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Article ; Online: Blockade of isoprenoids biosynthesis by simvastatin induces autophagy-mediated cell death via downstream c-Jun N-terminal kinase activation and cell cycle dysregulation in canine T-cell lymphoma cells.

Kobayashi, Kosuke / Baba, Kenji / Kambayashi, Satoshi / Okuda, Masaru

2024 Volume 169, Page(s) 105174

Abstract: Statins are inhibitors of the mevalonic acid pathway that mediates cellular metabolism by producing cholesterol and isoprenoids and are widely used in treating hypercholesterolaemia in humans. Lipophilic statins, including simvastatin, induce death in ... ...

Abstract	Statins are inhibitors of the mevalonic acid pathway that mediates cellular metabolism by producing cholesterol and isoprenoids and are widely used in treating hypercholesterolaemia in humans. Lipophilic statins, including simvastatin, induce death in various tumour cells. However, the cytotoxic mechanisms of statins in tumour cells remain largely unexplored. This study aimed to elucidate the cytotoxic mechanisms of simvastatin in canine lymphoma cells. Simvastatin induced cell death via c-Jun N-terminal kinase (JNK) activation and autophagy in canine T-cell lymphoma cell lines Ema and UL-1, but not in B-cell lines. Cell death was mediated by induction of caspase-dependent apoptosis in UL-1 cells, but not in Ema cells. Blockade of autophagy by lysosomal inhibitors attenuated simvastatin-induced JNK activation and cell death. Isoprenoids, including farnesyl pyrophosphate and geranylgeranyl pyrophosphate, attenuated simvastatin-induced autophagy, JNK activation, and cell death. In UL-1 cells, simvastatin treatment resulted in the cell cycle arrest at the G2/M phase, which was altered to G0/1 phase cell cycle arrest by treatment with lysosomal inhibitors. These findings demonstrate that depletion of isoprenoids by simvastatin induces autophagy-mediated cell death via downstream JNK activation and cell cycle dysregulation in canine T-cell lymphoma cells.
MeSH term(s)	Animals ; Dogs ; Humans ; Simvastatin/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Cell Line, Tumor ; Cell Cycle ; Cell Division ; Apoptosis ; Cell Death ; Antineoplastic Agents/pharmacology ; Autophagy ; Lymphoma, T-Cell/drug therapy ; Lymphoma, T-Cell/veterinary ; Terpenes/pharmacology ; Dog Diseases/drug therapy
Chemical Substances	Simvastatin (AGG2FN16EV) ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Antineoplastic Agents ; Terpenes
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2024.105174
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Article ; Online: Laparoscopic Portal Vein Ligation and Embolization During First-Stage Hepatectomy for Initially Unresectable Colorectal Liver Metastases.

Ono, Yoshihiro / Inoue, Yosuke / Kobayashi, Kosuke / Sato, Shoki / Kitano, Yuki / Oba, Atsushi / Sato, Takafumi / Ito, Hiromichi / Takahashi, Yu

Annals of surgical oncology

2024 Volume 31, Issue 5, Page(s) 3069–3070

Abstract: Background: Two-stage hepatectomy (TSH) is the only treatment for the patients with multiple bilobar colorectal liver metastases (CRMs) who are not candidates for one-step hepatectomy because of insufficient future remnant liver volume and/or impaired ... ...

Abstract	Background: Two-stage hepatectomy (TSH) is the only treatment for the patients with multiple bilobar colorectal liver metastases (CRMs) who are not candidates for one-step hepatectomy because of insufficient future remnant liver volume and/or impaired liver function. Methods: Three patients with initially unresectable bilateral CRMs received a median of chemotherapy 12 cycles, followed by conversion TSH. After right PV ligation, laproscopic PV embolization was performed by injection of 100% ethanol into the hepatic side of the right PV using a 23-gauge winged needle. After PV embolization, a spray adhesion barrier (AdSpray, Terumo, Tokyo, Japan) Results: During the first stage of hepatectomy, two patients underwent simultaneous laparoscopic colorectal resection (left hemicolectomy and high anterior resection). In the initial hepatectomy, two patients underwent two limited hepatectomies each, and one patient underwent six hepatectomies in the left lobe. After hepatectomy, all the patients underwent right PV embolization. During the second stage, two patients underwent open extended right hepatectomy (right adrenalectomy was performed because of adrenal invasion in one patient), and one patient underwent laparoscopic extended right hepatectomy. No postoperative complications occurred in the six surgeries. Conclusions: Laparoscopic TSH with PV embolization is recommended for safe completion of the second hepatectomy.
MeSH term(s)	Humans ; Hepatectomy ; Portal Vein/surgery ; Colorectal Neoplasms/pathology ; Liver Neoplasms/surgery ; Laparoscopy ; Embolization, Therapeutic ; Ligation ; Thyrotropin ; Treatment Outcome
Chemical Substances	Thyrotropin (9002-71-5)
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-024-14955-0
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Article ; Online: Association between fall-related serious injury and activity during fall in an acute care hospital.

Kobayashi, Kosuke / Kido, Naohiro / Wakabayashi, Shoji / Yamamoto, Kyoko / Hihara, Jun / Tamura, Masami / Sakahara, Tomoko

PloS one

2023 Volume 18, Issue 7, Page(s) e0288320

Abstract: Objectives: Few studies have evaluated the mechanism of serious injury in acute hospitalization. Thus, the association between fall-related serious injury and activity during falls in acute care hospital remains unclear. Herein, we investigated the ... ...

Abstract	Objectives: Few studies have evaluated the mechanism of serious injury in acute hospitalization. Thus, the association between fall-related serious injury and activity during falls in acute care hospital remains unclear. Herein, we investigated the relationship between serious injury caused by fall and activity at the time of the fall in an acute care hospital. Methods: This retrospective cohort study was conducted at Asa Citizens Hospital. All inpatients aged 65 years and older were eligible for the study, which was conducted from April 1, 2021, through March 31, 2022. The magnitude of the association between injury severity and activity during the fall was quantified using odds ratio. Results: Among the 318 patients with reported falls, 268 (84.3%) had no related injury, 40 (12.6%) experienced minor injury, 3 (0.9%) experienced moderate injury, 7 (2.2%) experienced major injury. Moderate or major injuries caused by a fall was associated with the activity during the fall (odds ratio: 5.20; confidence intervals: 1.43-18.9, p = 0.013). Conclusion: This study recognizes that falling during ambulation caused moderate or major injuries in an acute care hospital. Our study suggests that falls while ambulating in an acute care hospital were associated not only with fractures, but also with lacerations requiring sutures and brain injuries. Among the patients with moderate or major injuries, more falls occurred outside the patient's bedroom as compared with patients with minor or no injuries. Therefore, it is important to prevent moderate or major injuries related to falls that occur while the patient is walking outside their bedroom in an acute care hospital.
MeSH term(s)	Humans ; Retrospective Studies ; Fractures, Bone ; Hospitalization ; Hospitals ; Wounds and Injuries/epidemiology ; Risk Factors
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288320
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Article: Effect of simvastatin on cell proliferation and Ras activation in canine tumour cells

Kobayashi, Kosuke / Baba, Kenji / Kambayashi, Satoshi / Okuda, Masaru

Veterinary and comparative oncology. 2021 Mar., v. 19, no. 1

2021

Abstract: Statins are inhibitors of the mevalonate cascade that is responsible for cholesterol biosynthesis and the formation of intermediate metabolites, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) used in the prenylation of proteins. ... ...

Abstract	Statins are inhibitors of the mevalonate cascade that is responsible for cholesterol biosynthesis and the formation of intermediate metabolites, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) used in the prenylation of proteins. Although statins are widely used in the treatment of hypercholesterolemia, recent studies suggest that they also inhibit proliferation of tumour cells by reducing prenylation of small GTP‐binding proteins, such as, Ras. This study aimed to evaluate the effect of simvastatin on cell proliferation and Ras activation in various canine tumour cell lines, including hemangiosarcoma (HSA), melanoma, and lymphoma cell lines. Simvastatin inhibited cell proliferation of all cell lines tested in a concentration‐ and time‐dependent manner, but the susceptibilities were different amongst the cell lines. Simvastatin induced apoptotic cell death via activation of caspase‐3 and cell cycle arrest. The cytotoxic effects of simvastatin were attenuated by GGPP and FPP. Simvastatin decreased the amount of prenylated Ras and GTP‐bound Ras in HSA and melanoma cell lines, but not in lymphoma cell lines. These results indicate that simvastatin induces cytotoxic effects through the depletion of GGPP and FPP in a variety of canine tumour cells, whereas multiple mechanisms are involved in the effects. Further study is required to elucidate the underlying mechanisms of simvastatin‐induced cytotoxic effects in a variety of canine tumour cells.
Keywords	apoptosis ; biosynthesis ; caspase-3 ; cell cycle checkpoints ; cell proliferation ; cholesterol ; cytotoxicity ; dogs ; hemangiosarcoma ; hypercholesterolemia ; melanoma ; metabolites ; neoplasm cells ; simvastatin
Language	English
Dates of publication	2021-03
Size	p. 99-108.
Publishing place	Blackwell Publishing Ltd
Document type	Article
Note	NAL-light ; JOURNAL ARTICLE
ZDB-ID	2129634-0
ISSN	1476-5829 ; 1476-5810
ISSN (online)	1476-5829
ISSN	1476-5810
DOI	10.1111/vco.12644
Database	NAL-Catalogue (AGRICOLA)

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Article: A retrospective study of histological outcome for IPMN after surgery in Lausanne, Switzerland: A case series.

Litchinko, Alexis / Kobayashi, Kosuke / Halkic, Nermin

Annals of medicine and surgery (2012)

2020 Volume 60, Page(s) 110–114

Abstract: Introduction: Intraductal papillary mucinous neoplasm (IPMN) is a 21st century concept and its management is still controversial. Strong guidelines suggest that surgery is the safest way to prevent malignant evolution. Though the risk of neoplasia is ... ...

Abstract	Introduction: Intraductal papillary mucinous neoplasm (IPMN) is a 21st century concept and its management is still controversial. Strong guidelines suggest that surgery is the safest way to prevent malignant evolution. Though the risk of neoplasia is still debated, high-morbidity and mortality surgery must be proposed for high-risk patients to prevent malignant and most likely fatal pancreatic neoplasia. Methods: The aim of this study was to analyze histological results of patients who underwent operation for IPMN under the Sendai and Fukuoka guidelines. From January 2005 to August 2016, 491 consecutive patients who underwent pancreatic resection in Lausanne University Hospital were analyzed, including 18 IPMN with surgical indication according to the Sendai and Fukuoka criteria. Results: Thirteen (68.4%) patients had benign histopathology after surgery (the non-malignant group). Of the patients with malignant pathology, four (21%) had high-grade dysplasia and two (20.1%) had invasive carcinoma (the malignant group). The median patient age ( Discussion: The use of the current criteria is adequate, but it may be resulting in surgery on excessive numbers of patients with IPMN. A modern decision-making strategy should be based on clinical features, precise imaging data, and biological markers.
Language	English
Publishing date	2020-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2020.10.028
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Article ; Online: Liver resections between 2014 and 2020 in the Lausanne University Hospital, Switzerland.

Kobayashi, Kosuke / Uldry, Emilie / Demartines, Nicolas / Halkic, Nermin

Global health & medicine

2020 Volume 2, Issue 5, Page(s) 337–342

Abstract: Lausanne University Hospital is in the Francophone part of Switzerland and services a catchment population of about 1 million people. We recorded and analyzed baseline characteristics and surgical outcomes for 400 consecutive patients who underwent liver ...

Abstract	Lausanne University Hospital is in the Francophone part of Switzerland and services a catchment population of about 1 million people. We recorded and analyzed baseline characteristics and surgical outcomes for 400 consecutive patients who underwent liver resection there between January 2014 and February 2020. Their pathological results were primary liver cancer (including hepatocellular carcinoma and intrahepatic cholangiocarcinoma): 21.8%, extrahepatic cholangiocarcinoma (including perihilar cholangiocarcinoma and gallbladder cancer): 5.3%, liver metastases: 51.8%, echinococcosis: 10.8%, adenoma: 3.0%, and other diagnoses: 7.5%. Global morbidity rate (Clavien-Dindo classification ≥ 1) was 45.5% with major complication (Clavien-Dindo classification ≥ 3) identified in 81 patients (20.3%). Of the 400 patients, two died within 30 days of surgery (0.5%) and five died within 90 days (1.3%). The 2017-2019 subgroup had a significantly greater percentage of patients aged ≥ 75 years (20.5%) than did the 2014-2016 subgroup (10.9%;
Language	English
Publishing date	2020-12-04
Publishing country	Japan
Document type	Journal Article
ISSN	2434-9194
ISSN (online)	2434-9194
DOI	10.35772/ghm.2020.01059
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Article ; Online: Effect of simvastatin on cell proliferation and Ras activation in canine tumour cells.

Kobayashi, Kosuke / Baba, Kenji / Kambayashi, Satoshi / Okuda, Masaru

Veterinary and comparative oncology

2020 Volume 19, Issue 1, Page(s) 99–108

Abstract	Statins are inhibitors of the mevalonate cascade that is responsible for cholesterol biosynthesis and the formation of intermediate metabolites, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) used in the prenylation of proteins. Although statins are widely used in the treatment of hypercholesterolemia, recent studies suggest that they also inhibit proliferation of tumour cells by reducing prenylation of small GTP-binding proteins, such as, Ras. This study aimed to evaluate the effect of simvastatin on cell proliferation and Ras activation in various canine tumour cell lines, including hemangiosarcoma (HSA), melanoma, and lymphoma cell lines. Simvastatin inhibited cell proliferation of all cell lines tested in a concentration- and time-dependent manner, but the susceptibilities were different amongst the cell lines. Simvastatin induced apoptotic cell death via activation of caspase-3 and cell cycle arrest. The cytotoxic effects of simvastatin were attenuated by GGPP and FPP. Simvastatin decreased the amount of prenylated Ras and GTP-bound Ras in HSA and melanoma cell lines, but not in lymphoma cell lines. These results indicate that simvastatin induces cytotoxic effects through the depletion of GGPP and FPP in a variety of canine tumour cells, whereas multiple mechanisms are involved in the effects. Further study is required to elucidate the underlying mechanisms of simvastatin-induced cytotoxic effects in a variety of canine tumour cells.
MeSH term(s)	Amino Acid Chloromethyl Ketones/pharmacology ; Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Caspase Inhibitors/pharmacology ; Caspases/metabolism ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dog Diseases/metabolism ; Dogs ; Gene Expression Regulation, Neoplastic/drug effects ; Hemangiosarcoma/metabolism ; Hemangiosarcoma/veterinary ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Lymphoma/metabolism ; Lymphoma/veterinary ; Melanoma/metabolism ; Melanoma/veterinary ; Simvastatin/pharmacology ; ras Proteins/genetics ; ras Proteins/metabolism
Chemical Substances	Amino Acid Chloromethyl Ketones ; Caspase Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone ; Simvastatin (AGG2FN16EV) ; Caspases (EC 3.4.22.-) ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2020-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2129634-0
ISSN	1476-5829 ; 1476-5810
ISSN (online)	1476-5829
ISSN	1476-5810
DOI	10.1111/vco.12644
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Article ; Online: Survey on spontaneous miscarriage and induced abortion surgery safety at less than 12 weeks of gestation in Japan.

Nakamura, Eishin / Kobayashi, Kosuke / Sekizawa, Akihiko / Kobayashi, Hiroshi / Takai, Yasushi

The journal of obstetrics and gynaecology research

2021 Volume 47, Issue 12, Page(s) 4158–4163

Abstract: Aim: In Japan, dilatation and curettage (D&C) is a common procedure for spontaneous miscarriage and induced abortion, and its safety has long been an issue. Electric vacuum aspiration (EVA) is also common, but manual vacuum aspiration (MVA) was ... ...

Abstract	Aim: In Japan, dilatation and curettage (D&C) is a common procedure for spontaneous miscarriage and induced abortion, and its safety has long been an issue. Electric vacuum aspiration (EVA) is also common, but manual vacuum aspiration (MVA) was introduced recently, with medical abortions using mifepristone or misoprostol which are not yet legally accepted. This nationwide retrospective study surveyed the surgical methods and complications associated with spontaneous miscarriage and induced abortion at less than 12 weeks of gestation in Japan to assess their safety, in comparison with a similar survey for induced abortions in 2012. Methods: Questionnaires were sent to 4176 facilities with a license for induced abortion surgeries in 2019. The questions included were the methods used, number of spontaneous miscarriages and induced abortions, and number of complications (uterine perforation, incomplete abortion, and gross bleeding requiring blood transfusion). Results: Responses were received from 1706 facilities (40.9%). Although EVA with sharp curettage was the most common surgical method, which was used for 11 953 spontaneous miscarriages (28.9%) and 24 045 induced abortions (37.3%), the most common surgical method per facility was D&C, and the rates of D&C for spontaneous miscarriages (38.4%) and induced abortions (44.7%) performed in general hospitals were significantly higher than those in clinics (24.1% and 22.0%, respectively). There was no significant difference in the complication incidence rate among surgical methods for spontaneous miscarriages. However, in induced abortion surgery, the total complication and incomplete abortion incidence rates for D&C were significantly higher than those for EVA without sharp curettage (47/15 162 [0.31%] vs. 29/18 693 [0.16%], p = 0.00362, 45/15 162 [0.30%] vs. 27/18 693 [0.14%], p = 0.00285, respectively). There was no significant difference in the complication incidence rate between MVA and other surgical methods for each abortion surgery. Conclusion: In Japan, especially in general hospitals, D&C is still widely used for miscarriage and induced abortion surgery. Its complication-incidence rates significantly decreased compared with that of the nationwide survey in 2012, but were still significantly higher than EVA without sharp curettage. Few facilities used MVA, but its complication rate was comparable with those of other surgical methods.
MeSH term(s)	Abortion, Incomplete ; Abortion, Induced/adverse effects ; Abortion, Spontaneous/epidemiology ; Abortion, Spontaneous/surgery ; Female ; Humans ; Japan/epidemiology ; Pregnancy ; Pregnancy Trimester, First ; Retrospective Studies ; Surveys and Questionnaires ; Vacuum Curettage/adverse effects
Language	English
Publishing date	2021-09-27
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15014
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Article ; Online: New approach of circumferential lymph node dissection around the superior mesenteric artery for pancreatic cancer during pancreaticoduodenectomy (with video).

Ono, Yoshihiro / Inoue, Yosuke / Kato, Tomotaka / Kobayashi, Kosuke / Takamatsu, Manabu / Atsushi, Oba / Sato, Takafumi / Ito, Hiromichi / Takahashi, Yu

Langenbeck's archives of surgery

2023 Volume 408, Issue 1, Page(s) 422

Abstract: Purpose: Various approaches have been reported for the resection of the nervous and lymphatic tissues around the superior mesenteric artery (SMA) during pancreaticoduodenectomy (PD) for pancreatic cancer. We developed a new procedure for circumferential ...

Abstract	Purpose: Various approaches have been reported for the resection of the nervous and lymphatic tissues around the superior mesenteric artery (SMA) during pancreaticoduodenectomy (PD) for pancreatic cancer. We developed a new procedure for circumferential lymph node dissection around the SMA to minimize local recurrence. Methods: We included 24 patients who underwent PD with circumferential lymph node dissection around the SMA (circumferential dissection) and 94 patients who underwent classical mesopancreatic dissection (classical dissection) between 2019 and 2021. The technical details of this new method are described in the figures and videos, and the clinical characteristics and outcomes of this technique were compared with those of classical dissection. Results: The median follow-up durations in the circumferential and classical dissection groups were 39 and 36 months, respectively. The patients' characteristics, including tumor resectability, preoperative and adjuvant chemotherapy rates, postoperative complication rates, and tumor stage, were similar between the two groups. No differences were observed in recurrence-free survival and overall survival between the two groups; however, the classical dissection group tended to have more local recurrences than the circumferential dissection group (8.3% vs. 33.3%, P = 0.168). Although no case of nodular-type recurrence after circumferential dissection was observed, 61.1% of local recurrences after classical dissection were of the nodular-type, and 36.4% were located on the left side of the SMA. Conclusions: Performing circumferential lymph node dissection around the SMA during PD can be conducted safely with minimal risks of local recurrence and may enhance the completeness of local resection.
MeSH term(s)	Humans ; Pancreaticoduodenectomy/methods ; Mesenteric Artery, Superior/surgery ; Mesenteric Artery, Superior/pathology ; Pancreatic Neoplasms/pathology ; Lymph Node Excision/methods
Language	English
Publishing date	2023-11-01
Publishing country	Germany
Document type	Video-Audio Media ; Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-03159-x
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Article ; Online: Impact of preoperative self-expandable metal stent on benign hepaticojejunostomy anastomotic stricture after pancreaticoduodenectomy.

Mie, Takafumi / Sasaki, Takashi / Kobayashi, Kosuke / Takeda, Tsuyoshi / Okamoto, Takeshi / Kasuga, Akiyoshi / Inoue, Yosuke / Takahashi, Yu / Saiura, Akio / Sasahira, Naoki

DEN open

2023 Volume 4, Issue 1, Page(s) e307

Abstract: Objectives: Hepaticojejunostomy anastomotic stricture (HJAS) is a serious adverse event of pancreaticoduodenectomy. Preoperative biliary drainage with a self-expandable metal stent (SEMS) is often performed before pancreaticoduodenectomy. The purpose of ...

Abstract	Objectives: Hepaticojejunostomy anastomotic stricture (HJAS) is a serious adverse event of pancreaticoduodenectomy. Preoperative biliary drainage with a self-expandable metal stent (SEMS) is often performed before pancreaticoduodenectomy. The purpose of this study is to evaluate the risk factors and impact of preoperative SEMS placement on developing benign HJAS after pancreaticoduodenectomy. Methods: We retrospectively analyzed consecutive patients who underwent pancreatoduodenectomy at our institution between July 2014 and June 2020. Risk factors for benign HJAS were identified using univariate and multivariate logistic regression analysis. We also compared outcomes of preoperative biliary drainage using SEMS and non-SEMS. Results: Of the 626 included patients, benign HJAS occurred in 36 patients (5.8%). The median follow-up time was 36.7 months (interquartile range, 25.4-57.4 months). Multivariate logistic regression analysis revealed that lack of preoperative biliary drainage, preoperative bile duct diameter <5 mm, and former or current smoking were independent predictors of benign HJAS. In the preoperative biliary drainage group, the rate of preoperative bile duct diameter <5 mm was significantly lower in the SEMS group than in the non-SEMS group (2.0% vs. 12.8%, Conclusions: Preoperative biliary drainage with SEMS may be useful to maintain bile duct diameter ≥5 mm and to reduce benign HJAS as a result.
Language	English
Publishing date	2023-10-28
Publishing country	Australia
Document type	Journal Article
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.307
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