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  1. AU="Knopp, Lisa"
  2. AU="Stecca, Giuseppe"
  3. AU="Yantis, Jennifer"
  4. AU="Zhao, Xihan"
  5. AU="Gong, J N"
  6. AU=Jain Vijay Kumar
  7. AU="Tapia, Jose C"
  8. AU="Alelayan, Hasan"
  9. AU="Geerling, Elizabeth C"
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  22. AU=Ren Ziyuan
  23. AU="Tae-Houn Kim"
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  25. AU="Karagiannidis, Artemios G"
  26. AU="Alice H Reis"
  27. AU="Malik, Shahbaz A"
  28. AU=Mittal Rajat AU=Mittal Rajat
  29. AU="Seguin, Rebecca A"
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  1. Article: Towards a global seasonal and permanent reference water product from Sentinel-1/2 data for improved flood mapping

    Martinis, Sandro / Groth, Sandro / Wieland, Marc / Knopp, Lisa / Rättich, Michaela

    Remote sensing of environment. 2022 Sept. 01, v. 278

    2022  

    Abstract: Satellite-based flood mapping has become an important part of disaster response. In order to accurately distinguish flood inundation from normally present conditions, up-to-date, high-resolution information on the seasonal water cover is crucial. This ... ...

    Abstract Satellite-based flood mapping has become an important part of disaster response. In order to accurately distinguish flood inundation from normally present conditions, up-to-date, high-resolution information on the seasonal water cover is crucial. This information is usually neglected in disaster management, which may result in a non-reliable representation of the flood extent, mainly in regions with highly dynamic hydrological conditions. In this study, we present a fully automated method to generate a global reference water product specifically designed for the use in global flood mapping applications based on high resolution Earth Observation data. The proposed methodology combines existing processing pipelines for flood detection based on Sentinel-1/2 data and aggregates permanent as well as seasonal water masks over an adjustable reference time period. The water masks are primarily based on the analysis of Sentinel-2 data and are complemented by Sentinel-1-based information in optical data scarce regions. First results are demonstrated in five selected study areas (Australia, Germany, India, Mozambique, and Sudan), distributed across different climate zones and are systematically compared with external products. Further, the proposed product is exemplary applied to three real flood events in order to evaluate the impact of the used reference water mask on the derived flood extent. Results show, that it is possible to generate a consistent reference water product at 10–20 m spatial resolution, that is more suitable for the use in rapid disaster response than previous masks. The proposed multi-sensor approach is capable of producing reasonable results, even if only few or no information from optical data is available. Further it becomes clear, that the consideration of seasonality of water bodies, especially in regions with highly dynamic hydrological and climatic conditions, reduces potential over-estimation of the inundation extent and gives a more reliable picture on flood-affected areas.
    Keywords automation ; disaster preparedness ; satellites ; Australia ; Germany ; India ; Mozambique ; Sudan
    Language English
    Dates of publication 2022-0901
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 431483-9
    ISSN 0034-4257
    ISSN 0034-4257
    DOI 10.1016/j.rse.2022.113077
    Database NAL-Catalogue (AGRICOLA)

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  2. Book ; Online: What the River Carries

    Knopp, Lisa

    Encounters with the Mississippi, Missouri, and Platte

    2014  

    Language English
    Size Online-Ressource (248 p)
    Publisher University of Missouri Press
    Publishing place Columbia
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780826219749 ; 0826219748
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book ; Online: Interior places

    Knopp, Lisa

    2008  

    Abstract: A collection of essays embracing nonfiction from memoir and biography to travel writing and natural history, Interior Places offers a curiously detailed group photograph of the Midwest's interior landscape. Here is an essay about the origin, history, and ...

    Institution ebrary, Inc
    Author's details Lisa Knopp
    Abstract A collection of essays embracing nonfiction from memoir and biography to travel writing and natural history, Interior Places offers a curiously detailed group photograph of the Midwest's interior landscape. Here is an essay about the origin, history, and influence of corn. Here we find an exploration of a childhood meeting with Frederick Leopold, youngest brother of the great naturalist Aldo. Here also are a chronicle of the 146-year alliance between Burlington, Iowa, and the Burlington Route (later the CB&O, the BN, and finally, the BNSF) and a pilgrimage to Amelia Earhart's Kansas hometown
    Keywords Home/Psychological aspects ; Natural history ; Women authors, American ; Lincoln Region (Neb.) ; Nebraska
    Language English
    Size Online-Ressource (x, 289 p), 23 cm
    Publisher University of Nebraska Press
    Publishing place Lincoln
    Document type Book ; Online
    Note "Bison Books"--P. [i] ; Includes bibliographical references (p. 279-289)
    ISBN 9780803211438 ; 0803211430
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Online: Flight Dreams

    Knopp, Lisa / Stone, Albert E

    A Life in the Midwestern Landscape

    (Singular Lives)

    1998  

    Abstract: When I was eleven the world was filled with birds,”writes Lisa Knopp of her girlhood in Burlington, Iowa. Picking up where she left off in her first book, Field of Vision, Knopp knits together sections of her life story through a pattern of images ... ...

    Series title Singular Lives
    Abstract “When I was eleven the world was filled with birds,”writes Lisa Knopp of her girlhood in Burlington, Iowa. Picking up where she left off in her first book, Field of Vision, Knopp knits together sections of her life story through a pattern of images drawn from nature. The most prevalent of these unifying themes are metaphors of flight—birds, wind, moving upward and outward and across the midwestern landscape from Nebraska and Iowa to southern Illinois.Reminiscent of Thoreau's introspective nature writing and Dillard's taut, personal prose, each chapter in Flight Dreams
    Language English
    Size Online-Ressource (305 p.)
    Publisher University of Iowa Press
    Publishing place Iowa City
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780877456452 ; 0877456453
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Detailed stratified GWAS analysis for severe COVID-19 in four European populations.

    Degenhardt, Frauke / Ellinghaus, David / Juzenas, Simonas / Lerga-Jaso, Jon / Wendorff, Mareike / Maya-Miles, Douglas / Uellendahl-Werth, Florian / ElAbd, Hesham / Rühlemann, Malte C / Arora, Jatin / Özer, Onur / Lenning, Ole Bernt / Myhre, Ronny / Vadla, May Sissel / Wacker, Eike M / Wienbrandt, Lars / Blandino Ortiz, Aaron / de Salazar, Adolfo / Garrido Chercoles, Adolfo /
    Palom, Adriana / Ruiz, Agustín / Garcia-Fernandez, Alba-Estela / Blanco-Grau, Albert / Mantovani, Alberto / Zanella, Alberto / Holten, Aleksander Rygh / Mayer, Alena / Bandera, Alessandra / Cherubini, Alessandro / Protti, Alessandro / Aghemo, Alessio / Gerussi, Alessio / Ramirez, Alfredo / Braun, Alice / Nebel, Almut / Barreira, Ana / Lleo, Ana / Teles, Ana / Kildal, Anders Benjamin / Biondi, Andrea / Caballero-Garralda, Andrea / Ganna, Andrea / Gori, Andrea / Glück, Andreas / Lind, Andreas / Tanck, Anja / Hinney, Anke / Carreras Nolla, Anna / Fracanzani, Anna Ludovica / Peschuck, Anna / Cavallero, Annalisa / Dyrhol-Riise, Anne Ma / Ruello, Antonella / Julià, Antonio / Muscatello, Antonio / Pesenti, Antonio / Voza, Antonio / Rando-Segura, Ariadna / Solier, Aurora / Schmidt, Axel / Cortes, Beatriz / Mateos, Beatriz / Nafria-Jimenez, Beatriz / Schaefer, Benedikt / Jensen, Björn / Bellinghausen, Carla / Maj, Carlo / Ferrando, Carlos / de la Horra, Carmen / Quereda, Carmen / Skurk, Carsten / Thibeault, Charlotte / Scollo, Chiara / Herr, Christian / Spinner, Christoph D / Gassner, Christoph / Lange, Christoph / Hu, Cinzia / Paccapelo, Cinzia / Lehmann, Clara / Angelini, Claudio / Cappadona, Claudio / Azuure, Clinton / Bianco, Cristiana / Cea, Cristina / Sancho, Cristina / Hoff, Dag Arne Lihaug / Galimberti, Daniela / Prati, Daniele / Haschka, David / Jiménez, David / Pestaña, David / Toapanta, David / Muñiz-Diaz, Eduardo / Azzolini, Elena / Sandoval, Elena / Binatti, Eleonora / Scarpini, Elio / Helbig, Elisa T / Casalone, Elisabetta / Urrechaga, Eloisa / Paraboschi, Elvezia Maria / Pontali, Emanuele / Reverter, Enric / Calderón, Enrique J / Navas, Enrique / Solligård, Erik / Contro, Ernesto / Arana-Arri, Eunate / Aziz, Fátima / Garcia, Federico / García Sánchez, Félix / Ceriotti, Ferruccio / Martinelli-Boneschi, Filippo / Peyvandi, Flora / Kurth, Florian / Blasi, Francesco / Malvestiti, Francesco / Medrano, Francisco J / Mesonero, Francisco / Rodriguez-Frias, Francisco / Hanses, Frank / Müller, Fredrik / Hemmrich-Stanisak, Georg / Bellani, Giacomo / Grasselli, Giacomo / Pezzoli, Gianni / Costantino, Giorgio / Albano, Giovanni / Cardamone, Giulia / Bellelli, Giuseppe / Citerio, Giuseppe / Foti, Giuseppe / Lamorte, Giuseppe / Matullo, Giuseppe / Baselli, Guido / Kurihara, Hayato / Neb, Holger / My, Ilaria / Kurth, Ingo / Hernández, Isabel / Pink, Isabell / de Rojas, Itziar / Galván-Femenia, Iván / Holter, Jan Cato / Afset, Jan Egil / Heyckendorf, Jan / Kässens, Jan / Damås, Jan Kristian / Rybniker, Jan / Altmüller, Janine / Ampuero, Javier / Martín, Javier / Erdmann, Jeanette / Banales, Jesus M / Badia, Joan Ramon / Dopazo, Joaquin / Schneider, Jochen / Bergan, Jonas / Barretina, Jordi / Walter, Jörn / Hernández Quero, Jose / Goikoetxea, Josune / Delgado, Juan / Guerrero, Juan M / Fazaal, Julia / Kraft, Julia / Schröder, Julia / Risnes, Kari / Banasik, Karina / Müller, Karl Erik / Gaede, Karoline I / Garcia-Etxebarria, Koldo / Tonby, Kristian / Heggelund, Lars / Izquierdo-Sanchez, Laura / Bettini, Laura Rachele / Sumoy, Lauro / Sander, Leif Erik / Lippert, Lena J / Terranova, Leonardo / Nkambule, Lindokuhle / Knopp, Lisa / Gustad, Lise Tuset / Garbarino, Lucia / Santoro, Luigi / Téllez, Luis / Roade, Luisa / Ostadreza, Mahnoosh / Intxausti, Maider / Kogevinas, Manolis / Riveiro-Barciela, Mar / Berger, Marc M / Schaefer, Marco / Niemi, Mari E K / Gutiérrez-Stampa, María A / Carrabba, Maria / Figuera Basso, Maria E / Valsecchi, Maria Grazia / Hernandez-Tejero, María / Vehreschild, Maria J G T / Manunta, Maria / Acosta-Herrera, Marialbert / D'Angiò, Mariella / Baldini, Marina / Cazzaniga, Marina / Grimsrud, Marit M / Cornberg, Markus / Nöthen, Markus M / Marquié, Marta / Castoldi, Massimo / Cordioli, Mattia / Cecconi, Maurizio / D'Amato, Mauro / Augustin, Max / Tomasi, Melissa / Boada, Mercè / Dreher, Michael / Seilmaier, Michael J / Joannidis, Michael / Wittig, Michael / Mazzocco, Michela / Ciccarelli, Michele / Rodríguez-Gandía, Miguel / Bocciolone, Monica / Miozzo, Monica / Imaz Ayo, Natale / Blay, Natalia / Chueca, Natalia / Montano, Nicola / Braun, Nicole / Ludwig, Nicole / Marx, Nikolaus / Martínez, Nilda / Cornely, Oliver A / Witzke, Oliver / Palmieri, Orazio / Faverio, Paola / Preatoni, Paoletta / Bonfanti, Paolo / Omodei, Paolo / Tentorio, Paolo / Castro, Pedro / Rodrigues, Pedro M / España, Pedro Pablo / Hoffmann, Per / Rosenstiel, Philip / Schommers, Philipp / Suwalski, Phillip / de Pablo, Raúl / Ferrer, Ricard / Bals, Robert / Gualtierotti, Roberta / Gallego-Durán, Rocío / Nieto, Rosa / Carpani, Rossana / Morilla, Rubén / Badalamenti, Salvatore / Haider, Sammra / Ciesek, Sandra / May, Sandra / Bombace, Sara / Marsal, Sara / Pigazzini, Sara / Klein, Sebastian / Pelusi, Serena / Wilfling, Sibylle / Bosari, Silvano / Volland, Sonja / Brunak, Søren / Raychaudhuri, Soumya / Schreiber, Stefan / Heilmann-Heimbach, Stefanie / Aliberti, Stefano / Ripke, Stephan / Dudman, Susanne / Wesse, Tanja / Zheng, Tenghao / Bahmer, Thomas / Eggermann, Thomas / Illig, Thomas / Brenner, Thorsten / Pumarola, Tomas / Feldt, Torsten / Folseraas, Trine / Gonzalez Cejudo, Trinidad / Landmesser, Ulf / Protzer, Ulrike / Hehr, Ute / Rimoldi, Valeria / Monzani, Valter / Skogen, Vegard / Keitel, Verena / Kopfnagel, Verena / Friaza, Vicente / Andrade, Victor / Moreno, Victor / Albrecht, Wolfgang / Peter, Wolfgang / Poller, Wolfgang / Farre, Xavier / Yi, Xiaoli / Wang, Xiaomin / Khodamoradi, Yascha / Karadeniz, Zehra / Latiano, Anna / Goerg, Siegfried / Bacher, Petra / Koehler, Philipp / Tran, Florian / Zoller, Heinz / Schulte, Eva C / Heidecker, Bettina / Ludwig, Kerstin U / Fernández, Javier / Romero-Gómez, Manuel / Albillos, Agustín / Invernizzi, Pietro / Buti, Maria / Duga, Stefano / Bujanda, Luis / Hov, Johannes R / Lenz, Tobias L / Asselta, Rosanna / de Cid, Rafael / Valenti, Luca / Karlsen, Tom H / Cáceres, Mario / Franke, Andre

    Human molecular genetics

    2022  Volume 31, Issue 23, Page(s) 3945–3966

    Abstract: Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an ... ...

    Abstract Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
    MeSH term(s) Humans ; COVID-19/genetics ; SARS-CoV-2/genetics ; Genome-Wide Association Study ; Haplotypes ; Polymorphism, Genetic
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/ddac158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

    Degenhardt, Frauke / Ellinghaus, David / Juzenas, Simonas / Lerga-Jaso, Jon / Wendorff, Mareike / Maya-Miles, Douglas / Uellendahl-Werth, Florian / ElAbd, Hesham / Ruehlemann, Malte C. / Arora, Jatin / oezer, Onur / Lenning, Ole Bernt / Myhre, Ronny / Vadla, May Sissel / Wacker, Eike Matthias / Wienbrandt, Lars / Blandino Ortiz, Aaron / de Salazar, Adolfo / Garrido Chercoles, Adolfo /
    Palom, Adriana / Ruiz, Agustin / Mantovani, Alberto / Zanella, Alberto / Rygh Holten, Aleksander / Mayer, Alena / Bandera, Alessandra / Cherubini, Alessandro / Protti, Alessandro / Aghemo, Alessio / Gerussi, Alessio / Popov, Alexander / Ramirez, Alfredo / Braun, Alice / Nebel, Almut / Barreira, Ana / Lleo, Ana / Teles, Ana / Kildal, Anders Benjamin / Biondi, Andrea / Ganna, Andrea / Gori, Andrea / Glueck, Andreas / Lind, Andreas / Hinney, Anke / Carreras Nolla, Anna / Fracanzani, Anna Ludovica / Cavallero, Annalisa / Dyrhol-Riise, Anne Ma / Ruello, Antonella / Julia, Antonio / Muscatello, Antonio / Pesenti, Antonio / Voza, Antonio / Rando-Segura, Ariadna / Solier, Aurora / Cortes, Beatriz / Mateos, Beatriz / Nafria-Jimenez, Beatriz / Schaefer, Benedikt / Jensen, Bjoern / Bellinghausen, Carla / Maj, Carlo / Ferrando, Carlos / de la Horrra, Carmen / Quereda, Carmen / Skurk, Carsten / Thibeault, Charlotte / Scollo, Chiara / Herr, Christian / Spinner, Christoph D. / Lange, Christoph / Hu, Cinzia / Lehmann, Clara / Cappadona, Claudio / Azuure, Clinton / COVICAT study group / Covid-19 Aachen Study (COVAS) / Bianco, Cristiana / Sancho, Cristina / Lihaug Hoff, Dag Arne / Galimberti, Daniela / Prati, Daniele / Haschka, David / Jimenez, David / Pestana, David / Toapanta, David / Azzolini, Elena / Scarpini, Elio / Helbig, Elisa T. / Urrechaga, Eloisa / Paraboschi, Elvezia Maria / Pontali, Emanuele / Reverter, Enric / Calderon, Enrique J. / Navas, Enrique / Solligard, Erik / Contro, Ernesto / Arana, Eunate / Garcia, Federico / Garcia Sanchez, Felix / Ceriotti, Ferruccio / Martinelli-Boneschi, Filippo / Peyvandi, Flora / Kurth, Florian / Blasi, Francesco / Malvestiti, Francesco / Medrano, Francisco J. / Mesonero, Francisco / Rodriguez-Frias, Francisco / Hanses, Frank / Mueller, Fredrik / Bellani, Giacomo / Grasselli, Giacomo / Pezzoli, Gianni / Costantino, Giorgio / Albano, Giovanni / Bellelli, Giuseppe / Citerio, Giuseppe / Foti, Giuseppe / Lamorte, Giuseppe / Neb, Holger / My, Ilaria / Kurth, Ingo / Hernandez, Isabel / Pink, Isabell / de Rojas, Itziar / Galvan-Femenia, Ivan / Holter, Jan C. / Egil Afset, Jan Egil / Heyckendorf, Jan / Damas, Jan / Rybniker, Jan Kristian / Altmueller, Janine / Ampuero, Javier / Banales, Jesus M. / Ramon Badia, Joan / Dopazo, Joaquin / Schneider, Jochen / Bergan, Jonas / Barretina, Jordi / Walter, Joern / Hernandez Quero, Jose / Goikoetxea, Josune / Delgado, Juan / Guerrero, Juan M. / Fazaal, Julia / Kraft, Julia / Schroeder, Julia / Risnes, Kari / Banasik, Karina / Mueller, Karl Erik / Gaede, Karoline I. / Garcia-Etxebarria, Koldo / Tonby, Kristian / Heggelund, Lars / Izquierdo-Sanchez, Laura / Bettini, Laura Rachele / Sumoy, Lauro / Sander, Leif Erik / Lippert, Lena J. / Terranova, Leonardo / Nkambule, Lindokuhle / Knopp, Lisa / Gustad, Lise Tuset / Garbarino, Lucia / Santoro, Luigi / Tellez, Luis / Roade, Luisa / Ostadreza, Mahnoosh / Intxausti, Maider / Kogevinas, Manolis / Riveiro-Barciela, Mar / Berger, Marc M. / Niemi, Mari E.K. / Gutierrez-Stampa, Maria A. / Valsecchi, Maria Grazia / Hernandez-Tejero, Maria / Vehreschild, Maria J.G.T. / Manunta, Maria / D'Angio, Mariella / Cazzaniga, Marina / Grimsrud, Marit M. / Cornberg, Markus / Noethen, Markus M. / Marquie, Marta / Castoldi, Massimo / Cordioli, Mattia / Cecconi, Maurizio / D'Amato, Mauro / Augustin, Max / Tomasi, Melissa / Boada, Merce / Dreher, Michael / Seilmaier, Michael J. / Joannidis, Michael / Wittig, Michael / Mazzocco, Michela / Rodriguez-Gandia, Miguel / Imaz Ayo, Natale / Blay, Natalia / Chueca, Natalia / Montano, Nicola / Ludwig, Nicole / Marx, Nikolaus / Martinez, Nilda / Norwegian SARS-CoV-2 Study group / Cornely, Oliver A. / Witzke, Oliver / Palmieri, Orazio / Pa COVID-19 Study Group / Faverio, Paola / Bonfanti, Paolo / Tentorio, Paolo / Castro, Pedro / Rodrigues, Pedro M. / Espana, Pedro Pablo / Hoffmann, Per / Rosenstiel, Philip / Schommers, Philipp / Suwalski, Phillip / de Pablo, Raul / Ferrer, Ricard / Bals, Robert / Gualtierotti, Roberta / Gallego-Duran, Rocio / Nieto, Rosa / Carpani, Rossana / Morilla, Ruben / Badalamenti, Salvatore / Haider, Sammra / Ciesek, Sandra / May, Sandra / Bombace, Sara / Marsal, Sara / Pigazzini, Sara / Klein, Sebastian / Rolker, Selina / Pelusi, Serena / Wilfling, Sibylle / Bosari, Silvano / Brunak, Soren / Raychaudhuri, Soumya / Schreiber, Stefan / Heilmann-Heimbach, Stefanie / Aliberti, Stefano / Ripke, Stephan / Dudman, Susanne / The Humanitas COVID-19 Task Forse / The Humanitas Gavazzeni COVID-19 Task Force / Bahmer, Thomas / Eggermann, Thomas / Illig, Thomas / Brenner, Thorsten / Feldt, Torsten / Folseraas, Trine / Cejudo, Trinidad Gonzalez / Landmesser, Ulf / Protzer, Ulrike / Hehr, Ute / Rimoldi, Valeria / Skogen, Vegard / Keitel, Verena / Kopfnagel, Verena / Friaza, Vicente / Andrade, Victor / Moreno, Victor / Poller, Wolfgang / Farre, Xavier / Wang, Xiaomin / Khodamoradi, Yascha / Karadeniz, Zehra / Latiano, Anna / Goerg, Siegfried / Bacher, Petra / Koehler, Philipp / Tran, Florian / Zoller, Heinz / Schulte, Eva C. / Heidecker, Bettina / Ludwig, Kerstin U. / Fernandez, Javier / Romero-Gomez, Manuel / Albillos, Agustin / Invernizzi, Pietro / Buti, Maria / Duga, Stefano / Bujanda, Luis / Hov, Johannes R. / Lenz, Tobias L. / Asselta, Rosanna / de Cid, Rafael / Valenti, Luca / Karlsen, Tom H. / Caceres, Mario / Franke, Andre

    medRxiv

    Abstract: Due to the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), deepening the host genetic contribution to severe COVID-19 may further improve our understanding about underlying disease mechanisms. Here, we describe an extended GWAS ...

    Abstract Due to the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), deepening the host genetic contribution to severe COVID-19 may further improve our understanding about underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany, as well as hypothesis-driven targeted analysis of the human leukocyte antigen (HLA) region and chromosome Y haplotypes. We include detailed stratified analyses based on age, sex and disease severity. In addition to already established risk loci, our data identify and replicate two genome-wide significant loci at 17q21.31 and 19q13.33 associated with severe COVID-19 with respiratory failure. These associations implicate a highly pleiotropic ~0.9-Mb 17q21.31 inversion polymorphism, which affects lung function and immune and blood cell counts, and the NAPSA gene, involved in lung surfactant protein production, in COVID-19 pathogenesis.
    Keywords covid19
    Language English
    Publishing date 2021-07-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.07.21.21260624
    Database COVID19

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