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Article: Manganese Encephalopathy Caused by Homemade Methcathinone (Ephedrone) Prevalence in Poland

Habrat, Bogusław / Silczuk, Andrzej / Klimkiewicz, Anna

Nutrients. 2021 Oct. 03, v. 13, no. 10

2021

Abstract: Manganese encephalopathy is a known disorder in occupational medicine. A serious phenomenon has been the emergence of manganese encephalopathy in intravenous users of homemade methcathinone (ephedrone). A short survey was developed for clinical ... ...

Abstract	Manganese encephalopathy is a known disorder in occupational medicine. A serious phenomenon has been the emergence of manganese encephalopathy in intravenous users of homemade methcathinone (ephedrone). A short survey was developed for clinical environments dealing with people who use psychoactive substances. The data were obtained from 72 rehabilitation therapy centers. Surveys carried out in about a third of Polish centers dealing with providing medical assistance to people addicted to substances other than alcohol and tobacco have shown that over 4% of people treated there had symptoms of manganese encephalopathy, of which more than half are people in whom the probability of a clinical diagnosis of this disorder is significant. It has been shown that knowledge of manganese encephalopathy is none or minimal in more than 70% of the surveyed institutions. An urgent need for personnel training in this field was pointed out. Attention was paid to the importance of disseminating good review articles on new and dynamically developing problem phenomena.
Keywords	alcohols ; encephalopathy ; human resources ; intravenous injection ; manganese ; occupational health and safety ; people ; probability ; surveys ; tobacco ; Poland
Language	English
Dates of publication	2021-1003
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13103496
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Manganese Encephalopathy Caused by Homemade Methcathinone (Ephedrone) Prevalence in Poland.

Habrat, Bogusław / Silczuk, Andrzej / Klimkiewicz, Anna

Nutrients

2021 Volume 13, Issue 10

Abstract	Manganese encephalopathy is a known disorder in occupational medicine. A serious phenomenon has been the emergence of manganese encephalopathy in intravenous users of homemade methcathinone (ephedrone). A short survey was developed for clinical environments dealing with people who use psychoactive substances. The data were obtained from 72 rehabilitation therapy centers. Surveys carried out in about a third of Polish centers dealing with providing medical assistance to people addicted to substances other than alcohol and tobacco have shown that over 4% of people treated there had symptoms of manganese encephalopathy, of which more than half are people in whom the probability of a clinical diagnosis of this disorder is significant. It has been shown that knowledge of manganese encephalopathy is none or minimal in more than 70% of the surveyed institutions. An urgent need for personnel training in this field was pointed out. Attention was paid to the importance of disseminating good review articles on new and dynamically developing problem phenomena.
MeSH term(s)	Brain Diseases/chemically induced ; Brain Diseases/epidemiology ; Humans ; Manganese Poisoning/epidemiology ; Manganese Poisoning/etiology ; Poland/epidemiology ; Prevalence ; Propiophenones ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology
Chemical Substances	Propiophenones ; monomethylpropion (386QA522QG)
Language	English
Publishing date	2021-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13103496
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Polish Physicians' Perspectives on Medical Cannabis Policy and Educational Needs: Results of An Online Survey.

Hordowicz, Martyna / Jarosz, Jerzy / Czaplińska, Małgorzata / Leonhard, Agnieszka / Klimkiewicz, Anna

Journal of clinical medicine

2021 Volume 10, Issue 19

Abstract: 1) Background: In November 2017, medical cannabis was legalized in Poland. Until now, there have been no studies conducted to examine the perspectives of Polish physicians about their preferences regarding medical cannabis legal status and educational ... ...

Abstract	(1) Background: In November 2017, medical cannabis was legalized in Poland. Until now, there have been no studies conducted to examine the perspectives of Polish physicians about their preferences regarding medical cannabis legal status and educational needs. (2) Methods: The survey was a self-developed online questionnaire with 57 participants. Participation was voluntary. The link was shared through a personal network of medical doctors, regional medical chambers, and with doctors attending palliative care courses organized by our research group. Results: Between June and October 2020, 173 HCPs from Poland completed the survey. More than half of the study participants never received any education on medical cannabis (60.1%); 71.1% declared their knowledge was insufficient to counsel patients about medical cannabis use. The majority claimed that they would like to be able to answer patient questions (92.4%); 93.1% declared a need to create clear guidelines for using cannabinoids in clinical practice. Furthermore, 71.7% believed that medicines containing cannabinoids and 52.0% that herbal cannabis should be reimbursed (3). Conclusion: Most medical doctors do not feel prepared for patient counseling. They could benefit from targeted educational interventions. We have also identified physicians' preferences that might inspire the stakeholders involved who are critical for shaping policies regarding cannabis-based therapeutics.
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10194545
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Is There a Connection Between Spiritual Transcendence and Quality of Life? A Cross-Sectional Survey Study in Patients Under the End-of-Life Care.

Wysocka, Maria / Wawrzyniak, Małgorzata / Jarosz, Jerzy / Hordowicz, Martyna / Klimkiewicz, Anna

Journal of palliative care

2021 Volume 38, Issue 1, Page(s) 10–16

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Cross-Sectional Studies ; Quality of Life ; Spirituality ; Terminal Care ; Surveys and Questionnaires ; Neoplasms/therapy
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	639326-3
ISSN	2369-5293 ; 0825-8597
ISSN (online)	2369-5293
ISSN	0825-8597
DOI	10.1177/08258597211034642
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Article ; Online: Knowledge, attitudes, and prescribing patterns of cannabis and cannabinoid-containing medicines among European healthcare workers: a systematic literature review.

Hordowicz, Martyna / Klimkiewicz, Anna / Jarosz, Jerzy / Wysocka, Maria / Jastrzębska, Monika

Drug and alcohol dependence

2021 Volume 221, Page(s) 108652

Abstract: Background: Since the introduction of the National Medical Cannabis Programme in The Netherlands, many other countries in Europe have made medical cannabis (MC) and cannabis-based medicines (CBMs) available. However, each of them has implemented a ... ...

Abstract	Background: Since the introduction of the National Medical Cannabis Programme in The Netherlands, many other countries in Europe have made medical cannabis (MC) and cannabis-based medicines (CBMs) available. However, each of them has implemented a unique legal framework and reimbursement strategy for these products. Therefore, it is vital to study healthcare professionals' knowledge level (HCP) and HCPs in-training regarding both medical uses and indications and understand their safety concerns and potential barriers for MC use in clinical practice. Methods: A comprehensive, systematic literature review was performed using PubMed/MEDLINE, EMBASE, and Google Scholar databases, as well as PsychINFO. Grey literature was also included. Due to the high diversity in the questionnaires used in the studies, a narrative synthesis was performed. Results: From 6995 studies retrieved, ten studies, all of them being quantitative survey-based studies, were included in the review. In most studies, the majority of participants were in favor of MC and CBMs use for medical reasons. Other common findings were: the necessity to provide additional training regarding medical applications of cannabinoids, lack of awareness about the legal status of and regulations regarding MC among both certified physicians, as well as prospective doctors and students of other medicals sciences (e.g., nursing, pharmacy). Conclusions: For most European countries, we could not identify any studies evaluating HCPs' knowledge and attitudes towards medicinal cannabis. Therefore, similar investigations are highly encouraged. Available evidence demonstrates a need to provide medical training to the HCPs in Europe regarding medical applications of cannabinoids.
MeSH term(s)	Analgesics/therapeutic use ; Cannabinoids/therapeutic use ; Cannabis ; Drug Prescriptions ; Europe/epidemiology ; Hallucinogens/therapeutic use ; Health Knowledge, Attitudes, Practice ; Health Personnel/legislation & jurisprudence ; Health Personnel/trends ; Humans ; Medical Marijuana/therapeutic use ; Narration ; Prospective Studies
Chemical Substances	Analgesics ; Cannabinoids ; Hallucinogens ; Medical Marijuana
Language	English
Publishing date	2021-02-26
Publishing country	Ireland
Document type	Journal Article ; Systematic Review
ZDB-ID	519918-9
ISSN	1879-0046 ; 0376-8716
ISSN (online)	1879-0046
ISSN	0376-8716
DOI	10.1016/j.drugalcdep.2021.108652
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: To Treat or Not to Treat? Polish Physicians' Opinions about the Clinical Aspects of Cannabinoids-An Online Survey.

Hordowicz, Martyna Joanna / Jarosz, Jerzy / Klimkiewicz, Anna / Czaplińska, Małgorzata / Leonhard, Agnieszka / Wysocka, Maria

Journal of clinical medicine

2022 Volume 11, Issue 1

Abstract: Introduction: Medical cannabis' importance in Poland increased dramatically following its legalization as the 12th country in Europe in 2017. However, no studies have been published to give insight into Polish physicians' opinions about medical cannabis. ...

Abstract	Introduction: Medical cannabis' importance in Poland increased dramatically following its legalization as the 12th country in Europe in 2017. However, no studies have been published to give insight into Polish physicians' opinions about medical cannabis. Objectives: To investigate physician's opinions about cannabinoids' utility in clinical practice, concerns regarding their safety profile, and their clinical experience with cannabinoids. Methods: The survey using a self-developed tool was conducted online; participants were physicians with or without specialist training. Participation was voluntary. Physicians were recruited through personal networks, palliative care courses, and Medical Chambers. Results: From June to October 2020, we recruited 173 physicians from 15/16 voivodeships. The largest age group (43.9%; Conclusions: Polish physicians favored the legalization of medical cannabis. However, it is of concern that a limited number have any experience with prescribing cannabis. The creation of clear guidelines to advise physicians in their routine practice and education about pain management and the risks related to the consumption of recreational cannabis for medical conditions are needed.
Language	English
Publishing date	2022-01-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11010236
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Article: Femoral and Lateral Femoral Cutaneous Nerve Block as Anesthesia for High-Risk Intertrochanteric Fracture Repair Patients.

Klimkiewicz, Jakub / Klimkiewicz, Anna / Gutowski, Mateusz / Rustecki, Bartosz / Kochanowski, Dymitr / Ryczek, Robert / Lubas, Arkadiusz

Journal of clinical medicine

2022 Volume 11, Issue 13

Abstract: Introduction. Intertrochanteric fracture (IF) is a common injury among the elderly. Due to significant comorbidities, anesthesia for IF repair may be challenging. The authors propose femoral nerve block together with a lateral femoral cutaneous nerve ... ...

Abstract	Introduction. Intertrochanteric fracture (IF) is a common injury among the elderly. Due to significant comorbidities, anesthesia for IF repair may be challenging. The authors propose femoral nerve block together with a lateral femoral cutaneous nerve block and sedation as an anesthetic technique for most severe cases of IF with contraindications to spinal anesthesia. Methods. In total, 61 patients were enrolled prospectively in a study, 19 received general anesthesia (GA group), 22 spinal anesthesia (SA group), and 20 nerve blocks with sedation (PNB group). Results. Groups were comparable in terms of age, gender, independence, and several comorbidities: diabetes, obesity, underweight, cardiovascular, and cerebrovascular incidents in the past, dementia, chronic obstructive pulmonary disease, and frailty. Heart failure (p = 0.033), hemoglobin < 10 g/dL (p = 0.001) and eGFR < 30 mL/min (p = 0.039) were more frequent in PNB group. PNB group had higher American Society of Anesthesiologists (ASA) (p < 0.001), Nottingham Hip Fracture Score (NHFS) (p < 0.001), and Charlson Comorbidity Index (CCI) (p = 0.002) scales scores, and lower probability of 10-year survival according to CCI (p = 0.012). GA group had more frequent active malignancy (p = 0.041). GA and PNB groups had a higher frequency of hemostasis disorder (p < 0.001). Surgery was completed under the scheduled anesthesia technique. Survival, frequency of cardio and cerebrovascular incidents after surgery, loss of independence, and postoperative delirium were comparable between groups, as well as the length of postoperative stay. Conclusions. Surgical repair of intertrochanteric fracture with intramedullary nailing system among elderly, frail, and sick patients can be conducted under peripheral nerve block. FNB and LFCNB in the combination is a viable option for IT fracture repair.
Language	English
Publishing date	2022-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11133708
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Article ; Online: Factors related to opioid misuse among patients undergoing elective surgery in Poland.

Klimkiewicz, Jakub / Wysocka, Maria / Hordowicz, Martyna / Jarosz, Jerzy / Gutowski, Mateusz / Paryż, Kamil / Kieszkowska-Grudny, Anna / Klimkiewicz, Anna

Journal of addictive diseases

2023 , Page(s) 1–9

Abstract: In many countries, the consumption of illicit opioids is rising, becoming a major public health issue called the "opioid crisis". Many reasons contribute to this phenomenon. One of them is opioid misuse, defined as the use of legally prescribed opioids ... ...

Abstract	In many countries, the consumption of illicit opioids is rising, becoming a major public health issue called the "opioid crisis". Many reasons contribute to this phenomenon. One of them is opioid misuse, defined as the use of legally prescribed opioids for a purpose different than pain treatment. This matter has not been well studied in Poland, where the opioid crisis has not been identified so far. This study was conducted among patients admitted for elective surgery with opioid-based postoperative pain treatment. The frequency of opioid misuse was found to be 10.8% in a sample comprising 92 patients. The group of individuals with potential opioid use disorder had a more frequent history of inadequately controlled postoperative pain compared to the group of non-misusers (
Language	English
Publishing date	2023-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1077616-3
ISSN	1545-0848 ; 1055-0887
ISSN (online)	1545-0848
ISSN	1055-0887
DOI	10.1080/10550887.2023.2252721
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 Pandemic-Related Depression and Insomnia among Psychiatric Patients and the General Population.

Klimkiewicz, Anna / Jasionowska, Joanna / Schmalenberg, Adrianna / Klimkiewicz, Jakub / Jasińska, Agata / Silczuk, Andrzej

Journal of clinical medicine

2021 Volume 10, Issue 15

Abstract: Background: The COVID-19 pandemic and limited access to healthcare professionals pose a serious risk of worsening mental conditions. This study was designed to examine the changes in symptoms of insomnia and depression during the pandemic as compared to ...

Abstract	Background: The COVID-19 pandemic and limited access to healthcare professionals pose a serious risk of worsening mental conditions. This study was designed to examine the changes in symptoms of insomnia and depression during the pandemic as compared to before the pandemic, as well as the factors correlated with abovementioned mental state deterioration. Methods: The study was conducted from 1 April to 15 May 2020, on 212 psychiatric outpatients and 207 healthy controls. Participants completed a survey focused on symptoms during and prior to COVID-19 (the Beck Depression Inventory, the Athens Insomnia Scale). The following correlations were analyzed: demographics, social support, work status, income, and possible participants' and their relatives' COVID-19 diagnoses. Results: Insomnia and depression severity intensified during the pandemic in both groups and were associated with age, gender, education, employment, and financial status. No correlations between social support nor becoming sick with COVID-19 and insomnia or depression were observed. Maintaining work and enough money for one's own needs were found to be significant protective factors of depression (OR 0.37 and 0.29, respectively). Conclusions: Exacerbation of insomnia and depression during the pandemic needs to be addressed. Economic crisis seems to influence mental state even more than COVID diagnosis among study subjects/relatives.
Language	English
Publishing date	2021-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10153425
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Article: COVID-19 Pandemic Influence on Healthcare Professionals.

Klimkiewicz, Anna / Schmalenberg, Adrianna / Klimkiewicz, Jakub / Jasińska, Agata / Jasionowska, Joanna / Machura, Weronika / Wojnar, Marcin

Journal of clinical medicine

2021 Volume 10, Issue 6

Abstract: During the pandemic, many healthcare professionals (HCPs) are overburdened by work and stress. The aim of the study was to examine alcohol intake, sleep disorders, and depressive symptoms of HCPs during the pandemic in comparison with the pre-pandemic ... ...

Abstract	During the pandemic, many healthcare professionals (HCPs) are overburdened by work and stress. The aim of the study was to examine alcohol intake, sleep disorders, and depressive symptoms of HCPs during the pandemic in comparison with the pre-pandemic period. Another goal was to indicate risk factors for mental state deterioration and an increase in alcohol use. A cross-sectional survey study was conducted from 1 April to 15 May 2020. HCPs (
Language	English
Publishing date	2021-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10061280
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