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  1. Article ; Online: Reply to "Improvements in asthma control and quality of life with benralizumab are unrelated to baseline bronchodilator response".

    Milger, Katrin / Mümmler, Carlo / Kneidinger, Nikolaus

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 12, Page(s) 3342–3343

    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Letter
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.08.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  2. Article ; Online: Benefit of monoclonal antibodies in early treatment of COVID-19 after lung transplantation: a retrospective analysis in two centres.

    Gottlieb, Jens / Kolditz, Martin / Gade, Nils / Welte, Tobias / Kneidinger, Nikolaus

    The European respiratory journal

    2022  Volume 60, Issue 1

    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; COVID-19/therapy ; Humans ; Lung Transplantation ; Retrospective Studies
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Letter ; Multicenter Study
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00124-2022
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    Zs.MO 292: Show issues

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  3. Article ; Online: Einsatz antifibrotischer Medikamente bei interstitiellen Lungenerkrankungen.

    Kreutz, Claus-Peter / Gesierich, Wolfgang / Behr, Jürgen / Kneidinger, Nikolaus

    Deutsche medizinische Wochenschrift (1946)

    2022  Volume 147, Issue 21, Page(s) 1383–1390

    Abstract: The interstitial lung diseases ILDs are a heterogeneous group of diseases that often lead to progressive fibrosis of the lungs with corresponding functional impairment. With nintedanib, a tyrosinkinase inhibitor and angiokinase inhibitor, as well as ... ...

    Title translation Use of antifibrotic drugs in interstitial lung disease.
    Abstract The interstitial lung diseases ILDs are a heterogeneous group of diseases that often lead to progressive fibrosis of the lungs with corresponding functional impairment. With nintedanib, a tyrosinkinase inhibitor and angiokinase inhibitor, as well as pirfenidone, which unfolds its effect among other things by inhibiting the transforming growth factor β, there are currently 2 approved antifibrotic drugs. In the rapidly progressing idiopathic pulmonary fibrosis IPF, the antifibrotic drugs nintedanib and pirfenidone have been established and approved in therapy for several years. The initiation of antifibrotic therapy should be carried out early after diagnosis by multidisciplinary discussion (MDD). In systemic scleroderma with lung involvement nintedanib should be used in the case of relevant fibrosis in addition to immunosuppressive therapy. Recently, nintedanib has also become a new option for the treatment of progressive fibrosing ILDs (PF-ILDs). This describes the course of various disease entities such as connective tissue disease associated ILDs (CTD-ILDs), fibrosing hypersensitivity pneumonitis or fibrosing courses of non-IPF idiopathic interstitial pneumonitis (non-IPF IIPs) that have a corresponding fibrose-related worsening of respiratory symptoms, a deterioration of lung-functioning parameters or a disease progression in CT. Although pirfenidone also shows positive signals for this group of patients in some selected studies, its use in PF-ILD is not yet recommended. In particular, gastrointestinal side effects can occur under therapy with antifibrotic drugs and require a long-term close interdisciplinary connection of patients.
    MeSH term(s) Humans ; Disease Progression ; Fibrosis ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/metabolism ; Lung ; Lung Diseases, Interstitial/drug therapy ; Transforming Growth Factor beta/antagonists & inhibitors
    Chemical Substances Transforming Growth Factor beta
    Language German
    Publishing date 2022-10-24
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1825-4967
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  4. Conference proceedings: Impact of illness and treatment on lung transplant candidates: A mixed methods study

    Griesbeck, Tom / Bausewein, Claudia / Neurohr, Claus / Kneidinger, Nikolaus / Schunk, Michaela

    2023  , Page(s) 23dkvf411

    Event/congress 22. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkvf411
    Database German Medical Science

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  5. Conference proceedings: Versorgungsgeschehen und palliativmedizinische Versorgungsbedarfe bei gelisteten Patienten und Patientinnen für eine Lungentransplantation – eine retrospektive Datenanalyse

    Huber, Simone / Bausewein, Claudia / Neurohr, Claus / Kneidinger, Nikolaus / Schunk, Michaela

    2023  , Page(s) 23dkvf357

    Event/congress 22. Deutscher Kongress für Versorgungsforschung (DKVF); Berlin; Deutsches Netzwerk Versorgungsforschung; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-10-02
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkvf357
    Database German Medical Science

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  6. Book ; Online ; Thesis: Die Auswirkungen des Tacrolimusspiegels und dessen Schwankung nach Lungentransplantation auf das Überleben der Patienten

    Klaubert, Niklas [Verfasser] / Kneidinger, Nikolaus [Akademischer Betreuer]

    2022  

    Author's details Niklas Klaubert ; Betreuer: Nikolaus Kneidinger
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  7. Article ; Online: Tracheal stenosis in prolonged mechanically ventilated patients: prevalence, risk factors, and bronchoscopic management.

    Ghiani, Alessandro / Tsitouras, Konstantinos / Paderewska, Joanna / Munker, Dieter / Walcher, Swenja / Neurohr, Claus / Kneidinger, Nikolaus

    BMC pulmonary medicine

    2022  Volume 22, Issue 1, Page(s) 24

    Abstract: Background: Various complications may arise from prolonged mechanical ventilation, but the risk of tracheal stenosis occurring late after translaryngeal intubation or tracheostomy is less common. This study aimed to determine the prevalence, type, risk ... ...

    Abstract Background: Various complications may arise from prolonged mechanical ventilation, but the risk of tracheal stenosis occurring late after translaryngeal intubation or tracheostomy is less common. This study aimed to determine the prevalence, type, risk factors, and management of tracheal stenoses in mechanically ventilated tracheotomized patients deemed ready for decannulation following prolonged weaning.
    Methods: A retrospective observational study on 357 prolonged mechanically ventilated, tracheotomized patients admitted to a specialized weaning center over seven years. Flexible bronchoscopy was used to discern the type, level, and severity of tracheal stenosis in each case. We described the management of these stenoses and used a binary logistic regression analysis to determine independent risk factors for stenosis development.
    Results: On admission, 272 patients (76%) had percutaneous tracheostomies, and 114 patients (32%) presented mild to moderate tracheal stenosis following weaning completion, with a median tracheal cross-section reduction of 40% (IQR 25-50). The majority of stenoses (88%) were located in the upper tracheal region, most commonly resulting from localized granulation tissue formation at the site of the internal stoma (96%). The logistic regression analysis determined that obesity (OR 2.16 [95%CI 1.29-3.63], P < 0.01), presence of a percutaneous tracheostomy (2.02 [1.12-3.66], P = 0.020), and cricothyrotomy status (5.35 [1.96-14.6], P < 0.01) were independently related to stenoses. Interventional bronchoscopy with Nd:YAG photocoagulation was a highly effective first-line treatment, with only three patients (2.6%) ultimately referred to tracheal surgery.
    Conclusions: Tracheal stenosis is commonly observed among prolonged ventilated patients with tracheostomies, characterized by localized hypergranulation and mild to moderate airway obstruction, with interventional bronchoscopy providing satisfactory results.
    MeSH term(s) Aged ; Bronchoscopy ; Female ; Germany/epidemiology ; Humans ; Male ; Middle Aged ; Prevalence ; Respiration, Artificial/adverse effects ; Retrospective Studies ; Risk Factors ; Tracheal Stenosis/epidemiology ; Ventilator Weaning
    Language English
    Publishing date 2022-01-06
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-022-01821-6
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  8. Article ; Online: Mechanical power normalized to lung-thorax compliance indicates weaning readiness in prolonged ventilated patients.

    Ghiani, Alessandro / Paderewska, Joanna / Walcher, Swenja / Tsitouras, Konstantinos / Neurohr, Claus / Kneidinger, Nikolaus

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 6

    Abstract: Since critical respiratory muscle workload is a significant determinant of weaning failure, applied mechanical power (MP) during artificial ventilation may serve for readiness testing before proceeding on a spontaneous breathing trial (SBT). Secondary ... ...

    Abstract Since critical respiratory muscle workload is a significant determinant of weaning failure, applied mechanical power (MP) during artificial ventilation may serve for readiness testing before proceeding on a spontaneous breathing trial (SBT). Secondary analysis of a prospective, observational study in 130 prolonged ventilated, tracheotomized patients. Calculated MP's predictive SBT outcome performance was determined using the area under receiver operating characteristic curve (AUROC), measures derived from k-fold cross-validation (likelihood ratios, Matthew's correlation coefficient [MCC]), and a multivariable binary logistic regression model. Thirty (23.1%) patients failed the SBT, with absolute MP presenting poor discriminatory ability (MCC 0.26; AUROC 0.68, 95%CI [0.59‒0.75], p = 0.002), considerably improved when normalized to lung-thorax compliance (LTC
    MeSH term(s) Aged ; Female ; Humans ; Lung/physiopathology ; Lung Compliance ; Male ; Middle Aged ; Prospective Studies ; ROC Curve ; Respiration ; Thorax/physiopathology ; Tracheostomy ; Ventilator Weaning
    Language English
    Publishing date 2022-01-07
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-03960-y
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  9. Article: Riociguat in Patients with CTEPH and Advanced Age and/or Comorbidities.

    Barnikel, Michaela / Kneidinger, Nikolaus / Arnold, Paola / Waelde, Andrea / Behr, Jürgen / Milger, Katrin

    Journal of clinical medicine

    2022  Volume 11, Issue 4

    Abstract: Riociguat is licensed for the therapy of inoperable chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to investigate whether age and comorbidities influence its tolerability and efficacy. Retrospectively, we analyzed data of tolerability, ... ...

    Abstract Riociguat is licensed for the therapy of inoperable chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to investigate whether age and comorbidities influence its tolerability and efficacy. Retrospectively, we analyzed data of tolerability, non-invasive, and invasive efficacy at baseline and follow up (FU) of all patients with CTEPH treated with riociguat at the Department of Internal Medicine V, University of Munich (
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11041084
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  10. Article ; Online: Efficacy of pre-exposure prophylaxis to prevent SARS-CoV-2 infection after lung transplantation: a two center cohort study during the omicron era.

    Gottlieb, Jens / Simon, Susanne / Barton, Jürgen / Barnikel, Michaela / Bachmann, Marcus / Klingenberg, Merle-Sophie / Veit, Tobias / Kneidinger, Nikolaus

    Infection

    2023  Volume 51, Issue 5, Page(s) 1481–1489

    Abstract: Purpose: Lung transplant (LTx) recipients are at risk for poor outcomes from coronavirus disease 2019 (COVID-19). The aim of the study was to assess the outcome of patients receiving pre-exposure prophylaxis (PrEP) with tixagevimab and cilgavimab after ... ...

    Abstract Purpose: Lung transplant (LTx) recipients are at risk for poor outcomes from coronavirus disease 2019 (COVID-19). The aim of the study was to assess the outcome of patients receiving pre-exposure prophylaxis (PrEP) with tixagevimab and cilgavimab after LTx.
    Methods: All LTx recipients with outpatient visits from February 28th to October 31st, 2022 at two German centers were included. Baseline characteristics were recorded and patients followed until November 30rd, 2022. Infections with SARS-CoV-2, disease severity, and COVID-19-associated death were compared between patients with and without PrEP.
    Results: In total, 1438 patients were included in the analysis, and 419 (29%) received PrEP. Patients receiving PrEP were older and earlier after transplantation, had lower glomerular filtration rates, and lower levels of SARS-CoV-2-S antibodies. In total, 535 patients (37%) developed SARS-CoV-2 infection during a follow-up of median of 209 days. Fewer infections occurred in patients with PrEP during the study period (31% vs. 40%, p = 0.004). Breakthrough SARS-CoV-2 infections after PrEP occurred in 77 patients (19%). In total, 37 infections (8%) were severe or critical. No difference in severity of COVID-19 was observed between patients with and without PrEP. There were 15 COVID-19-associated deaths (n = 1 after PrEP). Compared to matched controls, there was a non-significant difference towards a lower risk for moderate to critical COVID-19 (p 0.184).
    Conclusion: The number of SARS-CoV-2 infections was lower in LTx recipients with PrEP. Despite being at higher risk for worse outcome severity of COVID-19 and associated mortality were similar in patients with and without PrEP.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pre-Exposure Prophylaxis ; SARS-CoV-2 ; Cohort Studies ; Lung Transplantation/adverse effects ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-03-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-023-02018-7
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    Zs.MO 528: Show issues

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