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  1. Article ; Online: Perspectives of Patients With Relapsed and Refractory Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome on Patient-Clinician Communication About Prognosis and the Future.

    Rao, Vinay / Linsky, Sarah / Knobf, M Tish

    Palliative medicine reports

    2024  Volume 5, Issue 1, Page(s) 53–62

    Abstract: Background: Patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) experience unpredictable disease trajectories and high prognostic uncertainty, which serve as barriers to patient-clinician communication about prognosis ...

    Abstract Background: Patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) experience unpredictable disease trajectories and high prognostic uncertainty, which serve as barriers to patient-clinician communication about prognosis and their values and preferences for the future in the event of worsening health. Little is known about patients' day-to-day lived experiences and how this shapes their willingness to engage in such conversations.
    Objectives: To explore participant perspectives on living with their illness and patient-clinician communication about prognosis and the future.
    Design: This is a qualitative study using semi-structured interviews.
    Setting/subjects: Patients with relapsed and refractory (R/R) AML and high-risk MDS from a northeastern U.S. cancer center.
    Data collection: Interviews were transcribed verbatim and thematic analysis was used to generate findings.
    Results: Of the 14 participants, the mean age was 66 years, 79% were men, 93% were White, married, and had AML. The overarching theme that describes the experience was
    Conclusions: These data describe a unique perspective of patients with R/R AML and high-risk MDS that clinicians could use to enhance communication strategies.
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ISSN 2689-2820
    ISSN (online) 2689-2820
    DOI 10.1089/pmr.2023.0064
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  2. Article ; Online: Sleep health in young women with breast cancer: a narrative review.

    Hwang, Youri / Knobf, M Tish

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2022  Volume 30, Issue 8, Page(s) 6419–6428

    Abstract: Purpose: The purpose of this narrative review was to synthesize the evidence on sleep health in young women with breast cancer and provide recommendations for clinical practice and research.: Methods: Multiple databases were searched (OVID Medline, ... ...

    Abstract Purpose: The purpose of this narrative review was to synthesize the evidence on sleep health in young women with breast cancer and provide recommendations for clinical practice and research.
    Methods: Multiple databases were searched (OVID Medline, OVID PsycINFO, OVID Embase, and Scopus) using the search terms "breast neoplasm", "young women", "sleep", "sleep disturbance", "sleep problems", "sleep deficiency", and "insomnia". There were 467 titles and abstracts screened, and 82 full-text papers were reviewed, yielding 11 research publications for inclusion.
    Results: Sleep problems are prevalent among young women with breast cancer and are associated with vasomotor symptoms of menopause and psychological symptom distress. The evidence, however, is weak due to methodological and design aspects of the studies.
    Conclusions: Poor sleep health in women with breast cancer is a clinically relevant problem that persists after treatment. As sleep is multidimensional and multifactorial, future research should evaluate sleep with objective sleep measures as well as self-reports; consider longitudinal designs; include factors that potentially contribute to poor sleep quality, such as physical and psychological symptom distress, family stressors, and competing life demands for this age group; and explore the perspective of this younger population of survivors on sleep. For clinical practice, survivorship visits should incorporate sleep assessment for all breast cancer survivors, especially younger women.
    MeSH term(s) Breast Neoplasms/psychology ; Cancer Survivors ; Female ; Humans ; Quality of Life/psychology ; Sleep ; Sleep Initiation and Maintenance Disorders/complications ; Survivors
    Language English
    Publishing date 2022-03-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-06953-3
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    Zs.A 3697: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: Symptom network approach for management in cancer care.

    Liang, Minyu / Zhu, Siying / Zhang, Wenwen / Knobf, M Tish / Ye, Zengjie

    Asia-Pacific journal of oncology nursing

    2024  Volume 11, Issue 5, Page(s) 100482

    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 2984639-0
    ISSN 2349-6673 ; 2347-5625
    ISSN (online) 2349-6673
    ISSN 2347-5625
    DOI 10.1016/j.apjon.2024.100482
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  4. Article ; Online: Prognostic Communication Between Parents and Clinicians in Pediatric Oncology: An Integrative Review.

    Ouyang, Na / Feder, Shelli L / Baker, Justin N / Knobf, M Tish

    The American journal of hospice & palliative care

    2023  Volume 41, Issue 5, Page(s) 545–557

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Child ; Humans ; Female ; Prognosis ; Parents ; Communication ; Medical Oncology ; Neoplasms
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1074344-3
    ISSN 1938-2715 ; 1049-9091
    ISSN (online) 1938-2715
    ISSN 1049-9091
    DOI 10.1177/10499091231183107
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    Zs.B 3090: Show issues Location:
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  5. Article ; Online: Decreasing 30-Day Readmission Rates in Patients With Heart Failure.

    Rizzuto, Nancy / Charles, Greg / Knobf, M Tish

    Critical care nurse

    2022  Volume 42, Issue 4, Page(s) 13–19

    Abstract: Background: Heart failure affects approximately 6.2 million adults in the United States and has an estimated national cost of $30.7 billion annually. Despite advances in treatment, heart failure is a leading cause of hospital readmissions. Nonadherence ... ...

    Abstract Background: Heart failure affects approximately 6.2 million adults in the United States and has an estimated national cost of $30.7 billion annually. Despite advances in treatment, heart failure is a leading cause of hospital readmissions. Nonadherence to treatment plans, lack of education, and lack of access to care contribute to poorer outcomes.
    Local problem: For patients with heart failure, the mean readmission rate is 21% nationally and 23% in New York State. Before the pilot heart failure program began, the 30-day readmission rate in the study institution was 28.6%.
    Methods: A multidisciplinary team created a heart failure self-care pilot program that was implemented on a hospital telemetry unit with 47 patients. Patients received education on their disease process, medications, diet, exercise, and early symptom recognition. Patients received a follow-up telephone call 48 to 72 hours after discharge and were seen by a cardiologist within a week of discharge.
    Results: The 30-day readmission rate for heart failure decreased by 16.6% after implementation of the pilot program, which improved patient adherence to their medication and treatment plan and resulted in a reduction of readmissions.
    Discussion: Patients in the pilot program represented diverse backgrounds. Socioeconomic factors such as the lack of affordable, healthy food choices and easy access to resources were associated with worse outcomes.
    Conclusions: The evidence-based heart failure program improved knowledge, early symptom recognition, lifestyle modification, and adherence to medication, treatment plan, and follow-up appointments. The multidisciplinary team approach to the heart failure program reduced gaps in care and improved coordination and transition of care.
    MeSH term(s) Adult ; Heart Failure/diagnosis ; Humans ; Patient Discharge ; Patient Readmission ; Self Care ; Telemetry ; United States
    Language English
    Publishing date 2022-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632663-8
    ISSN 1940-8250 ; 0279-5442
    ISSN (online) 1940-8250
    ISSN 0279-5442
    DOI 10.4037/ccn2022417
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    Zs.A 2102: Show issues Location:
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  6. Article: Metabolic Syndrome, Exercise, and Cardiovascular Fitness in Breast Cancer Survivors.

    Knobf, M Tish / Jeon, Sangchoon

    Journal of the advanced practitioner in oncology

    2020  Volume 11, Issue 1, Page(s) 98–102

    Abstract: Comorbid illness contributes to poorer cancer outcomes and higher mortality. Metabolic syndrome (MetS) includes a cluster of risk factors that are associated with an increased risk of comorbidities. Routine physical activity represents a risk reduction ... ...

    Abstract Comorbid illness contributes to poorer cancer outcomes and higher mortality. Metabolic syndrome (MetS) includes a cluster of risk factors that are associated with an increased risk of comorbidities. Routine physical activity represents a risk reduction strategy for cancer survivors. From 148 participants in a 12-month randomized control trial (RCT) of a fitness center exercise intervention compared to home physical activity group, a subset analysis was conducted to explore the effect of exercise on MetS risk factors. There were 32 (21.6%) breast cancer survivors who met the criteria for MetS at baseline. Over the 12 months, there were significantly fewer participants who met the criteria for MetS (
    Language English
    Publishing date 2020-01-01
    Publishing country United States
    Document type Journal Article
    ISSN 2150-0878
    ISSN 2150-0878
    DOI 10.6004/jadpro.2020.11.1.6
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  7. Article ; Online: Sentinel and networked symptoms in patients with breast cancer undergoing chemotherapy.

    Liang, Minyu / Zhong, Tong / Knobf, M Tish / Chen, Lisi / Xu, Min / Cheng, Beibei / Pan, Yichao / Zhou, Jian / Ye, Zengjie

    European journal of oncology nursing : the official journal of European Oncology Nursing Society

    2024  Volume 70, Page(s) 102566

    Abstract: Purpose: It was designed to identify the symptom clusters and sentinel symptoms among patients with breast cancer receiving chemotherapy at the community level, and to explore core and bridge symptoms at the global level.: Methods: A cross-sectional ... ...

    Abstract Purpose: It was designed to identify the symptom clusters and sentinel symptoms among patients with breast cancer receiving chemotherapy at the community level, and to explore core and bridge symptoms at the global level.
    Methods: A cross-sectional survey was conducted using the MD Anderson Symptom Inventory. Patients with breast cancer receiving chemotherapy, recruited from the "Be Resilient to Breast Cancer" project between January 2023 and December 2023, were included in the study. Symptom clusters and their sentinel symptoms were identified using exploratory factor analysis and Apriori algorithm. Core and bridge symptoms were identified using network analysis.
    Results: A total of 468 patients with breast cancer participated in the current study. At the community level, three symptom clusters and their corresponding sentinel symptoms were identified: a gastrointestinal symptom cluster (with nausea as the sentinel symptom), a psycho-sleep-related symptom cluster (with distress as the sentinel symptom), and a neurocognition symptom cluster (with dry mouth as the sentinel symptom). At the global level, fatigue emerged as the core symptom, while disturbed sleep and lack of appetite as bridge symptoms.
    Conclusion: Addressing nausea, distress, and dry mouth are imperative for alleviating specific symptom clusters at the community level. Furthermore, targeting fatigue, disturbed sleep, and lack of appetite are crucial to break the interactions among diverse symptoms at the global level.
    Language English
    Publishing date 2024-03-13
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2017117-1
    ISSN 1532-2122 ; 1462-3889
    ISSN (online) 1532-2122
    ISSN 1462-3889
    DOI 10.1016/j.ejon.2024.102566
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    Zs.A 6219: Show issues Location:
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  8. Article ; Online: A qualitative study of sleep in young breast cancer survivors: "No longer able to sleep through the night".

    Hwang, Youri / Conley, Samantha / Redeker, Nancy S / Sanft, Tara / Knobf, M Tish

    Journal of cancer survivorship : research and practice

    2023  Volume 18, Issue 3, Page(s) 828–835

    Abstract: Sleep disturbance is common among women with breast cancer and is associated with greater symptom distress and poorer outcomes. Yet, for the unique subgroup of young women with breast cancer (YWBC), there is limited information on sleep. To address the ... ...

    Abstract Sleep disturbance is common among women with breast cancer and is associated with greater symptom distress and poorer outcomes. Yet, for the unique subgroup of young women with breast cancer (YWBC), there is limited information on sleep. To address the gap in our understanding of sleep health in YWBC, we explored their perspective on sleep quality, sleep changes over time, contributing factors, and any strategies used to promote sleep. As part of an explanatory sequential mixed method study, we recruited a sub-sample of 35 YWBC (≤ 50 years of age at the time of diagnosis) from the larger quantitative study phase. These participants were within the first 5 years since diagnosis and completed primary and systemic adjuvant therapy. We conducted virtual semi-structured interviews, transcribed them verbatim, and analyzed data with an interpretive description approach. YWBC experience difficulty falling asleep, waking up at night, and not feeling refreshed in the morning. They attributed interrupted sleep to vasomotor symptoms, anxiety/worry, ruminating thoughts, everyday life stressors, and discomfort. The sleep disturbance was most severe during and immediately after treatment but persisted across the 5 years of survivorship. The participants reported trying pharmacologic and non-pharmacologic strategies to improve the quantity and quality of their sleep. Future research would benefit from longitudinal designs to capture temporal changes in sleep and develop interventions to improve sleep health. Clinically, assessment of sleep health is indicated for YWBC related to the prevalence of disturbed sleep. IMPLICATIONS FOR CANCER SURVIVORS: Early access to sleep assessment and management, ideally before cancer treatment, would be beneficial for young breast cancer survivors. In addition, cancer treatment plans should include physical and psychological symptoms, especially those reported by women in this study: vasomotor symptoms, anxiety and worry, discomfort, and pain.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/psychology ; Breast Neoplasms/complications ; Breast Neoplasms/therapy ; Cancer Survivors/psychology ; Adult ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/psychology ; Sleep Wake Disorders/epidemiology ; Middle Aged ; Qualitative Research ; Sleep Quality ; Quality of Life ; Sleep ; Young Adult
    Language English
    Publishing date 2023-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2388888-X
    ISSN 1932-2267 ; 1932-2259
    ISSN (online) 1932-2267
    ISSN 1932-2259
    DOI 10.1007/s11764-023-01330-3
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  9. Article ; Online: The transition experience to breast cancer survivorship.

    Knobf, M Tish

    Seminars in oncology nursing

    2015  Volume 31, Issue 2, Page(s) 178–182

    Abstract: Objectives: To provide an overview of the concerns and needs of breast cancer survivors and describe approaches to quality patient-centered breast cancer survivorship care.: Data sources: Review of the literature including research reports, review ... ...

    Abstract Objectives: To provide an overview of the concerns and needs of breast cancer survivors and describe approaches to quality patient-centered breast cancer survivorship care.
    Data sources: Review of the literature including research reports, review papers, and clinically based articles.
    Conclusion: Breast cancer survivors report unmet needs and desire information and support to manage symptoms, cope with uncertainty and fears of recurrence, and guidelines for healthy lifestyle behaviors. Individualized and tailored survivorship care is required to meet the needs of those with varied risk profiles and recovery patterns.
    Implications for nursing practice: Nurses can be leaders in the assessment of needs after treatment, identification of those at higher risk for distress and ineffective coping, and in the delivery of high-quality care to breast cancer survivors.
    MeSH term(s) Adaptation, Psychological ; Breast Neoplasms/mortality ; Breast Neoplasms/nursing ; Breast Neoplasms/psychology ; Female ; Humans ; Oncology Nursing/methods ; Patient-Centered Care/methods ; Quality of Life/psychology ; Survival Rate ; Survivors/psychology
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632682-1
    ISSN 1878-3449 ; 0749-2081
    ISSN (online) 1878-3449
    ISSN 0749-2081
    DOI 10.1016/j.soncn.2015.02.006
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    Zs.B 2849: Show issues Location:
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  10. Article ; Online: Parenting experiences and outcomes among former adolescent mothers: A mixed methods study.

    Flaherty, Serena Cherry / Knobf, M Tish / Holland, Margaret L / Slade, Arietta / Nelson, LaRon / Sadler, Lois S

    PloS one

    2024  Volume 19, Issue 5, Page(s) e0303119

    Abstract: The purpose of this explanatory sequential mixed methods study was to examine parenting outcomes and experiences over time among marginalized adolescent mothers enrolled in randomized clinical trials (RCT) between 2002 and 2016 testing Minding the Baby® ( ...

    Abstract The purpose of this explanatory sequential mixed methods study was to examine parenting outcomes and experiences over time among marginalized adolescent mothers enrolled in randomized clinical trials (RCT) between 2002 and 2016 testing Minding the Baby® (MTB), an early home visiting program. The quantitative phase examined associations between measures of maternal experiences and parenting outcomes from 71 participants 2-8 years since RCT completion. MTB mothers reported less hostile parenting and fewer child behavior problems. The sequential qualitative phase involved interviews with a subsample (n = 31) and revealed six themes about their personal and parenting maturation. Through integration of quantitative and qualitative data, we generated metainferences, revealing a nuanced understanding of participants' experiences. Integrated findings revealed the complex personal and parenting experiences among former adolescent mothers during their developmental phases of emerging and early adulthood. Findings inform clinical and research approaches to promote personal growth and positive parenting outcomes over time among women who began childbearing in adolescence.
    MeSH term(s) Humans ; Adolescent ; Female ; Parenting/psychology ; Mothers/psychology ; Pregnancy in Adolescence/psychology ; Pregnancy ; Young Adult ; Adult
    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0303119
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