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  1. Book ; Online ; E-Book: Phytocannabinoids

    Kinghorn, A. Douglas / Falk, Heinz / Gibbons, Simon / Kobayashi, Jun'ichi / Chandra, S.

    unraveling the complex chemistry and pharmacology of Cannabis sativa

    (Progress in the chemistry of organic natural products ; 103)

    2017  

    Author's details A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Jun'ichi Kobayashi, editors ; with contributions by S. Chandra [und 13 weiteren]
    Series title Progress in the chemistry of organic natural products ; 103
    Collection
    Language English
    Size 1 Online-Ressource (vii, 131 Seiten)
    Publisher Springer International Publishing
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019352492
    ISBN 978-3-319-45541-9 ; 9783319455396 ; 3-319-45541-9 ; 3319455397
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Search for New Bioactive Marine Natural Products and Application to Drug Development.

    Kobayashi, Jun'ichi

    Chemical & pharmaceutical bulletin

    2016  Volume 64, Issue 8, Page(s) 1079–1083

    Abstract: Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) ...

    Abstract Natural products are well recognized as an important source of lead compounds in drug development. During the past >30 years, we have discovered >1000 novel bioactive natural products from Okinawan marine organisms (sponges, tunicates, cone shells, etc.) and microorganisms (fungi, bacteria, dinoflagellates, etc.). Some of them are used as bioprobes useful for basic studies of life sciences, while others are expected to be candidates of drug leads.
    MeSH term(s) Animal Shells/chemistry ; Animals ; Bacteria/chemistry ; Biological Products/chemistry ; Dinoflagellida/chemistry ; Drug Discovery ; Fungi/chemistry ; Porifera ; Urochordata
    Chemical Substances Biological Products
    Language English
    Publishing date 2016
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c16-00281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficacy of KPR-5714, a selective transient receptor potential melastatin 8 antagonist, on chronic psychological stress-induced bladder overactivity in male rats.

    Watanabe, Shinjiro / Miyazaki, Shingo / Yumoto, Yu / Kobayashi, Jun-Ichi / Fujimori, Yoshikazu

    Neurourology and urodynamics

    2023  Volume 42, Issue 8, Page(s) 1812–1821

    Abstract: Aims: Chronic psychological stress aggravates lower urinary tract symptoms. Among others, water avoidance stress is a chronic psychological stressor that plays a causal role in the exacerbation and development of bladder dysfunction in rats. In this ... ...

    Abstract Aims: Chronic psychological stress aggravates lower urinary tract symptoms. Among others, water avoidance stress is a chronic psychological stressor that plays a causal role in the exacerbation and development of bladder dysfunction in rats. In this report, the effects of KPR-5714, which is a selective transient receptor potential melastatin 8 (TRPM8) antagonist, on bladder overactivity induced by water avoidance stress were examined.
    Methods: Male rats were subjected to water avoidance stress for 2 h per day for 10 consecutive days. The effects of water avoidance stress on voiding behavior using metabolic cages and histological bladder changes were investigated in rats. The involvement of bladder C-fiber afferent on voiding frequency in rats exposed to water avoidance stress was assessed using capsaicin. The effects of KPR-5714 on storage dysfunction in rats subjected to water avoidance stress were examined.
    Results: In voiding behavior measurements, water avoidance stress-induced storage dysfunction, causing a decrease in the mean voided volume and increasing voiding frequency. A comparison of bladders from normal rats and rats exposed to water avoidance stress showed no histological differences. Water avoidance stress-induced bladder overactivity was completely inhibited by pretreatment with capsaicin. KPR-5714 showed a tendency to increase the mean voided volume and significantly decreased the voiding frequency without affecting the total voided volume in these rats.
    Conclusion: The results suggest that KPR-5714 is a promising option for treating chronic psychological stress-induced bladder overactivity.
    MeSH term(s) Rats ; Male ; Animals ; Urinary Bladder ; Rats, Sprague-Dawley ; Capsaicin/pharmacology ; Disease Models, Animal ; Urinary Bladder, Overactive/etiology ; Urinary Bladder, Overactive/chemically induced ; Stress, Psychological/complications ; Water
    Chemical Substances Capsaicin (S07O44R1ZM) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Zamamiphidins B and C, Manzamine-Related Alkaloids from an Amphimedon sp. Marine Sponge Collected in Okinawa

    Kurimoto, Shin-ichiro / Suzuki, Shoichi / Ueno, Mayumi / Fromont, Jane / Kobayashi, Jun’ichi / Kubota, Takaaki

    Journal of natural products. 2022 Sept. 01, v. 85, no. 9

    2022  

    Abstract: Zamamiphidins B (1) and C (2), two new manzamine-related alkaloids with an unprecedented fused diazahexacyclic ring system, were isolated from an Amphimedon sp. marine sponge collected in Okinawa. The structures of zamamiphidins B (1) and C (2) including ...

    Abstract Zamamiphidins B (1) and C (2), two new manzamine-related alkaloids with an unprecedented fused diazahexacyclic ring system, were isolated from an Amphimedon sp. marine sponge collected in Okinawa. The structures of zamamiphidins B (1) and C (2) including the relative configurations were elucidated on the basis of spectroscopic data.
    Keywords Amphimedon ; Ryukyu Archipelago ; spectral analysis
    Language English
    Dates of publication 2022-0901
    Size p. 2226-2231.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.2c00395
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Ma'edamines E and F, rare bromotyrosine alkaloids possessing a 1,2,3,5-tetrasubstituted pyridinium moiety from an Okinawan marine sponge Suberea sp

    Kurimoto, Shin-ichiro / Okamoto, Ayano / Seino, Satsuki / Fromont, Jane / Kobayashi, Jun'ichi / Kubota, Takaaki

    Tetrahedron letters. 2022 Aug. 03, v. 103

    2022  

    Abstract: Two new bromotyrosine alkaloids, ma'edamines E (1) and F (2), were isolated from an Okinawan marine sponge Suberea sp., and their structures were elucidated by the analyses of spectroscopic (UV, IR, and NMR) and spectrometric (MS) data. Ma'edamines E (1) ...

    Abstract Two new bromotyrosine alkaloids, ma'edamines E (1) and F (2), were isolated from an Okinawan marine sponge Suberea sp., and their structures were elucidated by the analyses of spectroscopic (UV, IR, and NMR) and spectrometric (MS) data. Ma'edamines E (1) and F (2) are the second and third examples of natural products possessing an N-alkyl-3,5-diethyl-2-propylpyridinium moiety. Ma'edamine F (2) is the first bromotyrosine alkaloid having both pyridinium and quaternary ammonium moieties. Ma'edamines E (1) and F (2) showed moderate cytotoxicity against L1210 murine leukemia cells in vitro.
    Keywords Suberea ; alkaloids ; cytotoxicity ; leukemia ; mice ; moieties ; quaternary ammonium compounds
    Language English
    Dates of publication 2022-0803
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2022.153985
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: The manzamine alkaloids.

    Kubota, Takaaki / Kurimoto, Shin-Ichiro / Kobayashi, Jun'ichi

    The Alkaloids. Chemistry and biology

    2020  Volume 84, Page(s) 1–124

    Abstract: The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A-C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine ...

    Abstract The manzamine alkaloids are absolutely one of the most fascinating marine natural products. The representative manzamine alkaloids, manzamines A-C, were isolated from a marine sponge Haliclona sp. collected off Cape Manzamo, Okinawa, Japan. The manzamine alkaloids are a unique class of alkaloids possessing a characteristic heterocyclic system, and exhibit a diverse range of bioactivities including cytotoxicity, antimicrobial activity, antimalarial activity, antiviral and antiinflammatory activities, antiinsecticidal activity, and proteasome inhibitory activity. About 100 manzamine alkaloids have been isolated from more than 16 species of marine sponges belonging to 5 families. The unusual ring systems, an intriguing suggested biogenetic pathway, and promising biological activities of manzamine alkaloids have attracted great interest as challenging targets for the total synthesis. This review is the continuation of the previous review published in volume 60 of The Alkaloids and covers isolation, structure elucidation, biosynthesis and biogenesis, chemical synthesis, and biological activity of manzamine alkaloids reported from 2003 to 2018.
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/metabolism ; Alkaloids/pharmacology ; Animals ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Carbazoles/chemistry ; Carbazoles/metabolism ; Carbazoles/pharmacology ; Humans ; Indole Alkaloids/chemistry ; Indole Alkaloids/metabolism ; Indole Alkaloids/pharmacology ; Molecular Structure
    Chemical Substances Alkaloids ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Carbazoles ; Indole Alkaloids ; manzamine B ; manzamine A (104196-68-1)
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 7577-2
    ISSN 1099-4831 ; 0099-9598
    ISSN 1099-4831 ; 0099-9598
    DOI 10.1016/bs.alkal.2020.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Zamamiphidins B and C, Manzamine-Related Alkaloids from an

    Kurimoto, Shin-Ichiro / Suzuki, Shoichi / Ueno, Mayumi / Fromont, Jane / Kobayashi, Jun'ichi / Kubota, Takaaki

    Journal of natural products

    2022  Volume 85, Issue 9, Page(s) 2226–2231

    Abstract: Zamamiphidins B ( ...

    Abstract Zamamiphidins B (
    MeSH term(s) Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Animals ; Cell Line, Tumor ; Molecular Structure ; Porifera/chemistry
    Chemical Substances Alkaloids
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.2c00395
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  8. Article ; Online: KPR-5714, a selective transient receptor potential melastatin 8 antagonist, improves voiding dysfunction in rats with bladder overactivity but does not affect voiding behavior in normal rats.

    Watanabe, Shinjiro / Fujimori, Yoshikazu / Matsuzawa, Akane / Kobayashi, Jun-Ichi / Hirasawa, Hideaki / Mutai, Yosuke / Tanada, Fumiya

    Neurourology and urodynamics

    2022  Volume 41, Issue 6, Page(s) 1336–1343

    Abstract: Aims: Transient receptor potential melastatin 8 (TRPM8) has a role in the abnormal sensory transduction of the bladder and is involved in the pathophysiology of hyperactivity bladder disorders. The aim of this study is to examine the effects of KPR-5714, ...

    Abstract Aims: Transient receptor potential melastatin 8 (TRPM8) has a role in the abnormal sensory transduction of the bladder and is involved in the pathophysiology of hyperactivity bladder disorders. The aim of this study is to examine the effects of KPR-5714, a novel and selective TRPM8 antagonist, on voiding dysfunction induced by bladder afferent hyperactivity via mechanosensitive C-fibers in rats.
    Methods: The effects of intragastric administration of KPR-5714 on bladder overactivity induced by intravesical instillation of 10 mM ATP were investigated using cystometry in conscious female rats. We examined the effects of oral administration of KPR-5714 on voiding behavior using a metabolic cage in normal male rats and rats with an intratesticular injection of 3% acetic acid.
    Results: In cystometry measurements, the intercontraction interval was decreased by intravesical ATP instillation. KPR-5714 (0.1, 0.3, and 1 mg/kg) dose-dependently prolonged the shortened intercontraction interval provoked by ATP. In voiding behavior measurements, intratesticular injection of acetic acid decreased the mean voided volume and increased voiding frequency. KPR-5714 (0.1 and 0.3 mg/kg) dose-dependently increased the mean voided volume and decreased voiding frequency without affecting the total voided volume in these rats. However, KPR-5714 (1 and 10 mg/kg) did not influence the voiding behavior in normal rats.
    Conclusion: The present results suggest that KPR-5714 improves voiding dysfunction by inhibiting the enhanced activity of mechanosensitive bladder C-fibers in rats with bladder overactivity and shows no significant change in voiding behavior in normal rats.
    MeSH term(s) Acetic Acid/adverse effects ; Adenosine Triphosphate ; Animals ; Female ; Male ; Rats ; Rats, Sprague-Dawley ; Urinary Bladder ; Urinary Bladder, Overactive/chemically induced ; Urinary Bladder, Overactive/etiology ; Urination/physiology
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Acetic Acid (Q40Q9N063P)
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.24951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Search for antitumor macrolides from marine dinoflagellates and their biomedical application].

    Kobayashi, Jun'ichi

    The Japanese journal of antibiotics

    2009  Volume 62, Issue 5, Page(s) 471–480

    MeSH term(s) Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/isolation & purification ; Antibiotics, Antineoplastic/pharmacology ; Cloning, Molecular ; Dinoflagellida/chemistry ; Dinoflagellida/enzymology ; Dinoflagellida/metabolism ; Macrolides/chemistry ; Macrolides/isolation & purification ; Macrolides/metabolism ; Macrolides/pharmacology ; Molecular Conformation ; Polyketide Synthases/genetics ; Polyketide Synthases/physiology
    Chemical Substances Antibiotics, Antineoplastic ; Macrolides ; amphidinolide H ; Polyketide Synthases (79956-01-7)
    Language Japanese
    Publishing date 2009-10
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390804-5
    ISSN 0368-2781
    ISSN 0368-2781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Amphidinolides and its related macrolides from marine dinoflagellates.

    Kobayashi, Jun'ichi

    The Journal of antibiotics

    2008  Volume 61, Issue 5, Page(s) 271–284

    Abstract: This review covers the recent results described in our publications on several new cytotoxic macrolides isolated from dinoflagellates of the genus Amphidinium in addition to an overview of the isolation, structure elucidation, synthesis, biosynthesis, ... ...

    Abstract This review covers the recent results described in our publications on several new cytotoxic macrolides isolated from dinoflagellates of the genus Amphidinium in addition to an overview of the isolation, structure elucidation, synthesis, biosynthesis, and bioactivity of a series of cytotoxic macrolides, named amphidinolides, reported so far.
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/biosynthesis ; Antibiotics, Antineoplastic/isolation & purification ; Antibiotics, Antineoplastic/pharmacology ; Dinoflagellida/chemistry ; Dinoflagellida/metabolism ; Drug Screening Assays, Antitumor ; Humans ; Lactones/chemistry ; Macrolides/isolation & purification ; Macrolides/pharmacology ; Magnetic Resonance Spectroscopy ; Marine Biology
    Chemical Substances Antibiotics, Antineoplastic ; Lactones ; Macrolides
    Language English
    Publishing date 2008-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/ja.2008.39
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