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  1. Book ; Online ; E-Book: Drachenzucht Für Einsteiger

    Knoepfler, Paul / Knoepfler, Julie / Niehaus, Monika

    Ein "Gefährlicher" Zeitvertreib Für Hobby-Genetiker

    2021  

    Abstract: Kann man einen Drachen züchten? Kann er dann Feuer spucken und fliegen? Können wir ihm eine eindrucksvolle Größe verleihen? Wie schlau sollen wir unseren Drachen machen, und können wir ihn trainieren? Wie wahrscheinlich ist es, dass wir bei unserem ... ...

    Author's details Paul Knoepfler and Julie Knoepfler ; Aus dem Englischen übersetzt von Monika Niehaus-Osterloh
    Abstract Kann man einen Drachen züchten? Kann er dann Feuer spucken und fliegen? Können wir ihm eine eindrucksvolle Größe verleihen? Wie schlau sollen wir unseren Drachen machen, und können wir ihn trainieren? Wie wahrscheinlich ist es, dass wir bei unserem Versuch, einen Drachen zu bauen, umkommen? Und geht das auch mit Einhörnern? Die Welt begeistert sich seit Jahrhunderten für Drachen und sie haben noch immer einen festen Platz in der Popkultur wie Smaug in „Der kleine Hobbit“ und die Drachen in „Game of Thrones“. Die Leute lieben Drachen und sind neugierig zu erfahren, ob man tatsächlich einen Drachen erschaffen kann. In diesem ungewöhnlichen Buch geht es darum, wie wir mit den allerneuesten wissenschaftlichen Techniken theoretisch einen Drachen erschaffen könnten. Dabei behandeln wir modernste wissenschaftliche Themen wie CRISPR, Biohacking, Stammzellenforschung und Bioengineering. Das Buch steckt voller Fakten, doch der Humor kommt nicht zu kurz, und es regt Leser*innen überdies an, sich Gedanken über den Einfluss von Wissenschaft und Technik auf unsere Gesellschaft zu machen. Unterwegs wirft das Buch einen satirischen Blick auf die Wissenschaft an vorderster Front, die oft in den Medien maßlos gehypt wird. Es diskutiert Schlüsseltechnologien, die ins Spiel kommen, wenn wir uns vorstellen, unsere Idee, einen Drachen zu bauen, in feuerspuckende Realität umzusetzen. Während wir all diese Themen diskutieren, sprechen wir auch über die ethischen Probleme, die sich beim „Bau“ eines Drachens ergeben, und die Möglichkeiten, einen ähnlichen Ansatz zu nutzen, um andere mythische Wesen, wie z.B. ein Einhorn, zu erschaffen. Dieses Buch, das jeden ansprechen sollte, enthält viele eindrucksvolle Illustrationen und andere interessante Abbildungen, darunter Drachendarstellungen, Bilder von Flugsaurierskeletten und vieles mehr. Autor ist Paul Knoepfler, der der Öffentlichkeit durch seine naturwissenschaftliche Arbeit, seinen Blog The Niche und seine häufigen Beiträge für ein breites Publikum zu neuen wissenschaftlichen Konzepten wie Stammzellforschung und CRISPR bekannt ist. Auch sein TED-Talk mit fast 1,2 Millionen Zuschauern und seine beiden Bücher Stem Cells: An Insider‘s Guide und Genmanipulierte Menschheit sind beliebt. Seine Koautorin, Julie Knoepfler, ist gerade einmal 16 Jahre alt und wird das Buch besonders auch jüngeren Leser*innen näherbringen. .
    Keywords Dragons/History ; Animal breeding
    Subject code 398.2454
    Language German
    Size 1 online resource (XII, 215 S. 43 Abb., 39 Abb. in Farbe.)
    Edition First edition.
    Publisher Springer-Verlag GmbH
    Publishing place Berlin, Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-662-62526-1 ; 3-662-62525-3 ; 978-3-662-62526-2 ; 978-3-662-62525-5
    DOI 10.1007/978-3-662-62526-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Genmanipulierte Menschheit

    Knoepfler, Paul / Wiese, Martina / Wiesemann, Claudia

    Evolution selbst gemacht

    2018  

    Title translation GMO sapiens
    Author's details Paul Knoepfler ; aus dem Englischen übersetzt von Martina Wiese ; mit einem Geleitwort von Prof. Dr. Claudia Wiesemann ; unter Mitarbeit von Ulrike Roll
    Keywords Mensch ; Gentechnologie ; Embryonale Stammzelle
    Subject Gentechnik ; Genchirurgie ; Genetic engineering ; Genetische Manipulation ; Genetische Technik ; Genmanipulation ; Menschen ; Homo sapiens
    Language German
    Size 1 Online-Ressource (XVIII, 264 Seiten), Illustrationen
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019702297
    ISBN 978-3-662-56001-3 ; 9783662560006 ; 3-662-56001-1 ; 3662560003
    DOI 10.1007/978-3-662-56001-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Knockout tales: the versatile roles of histone H3.3 in development and disease.

    Klein, Rachel H / Knoepfler, Paul S

    Epigenetics & chromatin

    2023  Volume 16, Issue 1, Page(s) 38

    Abstract: Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes H3f3a and ... ...

    Abstract Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes H3f3a and H3f3b have provided important insights into H3.3 functions including in gametes as well as brain and lung development. Knockouts have also provided insights into the important roles of H3.3 in maintaining genomic stability and chromatin organization, processes that are also affected when H3.3 is mutated in human diseases such as pediatric tumors and neurodevelopmental syndromes. Overall, H3.3 is a unique histone linking development and disease via epigenomic machinery.
    MeSH term(s) Child ; Humans ; Histones/genetics ; Histones/metabolism ; Neoplasms ; Genomic Instability ; Brain/metabolism
    Chemical Substances Histones
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2462129-8
    ISSN 1756-8935 ; 1756-8935
    ISSN (online) 1756-8935
    ISSN 1756-8935
    DOI 10.1186/s13072-023-00512-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Gene editing: sloppy definitions mislead.

    Knoepfler, Paul

    Nature

    2018  Volume 564, Issue 7736, Page(s) 345

    MeSH term(s) CRISPR-Cas Systems ; Gene Editing ; Genome
    Language English
    Publishing date 2018-12-19
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-018-07802-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rapid change of a cohort of 570 unproven stem cell clinics in the USA over 3 years.

    Knoepfler, Paul S

    Regenerative medicine

    2019  Volume 14, Issue 8, Page(s) 735–740

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Health Facilities/legislation & jurisprudence ; Health Facilities/standards ; Health Facilities/trends ; Humans ; Stem Cell Transplantation/legislation & jurisprudence ; Stem Cell Transplantation/standards ; Stem Cell Transplantation/trends ; Stem Cells ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2019-08-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2019-0064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends.

    Knoepfler, Paul S

    Cell stem cell

    2018  Volume 23, Issue 1, Page(s) 18–20

    Abstract: Regulators are now more often distinguishing between perceived good citizens and "bad actors" in stem cell and regenerative medicine clinical research, resulting in relatively more polar, carrot-and-stick oversight approaches. Here, I discuss why there ... ...

    Abstract Regulators are now more often distinguishing between perceived good citizens and "bad actors" in stem cell and regenerative medicine clinical research, resulting in relatively more polar, carrot-and-stick oversight approaches. Here, I discuss why there may be too much carrot and not enough stick by regulators for effective enforcement.
    MeSH term(s) Humans ; Stem Cell Transplantation/legislation & jurisprudence ; Stem Cell Transplantation/standards ; Stem Cells/cytology
    Language English
    Publishing date 2018-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2018.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mapping and driving the stem cell ecosystem.

    Knoepfler, Paul S

    Regenerative medicine

    2018  Volume 13, Issue 7, Page(s) 845–858

    Abstract: The stem cell and regenerative medicine arena has become increasingly complicated in recent years with thousands of people involved. There are as many as a dozen or more main groups of stakeholders, who together may be viewed as one ecosystem that is now ...

    Abstract The stem cell and regenerative medicine arena has become increasingly complicated in recent years with thousands of people involved. There are as many as a dozen or more main groups of stakeholders, who together may be viewed as one ecosystem that is now rapidly evolving. The nature of the ecosystem and its evolution have major implications for not just those within it, but also for medicine and society at large. Here, I describe this ecosystem and its evolution, as well as the negative impacts within the ecosystem of a constellation of hundreds of unproven for-profit clinics and related businesses. Finally, I propose approaches for how to positively influence and drive the future of the global stem cell ecosystem.
    MeSH term(s) Biotechnology/standards ; Biotechnology/trends ; Cell- and Tissue-Based Therapy/standards ; Cell- and Tissue-Based Therapy/trends ; Clinical Trials as Topic ; Government Agencies/legislation & jurisprudence ; Humans ; Investments ; Regenerative Medicine/legislation & jurisprudence ; Regenerative Medicine/trends ; Research/economics ; Research/trends ; Stem Cell Transplantation/legislation & jurisprudence ; Stem Cell Transplantation/trends ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2018-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2018-0056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Anticipated impact of stem cell and other cellular medicine clinical trials for COVID-19.

    Kim, Mina / Knoepfler, Paul S

    Regenerative medicine

    2021  Volume 16, Issue 6, Page(s) 525–533

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) COVID-19 ; Clinical Trials as Topic ; Humans ; SARS-CoV-2 ; Stem Cell Transplantation ; Stem Cells
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2021-0025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Stem cell models help crack regional oncohistone codes driving childhood gliomas.

    Klein, Rachel H / Knoepfler, Paul S

    Cell stem cell

    2021  Volume 28, Issue 5, Page(s) 785–787

    Abstract: In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and ...

    Abstract In this issue of Cell Stem Cell, Funato et al. (2021) and Bressan et al. (2021) use stem cells as models to define functions of the histone H3.3 G34R mutation in childhood gliomas. Both studies find strong regional specificity to oncohistone activity and implicate specific elements of an aberrantly locked-in neural progenitor transcriptional circuitry.
    MeSH term(s) Glioma/genetics ; Histones/genetics ; Humans ; Mutation/genetics ; Neural Stem Cells ; Oncogenes
    Chemical Substances Histones
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2021.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer.

    Klein, Rachel Herndon / Knoepfler, Paul S

    Stem cell reports

    2021  Volume 16, Issue 12, Page(s) 2844–2851

    Abstract: Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in stem cells but also found to be reactivated in cancer. Despite ... ...

    Abstract Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in stem cells but also found to be reactivated in cancer. Despite their striking expression pattern, for many years the function of DPPA2 and DPPA4 remained a mystery; knockout of Dppa2 and Dppa4 did not affect pluripotency, but caused lung and skeletal defects late in development, long after Dppa2 and Dppa4 expression had been turned off. A number of recent papers have further clarified and defined the roles of these important factors, identifying roles in priming the chromatin and maintaining developmental competency through regulating both H3K4me3 and H3K27me3 at bivalent chromatin domains, and acting to remodel chromatin and facilitate reprogramming of somatic cells to induced pluripotency. These findings highlight an important regulatory role for DPPA2 and DPPA4 at the transitional boundary between pluripotency and differentiation and may have relevance to the functions of DPPA2 and 4 in the context of cancer cells as well.
    MeSH term(s) Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Epigenomics ; Humans ; Neoplasms/genetics ; Pluripotent Stem Cells/metabolism ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2021-11-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2021.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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