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Article ; Online: Complex home assessment of long-term non-invasive ventilation efficacy using transcutaneous monitoring of PCO

Mycroft, Katarzyna / Nasiłowski, Jacek / Klimiuk, Joanna / Przybyłowski, Tadeusz

2021 Volume 66, Issue 1, Page(s) 105–112

Abstract: Purpose: Home non-invasive ventilation (HNIV) during sleep is a standard treatment for chronic hypercapnic respiratory failure (CHRF). The aim of this study was to evaluate the feasibility of the complex overnight assessment of HNIV in adults performed ... ...

Abstract	Purpose: Home non-invasive ventilation (HNIV) during sleep is a standard treatment for chronic hypercapnic respiratory failure (CHRF). The aim of this study was to evaluate the feasibility of the complex overnight assessment of HNIV in adults performed at home and the efficacy of HNIV after one year of treatment. Methods: Stable patients with CHRF on HNIV for more than 12 months had unattended polygraphy (PG) with transcutaneous monitoring of PCO Results: Eighteen patients with CHRF (median age 66 [60-74] years, 10 female) were included. The quality of the PG tracings was good to excellent in 16 (89%) patients and the quality of the tcPCO Conclusions: Home-based monitoring using PG and tcPCO
MeSH term(s)	Adult ; Aged ; Blood Gas Monitoring, Transcutaneous/methods ; Carbon Dioxide/analysis ; Chronic Disease ; Cross-Sectional Studies ; Feasibility Studies ; Female ; Follow-Up Studies ; Home Care Services/statistics & numerical data ; Humans ; Male ; Middle Aged ; Noninvasive Ventilation/methods ; Polysomnography/methods ; Prognosis ; Prospective Studies ; Respiratory Insufficiency/metabolism ; Respiratory Insufficiency/therapy
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2021-01-15
Publishing country	Netherlands
Document type	Clinical Trial ; Journal Article
ZDB-ID	2273668-2
ISSN	1898-4002 ; 1896-1126
ISSN (online)	1898-4002
ISSN	1896-1126
DOI	10.1016/j.advms.2021.01.001
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Article ; Online: Impact of age on the diagnostic yield of four different biomarkers of tuberculous pleural effusion.

Korczynski, Piotr / Klimiuk, Joanna / Safianowska, Aleksandra / Krenke, Rafal

Tuberculosis (Edinburgh, Scotland)

2018 Volume 114, Page(s) 24–29

Abstract: The diagnostic value of pleural fluid biomarkers in tuberculous pleurisy (TP) is firmly established. However, it is less clear whether patients' age affects the diagnostic accuracy of TP biomarkers. The aim of the study was to assess the impact of age, ... ...

Abstract	The diagnostic value of pleural fluid biomarkers in tuberculous pleurisy (TP) is firmly established. However, it is less clear whether patients' age affects the diagnostic accuracy of TP biomarkers. The aim of the study was to assess the impact of age, on the predictive value of ADA, IFN-γ, IP-10 and Fas ligand in patients with pleural effusion. The study included 222 patients, median age 64.5 (54-77) years, 58.6% men, with pleural effusion: TPE (60 patients; 27.0%), malignant PE (90 patients; 40.5%), parapneumonic effusion/pleural empyema (35 patients; 15.8%), pleural transudate (30 patients, 13.5%) and other causes of PE (7 patients; 3.2%). The odds ratio for the diagnosis of TPE significantly decreased with increasing age (OR = 0.62/10 years) and significantly increased with increasing level of all evaluated pleural fluid biomarkers. Age affected the diagnostic accuracy of ADA with a trend towards reduction in OR for TPE in older patients (P = 0.077, 95% CI 0.59-1.03). Younger age and high pleural fluid ADA level are associated with very high probability of TP. This probability significantly decreases not only with decreasing pleural fluid ADA, but also with increasing age. Patient's age does not affect the diagnostic yield of pleural fluid IFN-γ, IP-10 and sFas.
MeSH term(s)	Adenosine Deaminase/analysis ; Age Factors ; Aged ; Biomarkers/analysis ; Chemokine CXCL10/analysis ; Fas Ligand Protein/analysis ; Female ; Humans ; Interferon-gamma/analysis ; Male ; Middle Aged ; Pleural Effusion/metabolism ; Pleural Effusion/microbiology ; Predictive Value of Tests ; Tuberculosis, Pleural/complications ; Tuberculosis, Pleural/diagnosis
Chemical Substances	Biomarkers ; CXCL10 protein, human ; Chemokine CXCL10 ; Fas Ligand Protein ; Interferon-gamma (82115-62-6) ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2018-11-15
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2046804-0
ISSN	1873-281X ; 1472-9792
ISSN (online)	1873-281X
ISSN	1472-9792
DOI	10.1016/j.tube.2018.11.004
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Article ; Online: Predictors of depressive symptoms among hospitalized COVID-19 patients with respiratory problems.

Zajenkowska, Anna / Wiśniewska, Dominika / Leniarska, Maria / Jasielska, Dorota / Bodecka, Marta / Zajenkowski, Marcin / Kaźmierczak, Izabela / Klimiuk, Joanna / Niemczyk, Longin / Niemczyk, Kazimierz / Pinkham, Amy E

Psychology, health & medicine

2022 Volume 28, Issue 5, Page(s) 1288–1297

Abstract: COVID-19 patients and survivors quite often experience depressive symptoms, which can increase risk for lower immune system response and poorer recovery. Vulnerability to depressive symptoms may be elevated in those patients who have the most severe ... ...

Abstract	COVID-19 patients and survivors quite often experience depressive symptoms, which can increase risk for lower immune system response and poorer recovery. Vulnerability to depressive symptoms may be elevated in those patients who have the most severe COVID-19 course of illness, that is, patients who require supplementary oxygen therapy or even intubation. The current study involved a unique sample of patients who were hospitalized due to COVID-19 and who required respiratory support (N = 34, 10 women) in which we investigated depressive symptoms as well as psychopathological personality traits (PID5) as predictors. The majority of patients (76.5%) presented some degree of depressive symptoms. Although we expected severe levels of depressive symptoms to be most prevalent, more patients showed rather moderate levels. At the same time, Negative Affectivity was most predictive of depressive symptoms. We suggest that medical care for patients with greater emotional sensitivity and vulnerability to stress be supplemented with psychological support in order to address depressive symptoms and foster recovery.
MeSH term(s)	Humans ; Female ; COVID-19 ; Depression/psychology
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1477841-5
ISSN	1465-3966 ; 1354-8506
ISSN (online)	1465-3966
ISSN	1354-8506
DOI	10.1080/13548506.2022.2121970
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Article: Rola biomarkerów w diagnostyce gruźliczego wysiękowegozapalenia opłucnej.

Klimiuk, Joanna / Krenke, Rafał

Pneumonologia i alergologia polska

2011 Volume 79, Issue 4, Page(s) 288–297

Abstract: Although tuberculosis is one of the most common causes of pleural effusion, diagnosis of tuberculous pleuritis still remains a challenge. This is due to paucity of M. tuberculosis organisms in pleural effusion which results in a relatively low ... ...

Title translation	Role of biomarkers in making the diagnosis of tuberculous pleurisy.
Abstract	Although tuberculosis is one of the most common causes of pleural effusion, diagnosis of tuberculous pleuritis still remains a challenge. This is due to paucity of M. tuberculosis organisms in pleural effusion which results in a relatively low sensitivity of the routinely used diagnostic methods. Thus, different biomarkers in pleural effusion have been extensively studied in order to improve the diagnostic accuracy. Pleural fluid deaminase adenosine activity (ADA) and interferon gamma (IFN-γ) concentration have been shown to be the most reliable and cost-effective markers of tuberculous pleurisy. Hence, these markers have been included in different diagnostic algorithms for patients suspected of tuberculous pleurisy. A high variability of the diagnostic performance and/or more advanced technical demands significantly limit the use of other relatively new diagnostic methods, such as nucleic acid amplification tests (NAATs) and IFN-γ releasing assays (IGRAs). The article presents a current data on the potential use of different biomarkers in the diagnosis of tuberculous pleurisy.
MeSH term(s)	Adenosine Deaminase/analysis ; Biomarkers/analysis ; Exudates and Transudates/chemistry ; Humans ; Interferon-gamma/analysis ; Pleural Effusion/etiology ; Pleural Effusion/metabolism ; Tuberculosis, Pleural/diagnosis
Chemical Substances	Biomarkers ; Interferon-gamma (82115-62-6) ; Adenosine Deaminase (EC 3.5.4.4)
Language	Polish
Publishing date	2011
Publishing country	Poland
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1173936-8
ISSN	2299-8292 ; 0867-7077
ISSN (online)	2299-8292
ISSN	0867-7077
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Article ; Online: Pleural Effusion in Meigs' Syndrome-Transudate or Exudate?: Systematic Review of the Literature.

Krenke, Rafal / Maskey-Warzechowska, Marta / Korczynski, Piotr / Zielinska-Krawczyk, Monika / Klimiuk, Joanna / Chazan, Ryszarda / Light, Richard W

Medicine

2015 Volume 94, Issue 49, Page(s) e2114

Abstract: Although Meigs' syndrome is regarded as a well-defined entity, contradictory data on pleural fluid characteristics have been presented, with some papers classifying it as a transudate, whereas others stating that it is an exudate.The aims of the study ... ...

Abstract	Although Meigs' syndrome is regarded as a well-defined entity, contradictory data on pleural fluid characteristics have been presented, with some papers classifying it as a transudate, whereas others stating that it is an exudate.The aims of the study were: (1) to evaluate pleural fluid characteristics in patients with Meigs' syndrome and (2) to analyze the prevalence of transudative and exudative pleural effusion in relation to the applied definition of the syndrome.We performed a search through medical databases (MEDLINE, EMBASE, SCOPUS, and GOOGLE SCHOLAR) to identify papers on Meigs' syndrome published between 1940 and 2013. Two authors independently reviewed each paper searching for prespecified data: (1) signs and symptoms, (2) tumor characteristics, (3) clinical and laboratory data on ascites, (4) clinical, radiological, and laboratory data on pleural fluid, (5) clinical course after tumor removal. All case reports were reclassified according to a new unequivocal classification of Meigs' syndrome-related entities.A total of 653 papers were initially identified, and 454 articles reporting 541 patients were included in the final analysis. After reclassification according to our case definitions, there were 196, 113, and 108 patients defined as classic Meigs' syndrome, nonclassic Meigs' syndrome, and pseudo-Meigs' syndrome, respectively. Significantly more patients presented with right-sided than left-sided and bilateral pleural effusions (P < 0.001). Median volume of withdrawn pleural fluid was 2950 (1500-6000) mL. The classification of pleural effusion with the use of Light's criteria was possible in only 7 patients. In 6 of these patients pleural effusion met the criteria for an exudate. When the protein concentration > 3.0 g/dL was applied as a criterion of pleural exudate, 88.8% (80/90) of effusions were classified as exudates. Increasing the cut-off level to 3.5 g/dL resulted in only a modest decrease in the percentage of exudative effusions (81%, 73/90).Surprisingly few reports on Meigs' syndrome present data reliably defining the character of pleural effusion. The available data indicate, however, that the majority of pleural effusions in patients with this entity are exudates. This finding may be a prerequisite for the verification of some earlier presented concepts.
MeSH term(s)	Female ; Humans ; Meigs Syndrome/complications ; Pleural Effusion/epidemiology ; Pleural Effusion/etiology ; Prevalence
Language	English
Publishing date	2015-11-02
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000002114
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Article ; Online: Hemoptysis and spontaneous hemothorax in a patient with multifocal nodular lung lesions.

Krenke, Rafal / Klimiuk, Joanna / Korczynski, Piotr / Kupis, Wlodzimierz / Szolkowska, Malgorzata / Chazan, Ryszarda

Chest

2011 Volume 140, Issue 1, Page(s) 245–251

MeSH term(s)	Aged ; Bronchoalveolar Lavage ; Bronchoscopy ; Diagnosis, Differential ; Female ; Hemangiosarcoma/complications ; Hemangiosarcoma/diagnosis ; Hemoptysis/diagnosis ; Hemoptysis/etiology ; Hemothorax/diagnosis ; Hemothorax/etiology ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Multiple Pulmonary Nodules/diagnosis ; Radiography, Thoracic ; Tomography, X-Ray Computed
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.10-1865
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Article: Wpływ czestych wizyt pielegniarskich na przestrzeganie przez pacjentów zaleceń domowego leczenia tlenem. Obserwacja 14-miesieczna.

Nasiłowski, Jacek / Przybyłowski, Tadeusz / Klimiuk, Joanna / Leśkow, Artur / Orska, Katarzyna / Chazan, Ryszarda

Pneumonologia i alergologia polska

2009 Volume 77, Issue 4, Page(s) 363–370

Abstract: Introduction: Long-term oxygen therapy (LTOT) is the only treatment improving survival of patients with respiratory failure due to chronic obstructive pulmonary disease (COPD). Benefits of treatment depend mainly on daily duration of oxygen use. The aim ...

Title translation	Effects of nurse home visits on compliance to long-term oxygen therapy. 14 months follow-up.
Abstract	Introduction: Long-term oxygen therapy (LTOT) is the only treatment improving survival of patients with respiratory failure due to chronic obstructive pulmonary disease (COPD). Benefits of treatment depend mainly on daily duration of oxygen use. The aim of the study was to assess daily use of oxygen and to evaluate influencing factors. Material and methods: Consecutive patients qualified to LTOT were included. Eligibility for LTOT was based on the ATS//ERS guidelines. All patients were instructed to use oxygen from oxygen concentrator for 15 hours per day or more. Duration of oxygen therapy was verified every 4 weeks by visiting respiratory nurse using counter clock of oxygen concentrator. The nurses were also encouraging patients to breathe oxygen for at least 15 h/d. Results: Study group consisted of 30 patients (77% with COPD) aged 67+/-9 yrs, mean FEV, 46+/-18% pred., RV%TLC 64+/-16%, PaO2 50+/-6 mm Hg. Mean duration of oxygen therapy for the group was 12.5+/-4.6 h/d. Eleven (37%) subjects followed prescription during whole follow-up period (mean oxygen use 17.4+/-2.6 h/d). Mean oxygen use in the non-compliant group was 9.6+/-2.7 h/d. In COPD group compliant patients had significantly lower TLC (100+/-19% pred. v. 152+/-36% pred., p=0.001) and lower PaCO2 (38+/-6 mm Hg v. 47+/-8 mm Hg, p<0.05) when compared to the non-compliant group. During the first month of treatment 48% of patients were compliant. From the second month onward percentage of compliant patients fell to 30% and remained stable to the end of the study. Fourteen patients (47% complained of electricity consumption and 7 patients (23%) complained of the noise of working concentrator. Daily oxygen use in the latest group was significantly lower when compared to those who did not complain of the noise (9+/-3.7 h/d v. 13.5+/-4.4 h/d; p=0.02). Conclusions: The best compliance to home oxygen therapy is observed at the beginning of treatment. Frequent home nurse visits do not improve compliance. We hypothesize that the use of other oxygen sources eg. liquid oxygen, that are silent and do not increase the cost of electricity, could improve compliance.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Home Care Services/statistics & numerical data ; Humans ; Male ; Middle Aged ; Oxygen/administration & dosage ; Oxygen Inhalation Therapy/nursing ; Oxygen Inhalation Therapy/statistics & numerical data ; Patient Compliance/statistics & numerical data ; Patient Education as Topic/statistics & numerical data ; Poland/epidemiology ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/nursing ; Respiratory Function Tests ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Oxygen (S88TT14065)
Language	Polish
Publishing date	2009
Publishing country	Poland
Document type	English Abstract ; Journal Article
ZDB-ID	1173936-8
ISSN	2299-8292 ; 0867-7077
ISSN (online)	2299-8292
ISSN	0867-7077
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Article: Limfocyty i ich subpopulacje w płynie z jamy opłucnej--porównanie płynów nowotworowych i nienowotworowych.

Klimiuk, Joanna / Domagała-Kulawik, Joanna / Krenke, Rafał / Chazan, Ryszarda

Polskie Archiwum Medycyny Wewnetrznej

2004 Volume 111, Issue 3, Page(s) 291–296

Abstract: The role of lymphocytes in host defence in neoplastic disorders is known. Accumulation of lymphocytes in pleural cavity frequently occurs in different diseases. The aim of the study was to evaluate: 1) the frequency of lymphocyte predominance in ... ...

Title translation	Lymphocyte and lymphocyte subsets in pleural fluid--comparison of malignant and non-malignant disorders.
Abstract	The role of lymphocytes in host defence in neoplastic disorders is known. Accumulation of lymphocytes in pleural cavity frequently occurs in different diseases. The aim of the study was to evaluate: 1) the frequency of lymphocyte predominance in different malignant and non-malignant pleural effusions; 2) lymphocyte phenotype and the ratio between helper (CD4+) and cytotoxic/suppressor (CD8+) lymphocytes in malignant and non-malignant effusions. Patients with mesothelioma, lung cancer, lymphoma and metastatic neoplasms were analysed. Analysis was performed on fluids with or without malignant cells. Non-malignant fluids were obtained from patients with: congestive heart failure, liver cirrhosis, pneumonia and tuberculosis. Lymphocytes were the predominant cell type in neoplastic effusions. For further analysis effusions with more than 10% of lymphocytes were included: 12 malignant and 9 non-malignant. For lymphocyte subpopulations analysis, the monoclonal antibodies anti-CD4 and anti-CD8 and APAAP method was used. We observed lower percentage of CD4+ lymphocytes (47%) and higher percentage of CD8+ (39%) lymphocytes in malignant when compared to non-malignant fluids (58% vs 31% respectively). The CD4+/CD8+ ratio was significantly lower in pleural fluid in cases with neoplastic disease when compared to benign cause of pleural involvement (1.03 vs 1.85). Our observations suggest the potential role of lymphocytes, especially CD8+ cells in local response in malignancy in pleural disease.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal ; CD4-CD8 Ratio ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; Carcinoma, Small Cell/immunology ; Female ; Fluorescent Antibody Technique ; Humans ; Lung Neoplasms/immunology ; Lymphocyte Subsets ; Lymphocytes ; Male ; Middle Aged ; Pleural Effusion/immunology ; Pleural Effusion/pathology ; Pleural Effusion, Malignant/pathology ; Time Factors
Chemical Substances	Antibodies, Monoclonal
Language	Polish
Publishing date	2004-03
Publishing country	Poland
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	1897-9483 ; 0032-3772
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Article: Heterozygous α1‑antitrypsin deficiency in liver transplant candidates.

Górska, Katarzyna / Korczyński, Piotr / Struniawski, Radosław / Krenke, Rafał / Ołdakowska-Jedynak, Urszula / Grabczak, Elżbieta M / Klimiuk, Joanna / Chorostowska-Wynimko, Joanna / Chazan, Ryszarda / Zieliński, Jan / Krawczyk, Marek

Polskie Archiwum Medycyny Wewnetrznej

2012 Volume 123, Issue 1-2, Page(s) 14–20

Abstract: Introduction: It is estimated that in about 1% of all liver transplant candidates liver cirrhosis is caused by hereditary homozygous α1‑antitrypsin (AAT) deficiency.: Objectives: The aim of the study was to evaluate the role of heterozygous AAT ... ...

Abstract	Introduction: It is estimated that in about 1% of all liver transplant candidates liver cirrhosis is caused by hereditary homozygous α1‑antitrypsin (AAT) deficiency. Objectives: The aim of the study was to evaluate the role of heterozygous AAT deficiency in the development of liver cirrhosis leading to liver transplantation. Patients and methods: In the years 2009-2011, we conducted a prospective study of 304 consecutive patients (men, 57%) scheduled for orthotopic liver transplantation. AAT phenotyping and the clinical assessment of hepatic and cardiopulmonary functions were performed in all subjects. Results: The most common causes of liver cirrhosis were viral hepatitis (21%) and alcohol abuse (12%). Normal protease inhibitor (Pi) MM phenotype was observed in 284 patients. The PiMZ phenotype was detected in 11 subjects (4%), which indicates its higher prevalence in patients with liver cirrhosis compared with the general population (2%). PiMS phenotype was found in 6 patients (2%), and this value was similar to that observed in the Polish population. In 3 patients, less common phenotypes were observed: MP, IM, and MX. Conclusions: The PiMZ phenotype may be an independent risk factor for the development of liver cirrhosis along with the most common causes, namely, viral hepatitis and alcohol abuse.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alcoholism/epidemiology ; Biomarkers/blood ; Causality ; Comorbidity ; Female ; Hepatitis, Viral, Human/epidemiology ; Heterozygote ; Humans ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/therapy ; Liver Transplantation ; Male ; Middle Aged ; Poland/epidemiology ; Prevalence ; Prospective Studies ; Risk Factors ; Young Adult ; alpha 1-Antitrypsin Deficiency/blood ; alpha 1-Antitrypsin Deficiency/epidemiology ; alpha 1-Antitrypsin Deficiency/genetics
Chemical Substances	Biomarkers
Language	English
Publishing date	2012-12-11
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.1583
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