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  1. Article ; Online: Lipoteichoic acid of

    Kim, Sun Kyung / Im, Jintaek / Ko, Eun Byeol / Lee, Dongwook / Seo, Ho Seong / Yun, Cheol-Heui / Han, Seung Hyun

    Frontiers in immunology

    2023  Volume 14, Page(s) 1056949

    Abstract: Streptococcus ... ...

    Abstract Streptococcus gordonii
    MeSH term(s) Humans ; Streptococcus gordonii/metabolism ; Cytokines/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Dendritic Cells
    Chemical Substances lipoteichoic acid (56411-57-5) ; Cytokines ; Lipopolysaccharides
    Language English
    Publishing date 2023-03-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1056949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Serine-Rich Repeat Adhesins Contribute to

    Ko, Eun Byeol / Kim, Sun Kyung / Seo, Ho Seong / Yun, Cheol-Heui / Han, Seung Hyun

    Frontiers in microbiology

    2017  Volume 8, Page(s) 523

    Abstract: Dendritic cells (DCs) play a pivotal role in the induction of immunity by recognition, capture, process, and presentation of antigens from infectious microbes. ...

    Abstract Dendritic cells (DCs) play a pivotal role in the induction of immunity by recognition, capture, process, and presentation of antigens from infectious microbes.
    Language English
    Publishing date 2017-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2017.00523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wall teichoic acid is an essential component of Staphylococcus aureus for the induction of human dendritic cell maturation.

    Hong, Sung Jun / Kim, Sun Kyung / Ko, Eun Byeol / Yun, Cheol-Heui / Han, Seung Hyun

    Molecular immunology

    2017  Volume 81, Page(s) 135–142

    Abstract: Staphylococcus aureus is a Gram-positive pathogen that can cause chronic skin inflammation, pneumonia, and septic shock. The immunomodulatory functions of wall teichoic acid (WTA), a glycopolymer abundantly expressed on the Gram-positive bacterial cell ... ...

    Abstract Staphylococcus aureus is a Gram-positive pathogen that can cause chronic skin inflammation, pneumonia, and septic shock. The immunomodulatory functions of wall teichoic acid (WTA), a glycopolymer abundantly expressed on the Gram-positive bacterial cell wall, are poorly understood. Here, we investigated the role of WTA in the phenotypic and functional activation of human monocyte-derived dendritic cells (DCs) treated with ethanol-killed S. aureus. WTA-deficient S. aureus mutant (ΔtagO) exhibited attenuated binding and internalization to DCs compared to the wild-type. ΔtagO induced lower expression of maturation markers on and cytokines in DCs than the wild-type S. aureus. Furthermore, autologous human peripheral blood mononuclear cells cocultured with ΔtagO-treated DCs exhibited a marked reduction in T cell proliferative activity, the expression of activation markers, and the production of cytokines compared to the wild-type S. aureus-stimulated DCs. Collectively, these results suggest that WTA is an important cell wall component of S. aureus for the induction of DC maturation and activation.
    MeSH term(s) Cell Differentiation/immunology ; Cell Wall/immunology ; Dendritic Cells/immunology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Lipopolysaccharides/immunology ; Lymphocyte Activation/immunology ; Staphylococcal Infections/immunology ; Staphylococcus aureus/immunology ; T-Lymphocytes/immunology ; Teichoic Acids/immunology
    Chemical Substances Lipopolysaccharides ; Teichoic Acids ; lipoteichoic acid (56411-57-5)
    Language English
    Publishing date 2017-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2016.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Staphylococcal LTA antagonizes the B cell-mitogenic potential of LPS.

    Kang, Seok-Seong / Kim, Sun Kyung / Baik, Jung Eun / Ko, Eun Byeol / Ahn, Ki Bum / Yun, Cheol-Heui / Han, Seung Hyun

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 1496

    Abstract: Lipoteichoic acid (LTA) of Gram-positive bacteria is regarded as the counterpart biomolecule of lipopolysaccharide (LPS) of Gram-negative bacteria because of their structural and immunological similarities. Although LPS induces a strong polyclonal ... ...

    Abstract Lipoteichoic acid (LTA) of Gram-positive bacteria is regarded as the counterpart biomolecule of lipopolysaccharide (LPS) of Gram-negative bacteria because of their structural and immunological similarities. Although LPS induces a strong polyclonal expansion of B cells, little is known about the effect of LTA on B cell proliferation. In the present study, we prepared LTAs from Gram-positive bacteria and examined their effect on splenic B cell proliferation. Unlike LPS, LTA did not induce B cell proliferation. Instead, Staphylococcus aureus LTA (Sa.LTA) appeared to inhibit LPS-induced B cell proliferation in vitro, ex vivo, and in vivo models. Such effect was observed neither in splenocytes from Toll-like receptor 2 (TLR2)-deficient mice nor in the purified splenic B cells. Furthermore, decreased ERK phosphorylation appeared to be responsible for this phenomenon. Collectively, our results support that Sa.LTA inhibited LPS-induced B cell proliferation through the decrease of ERK phosphorylation via TLR2 signaling pathway.
    MeSH term(s) Animals ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Cell Proliferation/drug effects ; Cells, Cultured ; Lipopolysaccharides/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction/drug effects ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/immunology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/immunology ; Teichoic Acids/pharmacology ; Toll-Like Receptor 2/physiology
    Chemical Substances Lipopolysaccharides ; Teichoic Acids ; Tlr2 protein, mouse ; Toll-Like Receptor 2 ; lipoteichoic acid (56411-57-5)
    Language English
    Publishing date 2018-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-19653-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gamma-irradiation-killed Streptococcus pneumoniae potently induces the expression of IL-6 and IL-8 in human bronchial epithelial cells.

    Jwa, Min Yong / Ko, Eun Byeol / Kim, Hyun Young / Kim, Sun Kyung / Jeong, Soyoung / Seo, Ho Seong / Yun, Cheol-Heui / Han, Seung Hyun

    Microbial pathogenesis

    2018  Volume 124, Page(s) 38–46

    Abstract: Streptococcus pneumoniae is a major respiratory pathogen that can cause pneumonia, meningitis, and otitis media. Although capsular polysaccharide-based vaccines are commercially available, there is a need for broad-spectrum, serotype-independent, and ... ...

    Abstract Streptococcus pneumoniae is a major respiratory pathogen that can cause pneumonia, meningitis, and otitis media. Although capsular polysaccharide-based vaccines are commercially available, there is a need for broad-spectrum, serotype-independent, and cost-effective vaccines. Recently, an intranasal vaccine formulated with gamma-irradiated nonencapsulated S. pneumoniae whole cells has been developed and its immunogenicity is under investigation. Since innate immunity influences the subsequent adaptive immunity, in the present study, we investigated the immunostimulatory activity of gamma-irradiated S. pneumoniae (r-SP) in the human bronchial epithelial cell-line, BEAS-2B, by comparing with heat-inactivated S. pneumoniae (h-SP) and formalin-inactivated S. pneumoniae (f-SP). r-SP potently induced interleukin (IL)-6 and IL-8 at both mRNA and protein levels in a dose- and time-dependent manner, whereas h-SP and f-SP poorly induced them. Of note, the mRNA levels of IL-6 and IL-8 were approximately two-fold higher when cells were stimulated with 3 × 10
    MeSH term(s) Bacterial Vaccines/immunology ; Cell Line ; Epithelial Cells/immunology ; Epithelial Cells/microbiology ; Formaldehyde ; Gamma Rays ; Gene Expression Profiling ; Hot Temperature ; Humans ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/radiation effects ; Vaccines, Inactivated/immunology
    Chemical Substances Bacterial Vaccines ; IL6 protein, human ; Interleukin-6 ; Interleukin-8 ; Vaccines, Inactivated ; Formaldehyde (1HG84L3525)
    Language English
    Publishing date 2018-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2018.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Gamma-irradiation of Streptococcus pneumoniae for the use as an immunogenic whole cell vaccine.

    Jwa, Min Yong / Jeong, Soyoung / Ko, Eun Byeol / Kim, A Reum / Kim, Hyun Young / Kim, Sun Kyung / Seo, Ho Seong / Yun, Cheol-Heui / Han, Seung Hyun

    Journal of microbiology (Seoul, Korea)

    2018  Volume 56, Issue 8, Page(s) 579–585

    Abstract: Streptococcus pneumoniae is a major respiratory pathogen that causes millions of deaths worldwide. Although subunit vaccines formulated with the capsular polysaccharides or their protein conjugates are currently-available, low-cost vaccines with wide ... ...

    Abstract Streptococcus pneumoniae is a major respiratory pathogen that causes millions of deaths worldwide. Although subunit vaccines formulated with the capsular polysaccharides or their protein conjugates are currently-available, low-cost vaccines with wide serotype coverage still remain to be developed, especially for developing countries. Recently, gamma- irradiation has been considered as an effective inactivation method to prepare S. pneumoniae vaccine candidate. In this study, we investigated the immunogenicity and protective immunity of gamma-irradiated S. pneumoniae (r-SP), by comparing with heat-inactivated S. pneumoniae (h-SP) and formalin-inactivated S. pneumoniae (f-SP), both of which were made by traditional inactivation methods. Intranasal immunization of C57BL/6 mice with r-SP in combination with cholera toxin as an adjuvant enhanced S. pneumoniaespecific antibodies on the airway mucosal surface and in sera more potently than that with h-SP or f-SP under the same conditions. In addition, sera from mice immunized with r-SP potently induced opsonophagocytic killing activity more effectively than those of h-SP or f-SP, implying that r-SP could induce protective antibodies. Above all, immunization with r-SP effectively protected mice against S. pneumoniae infection. Collectively, these results suggest that gamma- irradiation is an effective method for the development of a killed whole cell pneumococcal vaccine that elicits robust mucosal and systemic immune responses.
    MeSH term(s) Administration, Intranasal ; Animals ; Antibodies, Bacterial/analysis ; Antibodies, Bacterial/blood ; Blood Bactericidal Activity ; Disease Models, Animal ; Gamma Rays ; Mice, Inbred C57BL ; Opsonin Proteins/blood ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Pneumococcal Vaccines/immunology ; Pneumococcal Vaccines/isolation & purification ; Respiratory Mucosa/immunology ; Streptococcus pneumoniae/immunology ; Streptococcus pneumoniae/radiation effects ; Treatment Outcome ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/immunology ; Vaccines, Inactivated/isolation & purification
    Chemical Substances Antibodies, Bacterial ; Opsonin Proteins ; Pneumococcal Vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2018-07-25
    Publishing country Korea (South)
    Document type Comparative Study ; Journal Article
    ZDB-ID 2012399-1
    ISSN 1976-3794 ; 1225-8873
    ISSN (online) 1976-3794
    ISSN 1225-8873
    DOI 10.1007/s12275-018-8347-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5211: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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