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  1. Article ; Online: Waterborne Diseases That Are Sensitive to Climate Variability and Climate Change.

    Semenza, Jan C / Ko, Albert I

    The New England journal of medicine

    2023  Volume 389, Issue 23, Page(s) 2175–2187

    MeSH term(s) Humans ; Climate Change ; Waterborne Diseases/epidemiology ; Climate
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2300794
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  2. Article ; Online: Minimally-Invasive Resection of a Racemose Neurocysticercal Cyst.

    Trubin, Paul Albert / Omay, Sacit Bulent / Ko, Albert I

    The American journal of tropical medicine and hygiene

    2022  

    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.22-0100
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  3. Article: Eco-epidemiological study of seropositivity against Rickettsia and Leptospira agents in rural areas of Urabá, Colombia.

    Torres-Bustamante, Mariana / Cantillo-Barraza, Omar / Ko, Albert I / Wunder, Elsio A / Quintero-Vélez, Juan C

    Research square

    2024  

    Abstract: Rickettsioses and leptospirosis are infectious diseases that are often underdiagnosed due to a lack of knowledge about their epidemiology, pathophysiology, diagnosis, management, among others.: Objetive: to characterize the seroprevalence and ... ...

    Abstract Rickettsioses and leptospirosis are infectious diseases that are often underdiagnosed due to a lack of knowledge about their epidemiology, pathophysiology, diagnosis, management, among others.
    Objetive: to characterize the seroprevalence and seroincidence of both
    Methods: a secondary data analysis using information on
    Results: the concomitant seroprevalence against
    Conclusion: there is evidence of seroprevalent and seroincident cases of seropositivity against both
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3760267/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Leptospira Infection in Rural Areas of Urabá Region, Colombia: A Prospective Study.

    Quintero-Vélez, Juan C / Rodas, Juan D / Rojas, Carlos A / Ko, Albert I / Wunder, Elsio A

    The American journal of tropical medicine and hygiene

    2022  Volume 107, Issue 6, Page(s) 1267–1277

    Abstract: The objective of this study was to analyze the eco-epidemiological aspects of Leptospira seroprevalence and seroincidence and its associated factors in two municipalities of northwest Colombia. A prospective study was performed in rural areas of Urabá, ... ...

    Abstract The objective of this study was to analyze the eco-epidemiological aspects of Leptospira seroprevalence and seroincidence and its associated factors in two municipalities of northwest Colombia. A prospective study was performed in rural areas of Urabá, Antioquia, Colombia. The study enrolled 597 people between November 2015 and January 2016, of which 274 were followed up 1 year later. Serologic testing was performed by a microscopic agglutination. The outcomes were seroprevalent and seroincident cases, and the primary exposure was an outdoor occupation. A binary and mixed-effect multinomial logistic regression model was used to estimate factors associated with seroprevalent or seroincident cases of Leptospira infection. The overall Leptospira seroprevalence was 27.81% (95% confidence interval: 23.62-32.49), and the overall cumulative seroincidence for Leptospira was 14.60% (95% confidence interval: 10.33-20.23). Multivariable analysis showed that factors associated with L. interrogans serogroups seropositivity were outdoor occupation, male gender, older age, the presence of dirt floor in the household, and the presence of piglets and opossums. It also showed that factors associated with other Leptospira species serogroups were the presence of pit latrines and of turkeys. In addition, the multivariable model of seroincident cases of L. interrogans serogroups evidenced outdoor occupations, the presence of rats, and corn cultivation as risk factors. Likewise, the multivariable model for seroincident cases of other Leptospira species showed that the presence of hunting canines and cassava cultivation were risk factors. We found specific factors associated with the transmission of Leptospira serogroups contribute to the understanding of the epidemiology of Leptospira infection in rural areas of Urabá, Colombia.
    MeSH term(s) Swine ; Male ; Animals ; Rats ; Dogs ; Prospective Studies ; Seroepidemiologic Studies ; Colombia/epidemiology ; Antibodies, Bacterial ; Leptospirosis/epidemiology ; Leptospira
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.21-1103
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Closing the health inequity gap during the pandemic: COVID-19 mortality among racial and ethnic groups in Connecticut, March 2020 to December 2021.

    Schultes, Olivia / Lind, Margaret L / Brockmeyer, Jessica / Sosensky, Peri / Cummings, Derek A T / Ko, Albert I

    Journal of epidemiology and community health

    2022  Volume 76, Issue 7, Page(s) 695–696

    MeSH term(s) COVID-19 ; Connecticut/epidemiology ; Ethnicity ; Health Inequities ; Health Status Disparities ; Healthcare Disparities ; Humans ; Minority Groups ; Pandemics ; United States
    Language English
    Publishing date 2022-04-15
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391868-3
    ISSN 1470-2738 ; 0142-467X ; 0141-7681 ; 0143-005X
    ISSN (online) 1470-2738
    ISSN 0142-467X ; 0141-7681 ; 0143-005X
    DOI 10.1136/jech-2022-218975
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Bartonella in Norway rats (Rattus norvegicus) from the urban slum environment in Brazil.

    Zeppelini, Caio G / Oliveira, Daiana DE / Kosoy, Michael Y / Reis, Mitermayer G / Ko, Albert I / Childs, James E / Costa, Federico

    Anais da Academia Brasileira de Ciencias

    2023  Volume 95, Issue suppl 2, Page(s) e20220809

    Abstract: Bartonella are rodent-borne bacteria that cause varied human etiologies. Studies on synanthropic rodents are rare, causing gaps in epidemiological knowledge. We tested bloodclot samples from 79 rats from an urban slum in Salvador, Brazil through PCR ... ...

    Abstract Bartonella are rodent-borne bacteria that cause varied human etiologies. Studies on synanthropic rodents are rare, causing gaps in epidemiological knowledge. We tested bloodclot samples from 79 rats from an urban slum in Salvador, Brazil through PCR targeting gltA gene. Nine samples (11.4%) were positive: six had 100% identity with Bartonella sp. isolate JF429580 and 99.5% with B. queenslandensis strain AUST/NH8; three were 100% identical to isolate JF429532 and 99.7% to B. tribocorum. This is the second report on urban rat Bartonella indicating bacterial circulation at detectable rates. Its presence in rats from vulnerable human settlements demands public health attention.
    MeSH term(s) Humans ; Rats ; Animals ; Bartonella/genetics ; Disease Reservoirs ; Brazil ; Poverty Areas ; Rodentia/microbiology
    Language English
    Publishing date 2023-10-30
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2046885-4
    ISSN 1678-2690 ; 0001-3765
    ISSN (online) 1678-2690
    ISSN 0001-3765
    DOI 10.1590/0001-3765202320220809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Threatening the Future of Global Health - NIH Policy Changes on International Research Collaborations.

    Ko, Albert I / Abdool Karim, Salim S / Morel, Carlos / Swaminathan, Soumya / Daszak, Peter / Keusch, Gerald T

    The New England journal of medicine

    2023  Volume 389, Issue 10, Page(s) 869–871

    MeSH term(s) Humans ; Global Health ; Health Policy ; National Institutes of Health (U.S.) ; United States ; Biomedical Research/trends
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2307543
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infection.

    Zhu, Weinan / Passalia, Felipe J / Hamond, Camila / Abe, Cecília M / Ko, Albert I / Barbosa, Angela S / Wunder, Elsio A

    PLoS pathogens

    2023  Volume 19, Issue 7, Page(s) e1011313

    Abstract: Leptospirosis, a zoonosis with worldwide distribution, is caused by pathogenic spirochetes belonging to the genus Leptospira. Bacterial outer membrane proteins (OMPs), particularly those with surface-exposed regions, play crucial roles in pathogen ... ...

    Abstract Leptospirosis, a zoonosis with worldwide distribution, is caused by pathogenic spirochetes belonging to the genus Leptospira. Bacterial outer membrane proteins (OMPs), particularly those with surface-exposed regions, play crucial roles in pathogen dissemination and virulence mechanisms. Here we characterized the leptospiral Membrane Protein L36 (MPL36), a rare lipoprotein A (RlpA) homolog with a C-terminal Sporulation related (SPOR) domain, as an important virulence factor in pathogenic Leptospira. Our results confirmed that MPL36 is surface exposed and expressed during infection. Using recombinant MPL36 (rMPL36) we also confirmed previous findings of its high plasminogen (PLG)-binding ability determined by lysine residues of the C-terminal region of the protein, with ability to convert bound-PLG to active plasmin. Using Koch's molecular postulates, we determined that a mutant of mpl36 has a reduced PLG-binding ability, leading to a decreased capacity to adhere and translocate MDCK cell monolayers. Using recombinant protein and mutant strains, we determined that the MPL36-bound plasmin (PLA) can degrade fibrinogen. Finally, our mpl36 mutant had a significant attenuated phenotype in the hamster model for acute leptospirosis. Our data indicates that MPL36 is the major PLG binding protein in pathogenic Leptospira, and crucial to the pathogen's ability to attach and interact with host tissues during infection. The MPL36 characterization contributes to the expanding field of bacterial pathogens that explore PLG for their virulence, advancing the goal to close the knowledge gap regarding leptospiral pathogenesis while offering a novel potential candidate to improve diagnostic and prevention of this important zoonotic neglected disease.
    MeSH term(s) Cricetinae ; Animals ; Leptospira/genetics ; Plasminogen/metabolism ; Fibrinolysin/metabolism ; Leptospira interrogans/genetics ; Protein Binding ; Leptospirosis/microbiology ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
    Chemical Substances Plasminogen (9001-91-6) ; Fibrinolysin (EC 3.4.21.7) ; Bacterial Outer Membrane Proteins ; Recombinant Proteins
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011313
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  9. Article ; Online: Zika virus and microcephaly: where do we go from here?

    Costa, Federico / Ko, Albert I

    The Lancet. Infectious diseases

    2017  Volume 18, Issue 3, Page(s) 236–237

    MeSH term(s) Brazil ; Case-Control Studies ; Humans ; Microcephaly ; Pregnancy Complications, Infectious ; Risk Factors ; Zika Virus ; Zika Virus Infection
    Language English
    Publishing date 2017-12-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(17)30697-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
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  10. Article ; Online: Zika Virus Infection - After the Pandemic.

    Musso, Didier / Ko, Albert I / Baud, David

    The New England journal of medicine

    2019  Volume 381, Issue 15, Page(s) 1444–1457

    MeSH term(s) Brain/diagnostic imaging ; Brain/embryology ; Female ; Guillain-Barre Syndrome/etiology ; Guillain-Barre Syndrome/therapy ; History, 20th Century ; History, 21st Century ; Humans ; Magnetic Resonance Imaging ; Male ; Pandemics/history ; Pregnancy ; Pregnancy Complications, Infectious ; Ultrasonography, Prenatal ; Zika Virus ; Zika Virus Infection/congenital ; Zika Virus Infection/diagnosis ; Zika Virus Infection/epidemiology ; Zika Virus Infection/therapy
    Language English
    Publishing date 2019-09-09
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1808246
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