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  1. Book: Corona in der Seele

    Baer, Udo / Koch, Claus

    was Kindern und Jugendlichen wirklich hilft

    2021  

    Author's details Udo Baer, Claus Koch
    Keywords COVID-19 ; Kind ; Jugend ; Angst ; Psychische Belastung ; Bewältigung
    Subject Bewältigungsstrategie ; Coping ; Problembewältigung ; Psychische Bewältigung ; Bewältigungsverhalten ; Seelische Belastung ; Psychische Beanspruchung ; Mentale Belastung ; Mentale Beanspruchung ; Psychologische Belastung ; Ängstlichkeit ; Ängste ; Jugend ; Jugendalter ; Jugendlicher ; Teenager ; Kindheit ; Kindesalter ; Kindschaft ; Kinder ; Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
    Language German
    Size 158 Seiten
    Edition Zweite Auflage 2022
    Publisher Klett-Cotta ; CPI - Clausen & Bosse
    Publishing place Stuttgart ; Leck
    Publishing country Germany
    Document type Book
    HBZ-ID HT021344834
    ISBN 978-3-608-98086-8 ; 3-608-98086-5
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Fish-on-Chips: unveiling neural processing of chemicals in small animals through precise fluidic control.

    Sy, Samuel K H / Ko, Ho

    Neural regeneration research

    2024  Volume 19, Issue 11, Page(s) 2351–2353

    Language English
    Publishing date 2024-01-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.392876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits.

    Xie, Jiatian / Cheng, Jinping / Ko, Ho / Tang, Yamei

    EMBO molecular medicine

    2024  Volume 16, Issue 4, Page(s) 678–699

    Abstract: Cytosolic DNA sensors are a group of pattern recognition receptors (PRRs) that vary in structures, molecular mechanisms, and origins but share a common function to detect intracellular microbial DNA and trigger the innate immune response like type 1 ... ...

    Abstract Cytosolic DNA sensors are a group of pattern recognition receptors (PRRs) that vary in structures, molecular mechanisms, and origins but share a common function to detect intracellular microbial DNA and trigger the innate immune response like type 1 interferon production and autophagy. Cytosolic DNA sensors have been proven as indispensable defenders against the invasion of many pathogens; however, growing evidence shows that self-DNA misplacement to cytoplasm also frequently occurs in non-infectious circumstances. Accumulation of cytosolic DNA causes improper activation of cytosolic DNA sensors and triggers an abnormal autoimmune response, that significantly promotes pathological progression. Neurodegenerative diseases are a group of neurological disorders characterized by neuron loss and still lack effective treatments due to a limited understanding of pathogenesis. But current research has found a solid relationship between neurodegenerative diseases and cytosolic DNA sensing pathways. This review summarizes profiles of several major cytosolic DNA sensors and their common adaptor protein STING. It also discusses both the beneficial and detrimental roles of cytosolic DNA sensors in the genesis and progression of neurodegenerative diseases.
    MeSH term(s) Humans ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; DNA/metabolism ; Cytosol/metabolism ; Immunity, Innate
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.1038/s44321-024-00046-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neuroscience. Functional organization of synaptic connections in the neocortex.

    Ko, Ho

    Science (New York, N.Y.)

    2014  Volume 346, Issue 6209, Page(s) 555

    MeSH term(s) Animals ; Humans ; Interneurons/physiology ; Interneurons/ultrastructure ; Mice ; Motion Perception/physiology ; Neocortex/physiology ; Neocortex/ultrastructure ; Nerve Net/physiology ; Nerve Net/ultrastructure ; Pattern Recognition, Visual/physiology ; Pyramidal Cells/physiology ; Pyramidal Cells/ultrastructure ; Space Perception/physiology ; Synapses/physiology ; Synapses/ultrastructure ; Visual Cortex/physiology ; Visual Cortex/ultrastructure ; Visual Perception/physiology
    Language English
    Publishing date 2014-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1260780
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  5. Article ; Online: Pepper Mild Mottle Virus: An Infectious Pathogen in Pepper Production and a Potential Indicator of Domestic Water Quality.

    Ochar, Kingsley / Ko, Ho-Cheol / Woo, Hee-Jong / Hahn, Bum-Soo / Hur, Onsook

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Pepper ( ...

    Abstract Pepper (
    MeSH term(s) Animals ; Humans ; Water Quality ; Plant Breeding ; Tobamovirus/genetics ; Communicable Diseases
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Principles of deep immunohistochemistry for 3D histology.

    Yau, Chun Ngo / Lai, Hei Ming / Lee, Krit / Kwok, Andrew J / Huang, Junzhe / Ko, Ho

    Cell reports methods

    2023  Volume 3, Issue 5, Page(s) 100458

    Abstract: Deep immunohistochemistry (IHC) is a nascent field in three-dimensional (3D) histology that seeks to achieve thorough, homogeneous, and specific staining of intact tissues for visualization of microscopic architectures and molecular compositions at large ...

    Abstract Deep immunohistochemistry (IHC) is a nascent field in three-dimensional (3D) histology that seeks to achieve thorough, homogeneous, and specific staining of intact tissues for visualization of microscopic architectures and molecular compositions at large spatial scales. Despite the tremendous potential of deep IHC in revealing molecule-structure-function relationships in biology and establishing diagnostic and prognostic features for pathological samples in clinical practice, the complexities and variations in methodologies may hinder its use by interested users. We provide a unified framework of deep immunostaining techniques by discussing the theoretical considerations of the physicochemical processes involved, summarizing the principles applied in contemporary methods, advocating a standardized benchmarking scheme, and highlighting unaddressed issues and future directions. By providing the essential information to guide investigators in customizing immunolabeling pipelines, we also seek to facilitate the adoption of deep IHC for researchers to address a wide range of research questions.
    MeSH term(s) Immunohistochemistry ; Staining and Labeling
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2667-2375
    ISSN (online) 2667-2375
    DOI 10.1016/j.crmeth.2023.100458
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  7. Article ; Online: A Comprehensive Genome-Wide Association Study of Carotenoid and Capsaicinoid Contents in

    Haile, Mesfin / Ro, Nayoung / Ko, Ho-Cheol / Oh, Hyeonseok / Lee, Gi-An

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Pepper is a highly important vegetable globally, both economically and nutritionally. However, to efficiently select and identify genetic resources for pepper breeding programs, it is crucial to understand the association between important traits and ... ...

    Abstract Pepper is a highly important vegetable globally, both economically and nutritionally. However, to efficiently select and identify genetic resources for pepper breeding programs, it is crucial to understand the association between important traits and genetic factors. In this study, we investigated the genetic basis of carotenoid and capsaicinoid content in 160
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241813885
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  8. Article: A comparison of mortality and indicators of treatment success of resuscitative endovascular balloon occlusion of aorta (REBOA): a systematic review and meta-analysis.

    Ko, Ho Juen / Koo, Hui Fen / Al-Saadi, Nina / Froghi, Saied

    Indian journal of thoracic and cardiovascular surgery

    2022  Volume 39, Issue 1, Page(s) 27–36

    Abstract: Background: Emergency resuscitative thoracotomy (RT) is a recognised method of controlling non-compressible torso haemorrhage (NCTH) often in adjunct to emergency surgery. Recently, there is much debate regarding resuscitative endovascular balloon ... ...

    Abstract Background: Emergency resuscitative thoracotomy (RT) is a recognised method of controlling non-compressible torso haemorrhage (NCTH) often in adjunct to emergency surgery. Recently, there is much debate regarding resuscitative endovascular balloon occlusion of aorta (REBOA) on its role in civilian trauma cases in controlling NCTH. This study aims to provide an updated review on in-hospital mortality rates in patients who underwent REBOA versus RT and standard care without REBOA (non-REBOA) and to identify the potential indicators of REBOA survival.
    Methods: Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were used to perform the study. All adult trauma cases were included, while pre-hospital, military and non-English studies were excluded. A literature search was done on studies from 01 January 2005 to 30 June 2020 using EMBASE, MEDLINE and COCHRANE databases. Risk of bias was assessed using the Methodological Index for Non-Randomised Studies (MINORS) tool. Meta-analysis was conducted using a random effects model and the DerSimonian and Laird estimation method. A significance level of
    Results: Twenty-five studies were included in this study. The odds of in-hospital mortality of patients who underwent REBOA compared to RT was 0.18 (
    Conclusions: REBOA has a potential for wider application in civilian settings, with our study demonstrating lower in-hospital mortality compared to RT. Prospective multi-centre studies are needed for further evaluation of the indications and feasibility of REBOA.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12055-022-01413-3.
    Language English
    Publishing date 2022-11-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 2164386-6
    ISSN 0973-7723 ; 0970-9134
    ISSN (online) 0973-7723
    ISSN 0970-9134
    DOI 10.1007/s12055-022-01413-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Gastrointestinal Bleeding in Extracorporeal Membrane Oxygenation Patients: A Comprehensive Analysis of Risk Factors and Clinical Outcomes.

    Kim, Sahri / Lim, Jung Hyun / Ko, Ho Hyun / Kwon, Lyo Min / Lee, Hong Kyu / Ra, Yong Joon / Kim, Kunil / Kim, Hyoung Soo

    Journal of chest surgery

    2024  Volume 57, Issue 2, Page(s) 195–204

    Abstract: Background: Extracorporeal membrane oxygenation (ECMO) is an intervention for severe heart and lung failure; however, it poses the risk of complications, including gastrointestinal bleeding (GIB). Comprehensive analyses of GIB in patients undergoing ... ...

    Abstract Background: Extracorporeal membrane oxygenation (ECMO) is an intervention for severe heart and lung failure; however, it poses the risk of complications, including gastrointestinal bleeding (GIB). Comprehensive analyses of GIB in patients undergoing ECMO are limited, and its impact on clinical outcomes remains unclear.
    Methods: This retrospective study included 484 patients who received venovenous and venoarterial ECMO between January 2015 and December 2022. Data collected included patient characteristics, laboratory results, GIB details, and interventions. Statistical analyses were performed to identify risk factors and assess the outcomes.
    Results: GIB occurred in 44 of 484 patients (9.1%) who received ECMO. Multivariable analysis revealed that older age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01-1.06; p=0.0130) and need to change the ECMO mode (OR, 3.74; 95% CI, 1.75-7.96; p=0.0006) were significant risk factors for GIB, whereas no association was found with antiplatelet or systemic anticoagulation therapies during ECMO management. Half of the patients with GIB (22/44, 50%) underwent intervention, with endoscopy as the primary modality (19/22, 86.4%). Patients who underwent ECMO and developed GIB had higher rates of mortality (40/44 [90.9%] vs. 262/440 [59.5%]) and ECMO weaning failure (38/44 [86.4%] vs. 208/440 [47.3%]).
    Conclusion: GIB in patients undergoing ECMO is associated with adverse outcomes, including increased risks of mortality and weaning failure. Even in seemingly uncomplicated cases, it is crucial to avoid underestimating the significance of GIB.
    Language English
    Publishing date 2024-02-08
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2765-1606
    ISSN 2765-1606
    DOI 10.5090/jcs.23.136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Factors Influencing Chronic Kidney Disease Incidence: Database from the Korean National Health Insurance Sharing Service (NHISS).

    Ko, Ho-Joon / Ahn, Soon-Ki / Han, Suyeon / Kim, Moo-Jun / Na, Ki Ryang / Park, Hyerim / Choi, Dae Eun

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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