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  1. Article ; Online: Women satisfaction on choosing the cervical ripening method: Oral misoprostol versus balloon catheter.

    Flament, Emeline / Blanc-Petitjean, Pauline / Koch, Antoine / Deruelle, Philippe / Le Ray, Camille / Sananès, Nicolas

    European journal of obstetrics & gynecology and reproductive biology: X

    2023  Volume 19, Page(s) 100202

    Abstract: Objective: Induction of labor concerns about 29 % of women in Unites States and 33 % in Europe. Among the various methods for cervical ripening, the efficacy and safety profiles of oral misoprostol and balloon catheter are comparable, but data in the ... ...

    Abstract Objective: Induction of labor concerns about 29 % of women in Unites States and 33 % in Europe. Among the various methods for cervical ripening, the efficacy and safety profiles of oral misoprostol and balloon catheter are comparable, but data in the literature on maternal satisfaction during induction of labor are few. The objective of this study was to assess the satisfaction of women who chose the method of cervical ripening, i.e. either balloon catheter or oral misoprostol, for induction of labor.
    Study design: This retrospective study asked women who had undergone induction of labor between February 1, 2020 and February 28, 2021. After receiving verbal and written information, the choice of method between oral misoprostol and balloon catheter was left to the patient's free appreciation. Satisfaction was assessed by means of a questionnaire distributed to all women during their stay in the maternity unit. The principal assessment criterion was based on women' inclination to choose the same cervical ripening method if induction of labor were to prove necessary in a future pregnancy, and their willingness to recommend this method to a friend. Univariate analyses were conducted using Student's t-test, Chi-2 test or Fisher's exact test.
    Results: On 575 women eligible for analysis, 365 (63.5 %) of these women replied to the satisfaction questionnaire. Of this number, 236 (64.7 %) chose cervical ripening by balloon catheter, and 129 (35.3 %) by oral misoprostol. No significant difference was found between the two groups: 68.2 % of women in the balloon catheter group would opt for the same method of cervical ripening if it proved necessary in a future pregnancy and 64.7% would recommend it to a pregnant friend, versus 65.9 % and 63.6 % in the oral misoprostol group, respectively. Women were overall pleased to be able to choose their method of cervical ripening: 90.5 % of patients in the balloon catheter group and 95.3 % in the oral misoprostol group.
    Conclusions: When women choose the method of cervical ripening, satisfaction is overall good, irrespective of the method, whether by balloon catheter or misoprostol.
    Language English
    Publishing date 2023-06-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1613
    ISSN (online) 2590-1613
    DOI 10.1016/j.eurox.2023.100202
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  2. Article ; Online: Évaluation de la douleur lors des interruptions volontaires de grossesse médicamenteuses jusqu’à 14 semaines d’aménorrhées : une étude prospective comparative sur 1 an.

    Hauss, Anne-Sophie / Kiehl, Amélie / Arnalsteen, Charlotte / Deshaies, Anne / Deruelle, Philippe / Bettahar, Karima / Koch, Antoine

    Gynecologie, obstetrique, fertilite & senologie

    2023  Volume 51, Issue 11-12, Page(s) 511–516

    Abstract: Objectives: Pain assessment of patients requesting a medical abortion according to the term, up to 14 weeks, by a numerical rating scale (NRS).: Methods: This was a single-centre prospective observational study conducted at the University Hospitals ... ...

    Title translation Pain assessment during medical abortion up to 14 weeks: A 1-year prospective comparative study.
    Abstract Objectives: Pain assessment of patients requesting a medical abortion according to the term, up to 14 weeks, by a numerical rating scale (NRS).
    Methods: This was a single-centre prospective observational study conducted at the University Hospitals of Strasbourg from 1st October 2019 to 31st December 2020.
    Results: There was no significant difference in pain assessed by the NRS for medical abortion performed between 7-9 weeks and those performed between 9-14 weeks (6.5±2.5 vs. 6.6±2.2, P=0.85). Regardless of the term (before 7 weeks, between 7-9 weeks and between 9-14 weeks), patients felt relieved by taking painkillers in the case of medical abortion in 88.9%, 80.3% and 87.3% of cases respectively (P=0.18). The use of analgesics allowed a decrease of 3 points of the NRS in the 3 groups (P=0.67). Patients were more painful in case of medical protocol vs. surgical (maximum pain at 6.0±2.6 vs. 1.4±2.0, P<0.01), but declared to be relieved by analgesics in 85.1 and 94.3% of cases (P=0.24).
    Conclusions: As pain is similar whatever the term in the case of medical abortion, and its management by analgesics seems to be effective, this criterion should not guide the professional in the choice of method, particularly between 9 and 14 weeks. This choice must be made by the patient.
    MeSH term(s) Pregnancy ; Female ; Humans ; Pain Measurement ; Prospective Studies ; Abortion, Induced ; Analgesics/therapeutic use ; Pain/drug therapy ; Pain/etiology
    Chemical Substances Analgesics
    Language French
    Publishing date 2023-08-18
    Publishing country France
    Document type Observational Study ; English Abstract ; Journal Article
    ZDB-ID 2887456-0
    ISSN 2468-7189
    ISSN (online) 2468-7189
    DOI 10.1016/j.gofs.2023.07.007
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  3. Article ; Online: Trisomy 22: First and Second Trimester Cytogenetic Analysis and Phenotypic Presentation in a Series of Seven Cases.

    Minella, Chris / Jeandidier, Eric / Koch, Antoine / Antal, Maria Cristina / Favre, Romain / Sananes, Nicolas / Weingertner, Anne-Sophie

    Fetal diagnosis and therapy

    2023  Volume 51, Issue 2, Page(s) 112–124

    Abstract: Introduction: Trisomy 22 is a chromosomal disorder rarely encountered prenatally. Even fewer live births are observed and generally correspond to confined placental mosaic trisomy 22, or even more uncommonly, to true fetal mosaic trisomy 22.: Case ... ...

    Abstract Introduction: Trisomy 22 is a chromosomal disorder rarely encountered prenatally. Even fewer live births are observed and generally correspond to confined placental mosaic trisomy 22, or even more uncommonly, to true fetal mosaic trisomy 22.
    Case presentation: We examine and describe a series of seven cases of trisomy 22 encountered prenatally in terms of their cytogenetic and phenotypic presentations and discuss their interrelationships along with case management and outcomes. We aimed to identify aspects of prenatal data suggestive of fetal trisomy 22 and to determine whether a prognosis can be established from these factors.
    Conclusion: Our conclusion is that prenatal data elements can provide key elements of information to guide multidisciplinary care and support for the couple and the neonate.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; Pregnancy Trimester, Second ; Amniocentesis ; Placenta ; Mosaicism ; Trisomy/diagnosis ; Trisomy/genetics ; Cytogenetic Analysis ; Comparative Genomic Hybridization ; Chromosomes, Human, Pair 22
    Language English
    Publishing date 2023-11-03
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 1066460-9
    ISSN 1421-9964 ; 1015-3837
    ISSN (online) 1421-9964
    ISSN 1015-3837
    DOI 10.1159/000534619
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  4. Article ; Online: Morbidity associated with planned cesarean deliveries performed before the scheduled date: A cohort study.

    Sananès, Nicolas / Haller, Laure / Jochum, Floriane / Koch, Antoine / Lecointre, Lise / Rozenberg, Patrick

    European journal of obstetrics, gynecology, and reproductive biology

    2021  Volume 264, Page(s) 83–87

    Abstract: Objective: Women with planned cesareans can require delivery before the scheduled date. However, data describing the morbidity associated with planned cesarean deliveries performed before the originally scheduled date is lacking. The objective of this ... ...

    Abstract Objective: Women with planned cesareans can require delivery before the scheduled date. However, data describing the morbidity associated with planned cesarean deliveries performed before the originally scheduled date is lacking. The objective of this study was to compare the morbidity associated with planned cesarean delivery performed before compared with on the scheduled date.
    Study design: This retrospective single-center cohort study included all 3595 women with singleton pregnancies and cesarean deliveries after 36
    Results: Reasons for performing planned cesarean delivery before the scheduled date were as follows: onset of labor (n = 109; 50.0%), rupture of membranes (n = 85; 39.0%), preeclampsia (n = 9; 4.1%), scar pain in women with a previous cesarean (n = 6; 2.8%), unexplained vaginal bleeding (n = 5; 2.3%), and nonreassuring fetal heart rate (n = 4; 1.8%). Mean gestational age for planned cesarean deliveries before the scheduled date was 38.7 weeks ± 0.8 versus 39.2 weeks ± 0.7 for those performed when scheduled (P < 0.0001). The maternal morbidity composite outcome rate was significantly higher among planned cesareans performed early compared with those on the scheduled date: 18.3% vs 9.7%, respectively, P = 0.0002. It was still higher in the multivariable analysis: aOR 2.17, 95% CI 1.46-3.21, P = 0.0001. The neonatal composite outcome did not differ significantly between the two groups.
    Conclusion: In planned cesarean deliveries, maternal morbidity is higher for cesareans performed before rather than on the scheduled date. Studies without accurate intent-to-treat analyses underestimate the morbidity associated with planned cesareans. Accordingly, medical records must make it possible to distinguish planned cesarean deliveries performed before the scheduled date from those performed as planned.
    Language English
    Publishing date 2021-06-29
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2021.06.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: 3D-printed simulator for nasopharyngeal swab collection for COVID-19.

    Sananès, Nicolas / Lodi, Massimo / Koch, Antoine / Lecointre, Lise / Sananès, Axel / Lefebvre, Nicolas / Debry, Christian

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2020  Volume 278, Issue 7, Page(s) 2649–2651

    Abstract: Introduction: Testing for COVID-19 is a cornerstone of pandemic control. If conducted inappropriately, nasopharyngeal swab collection can be painful and preanalytical sample collection errors may lead to false negative results. Our objective was to ... ...

    Abstract Introduction: Testing for COVID-19 is a cornerstone of pandemic control. If conducted inappropriately, nasopharyngeal swab collection can be painful and preanalytical sample collection errors may lead to false negative results. Our objective was to develop a realistic and easily available synthetic simulator for nasopharyngeal swab collection.
    Materials and methods: The nasopharyngeal swab collection simulator was designed through different development steps: segmentation, computer-aided design (CAD), and 3D printing. The model was 3D printed using PolyJet technology, which allows multi-material printing using hard and soft materials.
    Results: The simulator splits in the parasagittal plane close to the septum to allow better visualization and understanding of nasal cavity landmarks. The model is able to simulate the softness and texture of different structural elements. The simulator allows the user to conduct realistic nasopharyngeal swab collection. A colored pad on the posterior wall of the nasopharynx provides real-time feedback to the user. The simulator also permits incorrect swab insertion, which is of obvious benefit from a training perspective. Comprehensive 3D files for printing and full instructions for manufacturing the simulator is freely available online via an open access link.
    Conclusion: In the context of the COVID-19 pandemic, we developed a nasopharyngeal swab collection simulator which can be produced by 3D printing via an open access link, which offers complete operating instructions.
    MeSH term(s) COVID-19 ; COVID-19 Testing ; Humans ; Nasopharynx ; Pandemics ; Printing, Three-Dimensional ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-020-06454-1
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  6. Article ; Online: Multicentric evaluation of a 3D-printed simulator for COVID- 19 nasopharyngeal swab collection in testing centers.

    Lecointre, Lise / Venkatasamy, Aïna / Wehr, Mégane / Koch, Antoine / Sananes, Axel / Debry, Christian / Lodi, Massimo / Sananes, Nicolas

    The Journal of infection

    2021  Volume 83, Issue 6, Page(s) 709–737

    MeSH term(s) COVID-19 ; Diagnostic Tests, Routine ; Humans ; Nasopharynx ; Printing, Three-Dimensional ; SARS-CoV-2 ; Specimen Handling
    Language English
    Publishing date 2021-09-24
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.09.015
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  7. Article ; Online: Risk factors for obstetric anal sphincter injuries (OASIS) and the role of episiotomy: A retrospective series of 496 cases.

    Mahgoub, Sara / Piant, Hélène / Gaudineau, Adrien / Lefebvre, François / Langer, Bruno / Koch, Antoine

    Journal of gynecology obstetrics and human reproduction

    2019  Volume 48, Issue 8, Page(s) 657–662

    Abstract: Objective: The objective of this study was to determine the prevalence and identify risk factors for obstetric anal sphincter injuries (OASIS), and to determine the prevalence of episiotomy and whether it is protective for the posterior perineum.: ... ...

    Abstract Objective: The objective of this study was to determine the prevalence and identify risk factors for obstetric anal sphincter injuries (OASIS), and to determine the prevalence of episiotomy and whether it is protective for the posterior perineum.
    Study design: This is a retrospective case-control study carried out in a level 2 maternity unit and a level 3 maternity unit between 1 January 2006 and 31 December 2015. The sample population included all vaginal deliveries at term of a living singleton foetus in cephalic presentation. The case group comprised patients with an OASIS. The control group comprised patients without OASIS. Statistical analysis was subdivided into descriptive and inferential parts.
    Results: 42,626 patients were included in the study of whom 496 were cases of OASIS, i.e. a rate of 1.2%. The overall episiotomy rate was 10.0%, which reflects a restrictive practice. Episiotomy doesn't appear to be a statistically significant protective factor for OASIS (OR=0.89-95%CI [0.68-1.16]). The principal independent risk factors for OASIS were nulliparity (ORa=4.19-95%CI [3.03-5.84] - p<0.001), previous caesarean (ORa=5.59-95%CI [3.68-8.44] - p<0.001), uterine fundal height greater than 32cm (ORa=1.35-95%CI [1.03-1.77] - p=0.03), gestational or pre-pregnancy diabetes (ORa=1.76-95%CI [1.22-2.46] - p=0.002), birthweight of more than 3500g (ORa=1.48-95%CI [1.17-1.87] - p=0.001), assisted delivery (ORa=1.81-95%CI [1.18-2.86] - p=0.007), and use of a second instrument or obstetrical manoeuvre (ORa=1.93-95%CI [1.05-3.30] - p=0.02).
    Conclusion: Episiotomy doesn't appear to be a statistically significant protective factor on the perineal prognosis. A deeper understanding of the factors which promote OASIS and greater awareness of them would improve the perineal prognosis of parturient women.
    MeSH term(s) Adult ; Anal Canal/injuries ; Anal Canal/surgery ; Birth Weight/physiology ; Body Mass Index ; Delivery, Obstetric/adverse effects ; Delivery, Obstetric/statistics & numerical data ; Episiotomy/methods ; Episiotomy/statistics & numerical data ; Female ; Humans ; Infant, Newborn ; Lacerations/epidemiology ; Lacerations/etiology ; Lacerations/prevention & control ; Male ; Obstetric Labor Complications/epidemiology ; Obstetric Labor Complications/etiology ; Obstetric Labor Complications/prevention & control ; Parity/physiology ; Perineum/injuries ; Perineum/surgery ; Pregnancy ; Pregnancy Complications/epidemiology ; Pregnancy Complications/surgery ; Prevalence ; Retrospective Studies ; Risk Factors ; Young Adult
    Language English
    Publishing date 2019-07-02
    Publishing country France
    Document type Journal Article
    ISSN 2468-7847
    ISSN (online) 2468-7847
    DOI 10.1016/j.jogoh.2019.07.004
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  8. Article ; Online: Fetoscopic Release of Amniotic Band Syndrome: An Update.

    Minella, Chris / Costantino, Benedicte / Ruano, Rodrigo / Koch, Antoine / Weingertner, Anne-Sophie / Favre, Romain / Sananes, Nicolas

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2020  Volume 40, Issue 5, Page(s) 1039–1048

    Abstract: Amniotic band syndrome is a rare condition. There have been few cases reported of fetoscopic band dissection. The aim of this case series is to report 3 cases of fetoscopic treatment for amniotic band syndrome, including indication for surgery, technical ...

    Abstract Amniotic band syndrome is a rare condition. There have been few cases reported of fetoscopic band dissection. The aim of this case series is to report 3 cases of fetoscopic treatment for amniotic band syndrome, including indication for surgery, technical aspects, complications and outcomes. Fetoscopic treatment was performed respectively at 23
    MeSH term(s) Amniotic Band Syndrome/diagnostic imaging ; Amniotic Band Syndrome/surgery ; Female ; Fetofetal Transfusion/surgery ; Fetoscopy ; Gestational Age ; Humans ; Infant, Newborn ; Laser Therapy ; Pregnancy
    Language English
    Publishing date 2020-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.15480
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  9. Article ; Online: Usefulness of diffusion-weighted imaging for diagnosis of adrenal ischemia during pregnancy: a preliminary report.

    Molière, Sébastien / Gaudineau, Adrien / Koch, Antoine / Leroi, Thomas / Roedlich, Marie-Noelle / Veillon, Francis

    Emergency radiology

    2017  Volume 24, Issue 6, Page(s) 705–708

    Abstract: This case report aims to illustrate the clinical usefulness of diffusion-weighted imaging for diagnosis of bilateral adrenal ischemia during pregnancy. We also provide a retrospective analysis of adrenal gland diffusion data in a control group of 12 ... ...

    Abstract This case report aims to illustrate the clinical usefulness of diffusion-weighted imaging for diagnosis of bilateral adrenal ischemia during pregnancy. We also provide a retrospective analysis of adrenal gland diffusion data in a control group of 12 pregnant women with no adrenal dysfunction, to assess the normal range of apparent diffusion coefficient of adrenal gland during pregnancy.
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1425144-9
    ISSN 1438-1435 ; 1070-3004
    ISSN (online) 1438-1435
    ISSN 1070-3004
    DOI 10.1007/s10140-017-1530-6
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  10. Article ; Online: Evaluation of Sequential Urine Analysis when Selecting Candidates for Vesicoamniotic Shunting in Lower Urinary Tract Obstruction.

    Koch, Antoine / Favre, Romain / Weingertner, Anne-Sophie / Zaloszyc, Ariane / Kohler, Monique / Guerra, Fernando / Rosenblatt, Jonathan / Muller, Françoise / Dreux, Sophie / Sananès, Nicolas

    Fetal diagnosis and therapy

    2021  Volume 48, Issue 4, Page(s) 265–271

    Abstract: Objective: The objective of our study was to assess the utility of sequential fetal urine analysis in severe lower urinary tract obstruction (LUTO) when selecting cases suitable for vesicoamniotic shunting.: Material and methods: This was a ... ...

    Abstract Objective: The objective of our study was to assess the utility of sequential fetal urine analysis in severe lower urinary tract obstruction (LUTO) when selecting cases suitable for vesicoamniotic shunting.
    Material and methods: This was a retrospective cohort study of cases of severe LUTO treated in our fetal medicine center from 1994 to 2013. Two fetal bladder samples were taken 24-48 h apart to assess renal function. A vesicoamniotic shunt was inserted in case of improvement in urinary biochemistry between the 2 samples. We assessed perinatal morbidity and mortality and renal function at 5 years.
    Results: Among a total of 26 LUTO cases with sequential urine analysis, 5 showed normal urinary biochemistry, 13 were abnormal, and 8 improved between the 2 samples. These 8 cases underwent vesicoamniotic shunt placement, leading to the birth of 6/8 (75%) live infants, 5/6 (83%) of whom had normal renal function at 5 years. The 5 cases with normal biochemistry occasioned 2 neonatal deaths and 3 children with normal renal function at 5 years. Elective termination of pregnancy was requested by parents for the fetuses exhibiting abnormal biochemistry.
    Conclusion: An improvement in urinary biochemistry between 2 sequential fetal bladder punctures in severe LUTO could be an effective criterion in the selection of candidates for vesicoamniotic shunting. However, the benefit of a shunt in fetuses with normal amniotic fluid remains to be evaluated in clinical trials.
    MeSH term(s) Amniotic Fluid ; Child ; Female ; Fetal Diseases/diagnostic imaging ; Fetal Diseases/surgery ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Retrospective Studies ; Ultrasonography, Prenatal ; Urethral Obstruction/diagnostic imaging ; Urethral Obstruction/surgery
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1066460-9
    ISSN 1421-9964 ; 1015-3837
    ISSN (online) 1421-9964
    ISSN 1015-3837
    DOI 10.1159/000514911
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