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  1. Book ; Thesis: Die bronchoalveoläre Lavage im Kindesalter

    Kluge, Annegret

    Standardisierung unter besonderer Berücksichtigung der lasernephelometrischen Bestimmung von Albumin, Alpha-1-Antitrypsin, C-reaktiven Protein, Fibronektin und Immunglobulin A

    1997  

    Author's details vorgelegt von Annegret Kluge
    Language German
    Size 102 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 1998
    HBZ-ID HT009069134
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    98 E 2510 order for loan Magazin

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  2. Book ; Thesis: In-vitro-Monitoring des Tractus perforans in intakten und lädierten organotypischen entorhinal- hippocampalen Komplexschnittkulturen

    Kluge, Annegret

    2001  

    Author's details vorgelegt von Annegret Kluge
    Language German
    Size 72 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2001
    HBZ-ID HT013134705
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 MB 2094 order for loan Magazin

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  3. Book ; Thesis: In-vitro-Monitoring des Tractus perforans in intakten und lädierten organotypischen entorhinal-hippocampalen Komplexschnittkulturen

    Kluge, Annegret

    2001  

    Author's details von Annegret Kluge
    Language German
    Size 1 Mikrofiche, Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Humboldt-Univ., Diss--Berlin, 2001
    Database Former special subject collection: coastal and deep sea fishing

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  4. Article: Electroencephalogram monitoring facilitates sedation with propofol for routine ERCP: a randomized, controlled trial.

    Wehrmann, Till / Grotkamp, Jörg / Stergiou, Nikos / Riphaus, Andrea / Kluge, Annegret / Lembcke, Bernhard / Schultz, Arthur

    Gastrointestinal endoscopy

    2002  Volume 56, Issue 6, Page(s) 817–824

    Abstract: Background: Endoscopy with the patient under sedation with propofol requires careful monitoring of patient consciousness and vital signs to achieve the desired hypnotic effect without overdosage. Because level of consciousness is difficult to judge by ... ...

    Abstract Background: Endoscopy with the patient under sedation with propofol requires careful monitoring of patient consciousness and vital signs to achieve the desired hypnotic effect without overdosage. Because level of consciousness is difficult to judge by clinical observation alone, electroencephalogram monitoring has been used to guide general anesthesia.
    Methods: Eighty consecutive patients (mean [SD] age 62 [14] years) undergoing ERCP for various indications were randomly allocated to 2 groups. In group A (n = 40), propofol sedation was guided by conventional monitoring (heart rate, blood pressure, oxygen saturation, electrocardiogram), whereas electroencephalogram monitoring was performed but not displayed to the physician who administered the drug. In group B (n = 40), electroencephalogram monitoring was displayed online and used to guide propofol administration to maintain a preselected sedation level. Procedure-related parameters, recovery time, and quality (postanesthesia recovery score), as well as patient cooperation and tolerance for the procedure (visual analog scale) were prospectively assessed.
    Results: The groups were comparable with regard to demographic, clinical, and procedure-related parameters. Mean propofol dose was significantly lower in group B than in group A (respectively, 290 [158] mg vs. 374 [166] mg; p = 0.02). The mean decrease in arterial blood pressure was significantly lower in group B than in group A (respectively, 11 [6] mm Hg vs. 14 [7] mm Hg; p < 0.05). Clinically relevant changes in vital signs to below critical values were observed in both groups, albeit infrequently. Efficacy of sedation was also rated similar in both groups, whereas mean recovery time was significantly faster in group B than in group A (respectively, 16 [7] minutes vs. 20 [8] minutes; p = 0.02). Accordingly, the recovery score tended to be better in group B compared with group A (respectively, 8.4 [1.0] points vs. 8.0 [0.9] points; p = 0.06). The predefined target level of sedation was maintained during 75% of the procedure time in group B but in only 58% of the time in group A (p < 0.05), and deeper sedation levels were achieved significantly more often in group B patients compared with group A patients (p < 0.05).
    Conclusion: Electroencephalogram monitoring enables more effective titration of propofol dosage for sedation during endoscopy and is, therefore, associated with faster patient recovery.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cholangiopancreatography, Endoscopic Retrograde ; Electroencephalography ; Female ; Hemodynamics/drug effects ; Humans ; Hypnotics and Sedatives/administration & dosage ; Male ; Middle Aged ; Monitoring, Physiologic ; Propofol/administration & dosage ; Prospective Studies
    Chemical Substances Hypnotics and Sedatives ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2002-12
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1067/mge.2002.129603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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