matched control patients ... ...

Abstract	Objectives: We analysed tortuosity of basilar artery (BA) to determine its relationship with the presence of aneurysm. Methods: We retrospectively analysed 71 patients with BA aneurysms along with 71 age- and risk factors-matched control patients without BA aneurysm. From patients' medical records, we obtained their history including previous and current diseases and medications. For each patient, we calculated relative length (RL), sum of angle metrics (SOAM), triangular index (TI), product of angle distance (PAD) and inflexion count metrics (ICM). We used t-test and Mann-Whitney U test for continuous variables and χ Results: We found significant positive correlation between age and SOAM (R = 0.195, p = 0.02) and PAD (R = 0.199, p = 0.018). Our study also showed that patients with BA aneurysm had significantly higher SOAM (0.21 ± 0.16 vs. 0.11 ± 0.08; p < 0.01), PAD (0.30 ± 0.19 vs. 0.18 ± 0.11; p < 0.01), TI (0.23 ± 0.23 vs. 0.10 ± 0.16; p < 0.01) and ICM (0.20 ± 0.16 vs. 0.15 ± 0.11; p = 0.045). In multivariate logistic regression analysis, after adjustment for all possible confounders, SOAM (OR = 1.086; 95% CI 1.046-1.136; p < 0.01) and TI (OR = 1.004; 95%C: 1.002-1.006; p < 0.01) remained independently associated with higher risk of BA aneurysm. Conclusions: Increased tortuosity of BA is associated with higher risk of its aneurysm development. Key points: • Basilar artery sum of angle metrics and product of angle distance are correlated with age. • Basilar artery tortuosity is independently associated with higher risk of its aneurysm development. • Basilar artery tortuosity is positively correlated with its diameter and bifurcation angle.
MeSH term(s)	Adult ; Aged ; Basilar Artery/anatomy & histology ; Basilar Artery/physiopathology ; Cerebral Angiography ; Female ; Hospitalization ; Humans ; Intracranial Aneurysm/etiology ; Intracranial Aneurysm/physiopathology ; Male ; Middle Aged ; Regression Analysis ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-05-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-020-06917-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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