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  1. Article ; Online ; Conference proceedings: Fifth Annual Stem Cell Summit.

    Knowlton, Daniel

    IDrugs : the investigational drugs journal

    2010  Volume 13, Issue 4, Page(s) 235–238

    Abstract: The Fifth Annual Stem Cell Summit, held in New York, included topics covering new commercial developments in the research field of stem cell-based therapies. This conference report highlights selected presentations on embryonic and adult stem cells, stem ...

    Abstract The Fifth Annual Stem Cell Summit, held in New York, included topics covering new commercial developments in the research field of stem cell-based therapies. This conference report highlights selected presentations on embryonic and adult stem cells, stem cell-based therapies for the treatment of orthopedic and cardiovascular indications and inflammatory diseases, as well as technologies for processing and storing stem cells. Investigational therapies discussed include placental expanded (PLX) cells (Pluristem Therapeutics Inc), StemEx (Gamida-Teva Joint Venture/Teva Pharmaceutical Industries Ltd) and remestemcel-L (Osiris Therapeutics Inc/Genzyme Corp/JCR Pharmaceuticals Co Ltd/ Mochida Pharmaceutical Co Ltd).
    MeSH term(s) Adult Stem Cells/cytology ; Cardiovascular Diseases/therapy ; Cell Culture Techniques/methods ; Cell Culture Techniques/trends ; Cell Separation/instrumentation ; Cell Separation/methods ; Cell Separation/trends ; Clinical Trials as Topic ; Cryopreservation/instrumentation ; Cryopreservation/methods ; Cryopreservation/trends ; Embryonic Stem Cells/cytology ; Humans ; Inflammation/therapy ; Mesenchymal Stromal Cells/cytology ; Orthopedic Procedures/methods ; Orthopedic Procedures/trends ; Regenerative Medicine/methods ; Regenerative Medicine/trends ; Stem Cell Transplantation/methods ; Stem Cell Transplantation/trends ; Stem Cells/cytology
    Language English
    Publishing date 2010-04
    Publishing country England
    Document type Congresses
    ZDB-ID 2086568-5
    ISSN 2040-3410 ; 1369-7056
    ISSN (online) 2040-3410
    ISSN 1369-7056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Grow better carrots. Improve incentives, prevention to find money to cover the uninsured.

    Knowlton, David

    Modern healthcare

    2009  Volume 39, Issue 34, Page(s) 26

    MeSH term(s) Chronic Disease/economics ; Health Care Reform ; Health Expenditures ; Health Services Accessibility ; Humans ; Medically Uninsured ; Reimbursement, Incentive/organization & administration ; United States
    Language English
    Publishing date 2009-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187602-8
    ISSN 0160-7480
    ISSN 0160-7480
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  3. Article: Helping physicians maintain control.

    Knowlton, D L

    New Jersey medicine : the journal of the Medical Society of New Jersey

    1998  Volume 95, Issue 3, Page(s) 59–61

    MeSH term(s) Humans ; Managed Care Programs/trends ; Marketing of Health Services ; Physicians ; Practice Management, Medical/organization & administration ; United States
    Language English
    Publishing date 1998-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632738-2
    ISSN 0885-842X ; 0025-7524
    ISSN 0885-842X ; 0025-7524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 152: Show issues Location:
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  4. Article: HIV care: a capitated alternative.

    Knowlton, D L

    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association

    1995  Volume 8 Suppl 1, Page(s) S74–9

    Abstract: Given sufficient and participatory planning, a cluster of excellence for HIV/AIDS could be designed that could yield benefits to payers, providers, and patients. Such a cluster of excellence would be at risk for all care provided to an enrollment ... ...

    Abstract Given sufficient and participatory planning, a cluster of excellence for HIV/AIDS could be designed that could yield benefits to payers, providers, and patients. Such a cluster of excellence would be at risk for all care provided to an enrollment population made up of PWAs and would be globally capitated based upon the average cost of providing care to this population in the current, unmanaged health care environment. The cluster would be freed from conventional use constraints and be free to manage the care of their enrollment population with minimal payer interference. But it would be at risk for managing the cost of care to the enrollees within the global capitation rate.
    MeSH term(s) Acquired Immunodeficiency Syndrome/economics ; Capitation Fee ; Chronic Disease/economics ; HIV Infections/economics ; HIV Infections/epidemiology ; HIV Infections/therapy ; Health Care Costs ; Humans ; Insurance, Health/trends ; Managed Care Programs/economics ; Models, Economic ; United States/epidemiology
    Language English
    Publishing date 1995
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2442: Show issues Location:
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  5. Article ; Online: Estimating health-related costs of ten US climate-sensitive events in 2012

    Vijay S Limaye, PhD / Wendy Max, ProfPhD / Juanita Constible, MS / Kim Knowlton, DrPH

    The Lancet Planetary Health, Vol 3, Iss , Pp S5- (2019)

    a retrospective study

    2019  

    Abstract: Background: Climate change threatens human health, but there is a lack of evidence on the economic toll of these risks. Health-related cost estimates for climate-sensitive impacts illuminate an understudied impact of climate change and highlight how this ...

    Abstract Background: Climate change threatens human health, but there is a lack of evidence on the economic toll of these risks. Health-related cost estimates for climate-sensitive impacts illuminate an understudied impact of climate change and highlight how this threat is affecting sectors beyond property and infrastructure. Furthermore, cost estimates can guide health interventions and help public health professionals assess whether climate change adaptation measures are achieving their intended benefits. Methods: We estimate mortality and morbidity costs associated with ten climate-sensitive case studies spanning eleven US states in 2012 (when the country experienced some of its warmest weather to date); the case studies include wildfires, extreme heat, West Nile Virus and Lyme disease, extreme precipitation and flooding, harmful algal blooms, allergenic pollen, ozone air pollution, and a major hurricane. We estimate the mortality and morbidity associated with each event using data reported in peer-reviewed epidemiology studies, state and federal data, and environmental public health tracking network data collected by state public health agencies. We augment this information with imputed incidence data from national healthcare utilisation statistics. Findings: Applying value of a statistical life and cost-of-illness approaches to publicly-available data from the Agency for Healthcare Research and Quality, we estimate total health-related costs associated with these case studies (from 917 deaths, 20 568 hospitalisations and 17 857 emergency department visits) of about $10·0 billion in 2018 dollars, with a sensitivity range of $2·7 billion to $24·6 billion. Interpretation: By better characterising these health damages in economic terms, this work helps characterise the burden that climate change already places on human health. In doing so, we provide a quantitative framework for broader estimation of climate-sensitive health-related costs. Expanded quantification of the budgetary pressures posed by climate change can ...
    Keywords Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing.

    Smith, Laura J / Wright, Jason / Clark, Gabriella / Ul-Hasan, Taihra / Jin, Xiangyang / Fong, Abigail / Chandra, Manasa / St Martin, Thia / Rubin, Hillard / Knowlton, David / Ellsworth, Jeff L / Fong, Yuman / Wong, Kamehameha K / Chatterjee, Saswati

    Proceedings of the National Academy of Sciences of the United States of America

    2018  Volume 115, Issue 31, Page(s) E7379–E7388

    Abstract: The precise correction of genetic mutations at the nucleotide level is an attractive permanent therapeutic strategy for human disease. However, despite significant progress, challenges to efficient and accurate genome editing persist. Here, we report a ... ...

    Abstract The precise correction of genetic mutations at the nucleotide level is an attractive permanent therapeutic strategy for human disease. However, despite significant progress, challenges to efficient and accurate genome editing persist. Here, we report a genome editing platform based upon a class of hematopoietic stem cell (HSC)-derived clade F adeno-associated virus (AAV), which does not require prior nuclease-mediated DNA breaks and functions exclusively through BRCA2-dependent homologous recombination. Genome editing is guided by complementary homology arms and is highly accurate and seamless, with no evidence of on-target mutations, including insertion/deletions or inclusion of AAV inverted terminal repeats. Efficient genome editing was demonstrated at different loci within the human genome, including a safe harbor locus, AAVS1, and the therapeutically relevant IL2RG gene, and at the murine Rosa26 locus. HSC-derived AAV vector (AAVHSC)-mediated genome editing was robust in primary human cells, including CD34
    MeSH term(s) BRCA2 Protein/physiology ; Dependovirus/genetics ; Gene Editing ; Genetic Vectors ; Hematopoietic Stem Cells/metabolism ; Homologous Recombination ; Humans ; Interleukin Receptor Common gamma Subunit/genetics ; K562 Cells
    Chemical Substances BRCA2 Protein ; BRCA2 protein, human ; IL2RG protein, human ; Interleukin Receptor Common gamma Subunit
    Language English
    Publishing date 2018-07-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1802343115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Stages of managed-care evolution.

    Knowlton, D / Group, M H / NA, N A

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    1996  Volume 2, Issue 6, Page(s) 425–428

    Abstract: In the United States, health care is undergoing a transformation. The stages of evolution to a managed-care setting could be characterized as follows: (1) "The Push," (2) "The Squeeze," (3) "The Purge," and (4) "The Promise." Although the pace of change ... ...

    Abstract In the United States, health care is undergoing a transformation. The stages of evolution to a managed-care setting could be characterized as follows: (1) "The Push," (2) "The Squeeze," (3) "The Purge," and (4) "The Promise." Although the pace of change differs in various locations, these same stages will be experienced throughout the country. In the first stage, the move is toward per diems for hospitals, and payers are still focused on volume. In stage 2, integrated systems are beginning to develop, and payers are purchasing volume by negotiating deals. Primary physicians begin to flex their muscles, and specialists begin to panic. In stage 3, price clout rules, and results of quality measures will be reported. In the final stage, fewer health-care providers will be available, but they will be coordinated in large groups, and capitation contracts will prevail. Capitation--a fixed payment per health plan enrollee being paid to a provider for a defined set of services for a prescribed period--will replace a fee-for-service arrangement. In this managed-care setting, the management of diabetes, which afflicts 14 million Americans, is a major issue. It accounts for 14.7% of every health-care dollar spent in the United States, and much of that investment is for treatment of unnecessary complications. Positioning of the clinical endocrinologist as the primary-care physician for patients with diabetes is proposed as the optimal strategy for appropriate management of the patient and attainment of cost control.
    Language English
    Publishing date 1996-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/EP.2.6.425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons.

    Li, Wei / Knowlton, David / Van Winkle, Donna M / Habecker, Beth A

    American journal of physiology. Heart and circulatory physiology

    2004  Volume 286, Issue 6, Page(s) H2229–36

    Abstract: Regional changes occur in the sympathetic innervation of the heart after myocardial infarction (MI), including loss of norepinephrine (NE) uptake and depletion of neuronal NE. This apparent denervation is accompanied by increased cardiac NE spillover. ... ...

    Abstract Regional changes occur in the sympathetic innervation of the heart after myocardial infarction (MI), including loss of norepinephrine (NE) uptake and depletion of neuronal NE. This apparent denervation is accompanied by increased cardiac NE spillover. One potential explanation for these apparently contradictory findings is that the sympathetic neurons innervating the heart are exposed to environmental stimuli that alter neuronal function. To understand the changes that occur in the innervation of the heart after MI, immunohistochemical, biochemical, and molecular analyses were carried out in the heart and stellate ganglia of control and MI rats. Immunohistochemistry with panneuronal markers revealed extensive denervation in the left ventricle (LV) below the infarct, but sympathetic nerve fibers were retained in the base of the heart. Western blot analysis revealed that tyrosine hydroxylase (TH) expression (normalized to a panneuronal marker) was increased significantly in the base of the heart and in the stellate ganglia but decreased in the LV below the MI. NE transporter (NET) binding sites, normalized to total protein, were unchanged, except in the LV, where [3H]nisoxetine binding was decreased. TH mRNA was increased significantly in the left and right stellate ganglia after MI, while NET mRNA was not. In the base of the heart, increased TH coupled with no change in NET may explain the increase in extracellular NE observed after MI. Coupled with substantial denervation in the LV, these changes likely contribute to the onset of cardiac arrhythmias.
    MeSH term(s) Adrenergic Fibers/pathology ; Adrenergic Fibers/physiology ; Animals ; Heart/innervation ; Immunohistochemistry ; Male ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Norepinephrine/physiology ; Norepinephrine Plasma Membrane Transport Proteins ; RNA, Messenger/analysis ; Rats ; Rats, Sprague-Dawley ; Symporters/genetics ; Symporters/metabolism ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/metabolism ; Ubiquitin Thiolesterase/metabolism
    Chemical Substances Norepinephrine Plasma Membrane Transport Proteins ; RNA, Messenger ; Slc6a2 protein, rat ; Symporters ; UCHL1 protein, human ; Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2004-01-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00768.2003
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  10. Article: Hyperlexia: a marker for improvement in children with pervasive developmental disorder?

    Burd, L / Fisher, W / Knowlton, D / Kerbeshian, J

    Journal of the American Academy of Child and Adolescent Psychiatry

    1987  Volume 26, Issue 3, Page(s) 407–412

    MeSH term(s) Adolescent ; Adult ; Autistic Disorder/diagnosis ; Child ; Child Development Disorders, Pervasive/diagnosis ; Child, Preschool ; Female ; Humans ; Intellectual Disability/diagnosis ; Male ; Prognosis ; Reading
    Language English
    Publishing date 1987-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1097/00004583-198705000-00022
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