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Article ; Online: Lachgas wordt niet algemeen toegepast bij kinderen op de SEH.

Hulshof, G W L / Welsing, Roy T C / Kluijfhout, Wouter P

2022 Volume 166

Abstract: Nitrous oxide was introduced in The Netherlands as an easily accessible and effective agent for procedural sedation and analgesia (PSA) in children at the Emergency Department. It was expected that its adoption would increase due to the rapid onset of ... ...

Title translation	Nitrous oxide is not widely used for children in the emergency departments in The Netherlands.
Abstract	Nitrous oxide was introduced in The Netherlands as an easily accessible and effective agent for procedural sedation and analgesia (PSA) in children at the Emergency Department. It was expected that its adoption would increase due to the rapid onset of action, limited side effects and the non-invasive character. In this article, we discuss the efficacy and use of nitrous oxide in The Netherlands. Nitrous oxide is a safe and effective agent for children undergoing low-complex procedures. However, the analgesic effect is limited for complex procedures such as fracture reposition, necessitating the use of additional agents such as opioids. Against our expectations, most Dutch Emergency Departments do not use nitrous oxide. Reasons for this are the limited analgesic effects for most procedures, the availability of good alternatives and cost and sustainability considerations.
MeSH term(s)	Child ; Humans ; Nitrous Oxide/therapeutic use ; Netherlands ; Prospective Studies ; Emergency Service, Hospital ; Analgesics
Chemical Substances	Nitrous Oxide (K50XQU1029) ; Analgesics
Language	Dutch
Publishing date	2022-09-14
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: Unilateral Clearance for Primary Hyperparathyroidism in Selected Patients with Multiple Endocrine Neoplasia Type 1: Reply.

Kluijfhout, Wouter P / Duh, Quan-Yang

World journal of surgery

2017 Volume 41, Issue 1, Page(s) 329

Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Letter
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-016-3810-9
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Zs.A 1336: Show issues

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Article ; Online: Compartimentsyndroom van de onderarm bij een jongere.

Kluijfhout, Wouter P / de Vries, Eefje N / de Ridder, Victor A / de Bruin, Ivar G J M

Nederlands tijdschrift voor geneeskunde

2021 Volume 165

Abstract: Background: Compartment syndrome is a rare but serious entity with various causes. Timely diagnosis and treatment are essential.: Case description: We present a case of a 14-year-old boy with a crush injury of the forearm including a fracture of the ... ...

Title translation	Compartment syndrome of the forearm in a child.
Abstract	Background: Compartment syndrome is a rare but serious entity with various causes. Timely diagnosis and treatment are essential. Case description: We present a case of a 14-year-old boy with a crush injury of the forearm including a fracture of the radius and ulna. In addition, a traction injury of the brachial plexus was present. Despite the absence of pain, a fasciotomy was performed because of excessive swelling of the forearm with obvious bulging of the muscles intra-operatively. Conclusion: Compartment syndrome can develop at several places in the body, including the forearm. Disproportional pain is the most relevant symptom which can however be absent due to concurrent neurological injury. Surgical exploration is always warranted in case of a clinical suspicion of compartment syndrome to prevent severe complications.
MeSH term(s)	Adolescent ; Brachial Plexus/injuries ; Compartment Syndromes/etiology ; Compartment Syndromes/surgery ; Crush Injuries/complications ; Crush Injuries/surgery ; Fasciotomy ; Forearm/blood supply ; Forearm/surgery ; Forearm Injuries/complications ; Forearm Injuries/surgery ; Humans ; Male
Language	Dutch
Publishing date	2021-03-18
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: 18F-fluorocholine-PET-CT-scan is effectief.

Kluijfhout, Wouter P / Vriens, Menno R / BorelRinkes, Inne H M / de Keizer, Bart

Nederlands tijdschrift voor geneeskunde

2021 Volume 165

Abstract: 18F-fluorocholine PET-CT was introduced in The Netherlands for detection of pathological parathyroid glands in patients with primary and secondary hyperparathyroidism around five years ago. This relatively new imaging technique is able to localise ... ...

Title translation	18F-fluorocholine PET-CT scan effective in localising pathological parathyroid glands.
Abstract	18F-fluorocholine PET-CT was introduced in The Netherlands for detection of pathological parathyroid glands in patients with primary and secondary hyperparathyroidism around five years ago. This relatively new imaging technique is able to localise pathological parathyroid glands in the case of negative or inconclusive conventional imaging, such as ultrasound and 99mTc-sestamibi scans. In this manuscript we review the performance and usage of 18F-fluorocholine PET-CT in the Netherlands. In the past five years many articles have been published, demonstrating its superior sensitivity and positive predictive value. All centers in The Netherlands have adopted this scan in their daily practice to enable minimal invasive surgery in patients with hyperparathyroidism, due to the relatively high costs, mostly as second line imaging modality. Studies regarding cost-effectiveness are currently lacking and will have to show if this new imaging modality should replace 99mTc-sestamibi scanning as a first-line localisation study.
MeSH term(s)	Choline/analogs & derivatives ; Humans ; Hyperparathyroidism, Primary ; Parathyroid Glands/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Technetium Tc 99m Sestamibi
Chemical Substances	fluorocholine (6029HGL0QP) ; Technetium Tc 99m Sestamibi (971Z4W1S09) ; Choline (N91BDP6H0X)
Language	Dutch
Publishing date	2021-05-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Article ; Online: The clinical consequences of functional adrenal uptake in the absence of cross-sectional mass on FDG-PET/CT in oncology patients.

Hsiao, Ralph / Chow, Alicia / Kluijfhout, Wouter P / Bongers, Pim J / Verzijl, Raoul / Metser, Ur / Veit-Haibach, Patrick / Pasternak, Jesse D

Langenbeck's archives of surgery

2022 Volume 407, Issue 4, Page(s) 1677–1684

Abstract: Purpose: Oncology patients undergoing positron emission tomography/computed tomography (PET/CT) occasionally show discrete adrenal [18F]-fluorodeoxyglucose (FDG) uptake without an associated nodule on CT, leaving the clinician uncertain about the need ... ...

Abstract	Purpose: Oncology patients undergoing positron emission tomography/computed tomography (PET/CT) occasionally show discrete adrenal [18F]-fluorodeoxyglucose (FDG) uptake without an associated nodule on CT, leaving the clinician uncertain about the need to proceed with biopsy or surgical referral. This study aimed to identify the prevalence of this radiological finding and to evaluate the effectiveness of FDG uptake values in risk stratification for adrenal metastasis. Methods: From 2014 to 2015, oncology patients who underwent FDG-PET/CT and demonstrated elevated FDG uptake in the adrenal gland without discrete nodularity on cross-sectional imaging were included in a retrospective cohort analysis. Clinical records and FDG-PET/CT scans were reviewed for clinicopathological data, follow-up data, SUVmax (highest SUV of either adrenal gland), and SUVratio (SUVmax/background liver uptake). A receiver operating characteristic analysis was conducted to evaluate the associations between SUV values and the progression to adrenal metastasis. Results: Of 3040 oncology patients who underwent FDG-PET/CT scans, 92 (3.0%) showed elevated adrenal uptake without associated mass. From the final study cohort of 66 patients with comprehensive follow-up data, 5 patients (7.6%) developed evidence of adrenal metastasis. At SUVmax < 3.25 (AUC = 0.757) and SUVratio < 1.27 (AUC = 0.907), 34.8% and 60.6% of patients could be excluded with 100% negative predictive value, respectively. Conclusions: Thresholds of SUVmax and SUVratio identified a significant proportion of patients who did not develop adrenal metastasis. In oncology patients who demonstrate increased adrenal FDG uptake without a discrete lesion on FDG-PET/CT, quantitative uptake values may be useful in selecting those not at risk of developing adrenal metastatic disease.
MeSH term(s)	Adrenal Gland Neoplasms/diagnostic imaging ; Adrenal Gland Neoplasms/pathology ; Fluorodeoxyglucose F18 ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography ; Radiopharmaceuticals ; Retrospective Studies
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-01-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-021-02379-3
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Article ; Online: Plate fixation of clavicle fractures: comparison between early and delayed surgery.

Kluijfhout, Wouter P / Tutuhatunewa, Eric D / van Olden, Ger D J

Journal of shoulder and elbow surgery

2019 Volume 29, Issue 2, Page(s) 266–272

Abstract: Background: The optimal treatment strategy for clavicle fractures remains a topic of debate. We evaluated our step-wise treatment protocol for patients with clavicle fractures to determine our success rate of conservative treatment. In addition, we ... ...

Abstract	Background: The optimal treatment strategy for clavicle fractures remains a topic of debate. We evaluated our step-wise treatment protocol for patients with clavicle fractures to determine our success rate of conservative treatment. In addition, we evaluated the incidence of complications after clavicle plate fixation in patients undergoing acute surgery vs. delayed surgery. Methods: This was a retrospective analysis in which we registered all patients aged 14 years or older with a clavicle fracture between January 2010 and May 2018 and at least 6 weeks' follow-up. Patients who underwent surgery were included from a prospectively maintained database. Functional outcomes were measured by Disabilities of the Arm, Shoulder and Hand and Constant-Murley scores 6 weeks after surgery. Results: Conservative treatment was successful in 1627 of 1748 patients (93%). Primary fixation was performed in 73 patients (61%) and delayed fixation in 48 (39%). In 8 patients (6.6%), radiologic widening of the acromioclavicular (AC) joint was present after surgery, suggestive of AC injury. The incidence of complications was significantly higher among patients who underwent delayed fixation vs. those who underwent primary fixation: 15 of 48 patients (31.3%) vs. 9 of 73 patients (12.3%). Conclusion: Most patients with clavicle fractures have an excellent outcome using conservative management. Acute surgery can be performed in high-demand patients, resulting in high performance scores. Delayed surgery is associated with a higher risk of complications, although the outcome is generally good. Associated AC joint dislocation found on postoperative radiographs does not influence outcomes. Shared decision making is key, and patients should be well aware of the potential risks and benefits of surgery.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Plates ; Clavicle/injuries ; Clavicle/surgery ; Conservative Treatment/statistics & numerical data ; Disability Evaluation ; Female ; Fracture Fixation, Internal ; Fractures, Bone/therapy ; Humans ; Male ; Middle Aged ; Postoperative Complications ; Retrospective Studies ; Time-to-Treatment ; Young Adult
Language	English
Publishing date	2019-08-28
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2019.06.022
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Zs.A 3973: Show issues

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Article ; Online: Well-differentiated thyroid cancer: Thyroidectomy or lobectomy?

Kluijfhout, Wouter P / Rotstein, Lorne E / Pasternak, Jesse D

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2016 Volume 188, Issue 17-18, Page(s) E517–E520

MeSH term(s)	Adenocarcinoma, Follicular/diagnostic imaging ; Adenocarcinoma, Follicular/pathology ; Adenocarcinoma, Follicular/surgery ; Adult ; Biopsy, Fine-Needle ; Carcinoma/diagnostic imaging ; Carcinoma/pathology ; Carcinoma/surgery ; Carcinoma, Papillary ; Female ; Humans ; Incidental Findings ; Magnetic Resonance Imaging ; Neoplasm Staging ; Thyroid Cancer, Papillary ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology ; Thyroid Nodule/surgery ; Thyroidectomy/methods ; Ultrasonography
Language	English
Publishing date	2016-09-26
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.160336
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Article ; Online: Long-term Risk of Thyroid Cancer After Initially Negative Thyroid Biopsy Results.

Bongers, Pim J / Kluijfhout, Wouter P / Devon, Karen / Rotstein, Lorne E / Vriens, Menno R / Urbach, David R / Pasternak, Jesse D

JAMA otolaryngology-- head & neck surgery

2019 Volume 145, Issue 6, Page(s) 579–580

MeSH term(s)	Adult ; Aged ; Biopsy ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Thyroid Gland/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Nodule/pathology
Language	English
Publishing date	2019-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701825-8
ISSN	2168-619X ; 2168-6181
ISSN (online)	2168-619X
ISSN	2168-6181
DOI	10.1001/jamaoto.2019.0386
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Article ; Online: Accuracy of

Hope, Thomas A / Graves, Claire E / Calais, Jeremie / Ehman, Eric C / Johnson, Geoffrey B / Thompson, Daniel / Aslam, Maya / Duh, Quan-Yang / Gosnell, Jessica E / Shen, Wen T / Roman, Sanziana A / Sosa, Julie A / Kluijfhout, Wouter P / Seib, Carolyn D / Villaneuva-Meyer, Javier E / Pampaloni, Miguel H / Suh, Insoo

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2021 Volume 62, Issue 11, Page(s) 1511–1516

Abstract: The purpose of this prospective study was to determine the correct localization rate (CLR) ... ...

Abstract	The purpose of this prospective study was to determine the correct localization rate (CLR) of
MeSH term(s)	Adult ; Aged ; Choline/analogs & derivatives ; Humans ; Middle Aged ; Parathyroid Neoplasms ; Positron Emission Tomography Computed Tomography ; Technetium Tc 99m Sestamibi
Chemical Substances	fluorocholine (6029HGL0QP) ; Technetium Tc 99m Sestamibi (971Z4W1S09) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.120.256735
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 328: Show issues

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Article ; Online: Low-level laser therapy as a treatment for androgenetic alopecia.

Afifi, Ladan / Maranda, Eric L / Zarei, Mina / Delcanto, Gina M / Falto-Aizpurua, Leyre / Kluijfhout, Wouter P / Jimenez, Joaquin J

Lasers in surgery and medicine

2017 Volume 49, Issue 1, Page(s) 27–39

Abstract: Background and objectives: Androgenetic alopecia (AGA) affects 50% of males by age 50 and 50% of females by age 80. Recently, the use of low-level laser therapy (LLLT) has been proposed as a treatment for hair loss and to stimulate hair regrowth in AGA. ...

Abstract	Background and objectives: Androgenetic alopecia (AGA) affects 50% of males by age 50 and 50% of females by age 80. Recently, the use of low-level laser therapy (LLLT) has been proposed as a treatment for hair loss and to stimulate hair regrowth in AGA. This paper aims to review the existing research studies to determine whether LLLT is an effective therapy for AGA based on objective measurements and patient satisfaction. Study design: A systematic literature review was done to identify articles on Medline, Google Scholar, and Embase that were published between January 1960 and November 2015. All search hits were screened by two reviewers and examined for relevant abstracts and titles. Articles were divided based on study design and assessed for risk of bias. Results: Eleven studies were evaluated, which investigated a total of 680 patients, consisting of 444 males and 236 females. Nine out of 11 studies assessing hair count/hair density found statistically significant improvements in both males and females following LLLT treatment. Additionally, hair thickness and tensile strength significantly improved in two out of four studies. Patient satisfaction was investigated in five studies, and was overall positive, though not as profound as the objective outcomes. Conclusion: The majority of studies covered in this review found an overall improvement in hair regrowth, thickness, and patient satisfaction following LLLT therapy. Although we should be cautious when interpreting these findings, LLLT therapy seems to be a promising monotherapy for AGA and may serve as an effective alternative for individuals unwilling to use medical therapy or undergo surgical options. Lasers Surg. Med. 49:27-39, 2017. © 2016 Wiley Periodicals, Inc.
MeSH term(s)	Adult ; Alopecia/diagnosis ; Alopecia/radiotherapy ; Esthetics ; Female ; Hair/growth & development ; Hair/radiation effects ; Humans ; Low-Level Light Therapy/methods ; Male ; Middle Aged ; Patient Satisfaction/statistics & numerical data ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604493-1
ISSN	1096-9101 ; 0196-8092
ISSN (online)	1096-9101
ISSN	0196-8092
DOI	10.1002/lsm.22512
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