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  1. Book: Fungal diseases

    Knox, Kenneth S.

    (Clinics in chest medicine ; 30,2)

    2009  

    Author's details guest ed. Kenneth S. Knox
    Series title Clinics in chest medicine ; 30,2
    Collection
    Language English
    Size XII S., S. 203 - 413 : Ill.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015971507
    ISBN 1-4377-0461-1 ; 978-1-4377-0461-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 805 -30,2- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Precepting medical students in the clinical setting: Its time, not money.

    Martinez, Guadalupe Federico / Knox, Kenneth S

    Medical education

    2022  Volume 56, Issue 7, Page(s) 698–700

    MeSH term(s) Humans ; Preceptorship ; Students, Medical
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.14815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 312: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Prophylaxis in Lung Transplant Recipients.

    Malo, Joshua / Natt, Bhupinder / Chaudhary, Sachin / Knox, Kenneth S

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 76, Issue 2, Page(s) 368–369

    MeSH term(s) Humans ; Transplant Recipients ; Lung Transplantation ; Antiviral Agents/therapeutic use ; Lung ; Retrospective Studies
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  4. Article ; Online: Perspective on coccidioidomycosis and histoplasmosis.

    Knox, Kenneth S

    American journal of respiratory and critical care medicine

    2014  Volume 189, Issue 6, Page(s) 752–753

    MeSH term(s) Coccidioidomycosis/diagnosis ; Diagnosis, Differential ; Histoplasmosis/diagnosis ; Humans ; Lung Diseases, Fungal/diagnosis
    Language English
    Publishing date 2014-03-15
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201311-2024LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Carbon nanotube stimulation of human mononuclear cells to model granulomatous inflammation.

    Kala, Mrinalini / Casanova, Nancy G / Feng, Anlin / Jacobsen, Jeffrey R / Grischo, Garrett / Liang, Ying / Moreno, Yesenia / Wang, Ting / Knox, Kenneth S

    American journal of translational research

    2023  Volume 15, Issue 3, Page(s) 1704–1714

    Abstract: Objectives: Sarcoidosis is a multisystem inflammatory granulomatous disease of unknown etiology. The disease most often affects the lung and leads to death in 5% of patients. Patients who die often succumb due to progressive fibrotic lung disease. ... ...

    Abstract Objectives: Sarcoidosis is a multisystem inflammatory granulomatous disease of unknown etiology. The disease most often affects the lung and leads to death in 5% of patients. Patients who die often succumb due to progressive fibrotic lung disease. Translational research in sarcoidosis is significantly limited by a paucity of available experimental models. Carbon nanotubes are released into the environment during fuel combustion, manufacturing, and natural fires. Exposed individuals are at risk for cancer, lung inflammation and other chronic pulmonary disorders, including diseases resembling sarcoidosis and pulmonary fibrosis. In this study, we developed and characterized an
    Methods: MWCNT-exposed PBMCs were cultured and analyzed by Giemsa staining, immunohistochemistry (IHC) and RNA-seq analysis on days 1 and 7. Normalization and differential expression were calculated using DESeq2, Limma and edgeR methods from Bioconductor (adjP, log2Fold change and rawP).
    Results: MWCNT stimulation of PBMCs from healthy subjects leads to the formation of granuloma-like cell clusters and stereotypical inflammatory cytokine secretion. PBMC transcriptomic analysis demonstrated activation of defense- and inflammation-related pathways, including the Jak-Stat pathway and TNF signaling pathway.
    Conclusions: This model is unique, as cell clustering is seen in the absence of specific antigenic stimulation (e.g., mycobacterial) or the addition of exogenous cytokines. Modeling with PBMCs provides a platform for precision medicine and evaluation of future therapies for granulomatous and fibrotic lung diseases.
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Exacerbation of CMV and Nontuberculous Mycobacterial Infections Following PD-1 Blockade for HIV-Associated Kaposi Sarcoma.

    Anidi, Ifeanyichukwu U / Sakai, Shunsuke / Brooks, Kelsie / Fling, Steven P / Wagner, Michael J / Lurain, Kathryn / Lindestam Arlehamn, Cecilia S / Sette, Alessandro / Knox, Kenneth S / Brenchley, Jason M / Uldrick, Thomas S / Sharon, Elad / Barber, Daniel L

    Open forum infectious diseases

    2024  Volume 11, Issue 5, Page(s) ofae183

    Abstract: Blockade of the co-inhibitory receptor PD-1 enhances antitumor responses by boosting the function of antigen-specific T cells. Although rare, PD-1 blockade in patients with cancer can lead to exacerbation of infection-associated pathology. Here, we ... ...

    Abstract Blockade of the co-inhibitory receptor PD-1 enhances antitumor responses by boosting the function of antigen-specific T cells. Although rare, PD-1 blockade in patients with cancer can lead to exacerbation of infection-associated pathology. Here, we detail the case of a 38-year-old man who was enrolled in a clinical trial for assessment of the safety and activity of anti-PD-1 therapy for Kaposi sarcoma in people with HIV well-controlled on antiretroviral therapy. Less than a week after receiving the first dose of anti-PD-1 antibody (pembrolizumab), he presented with severe abdominal pain associated with sudden exacerbations of preexisting cytomegalovirus (CMV) enteritis and nontuberculous mycobacterial mesenteric lymphadenitis. Plasma biomarkers of gastrointestinal tract damage were highly elevated compared with healthy controls, consistent with HIV-associated loss of gut epithelial barrier integrity. Moreover, CMV-specific CD8 T cells expressed high levels of PD-1, and 7 days following PD-1 blockade, there was an increase in the frequency of activated CD38
    Language English
    Publishing date 2024-03-31
    Publishing country United States
    Document type Clinical Trial
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Corrigendum: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused.

    Chaudhary, Sachin / Natt, Bhupinder / Bime, Christian / Knox, Kenneth S / Glassberg, Marilyn K

    Frontiers in medicine

    2021  Volume 7, Page(s) 604640

    Abstract: This corrects the article DOI: 10.3389/fmed.2020.00539.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmed.2020.00539.].
    Language English
    Publishing date 2021-03-11
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.604640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lung-Targeted Delivery of Dimethyl Fumarate Promotes the Reversal of Age-Dependent Established Lung Fibrosis

    Kato, Kosuke / Papageorgiou, Ioannis / Shin, Yoon-Joo / Kleinhenz, Jennifer M. / Palumbo, Sunny / Hahn, Seongmin / Irish, Joseph D. / Rounseville, Skye P. / Knox, Kenneth S. / Hecker, Louise

    Antioxidants. 2022 Feb. 28, v. 11, no. 3

    2022  

    Abstract: Idiopathic pulmonary fibrosis (IPF), a severe and deadly form of lung fibrosis, is widely regarded as a disease of aging. We previously demonstrated that aged mice with persistent lung fibrosis and IPF lung myofibroblasts exhibit deficient Nrf2-mediated ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF), a severe and deadly form of lung fibrosis, is widely regarded as a disease of aging. We previously demonstrated that aged mice with persistent lung fibrosis and IPF lung myofibroblasts exhibit deficient Nrf2-mediated antioxidant responses. Tecfidera is an orally administered FDA-approved drug for the treatment of multiple sclerosis, where the active pharmaceutical ingredient is dimethyl fumarate (DMF), an active Nrf2 activator. However, no studies have evaluated the efficacy of DMF for age-associated persistent lung fibrosis. Here, we demonstrate that in IPF lung fibroblasts, DMF treatment inhibited both TGF-β-mediated pro-fibrotic phenotypes and led to a reversal of established pro-fibrotic phenotypes. We also evaluated the pre-clinical efficacy of lung-targeted (inhaled) vs. systemic (oral) delivery of DMF in an aging murine model of bleomycin-induced persistent lung fibrosis. DMF or vehicle was administered daily to aged mice by oral gavage or intranasal delivery from 3–6 weeks post-injury when mice exhibited non-resolving lung fibrosis. In contrast to systemic (oral) delivery, only lung-targeted (inhaled) delivery of DMF restored lung Nrf2 expression levels, reduced lung oxidative stress, and promoted the resolution of age-dependent established fibrosis. This is the first study to demonstrate the efficacy of lung-targeted DMF delivery to promote the resolution of age-dependent established lung fibrosis.
    Keywords active pharmaceutical ingredients ; animal models ; antioxidants ; dimethyl fumarate ; drugs ; fibroblasts ; fibrosis ; lungs ; oxidative stress ; pulmonary fibrosis ; sclerosis
    Language English
    Dates of publication 2022-0228
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11030492
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Diagnosis and Management of Coccidioidomycosis.

    Gabe, Luke M / Malo, Joshua / Knox, Kenneth S

    Clinics in chest medicine

    2017  Volume 38, Issue 3, Page(s) 417–433

    Abstract: Coccidioidomycosis is a leading cause of community-acquired pneumonia within its traditional endemic zone in the Southwestern United States and portions of Mexico and Central and South America. Its incidence has increased dramatically within the endemic ... ...

    Abstract Coccidioidomycosis is a leading cause of community-acquired pneumonia within its traditional endemic zone in the Southwestern United States and portions of Mexico and Central and South America. Its incidence has increased dramatically within the endemic region; its presence outside of the region, facilitated by a mobile society, is also now substantial. Although only a fraction of the incident disease progresses beyond subclinical illness, this proportion is large in absolute terms and causes substantial disease burden. Diagnosis often depends on serologic interpretation. Treatment has been revolutionized by azole therapy. Controversy remains regarding the decision to treat in less severe disease.
    MeSH term(s) Antifungal Agents/therapeutic use ; Coccidioidomycosis/diagnosis ; Coccidioidomycosis/pathology ; Coccidioidomycosis/therapy ; Humans
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2017-06-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2017.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: PTK2-associated gene signature could predict the prognosis of IPF.

    Feng, Anlin / Caro, Yesenia Moreno / Gardner, Colin / Grischo, Garrett / Liang, Ying / Wickremasinghe, Praveen D / Polmann, Michaela / Kala, Mrinalini / Marlowe, Timothy / Black, Stephen M / Knox, Kenneth S / Wang, Ting

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 304

    Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have limited sensitivity and accuracy when evaluating clinical outcomes of IPF. Research has shown that focal ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have limited sensitivity and accuracy when evaluating clinical outcomes of IPF. Research has shown that focal adhesion kinase (FAK), produced by the protein tyrosine kinase 2 (PTK2) gene, is crucial in IPF development. FAK activation is a characteristic of lesional fibroblasts; Thus, FAK may be a valuable therapeutic target or prognostic biomarker for IPF. This study aimed to create a gene signature based on PTK2-associated genes and microarray data from blood cells to predict disease prognosis in patients with IPF. PTK2 levels were found to be higher in lung tissues of IPF patients compared to healthy controls, and PTK2 inhibitor Defactinib was found to reduce TGFβ-induced FAK activation and increase α-smooth muscle actin. Although the blood PTK2 levels were higher in IPF patients, blood PTK level alone could not predict IPF prognosis. From 196 PTK2-associated genes, 11 genes were prioritized to create a gene signature (PTK2 molecular signature) and a risk score system using univariate and multivariate Cox regression analysis. Patients were divided into high-risk and low-risk groups using PTK2 molecular signature. Patients in the high-risk group experienced decreased survival rates compared to patients in the low-risk group across all discovery and validation cohorts. Further functional enrichment and immune cell proportion analyses revealed that the PTK2 molecular signature strongly reflected the activation levels of immune pathways and immune cells. These findings suggested that PTK2 is a molecular target of IPF and the PTK2 molecular signature is an effective IPF prognostic biomarker.
    MeSH term(s) Humans ; Focal Adhesion Kinase 1/genetics ; Focal Adhesion Kinase 1/metabolism ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/metabolism ; Lung/metabolism ; Prognosis ; Biomarkers/metabolism
    Chemical Substances Focal Adhesion Kinase 1 (EC 2.7.10.2) ; Biomarkers ; PTK2 protein, human (EC 2.7.10.2)
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02582-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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