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  1. Article ; Conference proceedings: Unleashing Synergistic T Cell Power: Novel Insights into Cooperative Killing of Virus-Infected Hepatocytes by Conventional and Auto-Aggressive CD8 T Cells

    Eceiza, Ariane / Dudek, Michael / Wohlleber, Dirk / Knolle, Percy A.

    Zeitschrift für Gastroenterologie

    2024  Volume 62, Issue 01

    Event/congress 40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26
    Language German
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1777632
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
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  2. Article ; Online: Staying local-antigen presentation in the liver.

    Knolle, Percy A

    Current opinion in immunology

    2016  Volume 40, Page(s) 36–42

    Abstract: The liver is known as organ with unique immune competence. Besides its unique microenvironment that is determined by gut-derived portal venous blood constituents and the presence of enzymes with immune regulatory properties, liver antigen presenting cell ...

    Abstract The liver is known as organ with unique immune competence. Besides its unique microenvironment that is determined by gut-derived portal venous blood constituents and the presence of enzymes with immune regulatory properties, liver antigen presenting cell populations regulate antigen-specific immunity in a local fashion. In addition to bone marrow-derived dendritic cells and myeloid cells such as macrophages and monocytes, also truly liver-resident cell populations function as antigen presenting cells such as liver sinusoidal endothelial cells and hepatocytes. The functional outcome of antigen-presentation by these cell populations is diverse and ranges from generation of regulatory CD4 cells, to induction of memory CD8 T cells or deletional tolerance, which generates a complex network of antigen-presenting cells that determines hepatic immune regulation and local immune surveillance against viral infection.
    MeSH term(s) Animals ; Antigen Presentation ; Antigen-Presenting Cells/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cellular Microenvironment/immunology ; Hepatocytes/physiology ; Humans ; Immune Tolerance ; Immunologic Memory ; Immunologic Surveillance ; Liver/immunology ; Liver/pathology ; Lymphocyte Activation ; T-Lymphocytes, Regulatory/physiology ; Virus Diseases/immunology
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2016.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2773: Show issues Location:
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  3. Article ; Online: Hitting the right button: MAVS-mediated defense against HAV infection.

    Knolle, Percy A

    Cell research

    2016  Volume 27, Issue 1, Page(s) 7–8

    Abstract: Studying the immune response against infection with hepatitis viruses is hampered by the lack of suitable preclinical model systems. A recent publication in Science identifies the cytosolic adapter molecule MAVS as being responsible for species ... ...

    Abstract Studying the immune response against infection with hepatitis viruses is hampered by the lack of suitable preclinical model systems. A recent publication in Science identifies the cytosolic adapter molecule MAVS as being responsible for species restriction of infection with hepatitis A virus as well as linking cytosolic immune sensing in infected hepatocytes with innate effector functions and protective adaptive immunity.
    MeSH term(s) Adaptor Proteins, Signal Transducing ; Hepatitis A Virus, Human ; Hepatitis A virus ; Hepatocytes ; Humans ; Virulence
    Chemical Substances Adaptor Proteins, Signal Transducing
    Language English
    Publishing date 2016-11-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/cr.2016.139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5283: Show issues Location:
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  4. Article ; Online: Local tissue development of type 1 innate lymphoid cells: guided by interferon-gamma.

    Conlon, Thomas M / Knolle, Percy A / Yildirim, Ali Önder

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 287

    MeSH term(s) Immunity, Innate ; Interferon-gamma ; Lymphocytes
    Chemical Substances Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-07-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00705-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Precision-cut Liver Slices zur Untersuchung zellautonomer antiviraler Abwehr von Hepatozyten ex vivo bei erhaltenen zellulären dreidimensionalen Interaktionen

    Brugger, Marcus Verfasser] / [Knolle, Percy A. [Akademischer Betreuer] / Knolle, Percy A. [Gutachter] / Mogler, Carolin [Gutachter]

    2022  

    Author's details Marcus Brugger ; Gutachter: Percy A. Knolle, Carolin Mogler ; Betreuer: Percy A. Knolle
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  6. Book ; Online ; Thesis: Die Regulation der Produktion des Hepatocyte Growth Factor in sinusoidalen Leberendothelzellen

    Lüdemann, Max Verfasser] / [Knolle, Percy A. [Akademischer Betreuer] / Knolle, Percy A. [Gutachter] / Zehn, Dietmar [Gutachter]

    2022  

    Author's details Max Lüdemann ; Gutachter: Percy A. Knolle, Dietmar Zehn ; Betreuer: Percy A. Knolle
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  7. Article ; Conference proceedings: A tissue-rheostat induced by hepatic cells limits antiviral CD8 T cell immunity during persistent infections

    Fürst, Anna / Chattopadhyay, Sutirtha / Wintersteller, Hannah / Bosch, Miriam / Wohlleber, Dirk / Knolle, Percy A.

    Zeitschrift für Gastroenterologie

    2024  Volume 62, Issue 01

    Event/congress 40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26
    Language German
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1777628
    Database Thieme publisher's database

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    Zs.A 111: Show issues Location:
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  8. Article ; Online: Interfering with Kupffer cell replenishment: New insights into liver injury.

    Alazawi, William / Knolle, Percy A

    Journal of hepatology

    2018  Volume 68, Issue 4, Page(s) 635–637

    MeSH term(s) Hepatitis ; Humans ; Kupffer Cells ; Liver ; Receptor, Interferon alpha-beta ; Signal Transduction
    Chemical Substances Receptor, Interferon alpha-beta (156986-95-7)
    Language English
    Publishing date 2018-02-17
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2018.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
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  9. Article: Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing

    Luedemann, Max / Stadler, Daniela / Cheng, Cho-Chin / Protzer, Ulrike / Knolle, Percy A. / Donakonda, Sainitin

    Computational and Structural Biotechnology Journal. 2022, v. 20

    2022  

    Abstract: Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of SARS-CoV-2 infection and of ... ...

    Abstract Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of SARS-CoV-2 infection and of IL-6 production by immune cells. We created a computational structure model of the receptor binding domain (RBD) of the SARS-CoV-2 spike 1 protein, and used this model for insilico screening against a library of 6171 molecularly defined binding-sites from drug molecules. Molecular dynamics simulation of candidate molecules with high RBD binding-scores in docking analysis predicted montelukast, an antagonist of the cysteinyl-leukotriene-receptor, to disturb the RBD structure, and infection experiments demonstrated inhibition of SARS-CoV-2 infection, although montelukast binding was outside the ACE2-binding site. Molecular dynamics simulation of SARS-CoV-2 variant RBDs correctly predicted interference of montelukast with infection by the beta but not the more infectious alpha variant. With distinct binding sites for RBD and the leukotriene receptor, montelukast also prevented SARS-CoV-2-induced IL-6 release from immune cells. The inhibition of SARS-CoV-2 infection through a molecule binding distal to the ACE-binding site of the RBD points towards an allosteric mechanism that is not conserved in the more infectious alpha and delta SARS-CoV-2 variants.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antagonists ; binding sites ; biotechnology ; disease course ; drugs ; interleukin-6 ; models ; molecular dynamics
    Language English
    Size p. 799-811.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.01.024
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Montelukast is a dual-purpose inhibitor of SARS-CoV-2 infection and virus-induced IL-6 expression identified by structure-based drug repurposing.

    Luedemann, Max / Stadler, Daniela / Cheng, Cho-Chin / Protzer, Ulrike / Knolle, Percy A / Donakonda, Sainitin

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 799–811

    Abstract: Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of SARS-CoV-2 infection and of ... ...

    Abstract Drug-repurposing has been instrumental to identify drugs preventing SARS-CoV-2 replication or attenuating the disease course of COVID-19. Here, we identify through structure-based drug-repurposing a dual-purpose inhibitor of SARS-CoV-2 infection and of IL-6 production by immune cells. We created a computational structure model of the receptor binding domain (RBD) of the SARS-CoV-2 spike 1 protein, and used this model for
    Language English
    Publishing date 2022-01-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.01.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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