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  1. Article ; Online: AR101: eindelijk een therapie voor pinda-allergie?

    Knol, Edward F

    Nederlands tijdschrift voor geneeskunde

    2019  Volume 163

    Abstract: AR101: therapy for peanut allergy finally in view? Worldwide, the incidence of peanut allergy is increasing. Spontaneous tolerance only occurs in a small percentage of children who are allergic to peanuts. To date, no treatment for this potentially life- ... ...

    Title translation AR101: therapy for peanut allergy finally in view?
    Abstract AR101: therapy for peanut allergy finally in view? Worldwide, the incidence of peanut allergy is increasing. Spontaneous tolerance only occurs in a small percentage of children who are allergic to peanuts. To date, no treatment for this potentially life-threatening condition has been proven effective. However, the recently published results of the PALISADE trial on oral immunotherapy with AR101 are promising. As AR101 has many side effects, and as it is unclear if tolerance persists after therapy is stopped, there is still a long way to go before AR101 can be added to the standard treatment for peanut allergy.
    MeSH term(s) Administration, Oral ; Biological Factors/administration & dosage ; Child ; Desensitization, Immunologic/methods ; Humans ; Peanut Hypersensitivity/therapy
    Chemical Substances Biological Factors
    Language Dutch
    Publishing date 2019-05-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.18: Show issues Location:
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  2. Article: Allergy: Type I, II, III, and IV.

    Knol, Edward F / Gilles, Stefanie

    Handbook of experimental pharmacology

    2021  Volume 268, Page(s) 31–41

    Abstract: Hypersensitivity reactions are overreactions of the immune system clinically seen as allergic and autoimmune diseases. Gell and Coombs originally described four different types of hypersensitivity reactions almost 60 years ago, and their description ... ...

    Abstract Hypersensitivity reactions are overreactions of the immune system clinically seen as allergic and autoimmune diseases. Gell and Coombs originally described four different types of hypersensitivity reactions almost 60 years ago, and their description still applies in large parts. However, some modifications and extensions have been included in original definition. Especially in allergic diseases, it became clear that often, multiple types of hypersensitivity reaction can occur simultaneously. This improved insight is not only important for a better understanding of hypersensitivity disorders, but is especially of importance for improved diagnostics and directing therapeutic interventions.
    MeSH term(s) Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/etiology
    Language English
    Publishing date 2021-07-13
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2021_510
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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  3. Article ; Online: Basophil Stimulation and Signaling Pathways.

    Knol, Edward F / Gibbs, Bernhard F

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2163, Page(s) 311–322

    Abstract: Despite the growing use of flow cytometry to analyze the functional characteristics of basophils, the intracellular signaling cascades that control their ability to elaborate various pro-allergic and inflammatory mediators and cytokines remain ... ...

    Abstract Despite the growing use of flow cytometry to analyze the functional characteristics of basophils, the intracellular signaling cascades that control their ability to elaborate various pro-allergic and inflammatory mediators and cytokines remain comparatively obscure. Additionally, some studies require the analysis of pro-allergic and inflammatory mediators, such as histamine, LTC
    MeSH term(s) Basophils/metabolism ; Blotting, Western ; Calcium/analysis ; Calcium/metabolism ; Cell Degranulation/physiology ; Cells, Cultured ; Cytokines/analysis ; Cytokines/metabolism ; Eicosanoids/analysis ; Eicosanoids/metabolism ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry/methods ; Histamine/analysis ; Histamine/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Signal Transduction ; Spectrometry, Fluorescence/methods ; Staining and Labeling/methods
    Chemical Substances Cytokines ; Eicosanoids ; Intracellular Signaling Peptides and Proteins ; Histamine (820484N8I3) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0696-4_25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Legends of Allergy/Immunology: Carla Bruijnzeel-Koomen.

    Fieten, Karin B / Knol, Edward F

    Allergy

    2018  Volume 74, Issue 3, Page(s) 637–638

    Language English
    Publishing date 2018-11-05
    Publishing country Denmark
    Document type News
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13627
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    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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  5. Article: Basophil Stimulation and Signaling Pathways

    Knol, Edward F / Gibbs, Bernhard F

    Methods Mol Biol

    Abstract: Despite the growing use of flow cytometry to analyze the functional characteristics of basophils, the intracellular signaling cascades that control their ability to elaborate various pro-allergic and inflammatory mediators and cytokines remain ... ...

    Abstract Despite the growing use of flow cytometry to analyze the functional characteristics of basophils, the intracellular signaling cascades that control their ability to elaborate various pro-allergic and inflammatory mediators and cytokines remain comparatively obscure. Additionally, some studies require the analysis of pro-allergic and inflammatory mediators, such as histamine, LTC4, and various basophil-derived cytokines (e.g., IL-4 and IL-13). Elucidation of intracellular signaling proteins by Western blotting, cytosolic free calcium concentration by spectrofluorophotometry, and detection of mediator releases, as well as analysis of gene expressions by RT-PCR, generally requires relatively large numbers of purified basophils. In selected assays, flow cytometry enables the analysis of relatively low cell numbers and purity for the expression of intracellular signaling proteins or measurement of cytosolic free calcium concentrations by basophil-specific gating strategies. Unfortunately, many aspects of signal transduction relevant to human basophils cannot be readily extrapolated from the use of basophil or mast cell lines. This chapter therefore focuses on how to employ primary human basophils for studying mediator releases and signaling characteristics.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32766986
    Database COVID19

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  6. Article ; Online: Differential dynamics of TARC during JAK-inhibitor therapy compared to biological therapies targeting type 2 inflammation.

    Boesjes, Celeste M / Bakker, Daphne S / Knol, Edward F / de Graaf, Marlies / van Wijk, Femke / de Bruin-Weller, Marjolein S

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2023  Volume 54, Issue 4, Page(s) 294–296

    MeSH term(s) Humans ; Chemokine CCL17 ; Inflammation ; Biological Therapy
    Chemical Substances Chemokine CCL17
    Language English
    Publishing date 2023-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 767: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Atopic dermatitis: A tale of two distinct pathomechanisms that make you itch.

    Knol, Edward F / Hijnen, DirkJan

    European journal of immunology

    2016  Volume 46, Issue 11, Page(s) 2512–2515

    Abstract: Atopic dermatitis (AD) or eczema is the most common chronic inflammatory skin disease. It is a multifactorial disease with local and systemic immune changes. Current therapies focus on restoring the local skin barrier or inhibiting immune responses. In ... ...

    Abstract Atopic dermatitis (AD) or eczema is the most common chronic inflammatory skin disease. It is a multifactorial disease with local and systemic immune changes. Current therapies focus on restoring the local skin barrier or inhibiting immune responses. In this issue of the European Journal of Immunology, Sehra et al. [Eur. J. Immunol. 2016. 46:2609-2613] describe a mouse model with T-cell-specific expression of constitutively active Stat6 in Flaky tail mice, which have mutations in the Flg and Tmem79 genes. The authors describe that it is the combination of changes in the skin barrier proteins filaggrin and Tmem79, together with Th2 cytokine signaling in the constitutively active Stat6 transgene, that drives the immune-pathomechanism in AD. These results are consistent with human studies where it is demonstrated that diminished filaggrin expression in skin is a predisposing factor for AD, but is neither required nor sufficient for disease indicating that additional factors are required for disease development. The current mouse model by Sehra et al. could be instrumental in evaluation new therapeutic strategies for AD.
    MeSH term(s) Animals ; Dermatitis, Atopic/genetics ; Disease Models, Animal ; Humans ; Mice ; Mutation ; Skin/immunology
    Language English
    Publishing date 2016
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201646708
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    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 85: Show issues

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  8. Article ; Online: Ocular surface disease in moderate-to-severe atopic dermatitis patients and the effect of biological therapy.

    Achten, Roselie / Thijs, Judith / van der Wal, Marlot / van Luijk, Chantal / Bakker, Daphne / Knol, Edward / van Luin, Matthijs / El Amrani, Mohsin / Delemarre, Eveline / Elfiky, Ahmed M I / de Boer, Joke / van Wijk, Femke / de Graaf, Marlies / de Bruin-Weller, Marjolein

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2024  Volume 54, Issue 4, Page(s) 241–252

    Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease for which new targeted therapies are currently available. Due to the increased rates of ocular surface disease (OSD) reported during treatment with these new targeted treatments, more insight ... ...

    Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease for which new targeted therapies are currently available. Due to the increased rates of ocular surface disease (OSD) reported during treatment with these new targeted treatments, more insight into the occurrence and pathomechanism of OSD in moderate-to-severe AD patients is needed. Therefore, this review's first part highlights that most patients with moderate-to-severe AD already have characteristics of OSD before starting targeted treatment. Remarkably, not all AD patients with OSD report ocular symptoms. OSD in AD is associated with less conjunctival goblet cells (GC) compared to healthy controls. In addition, OSD severity in AD patients is associated with high AD activity, the presence of eyelid and/or facial eczema, and high levels of AD-related severity biomarkers in tear fluid. The second part of this review highlights that pre-existing ocular pathology (e.g. in combination with the use of ophthalmic medication or eyelid eczema) may be associated with the development of dupilumab-associated ocular surface disease (DAOSD). During dupilumab treatment, DAOSD (which can be new-onset OSD or worsening of pre-existing OSD) is observed in approximately one-third of the dupilumab-treated AD patients. Anti-inflammatory ophthalmic treatment improves DAOSD, and dose reduction of dupilumab may also be an effective treatment option. The pathomechanism of DAOSD is still not fully elucidated. In a prospective study low, but stable conjunctival GC numbers were observed in moderate-to-severe AD patients, before and during dupilumab treatment. However, the Mucin 5 AC (MUC5AC) expression of GCs decreased during dupilumab treatment, suggesting an impairment of the GC function by dupilumab treatment. In addition, higher dupilumab tear fluid levels were found in dupilumab-treated AD patients with moderate-to-severe OSD compared to patients with no or mild OSD, whereas the dupilumab serum levels are similar. Clinicians should be aware of the frequent occurrence of OSD in moderate-to-severe AD patients, and a low-threshold referral to an ophthalmologist is recommended.
    MeSH term(s) Humans ; Dermatitis, Atopic ; Antibodies, Monoclonal/therapeutic use ; Prospective Studies ; Eczema ; Treatment Outcome ; Biological Therapy ; Severity of Illness Index
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14461
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  9. Article ; Online: Basophil stimulation and signaling pathways.

    Knol, Edward F / Gibbs, Bernhard F

    Methods in molecular biology (Clifton, N.J.)

    2014  Volume 1192, Page(s) 193–203

    Abstract: Despite growing use of flow cytometry to analyze the functional characteristics of primary basophils the intracellular signaling cascades that control their ability to elaborate various inflammatory mediators and cytokines remain comparatively obscure. ... ...

    Abstract Despite growing use of flow cytometry to analyze the functional characteristics of primary basophils the intracellular signaling cascades that control their ability to elaborate various inflammatory mediators and cytokines remain comparatively obscure. Additionally, some studies require the analysis of pro-allergic and inflammatory mediators, such as histamine, LTC4, and various basophil-derived cytokines (e.g., IL-4 and IL-13). Elucidation of intracellular signaling proteins by Western blotting, cytosolic free calcium concentration by spectrofluorophotometry, and detection of mediator releases, as well as analysis of gene expressions by RT-PCR, generally require relatively large numbers of purified basophils. In selected assays, flow cytometry can enable the analysis of relatively low cell numbers and purity for the expression of intracellular signaling proteins or measurement of cytosolic free calcium concentrations by basophil-specific gating strategies. Unfortunately, many aspects of signal transduction relevant to human basophils cannot be readily extrapolated from the use of basophil or mast cell lines. This chapter therefore focuses on how to employ primary human basophils for studying mediator releases and signaling characteristics.
    MeSH term(s) Basophil Degranulation Test/methods ; Basophils/cytology ; Basophils/immunology ; Basophils/metabolism ; Cell Culture Techniques/methods ; Cells, Cultured ; Cytokines/analysis ; Cytokines/metabolism ; Eicosanoids/analysis ; Eicosanoids/metabolism ; Histamine/analysis ; Histamine/metabolism ; Humans ; Signal Transduction ; Staining and Labeling/methods
    Chemical Substances Cytokines ; Eicosanoids ; Histamine (820484N8I3)
    Keywords covid19
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-1173-8_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Historic overview of allergy research in the Netherlands.

    Aalberse, Rob C / Knol, Edward F

    Immunology letters

    2014  Volume 162, Issue 2 Pt B, Page(s) 163–172

    Abstract: Research in allergy has a long history in the Netherlands, although the relation with immunology has not always been appreciated. In many aspects Dutch researchers have made major contribution in allergy research. This ranges from the first ... ...

    Abstract Research in allergy has a long history in the Netherlands, although the relation with immunology has not always been appreciated. In many aspects Dutch researchers have made major contribution in allergy research. This ranges from the first characterization of house dust mite as an important allergen, the first characterization of human Th2 and Th1 T cell clones, to the development of diagnostic test systems. In this overview Aalberse and Knol have made an overview of the major contributions of Dutch immunologists in allergy.
    MeSH term(s) Allergens/immunology ; Animals ; Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/history ; Hypersensitivity/immunology ; Th1 Cells/immunology ; Th2 Cells/immunology
    Chemical Substances Allergens
    Language English
    Publishing date 2014-12
    Publishing country Netherlands
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2014.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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