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  1. Article ; Online: Protein homeostasis and degradation in quiescent neural stem cells.

    Kobayashi, Taeko

    Journal of biochemistry

    2024  

    Abstract: Tissue stem cells are maintained in the adult body throughout life and are crucial for tissue homeostasis as they supply newly functional cells. Quiescence is a reversible arrest in the G0/G1 phase of the cell cycle and a strategy to maintain the quality ...

    Abstract Tissue stem cells are maintained in the adult body throughout life and are crucial for tissue homeostasis as they supply newly functional cells. Quiescence is a reversible arrest in the G0/G1 phase of the cell cycle and a strategy to maintain the quality of tissue stem cells. Quiescence maintains stem cells in a self-renewable and differentiable state for a prolonged period by suppressing energy consumption and cell damage and depletion. Most adult neural stem cells in the brain maintain the quiescent state and produce neurons and glial cells through differentiation after activating from the quiescent state to the proliferating state. In this process, proteostasis, including proteolysis, is essential to transition between the quiescent and proliferating states associated with proteome remodeling. Recent reports have demonstrated that quiescent and proliferating neural stem cells have different expression patterns and roles as proteostatic molecules and are affected by age, indicating differing processes for protein homeostasis in these two states in the brain. This review discusses the multiple regulatory stages from protein synthesis (protein birth) to proteolysis (protein death) in quiescent neural stem cells.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvae006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.202: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Conference proceedings ; Online: Changes in antarctic bottom water off the Wilkes land coast in the Australian-antarctic basin

    Kobayashi, T.

    XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

    2023  

    Abstract: Long-term changes in Antarctic Bottom Water (AABW) off the Wilkes Land coast, East Antarctica, were investigated using historical hydrographic surveys and data from Deep Argo floats. Since the 1980s at the latest, AABW has contracted by approximately 11– ... ...

    Abstract Long-term changes in Antarctic Bottom Water (AABW) off the Wilkes Land coast, East Antarctica, were investigated using historical hydrographic surveys and data from Deep Argo floats. Since the 1980s at the latest, AABW has contracted by approximately 11–14 m yr -1 and undergone isothermal freshening by approximately –0.6 × 10 -3 yr -1 . The contraction and freshening of AABW has accelerated in recent decades, with the former being led by the latter. The contraction of AABW was mainly derived from thinning of the denser layers of AABW, which was compensated for by thickening of the upper AABW. This contrast between excessive thinning and compensative thickening has strengthened gradually over time, suggesting that the meridional overturning circulation driven by AABW formation has weakened in the Australian-Antarctic Basin. Dissolved oxygen in AABW appears to have remained constant for approximately 50 years, except for the possibility of some oxygenation after 2000, which was not statistically significant. After 2010, changes in AABW deviated from long-term trends, with contraction and freshening of AABW accelerating significantly from 2011 to 2015 and then slowing down from 2015 to 2019. Meanwhile, the bottommost AABW, which is defined as the layer over bottom 300 m, salinized significantly in the latter 2010s, mainly in response to contraction of AABW. These processes have resulted in the recent salinization of the bottommost AABW in the eastern Australian-Antarctic Basin, even in areas where the salinized Ross Sea Bottom Water has not arrived yet.
    Subject code 333
    Language English
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Mapping trasmembrane distribution of sphingomyelin.

    Kobayashi, Toshihide

    Emerging topics in life sciences

    2023  Volume 7, Issue 1, Page(s) 31–45

    Abstract: Our knowledge on the asymmetric distribution of sphingomyelin (SM) in the plasma membrane is largely based on the biochemical analysis of erythrocytes using sphingomyelinase (SMase). However, recent studies showed that the product of SMase, ceramide, ... ...

    Abstract Our knowledge on the asymmetric distribution of sphingomyelin (SM) in the plasma membrane is largely based on the biochemical analysis of erythrocytes using sphingomyelinase (SMase). However, recent studies showed that the product of SMase, ceramide, disturbs transmembrane lipid distribution. This led to the development of the complimentary histochemical method, which combines electron microscopy and SM-binding proteins. This review discusses the advantages and caveats of published methods of measuring transbilayer distribution of SM. Recent finding of the proteins involved in the transbilayer movement of SM will also be summarized.
    MeSH term(s) Sphingomyelins/metabolism ; Cell Membrane/metabolism ; Ceramides/metabolism ; Sphingomyelin Phosphodiesterase/metabolism ; Erythrocytes/metabolism
    Chemical Substances Sphingomyelins ; Ceramides ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2882721-1
    ISSN 2397-8554 ; 2397-8554 ; 2397-8562
    ISSN (online) 2397-8554
    ISSN 2397-8554 ; 2397-8562
    DOI 10.1042/ETLS20220086
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  4. Article ; Online: Social contagion induced by uncertain information.

    Kobayashi, Teruyoshi

    Physical review. E

    2023  Volume 107, Issue 6-1, Page(s) 64301

    Abstract: Information and individual activities often spread globally through the network of social ties. While social contagion phenomena have been extensively studied within the framework of threshold models, it is common to make an assumption that may be ... ...

    Abstract Information and individual activities often spread globally through the network of social ties. While social contagion phenomena have been extensively studied within the framework of threshold models, it is common to make an assumption that may be violated in reality: each individual can observe the neighbors' states without error. Here, we analyze the dynamics of global cascades under uncertainty in an otherwise standard threshold model. Each individual uses statistical inference to estimate the probability distribution of the number of active neighbors when deciding whether to be active, which gives a probabilistic threshold rule. Unlike the deterministic threshold model, the spreading process is generally nonmonotonic, as the inferred distribution of neighbors' states may be updated as a new signal arrives. We find that social contagion may occur as a self-fulfilling event in that misperception may trigger a cascade in regions where cascades would never occur under certainty.
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.107.064301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: [[Fundamentals] 2. Introduction to Data Structures for 2D and 3D Image Processing].

    Kobayashi, Takuma

    Nihon Hoshasen Gijutsu Gakkai zasshi

    2023  Volume 79, Issue 5, Page(s) 488–493

    MeSH term(s) Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods
    Language Japanese
    Publishing date 2023-05-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2269092-X
    ISSN 1881-4883 ; 0369-4305
    ISSN (online) 1881-4883
    ISSN 0369-4305
    DOI 10.6009/jjrt.2023-2197
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  6. Article ; Online: Limited roles of Piezo mechanosensing channels in articular cartilage development and osteoarthritis progression.

    Young, C / Kobayashi, T

    Osteoarthritis and cartilage

    2023  Volume 31, Issue 6, Page(s) 775–779

    Abstract: Objective: To investigate the role of Piezo1 and Piezo2 in surgically induced osteoarthritis (OA) in mice.: Design: Male conditional knockout (cKO) mice missing Piezo1 and Piezo2 in the joint using Gdf5-Cre transgenic mice were induced with post- ... ...

    Abstract Objective: To investigate the role of Piezo1 and Piezo2 in surgically induced osteoarthritis (OA) in mice.
    Design: Male conditional knockout (cKO) mice missing Piezo1 and Piezo2 in the joint using Gdf5-Cre transgenic mice were induced with post-traumatic OA by destabilization of the medial meniscus (DMM) of the right knee joint at 12 weeks of age. The severity of OA was histologically assessed at 24 weeks of age. OA-associated pain was evaluated by static weight bearing analysis. Additionally, articular chondrocytes isolated from cKO mice were exposed to fluid flow shear stress (FFSS) to evaluate the expression of OA-associated genes.
    Results: Mice with conditional deletion of Piezo1 and Piezo2 showed normal joint development with no overt histological changes in the knee joint at 12 weeks and 24 weeks. DMM surgery induced moderate to severe OA in both control and cKO mice (median OARSI score: control, 4.67; cKO, 4.23, P = 0.3082), although a few cKO mice showed milder OA. Pain assessment by static weight-bearing analysis suggested Piezo ablation in the joint has no beneficial effects on pain. FFSS increased the expression of OA-related genes both in control and cKO mice to similar extents.
    Conclusion: Piezo1 and Piezo2 are not essential for normal joint development. Genetic ablation of Piezo channels did not confer evident protective effects on OA progression in mice. In vitro data suggests that different mechanotransducers other than Piezo channels mediate FFSS in mechanical stress-induced gene expression.
    MeSH term(s) Mice ; Male ; Animals ; Cartilage, Articular/pathology ; Osteoarthritis/metabolism ; Mice, Transgenic ; Menisci, Tibial/pathology ; Pain/metabolism ; Chondrocytes/metabolism ; Disease Models, Animal ; Ion Channels/genetics ; Ion Channels/metabolism
    Chemical Substances Piezo1 protein, mouse ; Ion Channels
    Language English
    Publishing date 2023-02-17
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1167809-4
    ISSN 1522-9653 ; 1063-4584
    ISSN (online) 1522-9653
    ISSN 1063-4584
    DOI 10.1016/j.joca.2023.01.576
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Diffusion dynamics of competing information on networks.

    Kobayashi, Teruyoshi

    Physical review. E

    2022  Volume 106, Issue 3-1, Page(s) 34303

    Abstract: Information diffusion on social networks has been described as a collective outcome of threshold behaviors in the framework of threshold models. However, since the existing models do not take into account individuals' optimization problems, it remains an ...

    Abstract Information diffusion on social networks has been described as a collective outcome of threshold behaviors in the framework of threshold models. However, since the existing models do not take into account individuals' optimization problems, it remains an open question what dynamics emerge in the diffusion process when individuals face multiple (and possibly incompatible) information sources. Here, we develop a microfounded general threshold model that enables us to analyze the collective dynamics of individual behavior in the propagation of multiple information sources. The analysis reveals that the virality of competing information sources is fundamentally indeterminate. When individuals maximize coordination with neighbors, the diffusion process is described as a saddle path, thereby leading to unpredictable symmetry breaking. When individuals' choices are irreversible, there is a continuum of stable equilibria where a certain degree of social polarization takes place by chance.
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.106.034303
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  8. Article ; Online: RadiomicsJ: a library to compute radiomic features.

    Kobayashi, Tatsuaki

    Radiological physics and technology

    2022  Volume 15, Issue 3, Page(s) 255–263

    Abstract: Despite the widely recognized need for radiomics research, the development and use of full-scale radiomics-based predictive models in clinical practice remains scarce. This is because of the lack of well-established methodologies for radiomic research ... ...

    Abstract Despite the widely recognized need for radiomics research, the development and use of full-scale radiomics-based predictive models in clinical practice remains scarce. This is because of the lack of well-established methodologies for radiomic research and the need to develop systems to support radiomic feature calculations and predictive model use. Several excellent programs for calculating radiomic features have been developed. However, there are still issues such as the types of image features, variations in the calculated results, and the limited system environment in which to run the program. Against this background, we developed RadiomicsJ, an open-source radiomic feature computation library. RadiomicsJ will not only be a new research tool to enhance the efficiency of radiomics research but will also become a knowledge resource for medical imaging feature studies through its release as an open-source program.
    Language English
    Publishing date 2022-07-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2433581-2
    ISSN 1865-0341 ; 1865-0333
    ISSN (online) 1865-0341
    ISSN 1865-0333
    DOI 10.1007/s12194-022-00664-4
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  9. Article: [Clinical guidance for the peripartum management of patients with hereditary thrombophilia].

    Kobayashi, Takao

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2022  Volume 63, Issue 9, Page(s) 1223–1232

    Abstract: Hereditary thrombophilia is a condition in which individuals are susceptible to the formation of thrombi due to a hereditary deficiency in the anticoagulant factors antithrombin (AT), protein C, or protein S. The recommendations for peripartum management ...

    Abstract Hereditary thrombophilia is a condition in which individuals are susceptible to the formation of thrombi due to a hereditary deficiency in the anticoagulant factors antithrombin (AT), protein C, or protein S. The recommendations for peripartum management are as follows: 1) For women with acute venous thromboembolism (VTE) during pregnancy, anticoagulant therapy with a therapeutic dose of unfractionated heparin (UFH) is recommended; 2) For women with a history of VTE, a prophylactic dose of UFH is suggested during pregnancy; 3) For those with AT deficiency, supplementation with an AT preparation in addition to UFH is suggested; 4) For women with no history of VTE, anticoagulant therapy during pregnancy is considered for each thrombophilia type; 5) When anticoagulant therapy consisting of a prophylactic dose of UFH is administered during pregnancy, injection is discontinued with the onset of labor pains in cases of vaginal delivery and 6 hours before the start of delivery in cases of planned delivery or cesarean section; 6) In cases of AT deficiency, regardless of the thrombophilia type, supplementation with AT before and after delivery is suggested; 7) For women with thrombophilia and a history of VTE and for those who receive anticoagulant therapy during pregnancy, postpartum anticoagulant therapy is recommended.
    MeSH term(s) Anticoagulants/therapeutic use ; Antithrombins/therapeutic use ; Cesarean Section ; Female ; Heparin/therapeutic use ; Humans ; Peripartum Period ; Pregnancy ; Protein C ; Risk Factors ; Thrombophilia/drug therapy ; Thrombophilia/etiology
    Chemical Substances Anticoagulants ; Antithrombins ; Protein C ; Heparin (9005-49-6)
    Language Japanese
    Publishing date 2022-08-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.63.1223
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 535: Show issues

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  10. Article ; Online: Editorial Comment from Dr Kobayashi to Effect of active anticancer therapy on serologic response to SARS-CoV-2 BNT162b2 vaccine in patients with urothelial and renal cell carcinoma.

    Kobayashi, Takashi

    International journal of urology : official journal of the Japanese Urological Association

    2022  Volume 29, Issue 7, Page(s) 739

    MeSH term(s) BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Carcinoma, Renal Cell/drug therapy ; Humans ; Kidney Neoplasms/drug therapy ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-04-27
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.14919
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4460: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 278: Show issues

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