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Article ; Online: Damages of Skidder and Oxen Logging to Residual Trees in Uneven-Aged Mixed Forest

Knežević, Jelena / Musić, Jusuf / Halilović, Velid / Avdagić, Admir

Forests. 2023 Apr. 30, v. 14, no. 5

2023

Abstract: The negative influence of timber harvesting on the forest environment is reflected through damage to the residual trees, regeneration, and forest soil. Considering that skidding, a popular extraction method, can cause substantial and severe damage to the ...

Abstract	The negative influence of timber harvesting on the forest environment is reflected through damage to the residual trees, regeneration, and forest soil. Considering that skidding, a popular extraction method, can cause substantial and severe damage to the remaining stand, the aim of this research was to determine damage to residual trees during skidding by an LKT 81T cable skidder, including oxen bunching. The research was conducted in eastern Bosnia and Herzegovina, in an uneven-aged mixed fir (Abies alba Mill.) and spruce (Picea abies L.) forest with pine (Pinus sylvestris L.) on limestone soils. Tree felling was conducted using a Husqvarna 372 XP chainsaw. Extraction operations caused damage to 6.31% of the residual trees in the stand. The most damage was “removed bark” (65.34%) and occurred on the lower parts of the tree, the butt end (55.11%) and root collar (32.39%). The average size of the damage was 197.08 cm². A statistically significant correlation was found between the damage position and the diameter at the breast height (p < 0.05) and the damage position and damage size (p < 0.01) by Spearman correlation analysis. The conducted analysis by the chi-squared test showed that there is a statistically significant difference in the proportion of damage for trees with different distances to the nearest skid road (p = 0.0487), but the share of damaged trees did not decrease by increasing the distance from the skid road.
Keywords	Abies alba ; Picea abies ; Pinus sylvestris ; chainsaws ; forest soils ; forests ; limestone ; root crown ; trees ; Bosnia-Herzegovina
Language	English
Dates of publication	2023-0430
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f14050927
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Carbohydrate sulfotransferases: a review of emerging diagnostic and prognostic applications.

Begolli, Gramos / Marković, Ivana / Knežević, Jelena / Debeljak, Željko

Biochemia medica

2023 Volume 33, Issue 3, Page(s) 30503

Abstract: Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of ... ...

Abstract	Carbohydrate sulfotransferases (CHST) catalyse the biosynthesis of proteoglycans that enable physical interactions and signalling between different neighbouring cells in physiological and pathological states. The study aim was to provide an overview of emerging diagnostic and prognostic applications of CHST. PubMed database search was conducted using the keywords "carbohydrate sulfotransferase" together with appropriate inclusion and exclusion criteria, whereby 41 publications were selected. Additionally, 40 records on CHST genetic and biochemical properties were hand-picked from UniProt, GeneCards, InterPro, and neXtProt databases. Carbohydrate sulfotransferases have been applied mainly in diagnostics of connective tissue disorders, cancer and inflammations. The lack of CHST activity was found in congenital connective tissue disorders while CHST overexpression was detected in different malignancies. Mutations of
MeSH term(s)	Humans ; Prognosis ; COVID-19 ; Sulfotransferases/genetics ; Sulfotransferases/metabolism ; Mutation ; COVID-19 Testing
Chemical Substances	Sulfotransferases (EC 2.8.2.-)
Language	English
Publishing date	2023-08-05
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2023.030503
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Article ; Online: Theory of Mind in Typical Adults: Sex-Differences and Its Associations with Anxiety and Depression Symptoms.

Petrovic, Sanja Andric / Kaurin, Nina / Knezevic, Jelena / Maric, Nadja P

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

2023 Volume 38, Issue 6, Page(s) 913–921

Abstract: Objective: Despite an increased interest in research of theory of mind (ToM) in recent years - both related to psychopathology (depression and anxiety spectrum disorders) and within the typical adults, the existing literature is scarce and presents some ...

Abstract	Objective: Despite an increased interest in research of theory of mind (ToM) in recent years - both related to psychopathology (depression and anxiety spectrum disorders) and within the typical adults, the existing literature is scarce and presents some conflicting results. Present study aimed to explore sex differences in ToM, alongside its associations with current anxiety and depression symptoms, in a large sample of typical adults collected online. Method: Participants completed the 15-minutes survey obtaining socio-demographic data, current self-reported depression and anxiety symptom severity, and ToM ability (the Reading the Mind in the Eyes Task). The sample comprised 605 participants -mostly younger adults, women, and high school graduate/student population. Results: The majority of participants reported minimal/mild depressive and anxiety symptoms that were significantly more severe in women. Women also displayed significantly better overall ToM ability than men. Significant negative correlation between the severity of current depressive and anxiety symptoms and ToM ability was also observed, but only in individuals expressing the symptoms requiring clinical attention (such association was absent in those exhibiting minimal/mild symptoms). Conclusions: Present research adds to the existing knowledge on the association between ToM ability, anxiety, and depressive symptoms in typical adults as well as on the sex-differences in this important social cognitive domain. Exploring the factors representing indicators of vulnerability for depression-anxiety spectrum disorders is important for their timely detection and treatment.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Depression/complications ; Depression/psychology ; Theory of Mind ; Sex Characteristics ; Neuropsychological Tests ; Anxiety/psychology
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	632972-x
ISSN	1873-5843 ; 0887-6177
ISSN (online)	1873-5843
ISSN	0887-6177
DOI	10.1093/arclin/acad007
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Article ; Online: Indirect influence of microRNA-146a on the association of IL-6 and TNF-α genetic polymorphisms with the increased risk of hip osteoarthritis.

Tudor, Karlo / Baranasic, Jurica / Knezevic, Jelena / Serer Vicevic, Marta / Sutic, Maja / Dembic, Zlatko / Jotanovic, Zdravko

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2024

Abstract: Primary osteoarthritis (POA) is a complex hereditary disease that involves the interplay between genetics and epigenetics. MicroRNA molecules play important roles in epigenetic mechanisms. MicroRNA-146a (miR-146a) is a negative regulator of the immune ... ...

Abstract	Primary osteoarthritis (POA) is a complex hereditary disease that involves the interplay between genetics and epigenetics. MicroRNA molecules play important roles in epigenetic mechanisms. MicroRNA-146a (miR-146a) is a negative regulator of the immune response in osteoarthritis (OA). So, variations in the miR-146a gene could affect OA risk. The aim of this study was to investigate the relationships between single nucleotide polymorphisms (SNPs) in the miR-146a, interleukin-6 (IL-6), Toll-like receptor 10 (TLR10), and tumor necrosis factor-alpha (TNFA) genes and the risk for development of advanced-stage primary hip osteoarthritis (PHOA) and primary knee osteoarthritis (PKOA) in the Croatian population. A total of 609 POA patients and 656 healthy donors were genotyped for SNPs in the miR-146a (rs2910164, G>C). Since we used same patients and controls as two studies before us, we already had information about IL-6 (rs1800795, C>G), TLR10 (rs11096957, C>T), and TNFA (rs1800629, C>T) genotypes of our subjects. None of the differences were statistically significant comparing either allelic or genotypic frequencies of miR-146a SNP rs2910164 (G>C) between the PHOA and PKOA patients and controls. However, we found a significant association with risk to PHOA for the combination of genotypes (stratified miR-146a genotype with the IL-6, and stratified miR-146a genotype with the TNFA). In a multifactorial disease such as POA, we have shown the indirect relevance of a second modifying factor (miR-146a), which apparently contributes to the overall risk of PHOA. There was no risk association with the PKOA, indicating that these two localities (hip and knee) might have different risk-modifying factors.
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.25804
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Article ; Online: Psychiatric characteristics of homicide perpetrators in Serbia

Knežević Vladimir / Ratković Dragana / Ivanović-Kovačević Svetlana / Vejnović Ana Marija / Šobot Valentina / Čomić Maša / Knežević Jelena

Srpski Arhiv za Celokupno Lekarstvo, Vol 151, Iss 9-10, Pp 578-

2023 Volume 582

Abstract: Introduction/Objective. Homicide, a major public concern, has always attracted the attention of criminology, psychiatry, psychology, and other related disciplines. The objective of this study was to determine the frequency and type of mental disorders in ...

Abstract	Introduction/Objective. Homicide, a major public concern, has always attracted the attention of criminology, psychiatry, psychology, and other related disciplines. The objective of this study was to determine the frequency and type of mental disorders in 94 attempted/ committed homicide perpetrators. Methods. The authors conducted a psychiatric assessment of all perpetrators based on psychiatric interviews, psychological testing, and the examination of available medical records. Results. The key findings of this study imply that there is a large percentage of violent crime perpetrators with mental disorders (62%). When we excluded people with personality disorders from this group, we found that the most common major mental disorders among the perpetrators were psychosis and alcohol use disorders (approximately 10% each). Conclusion. The results highlight the importance of the early identification and treatment of people with mental disorders in the general population, as this could reduce the possibility of criminal behavior. The high overall incidence of mental disorders in the group of homicide perpetrators indicates the need for a reform of psychiatric services in Serbia and the promotion of psychiatry in the community, which would contribute to bringing professionals closer to people with mental disorders and thus, timely recognition and treatment of these patients.
Keywords	homicide ; mental illness ; psychosis ; alcohol use disorders ; personality disorders ; Medicine ; R
Subject code	150
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The size distribution of SARS-CoV-2 genetic material in airborne particles sampled in hospital and home care environments occupied by COVID-19 positive subjects

Cvitešić Kušan, Ana / Baranašić, Jurica / Frka, Sanja / Lucijanić, Tomo / Šribar, Andrej / Knežević, Jelena / Buonanno, Giorgio / Stabile, Luca

Science of the Total Environment. 2023 Sept., v. 892 p.164642-

2023

Abstract: Characterizing the size distribution of airborne particles carrying SARS-CoV-2 virus is essential for understanding and predicting airborne transmission and spreading of COVID-19 disease in hospitals as well as public and home indoor settings. ... ...

Abstract	Characterizing the size distribution of airborne particles carrying SARS-CoV-2 virus is essential for understanding and predicting airborne transmission and spreading of COVID-19 disease in hospitals as well as public and home indoor settings. Nonetheless, few data are currently available on virus-laden particle size distribution. Thus, the aim of this study is reporting the total concentrations and size distributions of SARS-CoV-2- genetic material in airborne particles sampled in hospital and home environments. A nanoMOUDI R122 cascade impactor (TSI, USA) was used to collect size-segregated aerosol down to the sub-micron range in home and in three different hospital environments in presence of infected patients in order to provide the concentration of airborne SARS-CoV-2 genetic material for each particle size range at different sampling locations. Providing one of the largest datasets of detailed size-fractionated airborne SARS-CoV-2 RNA to date, we found that 45.2 % of the total sub- and super-micrometric fractions were positive for SARS-CoV-2 with its genetic material being present in 17.7 % of sub-micrometric (0.18–1 μm) and 81.9 % of super-micrometric (>1 μm) fractions. The highest concentration of SARS-CoV-2 genetic material in total suspended particles (5.6 ± 3.4 RNA copies m⁻³) was detected in the room occupied with patients with more severe COVID-19 symptoms collected during the patients' high flow nasal oxygen therapy. The highest concentration at certain particle size fraction strongly depends on the sampling environment. However, the contribution of SARS-CoV-2 genetic material was in favour of super-micrometric compared to sub-micrometric particle size range. The evaluation of the individual risk of infection was carried out on the basis of the obtained data considering a hypothetical exposure scenario. The obtained results indicate the necessity of the protective masks in presence of infected subjects, especially while staying for longer period of time in the hospital environments.
Keywords	COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; aerosols ; airborne transmission ; data collection ; environment ; exposure scenario ; hospitals ; nose ; oxygen ; particle size ; particle size distribution ; risk ; therapeutics ; viruses ; Airborne virus transmission ; Indoor air ; Particle size-distribution ; Risk assessment ; Submicrometric particles
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164642
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases.

Marčetić, Dejan / Samaržija, Miroslav / Vukić Dugac, Andrea / Knežević, Jelena

Genes

2021 Volume 12, Issue 7

Abstract: Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways as their main pathophysiological manifestation. The lack of specific diagnostic and therapeutic biomarkers for many pulmonary diseases represents a major ... ...

Abstract	Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways as their main pathophysiological manifestation. The lack of specific diagnostic and therapeutic biomarkers for many pulmonary diseases represents a major challenge for pulmonologists. The majority of the currently approved therapeutic approaches are focused on achieving disease remission, although there is no guarantee of complete recovery. It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin-angiotensin-aldosterone system (RAAS), is expressed in the airways. It has been shown that ACE2 plays a role in systemic regulation of the cardiovascular and renal systems, lungs and liver by acting on blood pressure, electrolyte balance control mechanisms and inflammation. Its protective role in the lungs has also been presented, but the exact pathophysiological mechanism of action is still elusive. The aim of this study is to review and discuss recent findings about ACE2, including its potential role in the pathophysiology of chronic inflammatory lung diseases:, i.e., chronic obstructive pulmonary disease, asthma, and pulmonary hypertension. Additionally, in the light of the coronavirus 2019 disease (COVID-19), we will discuss the role of ACE2 in the pathophysiology of this disease, mainly represented by different grades of pulmonary problems. We believe that these insights will open up new perspectives for the future use of ACE2 as a potential biomarker for early diagnosis and monitoring of chronic inflammatory lung diseases.
MeSH term(s)	Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Asthma/diagnosis ; Asthma/enzymology ; Asthma/genetics ; COVID-19/enzymology ; COVID-19/genetics ; COVID-19 Testing ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/enzymology ; Hypertension, Pulmonary/genetics ; Inflammation/diagnosis ; Inflammation/enzymology ; Inflammation/genetics ; Lung/enzymology ; Lung/pathology ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/enzymology ; Pulmonary Disease, Chronic Obstructive/genetics ; Renin-Angiotensin System ; SARS-CoV-2/metabolism
Chemical Substances	ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-07-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12071054
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Role of Hyperthermia in Potentiation of Anti-Angiogenic Effect of Cisplatin and Resveratrol in Mice Bearing Solid Form of Ehrlich Ascites Tumour.

Kučan, Darko / Oršolić, Nada / Odeh, Dyana / Ramić, Snježana / Jakopović, Boris / Knežević, Jelena / Jazvinšćak Jembrek, Maja

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: The aim of this study was to investigate the therapeutic potential of resveratrol in combination with cisplatin on the inhibition of tumour angiogenesis, growth, and macrophage polarization in mice bearing the solid form of an Ehrlich ascites tumour (EAT) ...

Abstract	The aim of this study was to investigate the therapeutic potential of resveratrol in combination with cisplatin on the inhibition of tumour angiogenesis, growth, and macrophage polarization in mice bearing the solid form of an Ehrlich ascites tumour (EAT) that were exposed to whole-body hyperthermia treatment. In addition, we investigated whether a multimodal approach with hyperthermia and resveratrol could abolish cisplatin resistance in tumour cells through the modulation of histone deacetylase (HDAC) activity and levels of heat shock proteins (HSP70/HSP90) and contribute to the direct toxicity of cisplatin on tumour cells. The tumour was induced by injecting 1 × 10
MeSH term(s)	Animals ; Mice ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Resveratrol/pharmacology ; Resveratrol/therapeutic use ; Carcinoma, Ehrlich Tumor/drug therapy ; Carcinoma, Ehrlich Tumor/metabolism ; Hyperthermia, Induced ; Angiogenesis Inhibitors/therapeutic use
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Resveratrol (Q369O8926L) ; Angiogenesis Inhibitors
Language	English
Publishing date	2023-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241311073
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Article ; Online: The size distribution of SARS-CoV-2 genetic material in airborne particles sampled in hospital and home care environments occupied by COVID-19 positive subjects.

Cvitešić Kušan, Ana / Baranašić, Jurica / Frka, Sanja / Lucijanić, Tomo / Šribar, Andrej / Knežević, Jelena / Buonanno, Giorgio / Stabile, Luca

The Science of the total environment

2023 Volume 892, Page(s) 164642

Abstract	Characterizing the size distribution of airborne particles carrying SARS-CoV-2 virus is essential for understanding and predicting airborne transmission and spreading of COVID-19 disease in hospitals as well as public and home indoor settings. Nonetheless, few data are currently available on virus-laden particle size distribution. Thus, the aim of this study is reporting the total concentrations and size distributions of SARS-CoV-2- genetic material in airborne particles sampled in hospital and home environments. A nanoMOUDI R122 cascade impactor (TSI, USA) was used to collect size-segregated aerosol down to the sub-micron range in home and in three different hospital environments in presence of infected patients in order to provide the concentration of airborne SARS-CoV-2 genetic material for each particle size range at different sampling locations. Providing one of the largest datasets of detailed size-fractionated airborne SARS-CoV-2 RNA to date, we found that 45.2 % of the total sub- and super-micrometric fractions were positive for SARS-CoV-2 with its genetic material being present in 17.7 % of sub-micrometric (0.18-1 μm) and 81.9 % of super-micrometric (>1 μm) fractions. The highest concentration of SARS-CoV-2 genetic material in total suspended particles (5.6 ± 3.4 RNA copies m
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/genetics ; RNA, Viral ; Respiratory Aerosols and Droplets ; Hospitals
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-06-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164642
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Article: Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases

Marčetić, Dejan / Samaržija, Miroslav / Vukić Dugac, Andrea / Knežević, Jelena

Genes. 2021 July 09, v. 12, no. 7

2021

Abstract	Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways as their main pathophysiological manifestation. The lack of specific diagnostic and therapeutic biomarkers for many pulmonary diseases represents a major challenge for pulmonologists. The majority of the currently approved therapeutic approaches are focused on achieving disease remission, although there is no guarantee of complete recovery. It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin–angiotensin–aldosterone system (RAAS), is expressed in the airways. It has been shown that ACE2 plays a role in systemic regulation of the cardiovascular and renal systems, lungs and liver by acting on blood pressure, electrolyte balance control mechanisms and inflammation. Its protective role in the lungs has also been presented, but the exact pathophysiological mechanism of action is still elusive. The aim of this study is to review and discuss recent findings about ACE2, including its potential role in the pathophysiology of chronic inflammatory lung diseases:, i.e., chronic obstructive pulmonary disease, asthma, and pulmonary hypertension. Additionally, in the light of the coronavirus 2019 disease (COVID-19), we will discuss the role of ACE2 in the pathophysiology of this disease, mainly represented by different grades of pulmonary problems. We believe that these insights will open up new perspectives for the future use of ACE2 as a potential biomarker for early diagnosis and monitoring of chronic inflammatory lung diseases.
Keywords	COVID-19 infection ; asthma ; biomarkers ; blood pressure ; early diagnosis ; electrolytes ; hypertension ; immune response ; inflammation ; liver ; lungs ; mechanism of action ; pathophysiology ; peptidyl-dipeptidase A ; protective effect ; remission ; therapeutics
Language	English
Dates of publication	2021-0709
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12071054
Database	NAL-Catalogue (AGRICOLA)

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