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  1. Article ; Online: Eribulin Mesylate Improves Cisplatin-Induced Cytotoxicity of Triple-Negative Breast Cancer by Extracellular Signal-Regulated Kinase 1/2 Activation.

    Ko, Hyemi / Lee, Myungsun / Cha, Eunyoung / Sul, Jiyoung / Park, Junbeom / Lee, Jinsun

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Furans ; Humans ; Ketones ; Mitogen-Activated Protein Kinase 3/pharmacology ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism
    Chemical Substances Furans ; Ketones ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; eribulin (LR24G6354G) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58040547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  2. Article ; Online: In Vivo Efficacy of an Injectable Human Acellular Dermal Matrix.

    Ko, Hyemi / Kim, Donghyun / Shin, Chungmin / Gong, Na Young / You, Boram / Oh, Han Seul / Lee, Jinsun / Oh, Sang-Ha

    Aesthetic plastic surgery

    2023  Volume 47, Issue 6, Page(s) 2833–2840

    Abstract: Background: Human acellular dermal matrix (hADM) has found applications in a variety of settings, particularly in breast surgery. The most common hADM is a sheet. Recently, an injectable hADM has been introduced; we compared the biocompatibility and ... ...

    Abstract Background: Human acellular dermal matrix (hADM) has found applications in a variety of settings, particularly in breast surgery. The most common hADM is a sheet. Recently, an injectable hADM has been introduced; we compared the biocompatibility and long-term structural integrity of, an injectable hADM and a sheet-type hADM in mice.
    Methods: An injectable hADM (experimental group) and a sheet-type hADM (control group) were implanted into sub-panniculus pockets on the backs of 50 mice. The animals were sacrificed 2, 4, 8, 12, or 24 weeks later and the hADMs and surrounding tissues were recovered and stained for histopathological analyses. The microscopic endpoints included the thickness of the hADM and capsule around the hADM, and the extents of fibroblast proliferation and neovascularization.
    Results: No animal developed a complication or infection. The capsule was significantly thinner in the experimental than the control group. There were no significant differences between groups in the hADM thickness. Microscopically, the fibroblast density inside the hADM was significantly higher in the experimental group. The fibroblasts inside of the hADM lay significantly deeper in the experimental group. Similarly, the experimental group exhibited significantly deeper microvessels inside the hADM.
    Conclusions: The injectable hADM had a thinner capsule thickness (more biocompatible), than the sheet-type hADM. It maintained its thickness as well as the sheet-type hADM and had a more fibroblast proliferation and neovascularization. This means the tissue incorporation and long-term structural integrity of the injectable hADM may be as good as or better than that of the sheet-type hADM.
    No level assigned: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    MeSH term(s) Humans ; Animals ; Mice ; Acellular Dermis ; Breast Implants ; Fibroblasts
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-023-03353-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1296: Show issues Location:
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  3. Article ; Online: Single Cell Analysis of Human Thyroid Reveals the Transcriptional Signatures of Aging.

    Hong, Yourae / Kim, Hyun Jung / Park, Seongyeol / Yi, Shinae / Lim, Mi Ae / Lee, Seong Eun / Chang, Jae Won / Won, Ho-Ryun / Kim, Je-Ryong / Ko, Hyemi / Kim, Seon-Young / Kim, Seon-Kyu / Park, Jong-Lyul / Chu, In-Sun / Kim, Jin Man / Kim, Kun Ho / Lee, Jeong Ho / Ju, Young Seok / Shong, Minho /
    Koo, Bon Seok / Park, Woong-Yang / Kang, Yea Eun

    Endocrinology

    2023  Volume 164, Issue 4

    Abstract: The thyroid gland plays a critical role in the maintenance of whole-body metabolism. However, aging frequently impairs homeostatic maintenance by thyroid hormones due to increased prevalence of subclinical hypothyroidism associated with mitochondrial ... ...

    Abstract The thyroid gland plays a critical role in the maintenance of whole-body metabolism. However, aging frequently impairs homeostatic maintenance by thyroid hormones due to increased prevalence of subclinical hypothyroidism associated with mitochondrial dysfunction, inflammation, and fibrosis. To understand the specific aging-related changes of endocrine function in thyroid epithelial cells, we performed single-cell RNA sequencing (RNA-seq) of 54 726 cells derived from pathologically normal thyroid tissues from 7 patients who underwent thyroidectomy. Thyroid endocrine epithelial cells were clustered into 5 distinct subpopulations, and a subset of cells was found to be particularly vulnerable with aging, showing functional deterioration associated with the expression of metallothionein (MT) and major histocompatibility complex class II genes. We further validated that increased expression of MT family genes are highly correlated with thyroid gland aging in bulk RNAseq datasets. This study provides evidence that aging induces specific transcriptomic changes across multiple cell populations in the human thyroid gland.
    MeSH term(s) Humans ; Aging/genetics ; Aging/metabolism ; Hypothyroidism/genetics ; Thyroid Hormones ; Single-Cell Analysis
    Chemical Substances Thyroid Hormones
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqad029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.72: Show issues Location:
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  4. Article ; Online: ASO Author Reflections: Active Surveillance may be Possible in Patients with T1b Papillary Thyroid Carcinoma Over 55 Years of Age Without High-Risk Features on Preoperative Examinations.

    Won, Ho-Ryun / Jeon, Eonju / Heo, Da Beom / Chang, Jae Won / Shong, Minho / Kim, Je Ryong / Ko, Hyemi / Kang, Yea Eun / Yi, Hyon-Seung / Lee, Ju Hee / Joung, Kyong Hye / Kim, Ji Min / Lee, Younju / Kim, Sung-Woo / Jeong, Young Ju / Ji, Yong Bae / Tae, Kyung / Koo, Bon Seok

    Annals of surgical oncology

    2023  Volume 30, Issue 4, Page(s) 2254–2255

    MeSH term(s) Humans ; Thyroid Cancer, Papillary/surgery ; Thyroid Cancer, Papillary/pathology ; Watchful Waiting ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Thyroidectomy ; Patients
    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-13047-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4042: Show issues Location:
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  5. Article ; Online: Age-Dependent Clinicopathological Characteristics of Patients with T1b Papillary Thyroid Carcinoma: Implications for the Possibility of Active Surveillance.

    Won, Ho-Ryun / Jeon, Eonju / Heo, Da Beom / Chang, Jae Won / Shong, Minho / Kim, Je Ryong / Ko, Hyemi / Kang, Yea Eun / Yi, Hyon-Seung / Lee, Ju Hee / Joung, Kyong Hye / Kim, Ji Min / Lee, Younju / Kim, Sung-Woo / Jeong, Young Ju / Ji, Yong Bae / Tae, Kyung / Koo, Bon Seok

    Annals of surgical oncology

    2022  Volume 30, Issue 4, Page(s) 2246–2253

    Abstract: Background: Active surveillance (AS) of low-risk T1a papillary thyroid carcinoma (PTC) is generally accepted as an alternative to immediate surgery. The cut-off in the size criterion for AS has recently been extended in select individuals, especially ... ...

    Abstract Background: Active surveillance (AS) of low-risk T1a papillary thyroid carcinoma (PTC) is generally accepted as an alternative to immediate surgery. The cut-off in the size criterion for AS has recently been extended in select individuals, especially older patients. We evaluated the clinicopathological differences of T1b PTC according to age to investigate the possibility of AS in older patients.
    Patients and methods: From a cohort study of 1269 patients undergoing lobectomy for PTC, 1223 PTC patients with T1 stage disease (tumor ≤ 2 cm) were enrolled. The clinicopathological characteristics between T1a and T1b patients according to age were analyzed.
    Results: Among the 1223 T1 cases, 918 (75.1%) were T1a (≤ 1 cm) and 305 (34.9%) T1b (> 1 and ≤ 2 cm). T1b PTC was associated with male sex, minimal extrathyroidal extension, lymphovascular invasion, occult central lymph node (LN) metastasis, and a higher number of metastatic LNs than T1a. However, in patients over 55 years of age, the clinicopathological features of the patients with T1a and T1b PTC were not significantly different except for minimal extrathyroidal extension, although many clinicopathological differences were observed in patients under 55 years of age.
    Conclusion: The clinicopathological features of patients with T1b PTC over 55 years of age are similar to those with T1a PTC and less aggressive than those with T1b PTC under 55 years of age. These findings suggest that AS may be possible in patients with T1b PTC over 55 years of age without high-risk features on preoperative examinations.
    MeSH term(s) Aged ; Humans ; Male ; Middle Aged ; Cohort Studies ; Lymphatic Metastasis ; Retrospective Studies ; Thyroid Cancer, Papillary/surgery ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Thyroidectomy ; Watchful Waiting ; Female
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-13011-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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