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  1. Book ; Online: Kidney Inflammation, Injury and Regeneration 2020

    Baer, Patrick C. / Koch, Benjamin / Geiger, Helmut

    2021  

    Keywords Medicine ; inflammation ; chronic kidney disease ; anemia ; anemia of inflammation ; ESA hyporesponsiveness ; renal tubular epithelial cells ; macrophages ; lipocalin-2 ; iron ; cilastatin ; hypoxia inducible factor-1-α ; ischemia-reperfusion injury ; acute kidney injury ; cyclophilin A ; fibrosis ; renal fibrosis ; tubular necrosis ; preeclampsia ; podocytes ; VEGF ; FSGS ; proteinuria ; endocan ; ESM-1 ; renal replacement therapy ; kidney transplantation ; biomarker ; diabetic nephropathy ; focal segmental glomerulosclerosis ; innate immunity ; membranous nephropathy ; minimal change diseases ; TLR ; NOX1 ; ML171 ; reactive oxygen species ; ERK ; T cells ; glomerulonephritis ; chemokines ; renal disease ; DJ-1 ; ND-13 ; renal inflammation ; oxidative stress ; UUO ; autophagy ; apoptosis ; trehalose ; simvastatin ; endotoxin ; tubular apoptosis ; cytochrome C ; Bcl-XL ; survivin ; hypercholesterolemia ; xanthine oxidase ; NF-κB pathway ; tertiary lymphoid organs ; B cells ; BAFF ; kidney fibrosis ; myofibroblast activation ; extracellular matrix ; Hippo pathway ; verteporfin ; IgAN ; CKD ; progression ; ACEI ; corticosteroids ; costimulation ; coinhibition ; kidney transplant ; SPR ; protein binding affinity ; adaptive immunity ; epithelial-to-mesenchymal transition ; E. cava extracts ; dieckol ; spontaneously hypertensive rats ; angiotensin II ; n/a
    Size 1 electronic resource (318 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289604
    ISBN 9783036523699 ; 3036523693
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Kidney inflammation, injury and regeneration

    Baer, Patrick C. / Koch, Benjamin / Geiger, Helmut

    2020  

    Author's details Patrick Baer, Benjamin Koch, Helmut Geiger (Eds.)
    Language English
    Size 1 Online-Ressource (496 Seiten), Illustrationen
    Publisher MDPI
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT020566091
    ISBN 978-3-03928-538-9 ; 3-03928-538-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Kidney Inflammation, Injury and Regeneration

    Baer, Patrick C. / Koch, Benjamin / Geiger, Helmut

    2020  

    Abstract: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may ... ...

    Abstract Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets
    Keywords Medicine (General) ; Internal medicine
    Size 1 electronic resource (496 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020589452
    ISBN 9783039285389 ; 9783039285396 ; 3039285386 ; 3039285394
    DOI 10.3390/books978-3-03928-539-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: SARS-CoV-2 and human retroelements: a case for molecular mimicry?

    Koch, Benjamin Florian

    BMC genomic data

    2022  Volume 23, Issue 1, Page(s) 27

    Abstract: Background: The factors driving the late phase of COVID-19 are still poorly understood. However, autoimmunity is an evolving theme in COVID-19's pathogenesis. Additionally, deregulation of human retroelements (RE) is found in many viral infections, and ... ...

    Abstract Background: The factors driving the late phase of COVID-19 are still poorly understood. However, autoimmunity is an evolving theme in COVID-19's pathogenesis. Additionally, deregulation of human retroelements (RE) is found in many viral infections, and has also been reported in COVID-19.
    Results: Unexpectedly, coronaviruses (CoV) - including SARS-CoV-2 - harbour many RE-identical sequences (up to 35 base pairs), and some of these sequences are part of SARS-CoV-2 epitopes associated to COVID-19 severity. Furthermore, RE are expressed in healthy controls and human cells and become deregulated after SARS-CoV-2 infection, showing mainly changes in long interspersed nuclear element (LINE1) expression, but also in endogenous retroviruses.
    Conclusion: CoV and human RE share coding sequences, which are targeted by antibodies in COVID-19 and thus could induce an autoimmune loop by molecular mimicry.
    MeSH term(s) COVID-19 ; Epitopes ; Humans ; Molecular Mimicry ; Retroelements/genetics ; SARS-CoV-2/genetics
    Chemical Substances Epitopes ; Retroelements
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2730-6844
    ISSN (online) 2730-6844
    DOI 10.1186/s12863-022-01040-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Socioeconomic Behaviour and Foreign Policy Changes by International Law

    Koch, Benjamin [Verfasser]

    Impacts on Economic Growth Factors

    2023  

    Author's details Benjamin Koch
    Keywords Wirtschaft ; Economics
    Subject code sg330
    Language English
    Publisher epubli
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    ISBN 978-3-7584-4031-1 ; 3-7584-4031-9
    Database Digital theses on the web

    Full text online

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  6. Book ; Online ; Thesis: Unraveling the Neurobiological Correlates of Trauma and Resilience

    Koch, Benjamin [Verfasser]

    A Comprehensive Investigation

    2023  

    Author's details Benjamin Koch
    Keywords Psychologie ; Psychology
    Subject code sg150
    Language English
    Publisher epubli
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    ISBN 978-3-7584-4055-7 ; 3-7584-4055-6
    Database Digital theses on the web

    Full text online

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  7. Article ; Online: SARS-CoV-2 and human retroelements: a case for molecular mimicry?

    Koch, Benjamin Florian

    BMC Genom Data. 2022 Dec., v. 23, no. 1 p.27-27

    2022  

    Abstract: BACKGROUND: The factors driving the late phase of COVID-19 are still poorly understood. However, autoimmunity is an evolving theme in COVID-19’s pathogenesis. Additionally, deregulation of human retroelements (RE) is found in many viral infections, and ... ...

    Abstract BACKGROUND: The factors driving the late phase of COVID-19 are still poorly understood. However, autoimmunity is an evolving theme in COVID-19’s pathogenesis. Additionally, deregulation of human retroelements (RE) is found in many viral infections, and has also been reported in COVID-19. RESULTS: Unexpectedly, coronaviruses (CoV) – including SARS-CoV-2 – harbour many RE-identical sequences (up to 35 base pairs), and some of these sequences are part of SARS-CoV-2 epitopes associated to COVID-19 severity. Furthermore, RE are expressed in healthy controls and human cells and become deregulated after SARS-CoV-2 infection, showing mainly changes in long interspersed nuclear element (LINE1) expression, but also in endogenous retroviruses. CONCLUSION: CoV and human RE share coding sequences, which are targeted by antibodies in COVID-19 and thus could induce an autoimmune loop by molecular mimicry.
    Keywords COVID-19 infection ; Retroviridae ; Severe acute respiratory syndrome coronavirus 2 ; autoimmunity ; epitopes ; humans ; molecular mimicry ; pathogenesis
    Language English
    Dates of publication 2022-12
    Size p. 27.
    Publishing place BioMed Central
    Document type Article ; Online
    ISSN 2730-6844
    DOI 10.1186/s12863-022-01040-2
    Database NAL-Catalogue (AGRICOLA)

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  8. Book ; Online: Polarization-Dependent Loss of Optical Connectors Measured with High Accuracy (<0.004 dB) after Cancelation of Polarimetric Errors

    Noe, Reinhold / Koch, Benjamin

    2022  

    Abstract: State-of-the-art polarimeter calibration is reviewed. Producing many quasi-random polarization states and moving/bending a fiber without changing power allows finding a polarimeter calibration where the degree-of-polarization reaches unity and parasitic ... ...

    Abstract State-of-the-art polarimeter calibration is reviewed. Producing many quasi-random polarization states and moving/bending a fiber without changing power allows finding a polarimeter calibration where the degree-of-polarization reaches unity and parasitic polarization-dependent loss is small. Using a polarization scrambler/transformer and a polarimeter a device-under-test can be characterized. Its Mueller matrix can be decomposed into a product of a nondepolarizing Mueller-Jones matrix times a purely depolarizing Mueller matrix. Test polarizations may drift over time. With help of an optical switch the reference device can be measured against an internal reference path. Later, with possibly different test polarizations, the actual device-under-test is measured against the internal reference. Polarization drift and need for repeated reference device measurement are thus overcome. When a patchcord is inserted, connector PDL can be measured, provided that errors are calibrated away, again by fiber moving/bending. Experimentally we have measured PDL with errors <0.004 dB. This easily suffices to measure connector PDL, which is demonstrated. PDL >60 dB was measured when the device under test was a good polarizer. A 20 Mrad/s polarization scrambler with LiNbO3 device generates the test polarizations. The polarimeter can sample at 100 MHz and can store 64M Stokes vectors. During laser frequency scans Mueller matrices can be measured in time intervals as short as 5 us.

    Comment: 8 pages, 5 figures
    Keywords Physics - Optics ; Electrical Engineering and Systems Science - Signal Processing
    Subject code 600 ; 621
    Publishing date 2022-06-28
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Book: Übergewicht im Kindes- und Jugendalter

    Joisten, Christine / Dordel, Sigrid / Koch, Benjamin

    ein ganzheitliches Betreuungskonzept

    2009  

    Author's details Christine Graf, Sigrid Dordel, Benjamin Koch
    Keywords Kind ; Übergewicht ; Bewegungstherapie ; Jugend
    Subject Kinesiotherapie ; Mototherapie ; Trainingstherapie ; Funktionelle Bewegungstherapie ; Jugend ; Jugendalter ; Jugendlicher ; Teenager ; Kindheit ; Kindesalter ; Kindschaft ; Kinder
    Language German
    Size 200 S. : Ill.
    Publisher Verl. Modernes lernen
    Publishing place Dortmund
    Publishing country Germany
    Document type Book
    Accompanying material 1 CD-ROM
    HBZ-ID HT015843866
    ISBN 978-3-8080-0621-4 ; 3-8080-0621-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 C 105 order for loan Magazin
    2009 MO 774 <<[Begleitmaterial]>> order for loan Magazin

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  10. Article ; Online: Gliflozins Have an Anti-Inflammatory Effect on Renal Proximal Tubular Epithelial Cells in a Diabetic and Inflammatory Microenvironment In Vitro.

    Koch, Benjamin / Fuhrmann, Dominik C / Schubert, Ralf / Geiger, Helmut / Speer, Thimoteus / Baer, Patrick C

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Inflammation is intimately involved in the pathogenesis of diabetic kidney disease. Inhibition of SGLT-2 by a specific class of drugs, gliflozins, has been shown to reduce inflammation and attenuate the progression of diabetic nephropathy, in addition to ...

    Abstract Inflammation is intimately involved in the pathogenesis of diabetic kidney disease. Inhibition of SGLT-2 by a specific class of drugs, gliflozins, has been shown to reduce inflammation and attenuate the progression of diabetic nephropathy, in addition to its main effect of inhibiting renal glucose reabsorption. We used highly purified human renal proximal tubular epithelial cells (PTCs) as an in vitro model to study the cellular response to a diabetic (high glucose) and inflammatory (cytokines) microenvironment and the effect of gliflozins. In this context, we investigated the influence of SGLT-2 inhibition by empa- and dapagliflozin (500 nM) on the expression of pro-inflammatory factors (IL-1β, IL-6, TNF-α, MCP-1, and ICAM-1). The results clearly indicate an anti-inflammatory effect of both gliflozins. Although induced expression of the four cytokines was only slightly attenuated, there was a clear effect on the expression of the adhesion molecule ICAM-1, a master regulator of cellular responses in inflammation and injury resolution. The induced expression of ICAM-1 mRNA was significantly reduced by approximately 13.5% by empagliflozin and also showed an inhibitory trend with dapagliflozin. However, induced ICAM-1 protein expression was significantly inhibited from 24.71 ± 1.0 ng/mL to 18.81 ± 3.9 (empagliflozin) and 19.62 ± 2.1 ng/mL (dapagliflozin). In conclusion, an additional anti-inflammatory effect of empa- and dapagliflozin in therapeutically observed concentrations was demonstrated in primary human PTCs in vitro.
    MeSH term(s) Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Intercellular Adhesion Molecule-1/genetics ; Intercellular Adhesion Molecule-1/metabolism ; Diabetic Nephropathies/metabolism ; Glucose/metabolism ; Epithelial Cells/metabolism ; Inflammation/metabolism ; Cytokines/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Diabetes Mellitus/metabolism
    Chemical Substances empagliflozin (HDC1R2M35U) ; Sodium-Glucose Transporter 2 Inhibitors ; dapagliflozin (1ULL0QJ8UC) ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Glucose (IY9XDZ35W2) ; Cytokines ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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