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  1. Article ; Online: Eosinophil granulocytes in chronic inflammatory respiratory diseases and CRSwNP: Function, immunological basis, and clinical significance.

    Klimek, Felix / Bergmann, Christoph / Hagemann, Jan / Cuevas, Mandy / Becker, Sven / Pfaar, Oliver / Casper, Ingrid / Klimek, Ludger

    Allergologie select

    2024  Volume 8, Page(s) 40–50

    Abstract: Introduction: Eosinophils play an important regulatory and immunomodulatory role in airway mucosa and have antiparasitic and antiviral properties as well as pro-inflammatory effects that may also cause persistence of inflammation with tissue remodeling. ...

    Abstract Introduction: Eosinophils play an important regulatory and immunomodulatory role in airway mucosa and have antiparasitic and antiviral properties as well as pro-inflammatory effects that may also cause persistence of inflammation with tissue remodeling. The number of eosinophils and the detection of specific mediators in biological samples from, e.g., blood, nasal secretions, and bronchial fluid can serve as biomarkers that reflect the underlying pathophysiology of certain diseases, predict treatment success, and detect therapy effects.
    Materials and methods: A literature search was conducted to determine the immunologic basis, mode of action, clinical significance, and available evidence for therapeutic approaches using eosinophil-targeted monoclonal antibodies by searching Medline, Pubmed, and the national and international trial database (ClinicalTrials.gov) and guideline registries as well as the Cochrane Library. Human studies published on the topic in the period up to and including 10/2023 were considered.
    Results: Based on the international literature and previous experience, the results are summarized, and recommendations are given.
    Conclusion: The important role of eosinophils in immunological processes in the airway mucosa is comprehensively analyzed and can serve as a basis for current and future treatment approaches.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02469E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: EGPA: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) as a special presentation of chronic rhinosinusitis with nasal polyps (CRSwNP).

    Hagemann, Jan / Laudien, Martin / Becker, Sven / Cuevas, Mandy / Klimek, Felix / Kianfar, Roya / Casper, Ingrid / Klimek, Ludger

    Allergologie select

    2024  Volume 8, Page(s) 18–25

    Abstract: Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) was formerly known as Churg-Strauss syndrome. The condition is characterized by disseminated necrotizing vasculitis with extravascular granulomas associated with hypereosinophilia. The ... ...

    Abstract Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) was formerly known as Churg-Strauss syndrome. The condition is characterized by disseminated necrotizing vasculitis with extravascular granulomas associated with hypereosinophilia. The vasculitides affect small vessels and are associated with antineutrophil cytoplasmic antibodies (ANCAs) detectable in the blood. Distinguishing between type 2-mediated chronic airway inflammation such as chronic rhinosinusitis with nasal polyps (CRSwNP) without vasculitis can be clinically challenging and should be considered.
    Materials and methods: Immunological background, diagnosis, and therapy of EGPA were identified through literature searches in Medline, PubMed, as well as national and international studies (ClinicalTrials.gov) and the Cochrane Library. Human studies published up to and including 10/2023 on the topic were considered.
    Results: In cases of deteriorating general health with previously known eosinophilic inflammation of the upper and lower airways, EGPA and its interdisciplinary investigation should be considered. Various types of eosinophilic inflammation and syndromes must be considered differentially.
    Conclusion: Characterization of mucosal airway inflammation through biomarker determination is meaningful and occasionally makes the difference for targeted therapy.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02475E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [No title information]

    Klimek, Ludger / Hagemann, Jan / Döge, Julia / Koll, Laura / Cuevas, Mandy / Klimek, Felix / Hummel, Thomas

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2022  Volume 31, Issue 7, Page(s) 35–43

    Title translation Störungen des Riech- und Schmeckvermögens bei COVID-19.
    Language German
    Publishing date 2022-10-31
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-022-5602-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Olfactory and gustatory disorders in COVID-19.

    Klimek, Ludger / Hagemann, Jan / Döge, Julia / Freudelsperger, Laura / Cuevas, Mandy / Klimek, Felix / Hummel, Thomas

    Allergo journal international

    2022  Volume 31, Issue 7, Page(s) 243–250

    Abstract: Loss of olfaction is one of the symptoms most commonly reported by patients with coronavirus disease 2019 (COVID-19). Although the spontaneous recovery rate is high, recent studies have shown that up to 7% of patients remain anosmic for more than 12 ... ...

    Abstract Loss of olfaction is one of the symptoms most commonly reported by patients with coronavirus disease 2019 (COVID-19). Although the spontaneous recovery rate is high, recent studies have shown that up to 7% of patients remain anosmic for more than 12 months after the onset of infection, leaving millions of people worldwide suffering from severe olfactory impairment. Olfactory training remains the first recommended treatment. With the continued lack of approved drug treatments, new therapeutic options are being explored. This article reviews the current state of science on COVID-19-related olfactory disorders, focusing on epidemiology, pathophysiology, cure rates, currently available treatment options, and research on new treatments.
    Language English
    Publishing date 2022-06-20
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2197-0378
    ISSN 2197-0378
    DOI 10.1007/s40629-022-00216-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Allergen immunotherapy in house dust mite-associated allergic rhinitis

    Klimek, Ludger / Brehler, Randolf B.S. / Casper, Ingrid / Klimek, Felix / Hagemann, Jan Hendrik / Cuevas, Mandy / Bergmann, Karl-Christian

    efficacy of the 300 IR mite tablet

    2023  

    Abstract: 10 ... 17 ... Background: A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life of patients and is associated with a high socioeconomic burden. The most common symptoms of allergic rhinitis include a runny nose ... ...

    Abstract 10

    17

    Background: A perennial house dust mite-associated allergic rhinitis has a major impact on the quality of life of patients and is associated with a high socioeconomic burden. The most common symptoms of allergic rhinitis include a runny nose and nasal congestion, sneezing, itching of nose, mouth and/or throat, and/or ocular symptoms. Affected patients often develop allergic bronchial asthma. Therapy options for allergic rhinitis include allergen avoidance, symptomatic treatment, and allergen immunotherapy. Allergen immunotherapy is the only disease-modifying treatment that can permanently alleviate the symptoms of allergic rhinitis. In July 2021, a new sublingual mite tablet was approved in Germany. Methods: This review summarizes clinical studies on the 300 IR (index of reactivity) mite tablet in adolescents and adults with house dust mite-associated allergic rhinitis and presents the results. Results: In the phase II and phase III studies considered here, different dosages of the mite tablet were investigated. The 300 IR mite tablet showed the best benefit–risk profile and has been approved in Europe, Japan, South Korea, Australia, and New Zealand for the treatment of house dust mite-associated allergic rhinitis. Conclusion: Allergen immunotherapy with the 300 IR mite tablet is an effective treatment that relieves allergic symptoms, reduces the need for symptomatic medication, and improves the quality of life in both adults and adolescents with house dust mite-associated allergic rhinitis. At the same time, treatment with the 300 IR mite tablet is well tolerated. Mild to moderate reactions at the application site subside after a few days.

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    Keywords Allergen immunotherapy ; Allergic asthma ; Allergic rhinitis ; House mites ; Mite tablet
    Subject code 610
    Language English
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Über die allergene Aktivität von Hausstaubmilben-Allergenen

    Klimek, Ludger / Klimek, Felix / Brehler, Randolf

    Haut

    2023  Volume 34, Issue 2, Page(s) 64

    Language German
    Document type Article
    ZDB-ID 1129257-X
    ISSN 0938-2216
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3498: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: CME-Fortbildung. Molekulare Diagnostik bei Hausstaubmilbenallergie

    Klimek, Ludger / Klimek, Felix / Brehler, Randolf

    Haut

    2023  Volume 34, Issue 1, Page(s) 22

    Language German
    Document type Article
    ZDB-ID 1129257-X
    ISSN 0938-2216
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3498: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Epithelial immune regulation of inflammatory airway diseases: Chronic rhinosinusitis with nasal polyps (CRSwNP).

    Klimek, Ludger / Hagemann, Jan / Welkoborsky, Hans-Jürgen / Cuevas, Mandy / Casper, Ingrid / Förster-Ruhrmann, Ulrike / Klimek, Felix / Hintschich, Constantin A / Huppertz, Tilman / Bergmann, Christoph / Tomazic, Peter-Valentin / Becker, Sven

    Allergologie select

    2022  Volume 6, Page(s) 148–166

    Abstract: Background: The epithelial immune regulation is an essential and protective feature of the barrier function of the mucous membranes of the airways. Damage to the epithelial barrier can result in chronic inflammatory diseases, such as chronic ... ...

    Abstract Background: The epithelial immune regulation is an essential and protective feature of the barrier function of the mucous membranes of the airways. Damage to the epithelial barrier can result in chronic inflammatory diseases, such as chronic rhinosinusitis (CRS) or bronchial asthma. Thymic stromal lymphopoietin (TSLP) is a central regulator in the epithelial barrier function and is associated with type 2 (T2) and non-T2 inflammation.
    Materials and methods: The immunology of chronic rhinosinusitis with polyposis nasi (CRSwNP) was analyzed in a literature search, and the existing evidence was determined through searches in Medline, Pubmed as well as the national and international study and guideline registers and the Cochrane Library. Human studies or studies on human cells that were published between 2010 and 2020 and in which the immune mechanisms of TSLP in T2 and non-T2 inflammation were examined were considered.
    Results: TSLP is an epithelial cytokine (alarmin) and a central regulator of the immune reaction, especially in the case of chronic airway inflammation. Induction of TSLP is implicated in the pathogenesis of many diseases like CRS and triggers a cascade of subsequent inflammatory reactions.
    Conclusion: Treatment with TSLP-blocking monoclonal antibodies could therefore open up interesting therapeutic options. The long-term safety and effectiveness of TSLP blockade has yet to be investigated.
    Language English
    Publishing date 2022-04-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02296E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Monitoring mepolizumab treatment in chronic rhinosinusitis with nasal polyps (CRSwNP): Discontinue, change, continue therapy?

    Klimek, Ludger / Förster-Ruhrmann, Ulrike / Olze, Heidi / Beule, Achim G / Chaker, Adam M / Hagemann, Jan / Huppertz, Tilman / Hoffmann, Thomas K / Dazert, Stefan / Deitmer, Thomas / Strieth, Sebastian / Wrede, Holger / Schlenter, Wolfgang W / Welkoborsky, Hans-Jürgen / Wollenberg, Barbara / Becker, Sven / Bärhold, Fredericke / Klimek, Felix / Casper, Ingrid /
    Zuberbier, Jaron / Rudack, Claudia / Cuevas, Mandy / Hintschich, Constantin A / Guntinas-Lichius, Orlando / Stöver, Timo / Bergmann, Christoph / Werminghaus, Pascal / Pfaar, Oliver / Gosepath, Jan / Gröger, Moritz / Beutner, Caroline / Laudien, Martin / Weber, Rainer K / Hildebrand, Tanja / Hoffmann, Anna S / Bachert, Claus

    Allergologie select

    2024  Volume 8, Page(s) 26–39

    Abstract: Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and sinuses. Eosinophilic inflammation is described as a common endotype. The anti-IL-5 antibody mepolizumab was ... ...

    Abstract Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial inflammatory disease of the mucous membranes of the nose and sinuses. Eosinophilic inflammation is described as a common endotype. The anti-IL-5 antibody mepolizumab was approved in November 2021 as an add-on therapy to intranasal glucocorticosteroids for the treatment of adults with severe chronic rhinosinusitis with nasal polyps when systemic glucocorticosteroids or surgery do not provide adequate disease control. While national and international recommendations exist for the use of mepolizumab in CRSwNP, it has not yet been adequately specified how this therapy should be monitored, what follow-up documentation is necessary, and when it should be discontinued if necessary.
    Materials and methods: A literature search was performed to analyze previous data on the treatment of CRSwNP with mepolizumab and to determine the available evidence by searching Medline, Pubmed, the national and international trial and guideline registries, and the Cochrane Library. Human studies published in the period up to and including 10/2022 were considered.
    Results: Based on the international literature and previous experience by an expert panel, recommendations for follow-up, adherence to therapy intervals, and possible therapy breaks as well as discontinuation of therapy when using mepolizumab for the indication CRSwNP in the German healthcare system are given on the basis of a documentation sheet.
    Conclusion: Understanding the immunological basis of CRSwNP opens up new non-surgical therapeutic approaches with biologics for patients with severe, uncontrolled courses. Here, we provide recommendations for follow-up, adherence to therapy intervals, possible therapy pauses, or discontinuation of therapy when mepolizumab is used as add-on therapy with intranasal glucocorticosteroids to treat adult patients with severe CRSwNP that cannot be adequately controlled with systemic glucocorticosteroids and/or surgical intervention.
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02460E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [No title information]

    Klimek, Ludger / Förster-Ruhrmann, Ulrike / Beule, Achim G / Chaker, Adam M / Hagemann, Jan / Klimek, Felix / Casper, Ingrid / Huppertz, Tilman / Hoffmann, Thomas K / Dazert, Stefan / Deitmer, Thomas / Olze, Heidi / Strieth, Sebastian / Wrede, Holger / W Schlenter, Wolfgang / Welkoborsky, Hans-Jürgen / Wollenberg, Barbara / Bergmann, Christoph / Cuevas, Mandy /
    Beutner, Caroline / Gröger, Moritz / Becker, Sven

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2022  Volume 31, Issue 6, Page(s) 24–39

    Title translation Dokumentation von Biologika-Therapien bei chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP): Dupilumab, Omalizumab und Mepolizumab: Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC).
    Language German
    Publishing date 2022-09-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-022-5080-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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