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  1. Article ; Online: Minimal Impact Double Incision with Free Nipple Graft Technique for Gender-Affirming Top Surgery.

    Knudson, Sean A / DeLeon, Ashley / Crane, Curtis N / Santucci, Richard A

    Plastic and reconstructive surgery

    2021  Volume 149, Issue 1, Page(s) 152e–153e

    MeSH term(s) Female ; Gender Dysphoria/psychology ; Gender Dysphoria/surgery ; Humans ; Male ; Nipples/transplantation ; Quality of Life ; Sex Reassignment Surgery/methods ; Transgender Persons/psychology
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000008618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 293: Show issues

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  2. Article ; Online: Acquired Sinus of Valsalva Fistula and Turner Syndrome.

    Knudson, Sean A / Gottlieb, Erin A / Johnson, Gregory / Fraser, Charles D / Beckerman, Ziv

    The Annals of thoracic surgery

    2021  Volume 112, Issue 4, Page(s) e275–e277

    Abstract: A 21-year old woman with a history of Turner syndrome presented with a diastolic heart murmur, dizziness, dyspnea, and intermittent chest pain. Preoperative imaging revealed a fistula from the right sinus of Valsalva into the right atrium. Turner ... ...

    Abstract A 21-year old woman with a history of Turner syndrome presented with a diastolic heart murmur, dizziness, dyspnea, and intermittent chest pain. Preoperative imaging revealed a fistula from the right sinus of Valsalva into the right atrium. Turner syndrome is associated with both aortopathy and congenital heart malformations. Acquired sinus of Valsalva fistula is a rare disorder, and this report describes its presence in association with Turner syndrome.
    MeSH term(s) Female ; Humans ; Sinus of Valsalva ; Turner Syndrome/complications ; Vascular Fistula/diagnostic imaging ; Vascular Fistula/etiology ; Vascular Fistula/surgery ; Young Adult
    Language English
    Publishing date 2021-01-30
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2020.11.066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Same-Admission Microvascular Maxillofacial Ballistic Trauma Reconstruction Using Virtual Surgical Planning: A Case Series and Systematic Review.

    Knudson, Sean A / Day, Kristopher M / Kelley, Patrick / Padilla, Pablo / Collier, Ian X / Henry, Steven / Harshbarger, Raymond / Combs, Patrick

    Craniomaxillofacial trauma & reconstruction

    2021  Volume 15, Issue 3, Page(s) 206–218

    Abstract: Study design: Retrospective case series; systematic review.: Objective: It is unknown whether the use of virtual surgical planning (VSP) to facilitate same-admission microsurgical reconstruction of the mandible following acute maxillofacial ballistic ...

    Abstract Study design: Retrospective case series; systematic review.
    Objective: It is unknown whether the use of virtual surgical planning (VSP) to facilitate same-admission microsurgical reconstruction of the mandible following acute maxillofacial ballistic trauma (MBT) is sufficient to achieve definitive reconstruction and functional occlusion.
    Methods: A single-center retrospective analysis was conducted for patients who underwent microsurgical reconstruction of the mandible using VSP after acute MBT. The PubMed/MEDLINE, Embase, ScienceDirect, and Scopus databases were systematically reviewed using blinded screening. Studies were evaluated via thematic analysis.
    Results: Five patients were treated by same-admission and microsurgical reconstruction of the mandible using VSP. We observed an average of 16.4 ± 9.1 days between initial presentation and reconstruction, an average length of stay of 51.6 ± 17.9 days, 6.2 ± 2.8 operations, and 1.6 ± 0.9 free flaps per patient. Four types and 8 total flaps were employed, most commonly the anterior lateral thigh flap (37.5%). Care yielded complete flap survival. Each patient experienced at least 1 minor complication. All patients achieved centric occlusion, oral nutrition, and an approximation of their baseline facial aesthetic. Follow up was 191.0 ± 183.9 weeks. Systematic review produced 8 articles that adhered to inclusion criteria. Consensus themes in the literature were found for clinical goal and function of VSP when practicing MBT reconstruction, yet disagreement was found surrounding optimal treatment timeline.
    Conclusions: Same-admission microsurgical reconstruction after MBT is safe and effective to re-establish mandibular form and function. VSP did not delay reconstruction, given the need for preparation prior to definitive reconstruction.
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article
    ISSN 1943-3875
    ISSN 1943-3875
    DOI 10.1177/19433875211026432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.

    Voss, William N / Mallory, Michael A / Byrne, Patrick O / Marchioni, Jeffrey M / Knudson, Sean A / Powers, John M / Leist, Sarah R / Dadonaite, Bernadeta / Townsend, Douglas R / Kain, Jessica / Huang, Yimin / Satterwhite, Ed / Castillo, Izabella N / Mattocks, Melissa / Paresi, Chelsea / Munt, Jennifer E / Scobey, Trevor / Seeger, Allison / Premkumar, Lakshmanane /
    Bloom, Jesse D / Georgiou, George / McLellan, Jason S / Baric, Ralph S / Lavinder, Jason J / Ippolito, Gregory C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post- ... ...

    Abstract We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post-vaccination, mainly triggered an anti-spike antibody response to the S2 domain, while vaccination predominantly induced anti-RBD antibodies. Immunological imprinting persisted after a secondary (hybrid) exposure, with >60% of the ensuing serological response originating from the initial antibodies generated during the first exposure. We highlight one instance where hybrid immunity arising from breakthrough infection resulted in a marked increase in the breadth and affinity of a highly abundant vaccination-elicited plasma IgG antibody, SC27. With an intrinsic binding affinity surpassing a theoretical maximum (K
    Highlights: ▪ Infection and vaccination elicit unique IgG antibody profiles at the molecular level▪ Immunological imprinting varies between infection (S2/NTD) and vaccination (RBD)▪ Hybrid immunity maintains the imprint of first infection or first vaccination▪ Hybrid immune IgG plasma mAbs have superior neutralization potency and breadth.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.22.576742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination

    Voss, William N. / Mallory, Michael A. / Byrne, Patrick O. / Marchioni, Jeffrey M. / Knudson, Sean A. / Powers, John M. / Leist, Sarah R. / Dadonaite, Bernadeta / Townsend, Douglas R. / Kain, Jessica / Huang, Yimin / Satterwhite, Ed / Castillo, Izabella N. / Mattocks, Melissa / Paresi, Chelsea / Munt, Jennifer E. / Scobey, Trevor / Seeger, Allison / Premkumar, Lakshmanane /
    Bloom, Jesse D. / Georgiou, George / McLellan, Jason S. / Baric, Ralph S. / Lavinder, Jason J. / Ippolito, Gregory C.

    bioRxiv

    Abstract: We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post- ... ...

    Abstract We used plasma IgG proteomics to study the molecular composition and temporal durability of polyclonal IgG antibodies triggered by ancestral SARS-CoV-2 infection, vaccination, or their combination ("hybrid immunity"). Infection, whether primary or post-vaccination, mainly triggered an anti-spike antibody response to the S2 domain, while vaccination predominantly induced anti-RBD antibodies. Immunological imprinting persisted after a secondary (hybrid) exposure, with >60% of the ensuing serological response originating from the initial antibodies generated during the first exposure. We highlight one instance where hybrid immunity arising from breakthrough infection resulted in a marked increase in the breadth and affinity of a highly abundant vaccination-elicited plasma IgG antibody, SC27. With an intrinsic binding affinity surpassing a theoretical maximum (K<sub>D</sub> < 5 pM), SC27 demonstrated potent neutralization of various SARS-CoV-2 variants and SARS-like zoonotic viruses (IC<sub>50</sub> ~0.1–1.75 nM) and provided robust protection in vivo. Cryo-EM structural analysis unveiled that SC27 binds to the RBD class 1/4 epitope, with both VH and VL significantly contributing to the binding interface. These findings suggest that exceptionally broad and potent antibodies can be prevalent in plasma and can largely dictate the nature of serological neutralization.
    Keywords covid19
    Language English
    Publishing date 2024-01-23
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.01.22.576742
    Database COVID19

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