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  1. Book ; Thesis: Aussagekraft entwicklungsneurologischer Daten im frühen Kindesalter und späteres Outcome bei Hochrisikofrühgeborenen

    Koch, Till-Dominik

    2006  

    Author's details vorgelegt von Till-Dominik Koch
    Language German
    Size 94, [11] S. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2006
    HBZ-ID HT015050871
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 D 526 order for loan Magazin

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  2. Article ; Online: Endocarditis guidelines: call for an interdisciplinary approach.

    Koch, Till / Hennigs, Annette / Schmiedel, Stefan

    The Lancet. Infectious diseases

    2023  Volume 24, Issue 2, Page(s) e75

    MeSH term(s) Humans ; Endocarditis/therapy ; Endocarditis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00748-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The COVID-19 Vaccine Landscape.

    Koch, Till / Fathi, Anahita / Addo, Marylyn M

    Advances in experimental medicine and biology

    2021  Volume 1318, Page(s) 549–573

    Abstract: The history of vaccine development spans centuries. At first, whole pathogens were used as vaccine agents, either inactivated or attenuated, to reduce virulence in humans. Safety and tolerability were increased by including only specific proteins as ... ...

    Abstract The history of vaccine development spans centuries. At first, whole pathogens were used as vaccine agents, either inactivated or attenuated, to reduce virulence in humans. Safety and tolerability were increased by including only specific proteins as antigens and using cell culture methods, while novel vaccine strategies, like nucleic acid- or vector-based vaccines, hold high promise for the future. Vaccines have generally not been employed as the primary tools in outbreak response, but this might change since advances in medical technology in the last decades have made the concept of developing vaccines against novel pathogens a realistic strategy. Wandering the uncharted territory of a novel pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we can learn from other human Betacoronaviridae that emerged in the last decades, SARS-CoV-1 and MERS-CoV. We can identify the most likely target structures of immunity, establish animal models that emulate human disease and immunity as closely as possible, and learn about complex mechanisms of immune interaction such as cross-reactivity or antibody-dependent enhancement (ADE). However, significant knowledge gaps remain. What are the correlates of protection? How do we best induce immunity in vulnerable populations like the elderly? Will the immunity induced by vaccination (or by natural infection) wane over time? To date, at least 149 vaccine candidates against SARS-CoV-2 are under development. At the time of writing, at least 17 candidates have already progressed past preclinical studies (in vitro models and in vivo animal experiments) into clinical development. This chapter will provide an overview of this rapidly developing field.
    MeSH term(s) Aged ; Animals ; COVID-19 ; COVID-19 Vaccines ; Humans ; Middle East Respiratory Syndrome Coronavirus ; SARS-CoV-2 ; Vaccines ; Viral Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines ; Viral Vaccines
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-63761-3_31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early neuroborreliosis with leg paresis mimicking herpes zoster.

    Tegtmeyer, Jonathan / Abeck, Finn / Matthews, Hanna / Christolouka, Maria / Kött, Julian / Schmiedel, Stefan / Schneider, Stefan W / Koch, Till

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 38, Issue 4, Page(s) e329–e330

    MeSH term(s) Humans ; Leg ; Herpes Zoster/complications ; Herpes Zoster/diagnosis ; Herpesvirus 3, Human ; Paresis/diagnosis ; Paresis/etiology ; Nervous System Diseases
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3492: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 413: Show issues

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  5. Book ; Online ; Thesis: Indirect effector mechanisms on antibodies in hemodialysis patients

    Koch, Till Jakob

    2015  

    Title variant Indirekte Effektormechanismen von Antikörpern in Hämodialysepatienten
    Author's details Till Jakob Koch
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Diss.--Kiel,Univ., 2015
    Database Former special subject collection: coastal and deep sea fishing

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  6. Article: Correlates of Vaccine-Induced Protection against SARS-CoV-2.

    Koch, Till / Mellinghoff, Sibylle C / Shamsrizi, Parichehr / Addo, Marylyn M / Dahlke, Christine

    Vaccines

    2021  Volume 9, Issue 3

    Abstract: We are in the midst of a pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). SARS-CoV-2 has caused more than two million deaths after one year of the pandemic. ... ...

    Abstract We are in the midst of a pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). SARS-CoV-2 has caused more than two million deaths after one year of the pandemic. The world is experiencing a deep economic recession. Safe and effective vaccines are needed to prevent further morbidity and mortality. Vaccine candidates against COVID-19 have been developed at an unprecedented speed, with more than 200 vaccine candidates currently under investigation. Among those, 20 candidates have entered the clinical Phase 3 to evaluate efficacy, and three have been approved by the European Medicines Agency. The aim of immunization is to act against infection, disease and/or transmission. However, the measurement of vaccine efficacy is challenging, as efficacy trials need to include large cohorts with verum and placebo cohorts. In the future, this will be even more challenging as further vaccine candidates will receive approval, an increasing number of humans will receive vaccinations and incidence might decrease. To evaluate novel and second-generation vaccine candidates, randomized placebo-controlled trials might not be appropriate anymore. Correlates of protection (CoP) could be an important tool to evaluate novel vaccine candidates, but vaccine-induced CoP have not been clearly defined for SARS-CoV-2 vaccines. In this review, we report on immunogenicity against natural SARS-CoV-2 infection, vaccine-induced immune responses and discuss immunological markers that can be linked to protection. By discussing the immunogenicity and efficacy of forerunner vaccines, we aim to give a comprehensive overview of possible efficacy measures and CoP.
    Language English
    Publishing date 2021-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9030238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: Über das Risiko einer Kolonisation mit Methicillin resistentem Staphylococcus aureus bei Auslandsreisenden

    Tran, Dai Ton Verfasser] / Koch, Till [Akademischer Betreuer] / [Addo, Marylyn M. [Akademischer Betreuer]

    2021  

    Author's details Dai Ton Tran ; Till Koch, Marylyn Addo
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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    Inter-library loan at ZB MED

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  8. Book ; Online ; Thesis: Indirect effector mechanisms on antibodies in hemodialysis patients

    Koch, Till Jakob [Verfasser]

    2015  

    Author's details Till Jakob Koch
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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    Inter-library loan at ZB MED

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  9. Article ; Online: Prospective Single-Center Cohort Study on HIV Pre-exposure Prophylaxis Reveals Transient but Relevant Elevations in Transaminase Levels in Some Participants Albeit Otherwise High Tolerability.

    Weimann, Lukas / Schäfer, Guido / Matthews, Hanna / Florey, Maria / Scheiter, Robin / Hüfner, Anja / Jordan, Sabine / Grenz, Marc / Schmiedel, Stefan / Schulze Zur Wiesch, Julian / Degen, Olaf / Koch, Till

    Journal of acquired immune deficiency syndromes (1999)

    2023  Volume 93, Issue 1, Page(s) e1–e3

    MeSH term(s) Humans ; Male ; HIV Infections/drug therapy ; Cohort Studies ; Prospective Studies ; Transaminases ; Pre-Exposure Prophylaxis ; Anti-HIV Agents/therapeutic use ; Homosexuality, Male
    Chemical Substances Transaminases (EC 2.6.1.-) ; Anti-HIV Agents
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Letter
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: High burden of RSV and influenza in patients presenting with suspected pneumonia in the emergency room of a German tertiary hospital in fall of 2022.

    Ettemeyer, Marlene / Florey, Maria / Tanida, Konstantin / Jochum, Johannes / Schulze-Sturm, Ulf / Lütgehetmann, Marc / Baehr, Michael / Addo, Marylyn M / Schmiedel, Stefan / Rohde, Holger / Koch, Till

    Infection

    2023  Volume 51, Issue 5, Page(s) 1569–1575

    Abstract: Purpose: Bacterial pneumonia, a major cause of respiratory tract infections (RTI), can be challenging to diagnose and to treat adequately, especially when seasonal viral pathogens co-circulate. The aim of this study was to give a real-world snapshot of ... ...

    Abstract Purpose: Bacterial pneumonia, a major cause of respiratory tract infections (RTI), can be challenging to diagnose and to treat adequately, especially when seasonal viral pathogens co-circulate. The aim of this study was to give a real-world snapshot of the burden of respiratory disease and treatment choices in the emergency department (ED) of a tertiary care hospital in Germany in the fall of 2022.
    Methods: Anonymized analysis of a quality control initiative that prospectively documented all patients presenting to our ED with symptoms suggestive of RTI from Nov 7th to Dec 18th, 2022.
    Results: 243 patients were followed at the time of their ED attendance. Clinical, laboratory and radiographic examination was performed in 92% of patients (224/243). Microbiological work-up to identify causative pathogens including blood cultures, sputum or urine-antigen tests were performed in 55% of patients (n = 134). Detection of viral pathogens increased during the study period from 7 to 31 cases per week, while bacterial pneumonias, respiratory tract infections without detection of a viral pathogen and non-infectious etiologies remained stable. A high burden of bacterial and viral co-infections became apparent (16%, 38/243), and co-administration of antibiotic and antiviral treatments was observed (14%, n = 35/243). 17% of patients (41/243) received antibiotic coverage without a diagnosis of a bacterial etiology.
    Conclusion: During the fall of 2022, the burden of RTI caused by detectable viral pathogens increased unusually early. Rapid and unexpected changes in pathogen distribution highlight the need for targeted diagnostics to improve the quality of RTI management in the ED.
    MeSH term(s) Humans ; Influenza, Human/diagnosis ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Tertiary Care Centers ; Seasons ; Virus Diseases/diagnosis ; Respiratory Tract Infections/drug therapy ; Pneumonia, Bacterial ; Anti-Bacterial Agents/therapeutic use ; Emergency Service, Hospital
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-023-02069-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 881: Show issues Location:
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    Zs.MO 528: Show issues

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