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  1. Book ; Thesis: Einfluss von Thrombozytenaggregationshemmern auf das Risiko für Blutungskomplikationen nach chirurgischer oder endovaskulärer Behandlung von rupturierten zerebralen Aneurysmen und die Beeinflussung des Outcomes

    Kling, Louisa

    2023  

    Author's details vorgelegt von Louisa Kling geb. Merkelbach
    Language German
    Size 67 Seiten, Illustrationen, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2023
    HBZ-ID HT030005456
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 D 303 order for loan Magazin

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  2. Article ; Online: Anti-HEV seroprevalence and rate of viremia in a German cohort of dogs, cats, and horses.

    Pischke, S / Knoop, E V / Mader, M / Kling, L / Wolski, A / Wagner, A / Mueller, K / Horvatits, T / Stiller, J / Wisnewski, K / Kohn, B / Schulze Zur Wiesch, J / Groschup, M H / Eiden, M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 19240

    Abstract: Hepatitis E virus (HEV) genotype 3 infections in Germany are mainly transmitted zoonotically through the consumption of swine meat. Furthermore, there is evidence that pets might come into contact with HEV, but the relevance of companion animals as ... ...

    Abstract Hepatitis E virus (HEV) genotype 3 infections in Germany are mainly transmitted zoonotically through the consumption of swine meat. Furthermore, there is evidence that pets might come into contact with HEV, but the relevance of companion animals as possible sources of HEV transmission in Germany still needs to be defined. A monitoring study was therefore carried out on dogs, cats, and horses from Germany. In total 365 serum samples from pets (124 dogs, 119 cats, and 122 horses) were tested for HEV by PCR and for anti-HEV antibodies by a commercial ELISA. The HEV seroprevalence determined by the sero-assay varied significantly between dogs (10%), cats (6%), and horses (2%). Liver injury-related enzymes, alanine transaminase (ALT), and aspartate transaminase (AST) showed no differences between HEV-positive or negative animals. None of the pet serum samples tested positive for PCR. This serological study suggests that dogs and cats are significantly exposed to HEV in Germany, while horses are of minor relevance.
    MeSH term(s) Animals ; Cats ; Dogs ; Cat Diseases ; Dog Diseases/epidemiology ; Hepatitis E/epidemiology ; Hepatitis E/veterinary ; Hepatitis E virus ; Horses ; Seroepidemiologic Studies ; Viremia
    Language English
    Publishing date 2023-11-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-46009-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Author Correction: Anti-HEV seroprevalence and rate of viremia in a German cohort of dogs, cats, and horses.

    Pischke, S / Knoop, E V / Mader, M / Kling, L / Wolski, A / Wagner, A / Mueller, K / Horvatits, T / Stiller, J / Wisnewski, K / Kohn, B / Schulze Zur Wiesch, J / Groschup, M H / Eiden, M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20651

    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-47523-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Die Induktion der mikrosomalen Monooxygenasen der Mäuseleber durch Warfarin

    Kling, Lothar

    1985  

    Size 216 S. : Ill.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Marburg, Univ., Diss., 1986
    HBZ-ID HT003207312
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    87 D 2253 order for loan Magazin

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  5. Article ; Online: Characterizing Intraindividual Podocyte Morphology In Vitro with Different Innovative Microscopic and Spectroscopic Techniques.

    Kraus, Annalena / Rose, Victoria / Krüger, René / Sarau, George / Kling, Lasse / Schiffer, Mario / Christiansen, Silke / Müller-Deile, Janina

    Cells

    2023  Volume 12, Issue 9

    Abstract: Podocytes are critical components of the glomerular filtration barrier, sitting on the outside of the glomerular basement membrane. Primary and secondary foot processes are characteristic for podocytes, but cell processes that develop in culture were not ...

    Abstract Podocytes are critical components of the glomerular filtration barrier, sitting on the outside of the glomerular basement membrane. Primary and secondary foot processes are characteristic for podocytes, but cell processes that develop in culture were not studied much in the past. Moreover, protocols for diverse visualization methods mostly can only be used for one technique, due to differences in fixation, drying and handling. However, we detected by single-cell RNA sequencing (scRNAseq) analysis that cells reveal high variability in genes involved in cell type-specific morphology, even within one cell culture dish, highlighting the need for a compatible protocol that allows measuring the same cell with different methods. Here, we developed a new serial and correlative approach by using a combination of a wide variety of microscopic and spectroscopic techniques in the same cell for a better understanding of podocyte morphology. In detail, the protocol allowed for the sequential analysis of identical cells with light microscopy (LM), Raman spectroscopy, scanning electron microscopy (SEM) and atomic force microscopy (AFM). Skipping the fixation and drying process, the protocol was also compatible with scanning ion-conductance microscopy (SICM), allowing the determination of podocyte surface topography of nanometer-range in living cells. With the help of nanoGPS Oxyo
    MeSH term(s) Podocytes ; Kidney Glomerulus ; Microscopy, Electron, Scanning ; Glomerular Filtration Barrier ; Spectrum Analysis, Raman
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12091245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hypoxia-inducible factors not only regulate but also are myeloid-cell treatment targets.

    Kling, Lovis / Schreiber, Adrian / Eckardt, Kai-Uwe / Kettritz, Ralph

    Journal of leukocyte biology

    2020  Volume 110, Issue 1, Page(s) 61–75

    Abstract: Hypoxia describes limited oxygen availability at the cellular level. Myeloid cells are exposed to hypoxia at various bodily sites and even contribute to hypoxia by consuming large amounts of oxygen during respiratory burst. Hypoxia-inducible factors ( ... ...

    Abstract Hypoxia describes limited oxygen availability at the cellular level. Myeloid cells are exposed to hypoxia at various bodily sites and even contribute to hypoxia by consuming large amounts of oxygen during respiratory burst. Hypoxia-inducible factors (HIFs) are ubiquitously expressed heterodimeric transcription factors, composed of an oxygen-dependent α and a constitutive β subunit. The stability of HIF-1α and HIF-2α is regulated by oxygen-sensing prolyl-hydroxylases (PHD). HIF-1α and HIF-2α modify the innate immune response and are context dependent. We provide a historic perspective of HIF discovery, discuss the molecular components of the HIF pathway, and how HIF-dependent mechanisms modify myeloid cell functions. HIFs enable myeloid-cell adaptation to hypoxia by up-regulating anaerobic glycolysis. In addition to effects on metabolism, HIFs control chemotaxis, phagocytosis, degranulation, oxidative burst, and apoptosis. HIF-1α enables efficient infection defense by myeloid cells. HIF-2α delays inflammation resolution and decreases antitumor effects by promoting tumor-associated myeloid-cell hibernation. PHDs not only control HIF degradation, but also regulate the crosstalk between innate and adaptive immune cells thereby suppressing autoimmunity. HIF-modifying pharmacologic compounds are entering clinical practice. Current indications include renal anemia and certain cancers. Beneficial and adverse effects on myeloid cells should be considered and could possibly lead to drug repurposing for inflammatory disorders.
    MeSH term(s) Basic Helix-Loop-Helix Transcription Factors/chemistry ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Biomarkers ; Disease Susceptibility ; Humans ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/chemistry ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunity, Innate ; Myeloid Cells/drug effects ; Myeloid Cells/metabolism ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Biomarkers ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Transcription Factors ; endothelial PAS domain-containing protein 1 (1B37H0967P)
    Language English
    Publishing date 2020-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.4RI0820-535R
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Selected Genotypes with the Genetic Background of

    Schurig, Juliane / Ipach, Ulrike / Helmstätter, Brigitte / Kling, Lilo / Hahn, Matthias / Trapp, Oliver / Winterhagen, Patrick

    Plant disease

    2021  Volume 105, Issue 12, Page(s) 4132–4137

    Abstract: The ectoparasitic ... ...

    Abstract The ectoparasitic nematode
    MeSH term(s) Animals ; Genetic Background ; Genotype ; Nematoda ; Plant Diseases/genetics ; Vitis
    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-12-20-2716-RE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2043: Show issues

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  8. Article ; Online: Expositionsrisiko gegenüber HEV bei Hunden, Katzen und Pferden in Deutschland

    Wolski, Annika* / Knoop, E. V. / Mader, M. / Kling, L. / Wagner, A. / Horvatits, T. / Stiller, J. / Kohn, B. / Groschup, Martin H. / Schulze zur Wiesch, J. / Eiden, Martin / Pischke, S.

    2023  

    Keywords Text ; abstract_or_summary ; ddc:570
    Language German
    Publishing date 2023-06-16
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: Author Correction

    Pischke, S. / Knoop, E. V. / Mader, M. / Kling, L. / Wolski, A. / Wagner, A. / Mueller, K. / Horvatits, T. / Stiller, J. / Wisnewski, K. / Kohn, B. / Schulze zur Wiesch, J. / Groschup, Martin H. / Eiden, Martin

    Anti-HEV seroprevalence and rate of viremia in a German cohort of dogs, cats, and horses

    2023  

    Keywords Text ; ddc:570
    Language English
    Publishing date 2023-11-24
    Publisher Springer Science and Business Media LLC
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Anti-HEV seroprevalence and rate of viremia in a German cohort of dogs, cats, and horses

    Pischke, S. / Knoop, E. V. / Mader, M. / Kling, L. / Wolski, A. / Wagner, A. / Mueller, K. / Horvatits, T. / Stiller, J. / Wisnewski, Kira / Kohn, B. / Schulze zur Wiesch, J. / Groschup, Martin H. / Eiden, Martin

    2023  

    Abstract: Hepatitis E virus (HEV) genotype 3 infections in Germany are mainly transmitted zoonotically through the consumption of swine meat. Furthermore, there is evidence that pets might come into contact with HEV, but the relevance of companion animals as ... ...

    Abstract Hepatitis E virus (HEV) genotype 3 infections in Germany are mainly transmitted zoonotically through the consumption of swine meat. Furthermore, there is evidence that pets might come into contact with HEV, but the relevance of companion animals as possible sources of HEV transmission in Germany still needs to be defined. A monitoring study was therefore carried out on dogs, cats, and horses from Germany. In total 365 serum samples from pets (124 dogs, 119 cats, and 122 horses) were tested for HEV by PCR and for anti-HEV antibodies by a commercial ELISA. The HEV seroprevalence determined by the sero-assay varied significantly between dogs (10%), cats (6%), and horses (2%). Liver injury-related enzymes, alanine transaminase (ALT), and aspartate transaminase (AST) showed no differences between HEV-positive or negative animals. None of the pet serum samples tested positive for PCR. This serological study suggests that dogs and cats are significantly exposed to HEV in Germany, while horses are of minor relevance.
    Keywords article ; Text ; ddc:570
    Subject code 630
    Language English
    Publishing date 2023-11-07
    Publisher Springer Science and Business Media LLC
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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